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| 1 | Systemic treatment strategies for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2(EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. This review evaluates the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubM ed and conference databases was carried out to identify randomised clinical trials reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. Our review identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. TNBC is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to progression-free survival(PFS) without survival benefit in metastatic TNBC. Antiangiogenic agents, tyrosine kinase inhibitors and EGFR inhibitorsin combination with chemotherapy produced only modest gains in PFS and had little impact on survival. TNBC subgroups respond differentially to specific targeted agents. In future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. TNBC being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success. | Budhi Singh Yadav Suresh C Sharma Priyanka Chanana Swaty Jhamb | 2014 | World Journal of Clinical Oncology2014，5，2： | 18 |
| 2 | Identification, occurrence, and validation of DRE and ABRE Cis-regulatory motifs in the promoter regions of genes of Arabidopsis thaliana显示文摘Plants posses a complex co-regulatory network Researchwhich helps them to elicit a response under diverse adverse conditions.We used an in silico approach to identify the genes with both DRE and ABRE motifs in their promoter regions in Arabidopsis thaliana.Our results showed that Arabidopsis contains a set of 2,052 genes with ABRE and DRE motifs in their promoter regions.Approximately 72%or more of the total predicted 2,052 genes had a gap distance of less than 400 bp between DRE and ABRE motifs.For positional orientation of the DRE and ABRE motifs,we found that the DR form(one in direct and the other one in reverse orientation)was more prevalent than other forms.These predicted 2,052 genes include 155 transcription factors.Using microarray data from The Arabidopsis Information Resource(TAIR)database,we present 44 transcription factors out of 155 which are upregulated by more than twofold in response to osmotic stress and ABA treatment.Fifty-one transcripts from the onepredicted above were validated using semiquantitative expression analysis to support the microarray data in TAIR.Taken together,we report a set of genes containing both DRE and ABRE motifs in their promoter regions in A.thaliana,which can be useful to understand the role of ABA under osmotic stress condition. | Sonal Mishra Aparna Shukla Swati Upadhyay Sanchita Pooja Sharma Seema Singh Ujjal J.Phukan Abha Meena Feroz Khan Vineeta Tripathi Rakesh Kumar Shukla Ashok Shrama | 2014 | Journal of Integrative Plant Biology2014，56，4： | 5 |
| 3 | Development of a sensitive and rapid method for quantitation of (S)-(-)- and (R)-(+)-metoprolol in human plasma by chiral LC–ESI–MS/MS显示文摘A selective, sensitive and high throughput liquid chromatography-tandem mass spectrometry(LC–ESI–MS/MS) method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2(250 mm 4.6 mm, 5 mm) column. Solid phase extraction of(S)-()- and(R)-(t)-metoprolol and rac-metoprolol-d6 as an internal standard(IS)was achieved on Lichrosep DVB HL cartridges employing 200 mL human plasma. Both the analytes were chromatographically separated with a resolution factor of 2.24 using 15 mM ammonium acetate in water, pH 5.0 and 0.1%(v/v) diethyl amine in acetonitrile(50:50, v/v) as the mobile phase within 7.0 min. The precursor-product ion transitions for the enantiomers and IS were monitored in the multiple reaction monitoring and positive ionization mode. The method was validated over the concentration range of 0.500–500 ng/mL for both the enantiomers. Matrix effect was assessed by post-column analyte infusion experiment and the mean extraction recovery was greater than 94.0% for both the enantiomers at all quality control levels. The stability of analytes was evaluated in plasma and whole blood under different storage conditions. The method was successfully applied to a clinical study in 14 healthy volunteers after oral administration of200 mg metoprolol tablet under fasting conditions. The assay reproducibility is shown by reanalysis of 68 incurred samples. The suitability of the developed method was assessed in comparison | Primal Sharma Pritesh Contractor Swati Guttikar Daxesh P.Patel Pranav S.Shrivastav | 2014 | Journal of Pharmaceutical Analysis2014，4，1： | 3 |
