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| 1 | Prevalence and Factors Associated with Female Sexual Dysfunction in Beijing, China显示文摘 | Wen-Jia Lou Bo Chen Lan Zhu Shao-Mei Han Tao Xu Jing-He Lang Lei Zhang | 2017 | Chinese Medical Journal2017，，12： | 25 |
| 2 | Numerical Prediction and Performance Experiment in a Deep-well Centrifugal Pump with Different Impeller Outlet Width显示文摘The existing research of the deep-well centrifugal pump mainly focuses on reduce the manufacturing cost and improve the pump performance,and how to combine above two aspects together is the most difficult and important topic.In this study,the performances of the deep-well centrifugal pump with four different impeller outlet widths are studied by the numerical,theoretical and experimental methods in this paper.Two stages deep-well centrifugal pump equipped with different impellers are simulated employing the commercial CFD software to solve the Navier-Stokes equations for three-dimensional incompressible steady flow.The sensitivity analyses of the grid size and turbulence model have been performed to improve numerical accuracy.The flow field distributions are acquired and compared under the design operating conditions,including the static pressure,turbulence kinetic energy and velocity.The prototype is manufactured and tested to certify the numerical predicted performance.The numerical results of pump performance are higher than the test results,but their change trends have an acceptable agreement with each other.The performance results indicted that the oversize impeller outlet width leads to poor pump performances and increasing shaft power.Changing the performance of deep-well centrifugal pump by alter impeller outlet width is practicable and convenient,which is worth popularizing in the engineering application.The proposed research enhances the theoretical basis of pump design to improve the performance and reduce the manufacturing cost of deep-well centrifugal pump. | SHI Weidong ZHOU Ling LU Weigang PEI Bing LANG Tao | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 20 |
| 3 | Surgical treatment of hepatocellular carcinoma with inferior vena cava tumor thrombus: a new classification for surgical guidance显示文摘BACKGROUND: Hepatic resection is the main treatment modality for hepatic tumors. Advances in diagnostic technique, preoperative preparation, surgical technique, and postoperative management increased the success rate. The present study aimed to evaluate hepatectomy and resection of inferior vena cava tumor thrombus (IVCTT) in patients with hepatocellular carcinoma, and the relationship between IVCTT classification and selection of surgical technique. METHODS: We retrospectively reviewed 13 patients with hepatocellular carcinoma who had undergone hepatectomy with IVCTT resection between May 1997 and August 2009. Age, gender, diagnosis, findings of physical examination, results of preoperative laboratory investigations, radiological examination, criteria for resection, postoperative pathological results, incisions, operative technique, intraoperative transfusion, drains, and intraoperative and postoperative complications were evaluated for all patients. RESULTS: Type Ⅰ IVCTT (10 patients) was posterior to the liver and below the diaphragm; type Ⅱ IVCTT (2 patients) was above the diaphragm but still outside the atrium; and type Ⅲ IVCTT (1 patient) was above the diaphragm and in the right atrium. Type Ⅰ was treated by radical hepatectomy and removal of IVCTT with total hepatic vascular exclusion. Type Ⅱ was treated by radical hepatectomy and removal of IVCTT by incision of the diaphragm. Type Ⅲ was treated by hepatectomy and resection of the thrombus from the right atrium under cardiopulmonary bypass. There were no surgical complications and one patient has been survived for 4 years with cancer-free status. The median survival time was 18.2 months, and the 1-and 2-year survival rates were 53.8% and 15.4%, respectively. CONCLUSION: Surgical treatment is safe and feasible for treatment of IVCTT in patients with hepatocellular carcinoma, and surgical resectability can be judged according to the classification of tumor thrombus. | Ai-Jun Li Wei-Ping Zhou Chuan Lin Xi-Long Lang Zhen-Guang Wang Xiao-Yu Yang Qing-He Tang Ran Tao Meng-Chao Wu | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 15 |
