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| 1 | 利用微卫星进行奶牛数量性状基因位点定位的研究显示文摘采用孙女设计法对德国奶牛的3个数量性状——产奶量、乳脂产量及乳蛋白产量进行了数量性状基因位点的定位研究。实验共有20个父系半同胞家系的1 130头种公牛,共测定了30对染色体上的229个微卫星,表型性状的育种值由孙代母牛估计得到。连锁分析采用多重遗传标记回归法,临界F值由置换实验法计算得到。统计检验发现在某些染色体上存在着一些显著的QTL’s区域,特别是14号染色体上某一区域对所有3个产奶性状都有极显著的影响。进一步证实了Coppieters和Ron等人的实验结果。 | 徐宁迎 H Thomsen N Reinsch C Looft E Kalm | 2000 | Acta Genetica Sinica2000，27，9： | 20 |
| 2 | 玉米秸秆湿氧化预处理同步糖化发酵酒精显示文摘为了找到适合的玉米秸秆生产酒精工艺,该文采用碱性湿氧化预处理(195℃,15min,Na2CO32g/L,O21200kPa)与同步糖化发酵对玉米秸秆制备酒精进行了研究。结果表明:经过预处理,90%纤维素保留在固体中,回收率为95.87%。固体部分利用纤维素酶处理,在50℃24h酶解率达到了67.6%。底物8%(质量分数),经过142h同步糖化发酵,酒精产量达到了理论酒精产量的79.0%。假定五碳糖和六碳糖都能够被利用,相当于1t玉米秸秆能够产生262.7kg的酒精。发酵过程中没有明显的抑制作用。该文为玉米秸秆发酵生产酒精提供了试验数据。 | 张强 殷涌光 Anders Thygesen Anne Belinda Thomsen | 2010 | 农业工程学报2010，26，9： | 16 |
| 3 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 4 | Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects显示文摘Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver transplantation.NAFLD and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in NAFLD.Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 D.Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD.Therefore,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients.In the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways.We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients.The specific focus was liver histopathology as assessed by the invasive liver biopsy.Additionally,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery. | Tea L Laursen Christoffer A Hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K Knop Henning Grønbæk | 2019 | World Journal of Hepatology2019，11，2： | 11 |
| 5 | 不同脱毒方法对玉米秸秆水解液酒精发酵的影响显示文摘利用湿热预处理(195℃,15 min)后的玉米秸秆水解液,考察了3种不同脱毒方法(中和法、饱和生石灰法和Na2SO3法)对水解液中的抑制剂的去除效果,研究了树干毕赤酵母(Pichia stipitis 58376)对脱毒后的水解液酒精发酵情况。结果表明:玉米秸秆水解液经过3种方法脱毒处理后,醛类抑制剂(糠醛和5-羟甲基糠醛)平均减少41%,总酚类最高去除28.4%,酒精得率都得到明显提高。最佳的脱毒方法是饱和生石灰法,理论酒精得率达到69.31%,对应的酒精浓度和生产效率分别为12.2 g/L和0.056 g/(L·h)。饱和生石灰法是一种有效实用的脱毒方法。 | 张强 Anders Thygesen Anne Belinda Thomsen | 2011 | 化工进展2011，30，4： | 10 |
| 6 | 男性肥胖对精液质量和辅助生殖结局的影响显示文摘已有文献报道男性超重及肥胖造成内分泌紊乱,可能会降低男性的生育能力。然而,男性体重指数(BMI)对精液质量和辅助生殖结局的影响却仍具争议。本研究将肥胖男性与正常体重男性对比,探明男性BMI的升高对精液质量和辅助生殖结局的影响。本研究纳入的612例肥胖不育男性来自丹麦生育中心,记录身高和体重数据并计算BMI值。根据BMI值(kgm^-2)将男性分为4组:〈20为体重不足组,20-24.9为正常体重组,25—29.9为超重组,〉30为超重组。依据WHO指南进行常规精液分析,按照SCSA检测精液DNA完整性。结果发现,男性BMI对常规精液参数(包括精子浓度、精子数目、精子体积及活动力)并无统计学影响。此外,诸如受孕率、GQE等辅助生殖结局,妊娠结局并未因BMI的升高而受显著影响。 | Lise Thomsen Peter Humaidan Leif Bungum Mona Bungum | 2014 | Asian Journal of Andrology2014，16，5： | 9 |
| 7 | 玉米秸秆水解液脱毒处理发酵生产酒精研究显示文摘为了找到适宜的玉米秸秆生产酒精工艺,采用水热处理后的玉米秸秆固体与水解液进行酒精同步糖化发酵,研究了预水解后不同pH值以及饱和生石灰法脱毒相结合对酒精发酵的影响。结果表明:当pH值在4.8时,加入100%水解液,由于抑制作用,醪液中酒精质量浓度仅为0.31 g/L(酒精得率9.48%)。预水解后将pH值从4.8分别调整到5.5、6.0和6.5后,酒精得率都有明显提高,最高为pH值5.5时,酒精质量浓度为10.67 g/L。将水解液经过饱和生石灰法脱毒处理,预水解后重新将pH值调整为5.5,酒精质量浓度达到了10.96 g/L(酒精得率57.9%)。与初始pH值4.8时相比,酒精得率提高了近6倍。 | 张强 庄莉 Anne Belinda Thomsen | 2012 | 农业机械学报2012，43，7： | 5 |