| 4 | A rabbit model of non- cirrhotic portal hypertension by repeated injections of E. coli through indwelling cannulation of the gastrosplenic vein显示文摘BACKGROUND: Non-cirrhotic portal hypertension is acommon cause of portal hypertension in developing coun-tries. To understand its etiopathogenesis we developed ananimal model by repeated portal endotoxemia inducedthrough the gastrosplenic vein.METHODS: Twenty-nine rabbits (1.5-2.0 kg) were divid-ed into control (group n = 13) and experimental ( groupn = 16) groups. Heat killed E. coli were injected throughan indwelling cannula into the gastrosplenic vein in pre-sensitized animals. The animals were sacriflced at 1, 3 and6 months.RESULTS: The mean portal pressure in group animalswas significantly (P < 0. 05) higher than in group at 1(17.5 ±3.4 vs 10.4±2.2 mmHg), 3 (17.8±1.3 vs7.2 +3.6mmHg), and 6 (19.8±3.1 vs 10.3±4.8 mmHg) months.Similarly, the mean splenic weight in group was signifi-cantly greater than in group (P <0.05). Histopathologi-cally, the spleen showed medullary congestion, hemosid-rin-laden macrophages and mild fibrosis. Histologically,the liver had normal parenchyma with mild portal lympho-cytic infiltrates and kupffer cell hyperplasia. No significantanomalies were detected by liver function tests.CONCLUSIONS: The rabbit model showed significantsplenomegaly with a persistent increase in portal pressureand mild fibrosis without hepatic parenchymal injury, quiteakin to non-cirrhotic portal fibrosis as seen in humans. Re-current intra-abdominal infection may play an importantrole in the pathogenesis of non-cirrhotic portal fibrosis. | Swati Omanwar Moattar R. Rizvi Rachna Kathayat Brij K. Sharma Giryesh K. Pandey Mohammad A. Alam Veena Malhotra Shiv K. Sarin | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 2 |
| 5 | Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma:Experimental and clinical scenarios显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer worldwide.Viral hepatitis is a significant risk factor for HCC,although metabolic syndrome and diabetes are more frequently associated with the HCC.With increasing prevalence,there is expected to be>1 million cases annually by 2025.Therefore,there is an urgent need to establish potential therapeutic targets to cure this disease.Peroxisome-proliferator-activated receptor gamma(PPARγ)is a ligand-activated transcription factor that plays a crucial role in the pathophysiology of HCC.Many synthetic agonists of PPARγsuppress HCC in experimental studies and clinical trials.These synthetic agonists have shown promising results by inducing cell cycle arrest and apoptosis in HCC cells and preventing the invasion and metastasis of HCC.However,some synthetic agonists also pose severe side effects in addition to their therapeutic efficacy.Thus natural PPARγagonists can be an alternative to exploit this potential target for HCC treatment.In this review,the regulatory role of PPARγin the pathogenesis of HCC is elucidated.Furthermore,the experimental and clinical scenario of both synthetic and natural PPARγagonists against HCC is discussed.Most of the available literature advocates PPARγas a potential therapeutic target for the treatment of HCC. | Swati Katoch Vinesh Sharma Vikram Patial | 2022 | World Journal of Gastroenterology2022，28，28： | 2 |
| 6 | Ex- traction and identification of pentacyclic compound β- Amyrin (Terpenoid) 显示文摘 | Swati Sharma Rekha Vijayvergia Tribhuwan Singh | 2010 | Archives of Applied Science Re- search2010，2，2： | 1 |