| 4 | Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing显示文摘Development of tools for targeted modifications of specific DNA sequences in plants is of great importance to basic plant biology research as well as crop improvement.The ability to cut DNA at specific locations in the genome to generate doublestrand breaks(DSBs)in vivo is a prerequisite for any genome editing efforts.Several engineered nucleases including zinc finger nucleases(ZFNs)and transcriptional activator-like nucleases(TALENs)have been successfully used to edit genomes.However, | Yubing He Tao Zhang Ning Yang Meilian Xu Lang Yan Lihao Wang Rongchen Wang Yunde Zhao | 2017 | Journal of Genetics and Genomics2017，44，9： | 14 |
| 5 | The multiple-parameter fractional Fourier transform显示文摘The fractional Fourier transform(FRFT) has multiplicity,which is intrinsic in frac-tional operator.A new source for the multiplicity of the weight-type fractional Fou-rier transform(WFRFT) is proposed,which can generalize the weight coefficients of WFRFT to contain two vector parameters M,N ∈ZM.Therefore a generalized frac-tional Fourier transform can be defined,which is denoted by the multiple-parameter fractional Fourier transform(MPFRFT).It enlarges the multiplicity of the FRFT,which not only includes the conventional FRFT and general multi-fractional Fourier transform as special cases,but also introduces new fractional Fourier transforms.It provides a unified framework for the FRFT,and the method is also available for fractionalizing other linear operators.In addition,numerical simulations of the MPFRFT on the Hermite-Gaussian and rectangular functions have been performed as a simple application of MPFRFT to signal processing. | LANG Jun TAO Ran RAN QiWen WANG Yue | 2008 | Science in China(Series F)2008，51，8： | 12 |
| 6 | A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS_1 in Arabidopsis显示文摘DNA methylation is typically regarded as a repressive epigenetic marker for gene expression.Genome-wide DNA methylation patterns in plants are dynamically regulated by the opposing activities of DNA methylation and demethylation reactions. In Arabidopsis, a DNA methylation monitoring sequence(MEMS) in the promoter of the DNA demethylase gene ROS_1 functions as a methylstat that senses these opposing activities and regulates genome DNA methylation levels by adjusting ROS_1 expression. How DNA methylation in the MEMS region promotes ROS_1 expression is not known. Here, we show that several Su(var)3-9 homologs(SUVHs) can sense DNA methylation levels at the MEMS region and function redundantly to promote ROS_1 expression. The SUVHs bind to the MEMS region, and the extent of binding is correlated with the methylation level of the MEMS.Mutations in the SUVHs lead to decreased ROS_1 expression, causing DNA hypermethylation at more than 1,000 genomic regions. Thus, the SUVHs function to mediate the activation of gene transcription by DNA methylation. | Xinlong Xiao Jieqiong Zhang Tao Li Xing Fu Viswanathan Satheesh Qingfeng Niu Zhaobo Lang Jian-Kang Zhu Mingguang Lei | 2019 | Journal of Integrative Plant Biology2019，61，2： | 11 |
| 7 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 8 | The discrete multiple-parameter fractional Fourier transform显示文摘As a generalization of the Fourier transform (FT), the fractional Fourier transform (FRFT) has many applications in the areas of optics, signal processing, information security, etc. Therefore, the efficient discrete computational method is the vital fundament for the application of the fractional Fourier transform. The multiple-parameter fractional Fourier transform (MPFRFT) is a generalized fractional Fourier transform, which not only includes FRFT as special cases, but also provides a unified framework for the study of FRFT. In this paper, we present in detail the discretization method of the MPFRFT and define the discrete multiple-parameter fractional Fourier transform (DMPFRFT). Then, we utilize the tensor product to define two-dimensional multiple-parameter fractional Fourier transform (2D-MPFRFT) and the corresponding two-dimensional discrete multiple-parameter fractional Fourier transform (2D-DMPFRFT). Finally, as an application, a novel image encryption method based on 2D-DMPFRFT is proposed. Numerical simulations are performed to demonstrate that the proposed method is reliable and more robust to blind decryption than several existing methods. | LANG Jun, TAO Ran& WANG Yue Department of Electronic Engineering, Beijing Institute of Technology, Beijing 100081, China | 2010 | Science China(Information Sciences)2010，53，11： | 8 |
