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| 1 | 氧自由基清除剂对砷所致细胞DNA损伤的保护作用显示文摘目的 探讨砷引起细胞 DNA损伤和细胞毒性的机理。方法 用羟基自由基 (· OH/OH- )清除剂DMSO和过氧化氢 (H2 O2 )清除剂过氧化氢酶 (catalase,CAT)与不同浓度的砷共同处理人类早幼粒细胞系 HL6 0细胞和人淋巴细胞 ,用单细胞凝胶电泳 (SCGE)检测细胞 DNA损伤。结果 2 .4和 4.8μmol的砷分别引起了HL6 0和人淋巴细胞显著的 DNA损伤。DMSO和 CAT完全消除了低剂量砷引起的 DNA损伤 ,减少了 70 %以上的高剂量砷引起的 DNA损伤。结论 微量砷可引起人类细胞不同程度的 DNA损伤 ,DMSO和 CAT可保护或减轻细胞的这些损伤 ,表明砷通过活性氧自由基 ,主要是 H2 O2 和 O2 - ,引起人类细胞 | 李达圣 Kanehisa Morimoto Tatsuya Takeshita 吕玉泉 | 2001 | 中国地方病学杂志2001，20，4： | 19 |
| 2 | 应用单细胞凝胶电泳比较研究砷对人类细胞DNA的损伤显示文摘目的 探讨不同细胞对砷的基因毒性反应及其机理 ;探讨快速、敏感及经济的细胞基因毒性检测方法。方法 应用单细胞凝胶电泳 (Single cell gel electrophoresis,SCGE)或彗星试验 (com et assay)比较研究。结果 细胞 DNA损伤与砷处理量间呈显著的剂量反应关系和时效关系。受试细胞对砷的基因毒性反应的敏感性强弱顺序为 :PMA- HL 6 0 >DMSO- HL 6 0 >HL 6 0 >淋巴细胞。人工计数彗星尾分级频数与计算机自动测量彗星尾 DNA泳动量的结果完全一致 ,用非参数 Mann- Whitney多变量检验分析彗星尾分级频数的显著性与参数Tukey多变量检验分析量彗星尾 DNA泳动量的显著性完全相同 ,而且不同浓度的砷与 5级彗星尾频数的相关性比其与阳性彗星尾总数间的更为显著。结论 微量砷即可引起细胞不同程度的 DNA损伤 ,不同细胞亚群对砷的基因毒性反应不同。 SCGE是一个简便、快速、敏感及经济的细胞基因毒性检测方法 ,可应用于各级水平的环境与人类疾病 (砷污染 ) | 李达圣 Kanehisa Morimoto Tatsuya Takeshita 吕玉泉 | 2001 | 中国地方病学杂志2001，20，3： | 15 |
| 3 | 砷对人淋巴细胞DNA氧化损伤的作用显示文摘目的 探讨砷 (As)引起植物血凝集素 (PHA)刺激和无刺激人外周血淋巴细胞DNA氧化性损伤。方法 用 10 μmol/L砷处理细胞 2h ,经单细胞凝胶电泳 (SCGE ,或彗星试验 ) FPG(甲酰胺基嘧啶 DNA糖基化酶 )消化法检测砷引起的DNA碱基损伤。结果 砷引起的DNA链断裂的修复过程与过氧化氢 (H2 O2 )引起的修复过程类似。FPG消化产生的单链断裂 ,或砷引起的碱基损伤在PHA刺激淋巴细胞较未刺激细胞显著。在PHA刺激的淋巴细胞 ,砷和H2 O2 引起的DNA链断裂 2h分别修复 63 %和 68% ,但在未刺激细胞分别修复大约 3 4 %和 4 3 %。在PHA刺激的淋巴细胞 ,砷和H2 O2引起的碱基损伤 2h分别修复 4 0 %和 4 9% ,但在未刺激细胞分别修复大约 19%和 2 1%。结论 微量砷可引起人类细胞DNA氧化性损伤。损伤的碱基主要是嘌呤或甲酰胺基嘧啶。未分裂 (刺激 )淋巴细胞修复砷与H2 O2 | 李达圣 Kanehisa Morimoto Tatsuya Takeshita 吕玉泉 | 2002 | 中华预防医学杂志2002，36，1： | 9 |
| 4 | Pancreatic schwannoma:Case report and an updated 30-year review of the literature yielding 47 cases显示文摘Pancreatic schwannomas are rare neoplasms.Authors briefly describe a 64-year-old female patient with cystic pancreatic schwannoma mimicking other cystic tumors and review the literature.Databases for PubMed were searched for English-language articles from 1980 to 2010 using a list of keywords,as well as references from review articles.Only 41 articles,including 47 cases,have been reported in the English literature.The mean age was 55.7 years(range 20-87 years),with 45%of patients being male.Mean tumor size was 6.2 cm(range 1-20 cm).Tumor location was the head(40%),head and body(6%),body(21%),body and tail(15%),tail(4%),and uncinate process(13%).Thirty-four percent of patients exhibited solid tumors and 60%of patients exhibited cystic tumors.Treatment included pancreati-coduodenectomy(32%),distal pancreatectomy(21%),enucleation(15%),unresectable(4%),refused opera-tion(2%)and the detail of resection was not specified in 26%of patients.No patients died of disease with a mean follow-up of 15.7 mo(range 3-65 mo),although 5(11%)patients had a malignancy.The tumor size was significantly related to malignant tumor(13.8±6.2 cm for malignancy vs 5.5±4.4 cm for benign,P=0.001) and cystic formation(7.9±5.9 cm for cystic tumorvs 3.9 ±2.4 cm for solid tumor,P=0.005).The preoperative diagnosis of pancreatic schwannoma remains difficult.Cystic pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms and pseudocysts.In our case,intraoperative frozen section confirmed the diagnosis of a schwannoma.Simple enucleation may be adequate,if this is possible. | Toshiyuki Moriya Wataru Kimura Ichiro Hirai Akiko Takeshita Koji Tezuka Toshihiro Watanabe Masaomi Mizutani Akira Fuse | 2012 | World Journal of Gastroenterology2012，18，13： | 8 |