| 7 | Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction显示文摘BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac biomarkers.Rapid restoration of brisk flow in the coronary vasculature is critical in reducing mortality and morbidity.In patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective option.AIM To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after thrombolysis.METHODS This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary arteries.Patients received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another group.The primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the procedure.The secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 d.RESULTS The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,respectively.Smoking rate was 54.6%and 55.8%in the routine and delayed groups,respectively.Thrombolysis was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,respectively.No significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reported MACCE in the two groups did not demonstrate any significant correlation.Secondary endpoints such as angina,dyspnea,and major bleeding were non-significantly different between the two groups.CONCLUSION Delayed PCI pharmacoinvasive strategy in a critical diseased but not completely occluded artery beyond 24 h in patients who have been timely thrombolyzed seems a reasonable strategy. | Rishi Sethi Lalit Mohan Pravesh Vishwakarma Abhishek Singh Swati Sharma Monika Bhandari Ayush Shukla Akhil Sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi | 2023 | World Journal of Cardiology2023，15，1： | 1 |
| 8 | Evaluation of Cytotoxic Effects of Bevacizumab on Human Corneal Cells显示文摘 | Kakarla V Shalam Swati Agarwal Vikram S Brar Ravi K Murthy Rajesh K Sharma | 2009 | Cornea2009，，3： | 1 |
| 9 | An amperometric biosensor based on laccase immobilized onto nickel nanoparticles/carboxylated multiwalled carbon nanotubes/polyaniline modified gold electrode for determination of phenolic content in fruit juices显示文摘 | Sheetal Chawla Rachna Rawal Swati Sharma | 2012 | Biochemical Engineering Journal2012，68，15： | 1 |
| 10 | ERCC1 expression is a predictor otsurvival in resected patients with non small cell lung cancer显示文摘 | George RS Swati Sharma Alan Cantor | 2005 | Chest2005，127，： | 1 |
| 11 | Efficacy and Safety of Tacrolimus Versus Cyclosporine in Children With Steroid-Resistant Nephrotic Syndrome: A Randomized Controlled Trial显示文摘 | Swati Choudhry Arvind Bagga Pankaj Hari Sonika Sharma Mani Kalaivani Amit Dinda | 2009 | American Journal of Kidney Diseases2009，，5： | 1 |
| 12 | Bioprospection of marine actinomycetes: recent advances,challenges and future perspectives显示文摘In exploring new sources for economically important products, marine environment draws particular attention because of its remarkable diversity and extreme conditions;it is known to produce metabolic products of great value. It represents untapped source for the discovery of novel secondary metabolites with varying potential such as antibiotic, anti-tumor, antifouling and cytotoxic properties. Marine actinomycetes distributed throughout the marine environment from shallow to deep sea sediments have proved to be a finest source for this discovery. Secondary metabolites derived from marine actinomycetes have proved their worth in industries based on the research on their properties and wide range applications. Spotlight of the review is range of marine based actinomycetes products and significant research in this field. This shows the capability of marine actinomycetes as bioactive metabolite producers. Additionally, the present review addresses some effective and novel approaches of procuring marine microbial compounds utilizing the latest screening strategies of drug discovery from which traditional resources such as marine actinobacteria has decreased due to declining yields. The aim is in the context of promoting fruitful and profitable results in the near future. The recent surfacing of new technologies for bioprospection of marine actinomycetes are very promising, resulting in high quality value added products, and will be de?ning a new era for bioactive compounds with medical and biotechnological applications. | Swati Sharma Abhay B. Fulke Asha Chaubey | 2019 | Acta Oceanologica Sinica2019，38，6： | 1 |
| 13 | A new proxy blind signature scheme based on DLP显示文摘 | Swati Verma Birendra Kumar Sharma | 2012 | International Journal of Information&Network Security2012，1，2： | 1 |
| 14 | RRM1 modulated in vitro and in vivo efficacy of gemcitabine and plati- num in non -small cell lung cancer显示文摘 | Gerold Bepler Irina Kusmartseva Swati Sharma | 2006 | J C!in Oncol2006，24，： | 1 |
| 15 | RRM1 and PTEN as prognostic for overall and disease - free survival in pa- tients with non - small - cell lung cancer 显示文摘 | Gerold Bep|er Swati Sharma Man Cantor | 2004 | J Clin Oncol2004，22，： | 1 |