| 9 | A novel impedance immunosensor based on O-phenylenediamine modified gold electrode to analyze abscisic acid显示文摘An impedance immunosensor based on O-phenylenediamine modified gold electrode for the determination of phytohormone abscisic acid(ABA) was proposed.The operating pH,absorption time,absorption temperature and concentration of anti-ABA antibody were investigated to optimize the analytical performance.The calibration curve for the determination of ABA was obtained from this impedance immunosensor under optimal conditions.The results showed that the detection limit at about 1 ng/mL in the range of 10-5000 ng... | Li, Qian Wang, Ruo Zhong Huang, Zhi Gang Li, He Song Xiao, Lang Tao | 2010 | Chinese Chemical Letters2010，21，4： | 7 |
| 10 | A 14-year multi-institutional collaborative study of Chinese pelvic floor surgical procedures related to pelvic organ prolapse显示文摘Background:It has been a global trend that increasing complications related to pelvic floor surgeries have been reported over time.The current study aimed to outline the development of Chinese pelvic floor surgeries related to pelvic organ prolapse(POP)over the past 14 years and investigate the potential influence of enhanced monitoring conducted by the Chinese Association of Urogynecology since 2011.Methods:A total of 44,594 women with POP who underwent pelvic floor surgeries between October 1,2004 and September 30,2018 were included from 22 tertiary academic medical centers.The data were reported voluntarily and obtained from a database.We compared the proportion of each procedure in the 7 years before and 7 years after September 30,2011.The data were analyzed by performing Z test(one-sided).Results:The number of different procedures during October 1,2011-September 30,2018 was more than twice that during October 1,2004-September 30,2011.Regarding pelvic floor surgeries related to POP,the rate of synthetic mesh procedures increased from 38.1%(5298/13,906)during October 1,2004-September 30,2011 to 46.0%(14,107/30,688)during October 1,2011-September 30,2018,whereas the rate of non-mesh procedures decreased from 61.9%(8608/13,906)to 54.0%(16,581/30,688)(Z=15.53,P<0.001).Regarding synthetic mesh surgeries related to POP,the rates of transvaginal placement of surgical mesh(TVM)procedures decreased from 94.1%(4983/5298)to 82.2%(11,603/14,107)(Z=20.79,P<0.001),but the rate of laparoscopic sacrocolpopexy(LSC)procedures increased from 5.9%(315/5298)to 17.8%(2504/14,107).Conclusions:The rate of synthetic mesh procedures increased while that of non-mesh procedures decreased significantly.The rate of TVM procedures decreased while the rate of LSC procedures increased significantly.Trial registration number:NCT03620565,http://gffzz111276e5ed644ca6snbbwp0w5puvq6knb.ffgz.tsg.suse.edu.cn. | Zhi-Jing Sun Xiu-Qi Wang Jing-He Lang Tao Xu Yong-Xian Lu Ke-Qin Hua Jin-Song Han Huai-Fang Li Xiao-Wen Tong Ping Wang Jian-Liu Wang Xin Yang Xiang-Hua Huang Pei-Shu Liu Yan-Feng Song Hang-Mei Jin Jing-Yan Xie Lu-Wen Wang Qing-Kai Wu Jian Gong Yan Wang Li-Qun Wang Zhao-Ai Li Hui-Cheng Xu Zhi-Jun Xia Li-Na Gu Qing Liu Lan Zhu | 2021 | Chinese Medical Journal2021，，2： | 7 |
| 11 | Tension-free Polypropylene Mesh-related Surgical Repair for Pelvic Organ Prolapse has a Good Anatomic Success Rate but a High Risk of Complications显示文摘 | Lei Zhang Lan Zhu Juan Chen Tao Xu Jing-He Lang | 2015 | Chinese Medical Journal2015，，3： | 6 |
| 12 | Preparation and application of monoclonal antibodies against hepatitis C virus nonstructural proteins显示文摘PreparationandapplicationofmonoclonalantibodiesagainsthepatitisCvirusnonstructuralproteinsGAOJianEn,TAOQiMin,GUOJianPin... | GAO Jian En, TAO Qi Min, GUO Jian Ping, JI He Ping, LANG Zheng Wei, JI Ying and FENG Bai Fang | 1997 | World Journal of Gastroenterology1997，3，2： | 6 |
| 13 | EBV-Induced Human CD8^+ NKT Cells Synergise CD4^+ NKT Cells Suppressing EBV-Associated Tumours upon Induction of Thl-Bias显示文摘 | Wei Xiao Li Li Rui Zhou Ruijing Xiao Yujuan Wang Xiang Ji Mengjun Wu Lan Wang Wei Huang Xiaoling Zheng Xinti Tan Lang Chen Tao Xiong Jie Xiong Youxin Jin Jinquan Tan Yuling He | 2009 | Cellular & Molecular Immunology2009，6，5： | 5 |