| 8 | 利用树干毕赤酵母发酵玉米秸秆制备燃料酒精显示文摘采用湿热预处理(195℃,15min)与同步糖化发酵对玉米秸秆制备酒精进行了研究。结果表明:玉米秸秆经过湿热预处理后,86.5%纤维素保留在滤饼中,而大部分半纤维素被溶解。在底物质量体积含量50g/L,温度30℃,pH值5.5,摇床转速130r/min条件下,树干毕赤酵母(Pichia stipitis)利用预处理后的玉米秸秆经过192h同步糖化发酵,酒精浓度达到了12.12g/L,对应的酒精产量和生产效率分别为0.34g/g(葡萄糖+木糖)和0.065g/(L·h)。该项研究为工业化生产打下了基础。 | 张强 戈兴炜 Anders Thygesen Anne Belinda Thomsen | 2010 | 化工进展2010，29，12： | 4 |
| 9 | 湿氧预处理玉米秸秆酶解与酒精发酵显示文摘对湿氧预处理后的玉米秸秆酒精发酵进行了研究,并考察了预处理后纤维素及半纤维素回收率、纤维素酶解转化和酒精得率。结果表明:玉米秸秆经过湿氧预处理(195℃,15min,12×105Pa O2)后,纤维素回收率为94.6%,其中88.3%纤维素保留在滤饼中,而大部分半纤维素和木质素被溶解。滤饼利用纤维素酶处理,50℃下24 h酶解率达到了65.8%。底物质量分数为8%,经过活性干酵母142 h同步糖化发酵,酒精产量达到了理论酒精产量的75.2%。仅考虑纤维素被完全利用,相当于1 t玉米秸秆能够产生165.7 kg的酒精。 | 张强 Anders Thygesen Anne Belinda Thomsen | 2011 | 吉林大学学报(工学版)2011，41，4： | 3 |
| 10 | World Gastroenterology Organisation Global Guideline: Constipation—A Global Perspective显示文摘 | Greger Lindberg Saeed S. Hamid Peter Malfertheiner Ole Ostergaard Thomsen Luis Bustos Fernandez James Garisch Alan Thomson Khean-Lee Goh Rakesh Tandon Suliman Fedail Benjamin C.Y. Wong Aamir Ghafoor Khan Justus H. Krabshuis Anton LeMair | 2011 | Journal of Clinical Gastroenterology2011，，6： | 3 |
| 11 | Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis显示文摘AIM To evaluate the liver regeneration capacity(LRC) after partial hepatectomy(PH) in experimental non-alcoholic steatohepatitis(NASH).METHODS Fifty-four female rats were fed a high-fat, high-cholesterol diet(HFCD, 65% fat, 1% cholesterol) or standard diet(STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d postPH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio(RPR), prothrombin-proconvertin ratio(PP), and m RNA expression of genes related to regeneration.RESULTS The HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline(P < 0.001), as well as a significantly elevated bilirubin at day 2 after PH(P < 0.05). HFCD animals had a higher N(Ki-67, lobe) at baseline,(P < 0.0001), day 2 after PH(P = 0.06) and day 5 after PH(P < 0.025). We found no significant difference in RPR or PP neither 2 or 5 d post-PH. Expression of liver regeneration genes(e.g., hepatic growth factor) was higher at both day 2 and 5 post-PH in HFCD groups(P < 0.05).CONCLUSION NASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC. | David Haldrup Sara Heeboll Karen Louise Thomsen Kasper Jarlhelt Andersen Michelle Meier Frank Viborg Mortensen Jens Randel Nyengaard Stephen Hamilton-Dutoit Henning Gronbaek | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 12 | 甘蔗糖料压榨系统的现况及新技术方案显示文摘本文论述了辊式压榨机的现状及其技术改进趋势,并分析了其固有缺陷,认为这是造成甘蔗汁液排放困难、重吸现象严重的根本原因,进而提出了改变压榨形式,延长压榨时间,采用外力排放糖汁等新的压榨技术方案,通过改善甘蔗糖料的压榨过程,强化固液萃取(渗出)分离过程,消除重吸现象,提高压榨效率,取代传统辊式压榨机,降低能耗,以满足清洁生产之需要。 | Yangsheng Lu(Eng) Jens Thomsen(Eng) | 2009 | 广西蔗糖2009，，4： | 2 |