| 5 | Primary hepatic benign schwannoma显示文摘Schwannoma is predominantly a benign neoplasm of the Schwann cells in the neural sheath of the peripheral nerves.Occurrence of schwannoma in parenchymatous organs,such as liver,is extremely rare.A 64-year-old man without neurofibromatosis was observed to have a space-occupying lesion of 23mm diameter in the liver during follow-up examination for a previously resected gastrointestinal stromal tumor(GIST)in the small intestine.He underwent lateral segmentectomy of the liver under a provisional diagnosis of hepatic metastatic recurrence of the GIST.Histological examination confirmed the diagnosis of a benign schwannoma,confirmed by characteristic pathological findings and positive immunoreactions with the neurogenic marker S-100 protein,but negative for c-kit,or CD34.The tumor was the smallest among the reported cases.When the primary hepatic schwannoma is small in size,preopera- tive clinical diagnosis is difficult.Therefore,this disease should be listed as differential diagnosis for liver tumor with clinically benign characteristics. | Michihiro Hayashi Atsushi Takeshita Kazuhiro Yamamoto Nobuhiko Tanigawa | 2012 | World Journal of Gastrointestinal Surgery2012，4，3： | 7 |
| 6 | Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma显示文摘AIM: To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocellular carcinoma (HCC) patients who underwent hepatectomy based on our preliminary study. METHODS: We examined relationships between MVC and clinicopathological factors in 128 HCC patients. The modifi ed Japan Integrated Staging score (mJIS) was applied to examine subsets of HCC patients. RESULTS: Median MVC was 178/mm^2, which was used as a cut-off value. MVC was not signif icantly associated with any clinicopathologic factors or postoperative recurrent rate. Lower MVC was associated with poor disease-free and overall survivals by univariate analysis (P = 0.039 and P = 0.087, respectively) and lower MVC represented an independent poor prognostic factor in disease-free survival by Cox’s multivariateanalysis (risk ratio, 1.64; P = 0.024), in addition to tumor size, vascular invasion, macroscopic fi nding and hepatic dysfunction. Signifi cant differences in disease-free and overall survivals by MVC were observed in HCC patients with mJIS 2 (P = 0.046 and P = 0.0014, respectively), but not in those with other scores. CONCLUSION: Tumor MVC appears to offer a useful prognostic marker of HCC patient survival, particularly in HCC patients with mJIS 2. | Atsushi Nanashima Toshiyuki Nakayama Yorihisa Sumida Takafumi Abo Hiroaki Takeshita Kenichirou Shibata Shigekazu Hidaka Terumitsu Sawai Toru Yasutake Takeshi Nagayasu | 2008 | World Journal of Gastroenterology2008，14，31： | 7 |
| 7 | 砷与5-氮胞苷对人淋巴细胞DNA损伤的联合作用显示文摘为探讨砷和 5 -氮胞苷对人淋巴细胞 DNA损伤及修复的联合作用 ,应用单细胞凝胶电泳 (SCGE)技术比较研究了 5 -氮胞苷与砷同时和前后作用于人类淋巴细胞产生的联合毒性 ,结果显示 10 μmol/ L 5 -氮胞苷和 10 μmol/ L砷单独处理人淋巴细胞 2 h引起明显的 DNA泳动 (彗星尾 ) ,但两试剂引起的 DNA泳动 (彗星尾 )间无显著差异 ,5 -氮胞苷前处理与砷后处理 2 h引起的彗星尾与其单独处理组比较非常显著 ,砷前处理与 5 -氮胞苷后处理引起的彗星尾与其单独处理组比较无显著性差异 ,但较对照组差异显著。 10 μmol/ L 5 -氮胞苷和 10 μmol/ L砷分别单独处理 2 h引起了人淋巴细胞显著的 DNA损伤 (链断裂 ) ,5 -氮胞苷与砷在对淋巴细胞 DNA的损伤上表现为单纯相加作用。 5 -氮胞苷前处理显著增加了细胞对砷的基因毒性的敏感性 ,或砷后处理显著增加了 5 -氮胞苷引起的 DNA损伤 ,5 -氮胞苷后处理 2 h显著抑制了细胞对砷所致 | 李达圣 MORIMOTO Kanehisa TAKESHITA Tatsuya 吕玉泉 | 2002 | 地方病通报2002，17，1： | 5 |
