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| 1 | Water demand forecasting of Beijing using the Time Series Forecasting Method显示文摘建立水资源利用并且利用计划是必要的,它主要基于认出并且预报水讲道理地并且科学地消费了结构。在过去的 30 年(19802009 ) 期间,分别地,当全部的水消费历史上在一样的时期期间到达了尖顶时,吝啬的年度降水和北京的全部的水资源与那些长期的价值相比在 6.89% 和 31.37% 减少了。因此,它具有为在社会经济的开发和环境开发之间的和谐的大意义。把消费的水的水消费,农业、工业、国内、环境的水消费,和进化组织的总数基于分析,全部的水消费和水的进化的进一步的驱动力消费了结构系统地被揭示。预言和讨论为全部的水消费的进化被完成,水在不久的将来用时间系列预报北京消费了水资源的结构,和供应要求状况方法。这份报纸的努力的目的是为在 socio 经济和水资源之间的和谐开发提供科学基础,为水资源的合理战略计划的建立,并且为有科学的库的北京的社会持续开发。 | ZHAI Yuanzheng | 2012 | Journal of Geographical Sciences2012，22，5： | 15 |
| 2 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 3 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 4 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 5 | Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation显示文摘Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride(CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a doubleblinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were pro?led via 16 S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index.Cetylpyridinium chloride conferred gingival bene?ts, as progression of gingival in?ammation resulting from a lack of dental hygiene was signi?cantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque α and β diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitisenriched taxa. The ?ndings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population. | Fei Teng Tao He Shi Huang Cun-Pei Bo Zhen Li Jin-Lan Chang Ji-Quan Liu Duane Charbonneau Jian Xu Rui Li Jun-Qi Ling | 2016 | International Journal of Oral Science2016，8，3： | 6 |
| 6 | Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy显示文摘Diabetic retinopathy(DR) is one of the most important types of diabetic microangiopathy, which is a specific change of fundus lesions and is one of the most serious complications of diabetes. When DR develops to proliferative DR, the main factors of decreasing vision, and even blindness, include retinal detachment and vitreous hemorrhage caused by contraction of blood vessels by fiber membrane. Recent studies reported that the formation of fiber vascular membrane is closely related to retinal fibrosis. The connective tissue growth factor(CTGF) is a cytokine that is closely related to DR fibrosis. However, its mechanism is poorly understood. This paper summarizes the recent studies about CTGF on DR fibrosis for a comprehensive understanding of the role and mechanism of CTGF in PDR. | Teng Ma Li-Jie Dong Xue-Li Du Rui Niu Bo-Jie Hu | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 6 |
| 7 | Electroless Nickel Plating and Electroplating on FBG Temperature Sensor显示文摘Metal-coated fiber Bragg grating(FBG)temperature sensors were prepared via electroless nickel(EN)plating and tin electroplating methods on the surface of normal bare FBG.The surface morphologies of the metal-coated layers were observed under a metallographic microscope.The effects of pretreatment sequence,pH value of EN plating solution and current density of electroplating on the performance of the metal-coated layers were analyzed.Meanwhile, the Bragg wavelength shift induced by temperature was monitored by an optical spectrum analyzer.Sensitivity of the metal-coated FBG(MFBG)sensor was almost two times that of normal bare FBG sensor.The measuring temperature of the MFBG sensor could be up to 280°C,which was much better than that of conventional FBG sensor. | SHEN Ren-sheng TENG Rui LI Xiang-ping ZHANG Jin XIA Dao-cheng FAN Zhao-qi YU Yong-sen ZHANG Yu-shu DU Guo-tong | 2008 | Chemical Research in Chinese Universities2008，24，5： | 4 |
| 8 | Efficient 16 Boolean logic and arithmetic based on bipolar oxide memristors显示文摘The physically separated memory and logic units in traditional von Neumann computers place essential limits on the performance and cause increased energy consumption,and hence in-memory computing is required to overcome this bottleneck.Here,a new bipolar memristor based in-memory logic approach is proposed,which is capable of achieving all 16 possible Boolean logic functions in a single device in less than3 steps.This approach does not require initialization and can facilitate logic cascading,and the calculation taking place in-situ is showcased by 1-bit full adder and 2-bit multiplier with improved efficiency,thus showing a great prospect in future in-memory computing architecture. | Rui YUAN Mingyuan MA Liying XU Zhenhua ZHU Qingxi DUAN Teng ZHANG Yu ZHU Yu WANG Ru HUANG Yuchao YANG | 2020 | Science China(Information Sciences)2020，63，10： | 3 |