| 14 | An epidemiology study of fecal incontinence in adult Chinese women living in urban areas显示文摘Background:Fecal incontinence(FI)has been shown to be a common symptom in Western countries;however,there is few researches focusing on its epidemic condition in Chinese women.We conducted this national population-based epidemiology study to estimate the prevalence and risk factors of FI among adult Chinese women living in urban regions.Methods:This is a subgroup analysis of a national population-based epidemiology study of FI.Total 28,196 adult women from urban regions of six provinces and municipalities participated in this research from 2014 to 2015.They finished the questionnaire under the direction of trained interviewers.FI was defined as accidental leakage of flatus and/or liquid or solid stool at least once in the past.The FI prevalence trend and risk factors were identified by the Cochran-Armitage test,Chi-square test,and multivariable logistic regression.Results:The prevalence of FI in adult females in urban China was 0.43%(95%confidence interval:0.35%-0.51%).Among women with FI,42.96%,82.96%,and 42.22%reported having leakage of solid,liquid stool,and gas,respectively.The overall FI prevalence and the incidence rate of solid stool/liquid stool/gas leakage increased with age.The mean Wexner score was 4.0%and 12.0%FI patients reported Wexner score≥9.Body mass index≥24 kg/m2,pelvic organ prolapses,chronic constipation,chronic cough,alcohol consumption,physical diseases including chronic bronchitis and cancer,gynecological diseases like gynecological inflammation are risk factors for FI.Vaginal delivery was the risk factor for FI in females with labor history.Conclusions:FI was not a common symptom in adult Chinese women living in urban areas and there were some potential modifiable risk factors. | Yuan Yuan Lin Qiu Zhi-Yi Li Lei Zhang Tao Xu Jing-He Lang Zhao-Ai Li Jian Gong Qing Liu Xiao-Chun Liu Jun-Tao Wang Zhi-Jun Xia Zhu Lan | 2020 | Chinese Medical Journal2020，，3： | 5 |
| 15 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 16 | Technique of Anatomical Retroperitoneoscopic Adrenalectomy With Report of 800 Cases显示文摘 | Xu Zhang Bin Fu Bin Lang Jun Zhang Kai Xu Hong-Zhao Li Xin Ma Tao Zheng | 2007 | The Journal of Urology2007，，4： | 3 |
| 17 | Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma显示文摘Although there is an accumulating appreciation of the key roles that long intergenic non-coding RNAs(linc RNAs) play in diverse cellular processes, our knowledge of how linc RNAs function in cancer remains sparse. Here, we present a comprehensive landscape of RNA-seq transcriptome profiles of lung adenocarcinomas and their paired normal counterparts to unravel gene regulation rules of linc RNAs.Consistent with previous findings of co-expression between neighboring protein-coding genes, linc RNAs were typically co-expressed with their neighboring genes, which was found in both cancerous and normal tissues. By building a mathematical model based on correlated gene expression, we distinguished an additional subset of linc RNAs termed 'regulatory linc RNAs', representing their dominant roles in gene regulation. The number of regulatory linc RNAs was significantly higher in cancerous compared to normal tissues, and most of them positively regulated protein-coding genes in trans. Functional validation, using knockdown, determined that regulatory linc RNA,GAS5, affected its predicted protein-coding targets. Moreover, we discovered hundreds of differentially expressed regulatory linc RNAs with inclusion of some cancer-associated linc RNAs. Our integrated analysis reveals enhanced regulatory effects of linc RNAs and provides a resource for the study of regulatory linc RNAs that play critical roles in lung adenocarcinoma. | You Zhou Kai Wu Jianping Jiang Jinfei Huang Peiwei Zhang Yufei Zhu Guohong Hu Jingyu Lang Yufang Shi Landian Hu Tao Huang Xiangyin Kong | 2015 | Journal of Genetics and Genomics2015，42，8： | 3 |