| 8 | Successful resection of metachronous para-aortic, Virchow lymph node and liver metastatic recurrence of rectal cancer显示文摘A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, c SS, c N0, c H0, c P0, c M0 c Stage Ⅱ, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were resected. Histological examination showed moderately differentiated adenocarcinoma, p SS, p N3, p H0, p P1, p M1(para-aortic lymph node, dissemination) f Stage Ⅳ. After the operation, the patient received chemotherapy with FOLFIRI regimen. After 12 cycles of FOLFIRI regimen, computed tomography(CT) detected an 11 mm of liver metastasis in the posteroinferior segment of right hepatic lobe. With diagnosis of liver metastatic recurrence, we performed partial hepatectomy. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer with cut end microscopically positive. After the second operation, the patient received chemotherapy with TS1 alone for 2 years. Ten months after the break, CT detected a 20 mm of paraaortic lymph node metastasis and a 10 mm of lymph node metastasis at the hepato-duodenal ligament. With diagnosis of lymph node metastatic recurrences, we performed lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as metastatic rectal cancer in paraaortic and hepato-duodenal ligament areas. After the third operation, we started chemotherapy with modified FOLFOX6 regimen. After 2 cycles of modified FOLFOX6 regimen, due to the onset of neutropenia and liver dysfunction, we switched to capecitabine aloneand continued it for 6 mo and then stopped. Eleven months after the break, CT detected two swelling 12 mm of lymph nodes at the left supraclavicular region. With diagnosis of Virchow lymph node metastatic recurrence, we started chemotherapy with capecitabine plus bevacizumab regimen. Due to the onset of neutropenia and hand foot syndrome(Grade 3), we managed to continue capecitabine administration with extension of interval period and dose reduction. After 2 years and 2 mo from starting capecitabine plus bevacizumab regimen, Virchow lymph nodes had slowly grown up to 17 mm. Because no recurrence had been detected besides Virchow lymph nodes for this follow up period, considering the side effects and quality of life, surgical resection was selected. We performed left supraclavicular lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer. After the fourth operation, the patient selected follow up without chemotherapy. Now we follow up her without recurrence and keep her quality of life high. | Nobuyoshi Takeshita Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Isamu Hoshino Takumi Ota Tetsuro Maruyama Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，44： | 4 |
| 9 | Comparison of the effects of retrieval balloons and basket catheters for bile duct stone removal on the rate of post-ERCP pancreatitis显示文摘To the Editor:Endoscopic retrograde cholangiopancreatography(ERCP)is one of the most important techniques for diagnosis and treatment in pancreatobiliary medicine.Post-ERCP pancreatitis(PEP)is a common complication of ERCP with incidence about 3.8%–15.1%[1–4].The precutting technique,contrast injection into the pancreatic duct,prolonged cannulation and procedure times,sphincterotomy. | Kotaro Takeshita Satoshi Asai Naoki Fujimoto Takumi Ichinona Eisuke Akamine | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，2： | 3 |
