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14篇 您的检索式：作者名="Sutherland James"

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		题名	作者	年代	出处	被引量
	1	A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance显示文摘	Eva van Rooij Daniel Quiat Brett A. Johnson Lillian B. Sutherland Xiaoxia Qi James A. Richardson Robert J. Kelm Eric N. Olson	2009	Developmental Cell2009，，5：	2
	2	The nature of scour development and scour protection at offshore wind farm foundations 显示文摘	Whitehouse Richard J S Harris John M Sutherland James	2011	Marine Pollution Bulletin2011，62，1：	1
	3	Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction显示文摘	Eric M. Small Jeffrey E. Thatcher Lillian B. Sutherland Hideyuki Kinoshita Robert D. Gerard James A. Richardson J. Michael DiMaio Hesham Sadek Koichiro Kuwahara Eric N. Olson		Circulation Research0，，：	1
	4	Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation显示文摘	May Kung Sutherland James C. Geoghegan Changpu Yu Eileen Turcott John E. Skonier David G. Winkler John A. Latham	2004	Bone2004，，4：	1
	5	How to detect early left atrial remodelling and dysfunction in mild-to-moderate hypertension显示文摘	Aigul Baltabaeva Maciej Marciniak Bart Bijnens Chirine Parsai James Moggridge Tarek F Antonios Graham A MacGregor George R Sutherland	2009	Journal of Hypertension2009，，10：	1
	6	2-Methoxyestradiol – a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents显示文摘	Tara E. Sutherland Robin L. Anderson Richard A. Hughes Emile Altmann Michael Schuliga James Ziogas Alastair G. Stewart	2007	Drug Discovery Today2007，，13：	1
	7	Surveillance of HIV drug resistance transmission in Iran: experience gained from a pilot study显示文摘	Seyed Mohsen Mousavi Rasool Hamkar Mohammad Mehdi Gouya Afshin Safaie Seyed Mohsen Zahraei Zinab Yazdani Somayeh Asbaghi Namini Silvia Bertagnolio Donald Sutherland Paul Sandstrom James Brooks	2010	Archives of Virology2010，，3：	1
	8	Early induction of aatophagy inhuman fibroblasts after Infection with Human Cytomegalovirus or Herpes Simplex Virus 1 显示文摘	Steven McFarlane James Aitken Jane S Sutherland	2011	Journal of Virology2011，85，9：	1
	9	Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery Disease显示文摘	Matthew J. Budoff David Dowe James G. Jollis Michael Gitter John Sutherland Edward Halamert Markus Scherer Raye Bellinger Arthur Martin Robert Benton Augustin Delago James K. Min	2008	Journal of the American College of Cardiology2008，，21：	1
	10	Association of Fibrinogen With Cardiovascular Risk Factors and Cardiovascular Disease in the Framingham Offspring Population显示文摘	James J. Stec Halit Silbershatz Geoffrey H. Tofler Travis H. Matheney Patrice Sutherland Izabela Lipinska Joseph M. Massaro Peter F. W. Wilson James E. Muller Ralph B. D’Agostino	2000	Circulation: Journal of the American Heart Association2000，，14：	1
	11	Long-term omega-3 polyunsaturated fatty acid supplementation reduces the recurrence of persistent atrial fibrillation after electrical cardioversion显示文摘	Saurabh Kumar Fiona Sutherland Joseph B. Morton Geoffrey Lee John Morgan James Wong David E. Eccleston John Voukelatos Manohar L. Garg Paul B. Sparks	2012	Heart Rhythm2012，，：	1
	12	Are there living bacteria in permanently frozen subsoil显示文摘	James N Sutherland M L	1942	Can J Res Sect C Bot Sci1942，20，6：	1
	13	Surveillance of HIV drug resistance transmission in Iran: experience gained from a pilot study显示文摘	Seyed Mohsen Mousavi Rasool Hamkar Mohammad Mehdi Gouya Afshin Safaie Seyed Mohsen Zahraei Zinab Yazdani Somayeh Asbaghi Namini Silvia Bertagnolio Donald Sutherland Paul Sandstrom James Brooks	2010	Archives of Virology2010，，3：	1
	14	Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism显示文摘Alkaptonuria (AKU) is an inherited disorder of tyrosine metabolism caused by lack of active enzyme homogentisate 1,2-dioxygenase (HGD). The primary consequence of HGD deficiency is increased circulating homogentisic acid (HGA), the main agent in the pathology of AKU disease. Here we report the first metabolomic analysis of AKU homozygous Hgd knockout (Hgd−/−) mice to model the wider metabolic effects of Hgd deletion and the implication for AKU in humans. Untargeted metabolic profiling was performed on urine from Hgd−/− AKU (n = 15) and Hgd+/− non-AKU control (n = 14) mice by liquid chromatography high-resolution time-of-flight mass spectrometry (Experiment 1). The metabolites showing alteration in Hgd−/− were further investigated in AKU mice (n = 18) and patients from the UK National AKU Centre (n = 25) at baseline and after treatment with the HGA-lowering agent nitisinone (Experiment 2). A metabolic flux experiment was carried out after administration of 13C-labelled HGA to Hgd−/−(n = 4) and Hgd+/−(n = 4) mice (Experiment 3) to confirm direct association with HGA. Hgd−/− mice showed the expected increase in HGA, together with unexpected alterations in tyrosine, purine and TCA-cycle pathways. Metabolites with the greatest abundance increases in Hgd−/− were HGA and previously unreported sulfate and glucuronide HGA conjugates, these were decreased in mice and patients on nitisinone and shown to be products from HGA by the 13C-labelled HGA tracer. Our findings reveal that increased HGA in AKU undergoes further metabolism by mainly phase II biotransformations. The data advance our understanding of overall tyrosine metabolism, demonstrating how specific metabolic conditions can elucidate hitherto undiscovered pathways in biochemistry and metabolism.	Brendan P.Norman Andrew S.Davison Juliette H.Hughes Hazel Sutherland Peter J.M.Wilson Neil G.Berry Andrew T.Hughes Anna M.Milan Jonathan C.Jarvis Norman B.Roberts Lakshminarayan R.Ranganath George Bou-Gharios James A.Gallagher	2022	Genes & Diseases2022，9，4：	0

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