| 9 | Multi-modality imaging on multiple evanescent white dot syndrome-A Spectralis Study显示文摘AIM: To present retinal microstructure, metabolism and function abnormalities in the course of multiple evanescent white dot syndrome (MEWDS) by Heidelberg spectralis modality imaging platform and observe its outcome by EDI-SD-OCT and two wavelength autofluorescence.METHODS: A case of multiple evanescent white dot syndrome in a 23-year-old female presented initially with a 15-day history of floaters and a central scotoma in the right eye. To establish the diagnosis, multimodality imaging was performed, namely, blue light-fundus autofluorescence (BL-FAF, excitation 488nm, emission >500nm), near-infrared fundus autofluorescence (NIR-FAF, excitation 787nm, emission >800nm) using a confocal scanning laser ophthalmoscope, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), spectrum-domain enhance depth imaging optical coherence tomography (SD-EDI-OCT), multifocal electroretinography (mf-ERG) and fundus photogragh were performed and followed up at the eighth month after initially visiting.RESULTS: Optical coherence tomography (OCT) showed a transient disruption of the foveal photoreceptor outer segments in correspondence to foveal granularity. NIR-FAF showed hypoautofluorescent areas, ≤40μm in size, mostly concentrated around the posterior pole and its temporal side less than that in BL-FAF. Mf-ERG show pinnacle disappeared in fovea and macula and responses decreased markedly compared with the follow eye. At the eighth month follow up, hyperfluorescence in BL-FAF were disappear, while, NIR-FAF Hypofluorescent spots in early stage of such lesion were reduced. But OCT demonstrated the structure was recovered in residual Hypofluorescent area in NIR-FAF. The subfoveal choroidal thickness was decreased from 372μm to 307μm slightly and cost line was recovered. CONCLUSION: MEWDS is a benign self-healing disease and there is no pathological evidence to investigate the natural course of such disease. SD-OCT allows highly detailed images approaching histopathology to certify the microstructural changes. Two-wave length FAF and mf-ERG provide more information about metabolism in outer retina especial RPE and photoreceptor. Spectralis OCT combined with two-wavelength FAF and mf-ERG provide a new way to analyze this disease and offer more details for therapy and follow-up. | Rui Hua, Wei-Ping Teng | 2012 | International Journal of Ophthalmology(English edition)2012，5，5： | 3 |
| 10 | Imaging findings of primary pulmonary synovial sarcoma with secondary distant metastases:A case report显示文摘BACKGROUND Synovial sarcoma(SS)accounting for 6%-10%of primary soft tissue malignancies mainly occurs in deep soft tissue adjacent to joints of the limbs.Primary pulmonary SS(PPSS)is rare and has a poor prognosis.Cases of secondary distant metastases of PPSS occur rarely and there is a lack of corresponding imaging reports.We summarized the imaging findings of PPSS with multiple metastases confirmed by surgery and pathology,and shared valuable information on PPSS.CASE SUMMARY A 43-year-old female patient had a solid space occupying lesion in the right upper lobe of the lung.The results of a hemogram,erythrocyte sedimentation rate(ESR)and tumor markers were all within the normal range,tuberculin skin test(5 TU PPD)was negative(-).Chest computed tomography examination showed similar round soft tissue density in the posterior segment of the right upper lobe.Thoracoscopic-assisted wedge resection of the right upper lobe of the lung,right upper lobe resection and lymph node dissection were performed.Nine months after surgery,ultrasound examination showed multiple metastases on the chest wall and kidney.CONCLUSION PPSS is a rare malignant lung tumor with strong invasiveness,early distant metastasis and poor prognosis.There are very few imaging reports.PPSS is often manifested as irregular tumor and calcification,and the metastases have extremely low echo on ultrasonography.Contrast-enhanced ultrasound indicates that the arterial phase of tumor metastases shows rapid centripetal high enhancement,manifested as“fast forward and fast regression”. | Rui Li Xin Teng Wei-Hong Han Yan Li Qing-Wei Liu | 2021 | World Journal of Clinical Cases2021，9，8： | 2 |