| 16 | Measurement techniques for GHG emission from hydropower Reservoirs 显示文摘 | Swati K Sharma M P Arun K | 2012 | International Journal of Energy Science2012，2，6： | 1 |
| 17 | In- spiring Children as Storytellers in India 显示文摘 | Ameena Batada Ira Joshi Garima Sharma Swati Mehta | 2010 | Yong children november2010，65，6： | 1 |
| 18 | Maternal serum interleukin-6 and its association with clinicopathological infectious morbidity in preterm premature rupture of membranes: a prospective cohort study显示文摘 | Shilpa Gulati Swati Agrawal Chitra Raghunandan Jayashree Bhattacharya Arvind Saili Shilpi Agarwal Deepika Sharma | 2012 | Journal of Maternal-Fetal and Neonatal Medicine2012，，： | 1 |
| 19 | Laser-induced hierarchical carbon patterns on polyimide substrates for flexible urea sensors显示文摘Thermochemical decomposition of organic materials under heat-treatment in the absence of oxygen,known as the pyrolysis process,is often employed to convert micro and nano patterned polymers into carbon structures,which are subsequently used as device components.Pyrolysis is performed at≥900℃,which entails substrate materials with a high thermal stability that excludes flexible,polymeric substrates.We use optimized laser radiation to pattern graphitic carbon structures onto commercially available polyimide(Kapton)sheets in the micrometer to millimeter scale by inducing a localized,rapid pyrolysis,for the fabrication of flexible devices.Resulting laser carbon films are electrically conductive and exhibit a high-surface area with a hierarchical porosity distribution along their cross-section.The material is obtained using various combinations of laser parameters and pyrolysis environment(oxygen-containing and inert).Extensive characterization of laser carbon is performed to understand the correlation between the material properties and laser parameters,primarily fluence and power.A photothermal carbonization mechanism based on the plume formation is proposed.Further,laser carbon is used for the fabrication of enzymatic,pH-based urea sensors using two approaches:(i)direct urease enzyme immobilization onto carbon and(ii)electrodeposition of an intermediate chitosan layer prior to urease immobilization.This flexible sensor is tested for quantitative urea detection down to 10^(−4) M concentrations,while a qualitative,color-indicative test is performed on a folded sensor placed inside a tube to demonstrate its compatibility with catheters.Laser carbon is suitable for a variety of other flexible electronics and sensors,can be conveniently integrated with an external circuitry,heating elements,and with other microfabrication techniques such as fluidic platforms. | Emil R.Mamleyev Stefan Heissler Alexei Nefedov Peter G.Weidler Nurdiana Nordin Vladislav V.Kudryashov Kerstin Länge Neil MacKinnon Swati Sharma | 2019 | npj Flexible Electronics2019，3，1： | 0 |
| 20 | Physico-functional evaluation,process optimization and economic analysis for preparation of muffin premix using apple pomace as novel supplement显示文摘Apple pomace is a rich source of dietary fiber that can be easily incorporated in bakery products to enhance the nutritional quality of the product.In the present study,apple pomace powder was utilized for formulating fiber-enriched muffin pre-mix.Apple pomace powder(APP)was supplemented in refined wheat flour at different concentration and 33%was found highly acceptable by the sensory panelists on a 9 point hedonic scale.Samples were analyzed for proximate composition,functional properties(water holding,swelling,foaming and emulsion),phenolic content and calorific value.Storage study of polyethylene and aluminium laminate pouch(ALP)packed fiber-enriched muffin pre-mix was also conducted for six months at ambient conditions.Cost evaluation showed that the cost of APP-based pre-mix was comparable to conventional wheat-based pre-mix.Results of this study support the possibility of producing high-fiber muffin pre-mix with desirable quality and quantity in a sustainable manner. | Taru Negi Devina Vaidya Ayon Tarafdar Shubham Samkaria Nilakshi Chauhan Swati Sharma Ranjna Sirohi | 2021 | Systems Microbiology and Biomanufacturing2021，1，3： | 0 |
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