| 10 | An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient:A case report显示文摘Enteropathy-associated T-cell lymphoma(EATL) is a rare peripheral T-cell lymphoma classified into 2 types,with or without celiac disease,based on histology.Type 2 EATL is less commonly associated with celiac disease,in which cells are characterized by being monomorphic and small-to medium-sized.Cells are characterized by CD8 and CD56 expression and c-MYC oncogene locus gain.We present an atypical case of type 2 EATL in the jejunum,with human T-lymphotropic virus-1 that was CD4-CD8+ CD56-CD30-CD25-TIA-1+ and granzyme B+ on immunohistological staining.It also displayed translocation of chromosome 8p24(c-MYC),as determined by fluorescent in situ hybridization.Mucosal spreading and intraepithelial invasion by lymphoma with villous atrophy were detected adjacent to the mucosal layer.The lymphoma may be derived from intraepithelial CD8+ T cells,similar to celiac disease. | Kenji Okumura Masahiko Ikebe Tatsuro Shimokama Morishige Takeshita Nao Kinjo Keishi Sugimachi Hidefumi Higashi | 2012 | World Journal of Gastroenterology2012，18，19： | 3 |
| 11 | Peritoneovenous shunt for intractable ascites due to hepatic lymphorrhea after hepatectomy显示文摘A peritoneovenous shunt has become one of the most effi cient procedures for intractable ascites due to liver cirrhosis.A case of intractable ascites due to hepatic lymphorrhea after hepatectomy for hepatocellular carcinoma that was successfully treated by the placement of a peritoneovenous shunt is presented.A 72-year-old Japanese man underwent partial resection of the liver for hepatocellular carcinoma associated with hepatitis C viral infection.After hepatectomy,a considerable amount of ascites ranging from 800-4600 mL per day persisted despite conservative therapy,including numerous infusions of albumin and plasma protein fraction and administration of diuretics.Since the patient's general condition deteriorated,based on the diagnosis of intractable hepatic lymphorrhea,a subcutaneous peritoneovenous shunt was inserted.The patient's postoperative course was uneventful and the ascites decreased rapidly,with serum total protein and albumin levels and hepatic function improving accordingly.For intractable ascites due to hepatic lymphorrhea after hepatectomy,we recommend the placement of a peritoneovenous shunt as a procedure that can provide immediate effectiveness without increased surgical risk. | Yoshihiro Inoue Michihiro Hayashi Fumitoshi Hirokawa Atsushi Takeshita Nobuhiko Tanigawa | 2011 | World Journal of Gastrointestinal Surgery2011，3，1： | 3 |
| 12 | Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach显示文摘 | Yun-Qing Bai Hiroshi Yamamoto Yoshimitsu Akiyama Hiroyuki Tanaka Touichirou Takizawa Morio Koike Osmar Kenji Yagi Kiyoshi Saitoh Kimiya Takeshita Takehisa Iwai Yasuhito Yuasa | 2002 | Cancer Letters2002，，1： | 2 |