| 18 | Carbohydrate antigen 19-9 as a novel prognostic biomarker in distal cholangiocarcinoma显示文摘BACKGROUND Distal cholangiocarcinoma(DCC)presents as one of the relatively rare malignant tumors in the digestive system and has a poor long-term prognosis.Curative resection is currently the most appropriate therapy for patients with DCC because of the lack of effective adjuvant therapies.Therefore,it is important to accurately predict the prognosis for formulating a reasonable treatment plan and avoiding unnecessary surgical trauma.AIM To minimize the interference of obstructive jaundice on carbohydrate antigen 19-9(CA19-9)level by adapting CA19-9 toγ-glutamyltransferase(GGT)as an indicator,to determine the strong associations between CA19-9/GGT and postoperative neoplasm recurrence and long-term outcome of DCC.METHODS We enrolled 186 patients who were diagnosed with DCC between January 2010 and December 2019 and performed radical excision with strict criteria as follows in our hospital.Receiver operating characteristic curves were drawn according to preoperative CA19-9/GGT and 1-year survival.Based on this,patients were divided into two groups(group 1,low-ratio,n=81;group 2,high-ratio,n=105).Afterwards,by the way of univariate and multivariate analysis,the risk factors influencing postoperative tumor recrudesce and long-term prognosis of patients with DCC were screened out.RESULTS Optimum cut-off value of CA19-9/GGT was 0.12.Patients in group 2 represented higher CA19-9 and lymphatic metastasis rate accompanied by lower GGT,when compared with group 1(P<0.05).The 1-,3-and 5-year overall survival rates of patients in groups 1 and 2 were 88.3%,59.2%and 48.1%,and 61.0%,13.6%and 13.6%,respectively(P=0.000).Multivariate analysis indicated that CA19-9/GGT,lymphatic metastasis and tumor differentiation were independent risk factors for tumor recurrence and long-term prognosis of DCC.CONCLUSION Elevation of CA19-9/GGT performed better as a biomarker of aggressive carcinoma and predictor of poor clinical outcomes by reducing the effect of obstruction of biliary tract on CA19-9 concentration in patients with DCC. | Tao Jiang Shao-Cheng Lyu Lin Zhou Jing Wang Han Li Qiang He Ren Lang | 2021 | World Journal of Gastrointestinal Surgery2021，13，9： | 3 |
| 19 | Amperometric Determination of lndole-3-acetic Acid Based on Platinum Nanowires and Carbon Nanotubes显示文摘Platinum nanowire (PtNW) can be grown by electrodeposition in polycarbonate membrane, with the average diameter of the nanowires about 250 nm. The PtNW and multiwalled carbon nanotubes (CNT) are then dispersed into chitosan (CHIT) solution. The resulting PtNW-CNT-CHIT material brings new capabilities for electrochemical devices by using the synergistic action of the electrocatalytic activity of PtNW and CNT. By dropping the PtNW-CNT-CHIT film onto the glassy carbon (GC) electrode surface, and after evaporation an amperometric sensor for the determination of indole-3-acetic acid (IAA) was developed. The oxidation current of IAA increased significantly at the PtNW-CNT-CHIT film coated GC electrode, in contrast to that at the CNT-CHIT modified GC. The linear response of the sensor is from 50 ng/ml to 50 μg/ml with a detection limit of 25 ng/mL. | Ruo Zhong WANG Lang Tao XIAO Ming Hui YANG Jun Hui DING Feng Li QU Guo Li-SHEN | 2006 | Chinese Chemical Letters2006，17，12： | 3 |
| 20 | Advances and perspective on animal models and hydrogel biomaterials for diabetic wound healing显示文摘Diabetic wounds are a common complication in diabetes patients.Due to peripheral nerve damage and vascular dysfunction,diabetic wounds are prone to progress to local ulcers,wound gangrene and even to require amputation,bringing huge psychological and economic burdens to patients.However,the current treatment methods for diabetic wounds mainly include wound accessories,negative pressure drainage,skin grafting and surgery;there is still no ideal treatment to promote diabetic wound healing at present.Appropriate animal models can simulate the physiological mechanism of diabetic wounds,providing a basis for translational research in treating diabetic wound healing.Although there are no animal models that can fully mimic the pathophysiological mechanisms of diabetic wounds in humans,it is vital to explore animal simulation models used in basic research and preclinical studies of diabetic wounds.In addition,hydrogel materials are regarded as a promising treatment for diabetic wounds because of their good antimicrobial activity,biocompatibility,biodegradation and appropriate mechanical properties.Herein,we review and discuss the different animal models used to investigate the pathological mechanisms of diabetic wounds.We further discuss the promising future application of hydrogel biomaterials in diabetic wound healing. | Yiqiang Hu Yuan Xiong Ranyang Tao Hang Xue Lang Chen Ze Lin Adriana C.Panayi Bobin Mi Guohui Liu | 2022 | Biomaterials Translational2022，3，3： | 2 |
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