| 11 | Analysis on the fault characteristics of three-phase short-circuit for half-wavelength AC transmission lines显示文摘Half-wavelength AC transmission(HWACT) is an ultra-long distance AC transmission technology, whose electrical distance is close to half-wavelength at the system power frequency. It is very important for the construction and operation of HWACT to analyze its fault features and corresponding protection technology. In this paper, the steady-state voltage and current characteristics of the bus bar and fault point and the steady-state overvoltage distribution along the line will be analyzed when a three-phase symmetrical short-circuit fault occurs on an HWACT line. On this basis, the threephase fault characteristics for longer transmission lines are also studied. | Xuankun Song Teng Feng Liu Han Travis MSmith Xinzhou Dong Wenxuan Liu Rui Zhang | 2018 | Global Energy Interconnection2018，1，2： | 2 |
| 12 | The Environmental Functions and Ecological Effects of Organic Carbon in Silt显示文摘Silt is a kind of unconsolidated sediment consisting of fine particles;silt is generally deposited across wide areas on the surfaces of drainages and in oceans under static or slow-hydrodynamic conditions. The organic carbon(OC) in silt has multiple essential environmental functions. This paper elaborates the morphological and environmental indication functions of OC in silt, and the effect of its own migration and transformation on environmental deterioration. Organic carbon exists in silt in two forms, free and mineral-binding. Meanwhile, based on its formation and structure, OC can be divided into light and heavy fraction of OC. Environmental information including data related to paleoclimates, ancient levels of productivity level, and variations in regional organism abundance can be discovered from total organic carbon, the C/N ratio, and OC isotope content. Degradation of OC is believed to participate in the emission of greenhouse gases, release of heavy metals and other contaminants. Finally, from the view of silt deposition, the possible influence of complex water-rock interaction in which OC is involved during the evolution of silt to a clayey aquitard on the hydrochemical composition of groundwater is discussed, which provides a new perspective for future research on the carbon cycle in nature. | Rui Liu Teng Ma Wenkai Qiu Ziqi Peng Chenxuan Shi | 2020 | Journal of Earth Science2020，31，4： | 2 |
| 13 | The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation显示文摘Triggering receptor expressed on myeloid cells-like 2(TREML2)is a newly identified susceptibility gene for Alzheimer's disease(AD).It encodes a microglial inflammation-associated receptor.To date,the potential role of mic roglial TREML2 in neuroinflammation in the context of AD remains unclear.In this study,APP/PS1 mice were used to investigate the dynamic changes of TREML2 levels in brain during AD progression.In addition,lipopolysaccharide(LPS)stimulation of primary microglia as well as a lentivirus-mediated TREML2 overexpression and knockdown were employed to explore the role of TREML2 in neuroinflammation in the context of AD.Our res ults show that TREML2 levels gradually increased in the brains of AP P/PS1 mice during disease progression.LPS stimulation of primary microglia led to the release of inflammato ry cytokines including interleukin-1β,inte rleukin-6,and tumor necrosis factor-a in the culture medium.The LPS-induced mic roglial release of inflammatory cytokines was enhanced by TREML2 overexpression and was attenuated by TREML2 knoc kdown.LPS increased the levels of mic roglial M1-type polarization marker inducible nitric oxide synthase.This effect was enhanced by TREML2 overexpression and ameliorated by TREML2 knockdown.Furthermore,the levels of microglial M2-type polarization markers CD206 and ARG1 in the primary microglia were reduced by TREML2 overexpression and elevated by TREML2 knockdown.LPS stimulation increased the levels of NLRP3 in primary microglia.The LPS-induced increase in NLRP3 was further elevated by TREML2 overexpression and alleviated by TREML2 knockdown.In summary,this study provides the first evidence that TREML2 modulates inflammation by regulating microglial polarization and NLRP3 inflammasome activation.These findings reveal the mechanisms by which TREML2 regulates microglial inflammation and suggest that TREML2 inhibition may represent a novel therapeutic strategy for AD. | Si-Yu Wang Xin-Xin Fu Rui Duan Bin Wei Hai-Ming Cao Yan E Shuai-Yu Chen Ying-Dong Zhang Teng Jiang | 2023 | Neural Regeneration Research2023，18，2： | 2 |