| 13 | The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial显示文摘 | Yumie Takeshita Toshinari Takamura Masao Honda Yuki Kita Yoh Zen Ken-ichiro Kato Hirofumi Misu Tsuguhito Ota Mikiko Nakamura Kazutoshi Yamada Hajime Sunagozaka Kuniaki Arai Tatsuya Yamashita Eishiro Mizukoshi Shuichi Kaneko | 2014 | Diabetologia2014，，5： | 2 |
| 14 | Cause and Management of Recurrent Primary Spontaneous Pneumothorax After Thoracoscopic Stapler Blebectomy显示文摘 | Takashi Muramatsu Mie Shimamura Motohiko Furuichi Tatsuhiko Nishii Shinji Takeshita Shinichiro Ishimoto Hiroaki Morooka Yoko Tanaka Chiyoshi Yagasaki Kazumitsu Ohmori Motomi Shiono | 2011 | Asian Journal of Surgery2011，，2： | 2 |
| 15 | Surgical Outcomes of Gastrectomy for Elderly Patients with Gastric Cancer显示文摘 | Hiroki Takeshita Daisuke Ichikawa Shuhei Komatsu Takeshi Kubota Kazuma Okamoto Atsushi Shiozaki Hitoshi Fujiwara Eigo Otsuji | 2013 | World Journal of Surgery2013，，12： | 2 |
| 16 | Forty-Year Experience With Flow-Diversion Surgery for Patients With Congenital Choledochal Cysts With Pancreaticobiliary Maljunction at a Single Institution显示文摘 | Nobuhiro Takeshita Takehiro Ota Masakazu Yamamoto | 2011 | Annals of Surgery2011，，6： | 2 |
| 17 | A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma显示文摘 | Shigeyuki Takeshita Tatsuki Ichikawa Kazuhiko Nakao Hisamitsu Miyaaki Hidetaka Shibata Toshihisa Matsuzaki Toru Muraoka Takuya Honda Masashi Otani Motohisa Akiyama Satoshi Miuma Esuke Ozawa Masumi Fujimito Katsumi Eguchi | 2009 | Nutrition Research2009，，2： | 2 |
| 18 | Esophageal intramural pseudodiverticulosis of the residual esophagus after esophagectomy for esophageal cancer显示文摘A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer(T3N2M0 Stage Ⅲ) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation,including redness,erosion,edema,bleeding,friability,and exudate with white plaques; and multiple depressions in the residual esophagus. Radiographical examination revealed numerous fine,gastrografinfilled projections and an anastomotic stricture. Biopsy specimens from the area of the anastomotic stricture revealed inflammatory changes without signs of malignancy. Candida glabrata was detected with a culture test of the biopsy specimens. The stricture was diagnosed as a benign stricture that was caused by esophageal intramural pseudodiverticulosis. Accordingly,endoscopic balloon dilatation was performed and antifungal therapy was started in the hospital. Seven weeks later,endoscopic examination revealed improvement in the mucosal inflammation; only the pseudodiverticulosis remained. Consequently,the patient was discharged. At the latest follow-up,the patient was symptomfree and the pseudodiverticulosis remained in the residual esophagus without any signs of stricture or inflammation. | Nobuyoshi Takeshita Naoki Kanda Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Masaya Uesato Tetsutaro Sazuka Tetsuro Maruyama Naohiro Aida Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 19 | Efficacy and safety of nicardipine prolonged-release implants for preventing vasospasm in humans 显示文摘 | Kasuya H Onda H Takeshita M | 2002 | Stroke2002，33，4： | 1 |
| 20 | Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression显示文摘 | Takeshita K Fujimori T Kurotaki Y | 2004 | Circulation2004，109，： | 1 |
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