| 14 | Flexible Piezoresistive Sensors based on Conducting Polymer-coated Fabric Applied to Human Physiological Signals Monitoring显示文摘This paper describes a flexible pressure sensor based on polypyrrole(PPy)-Cotton composites,in which PPy is grown on cellulose fibers of cotton pads via an in situ vapor growth method,which is beneficial to the homogeneity of the composites.The resulting devices exhibits rapid response and recovery speed,the response and recovery times are 220 ms and 240 ms,respectively.The optimal PPy-Cotton Pads(PCPs)sensor shows low detection limit,which is about 50 Pa.At the same time,it exhibits excellent durability in the measurement of repeated loading-unloading pressure over 1000 cycles.The resultant sensor can be attached on different positions of body and applied to recording physiological signals,such as wrist pulse,vocal cord vibration,respiration and eyes blinking.Finally,a 4×4 pressure sensor array shows that the PCPs sensor has capability in pressure distribution detection and represents great potential in the fields of wearable electronics and biomedical devices. | Xiuzhu Lin Tong Zhang Junhou Cao Han Wen Teng Fei Sen Liu Rui Wang Hui Ren Hongran Zhao | 2020 | Journal of Bionic Engineering2020，17，1： | 1 |
| 15 | Nanoparticle‑Loaded Polarized‑Macrophages for Enhanced Tumor Targeting and Cell‑Chemotherapy显示文摘Cell therapy is a promising strategy for cancer therapy.However,its therapeutic efficiency remains limited due to the complex and immunosuppressive nature of tumor microenvironments.In this study,the“cell-chemotherapy”strategy was presented to enhance antitumor efficacy.M1-type macrophages,which are therapeutic immune cells with both of immunotherapeutic ability and targeting ability,carried sorafenib(SF)-loaded lipid nanoparticles(M1/SLNPs)were developed.M1-type macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver SF to tumor tissues for chemotherapy simultaneously.M1-type macrophages were obtained by polarizing macrophages using lipopolysaccharide,and M1/SLNPs were obtained by incubating M1-type macrophages with SLNP.Tumor accumulation of M1/SLNP was increased compared with SLNP(p<0.01),which proved M1/SLNP could enhance tumor targeting of SF.An increased ratio of M1-type macrophages to M2-type macrophages,and the CD3^+CD4^+T cells and CD3^+CD8^+T cell quantities in tumor tissues after treatment with M1/SLNP indicated M1/SLNP could relieve the immunosuppressive tumor microenvironments.The tumor volumes in the M1/SLNP group were significantly smaller than those in the SLNP group(p<0.01),indicating M1/SLNP exhibited enhanced antitumor efficacy.Consequently,M1/SLNP showed great potential as a novel cellchemotherapeutic strategy combining both cell therapy and targeting chemotherapy. | Teng Hou Tianqi Wang Weiwei Mu Rui Yang Shuang Liang Zipeng Zhang Shunli Fu Tong Gao Yongjun Liu Na Zhang | 2021 | Nano-Micro Letters2021，13，1： | 1 |
| 16 | Water Distribution in Tofu and Application of T2Relaxation Measurements in Determination of Tofu’s Water-Holding Capacity显示文摘 | Teng Li Xin Rui Wei Li | 2014 | J Agric Food Chem2014，，62： | 1 |
| 17 | Water distribution in tofu and application o T2relaxation measurements in determination of tofu's water-holding capacity显示文摘 | LI TENG RUI XIN L I | 2014 | Journal of agricultural and food chemistry2014，62，34： | 1 |
| 18 | Sorption and retardation of strontium in fine-particle media from a VLLW dis- posal site 显示文摘 | RUI ZUO YANGUO TENG JINSHENGi WANG | 2009 | Journal of Radioanalytical and Nuclear Chemistry2009，279，3： | 1 |
| 19 | Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis显示文摘 | Rui Liu Cheng Han Di Wu Xinghai Xia Jianqiu Gu Haixia Guan Zhongyan Shan Weiping Teng Lorenzo Cavagna | 2015 | BioMed Research International2015，，： | 1 |
| 20 | Water distribution in tofu and application of Tz relaxation measurements in determination of Tofu' s water-holding capacity显示文摘 | Li Teng Rui Xin Li Wei | 2014 | Journal of Agricultural and Food Chemistry2014，62，： | 1 |
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