| 13 | MicroRNA bta-miR-365-3p inhibits proliferation but promotes differentiation of primary bovine myoblasts by targeting the activin A receptor type Ⅰ显示文摘Background: MicroRNAs act as post-transcriptional regulators that repress translation or degrade mRNA transcripts.Each microRNA has many mRNA targets and each mRNA may be targeted by several microRNAs. Skeletal muscles express a plethora of microRNA genes that regulate muscle development and function by controlling the expression of protein-coding target genes. To expand our understanding of the role of microRNA, specifically btamiR-365-3 p, in muscle biology, we investigated its functions in regulating primary bovine myoblast proliferation and differentiation.Results: Firstly, we found that bta-miR-365-3 p was predominantly expressed in skeletal muscle and heart tissue in Chinese Qinchuan beef cattle. Quantitative PCR and western blotting results showed that overexpression of btamiR-365-3 p significantly reduced the expression levels of cyclin D1(CCND1), cyclin dependent kinase 2(CDK2) and proliferating cell nuclear antigen(PCNA) but stimulated the expression levels of muscle differentiation markers, i.e.,MYOD1, MYOG at both mRNA and protein level. Moreover, downregulation of bta-miR-365-3 p increased the expression of CCND1, CDK2 and PCNA but decreased the expression of MYOD1 and MYOG at both mRNA and protein levels. Furthermore, flow cytometry, EdU proliferation assays and immunostaining results showed that increased levels of bta-miR-365-3 p suppressed cell proliferation but promoted myotube formation, whereas decreased levels of bta-miR-365-3 p resulted in the opposite consequences. Finally, we identified that activin A receptor type I(ACVR1) could be a direct target of bta-miR-365-3 p. It was demonstrated that bta-miR-365-3 p can bind to the 3'UTR of ACVR1 gene to regulate its expression based on dual luciferase gene reporter assays.Consistently, knock-down of ACVR1 was associated with decreased expressions of CDK2, CCND1 and PCNA but increased expression of MYOG and MYOD1 both at mRNA and protein level.Conclusion: Collectively, these data suggested that bta-miR-365-3 p represses proliferation but promotes differentiation of bovine myoblasts through several biological mechanisms involving downregulation of ACVR1. | Dan Hao Xiaogang Wang Xiao Wang Bo Thomsen Yu Yang Xianyong Lan Yongzhen Huang Hong Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 2 |
| 14 | Continuous Therapy With Certolizumab Pegol Maintains Remission of Patients With Crohn’s Disease for up to 18 Months显示文摘 | Gary R. Lichtenstein Ole ?. Thomsen Stefan Schreiber Ian C. Lawrance Stephen B. Hanauer Ralph Bloomfield William J. Sandborn | 2010 | Clinical Gastroenterology and Hepatology2010，，7： | 2 |
| 15 | The prevalence of Human Papillomavirus in colorectal adenomas and adenocarcinomas: A systematic review and meta-analysis显示文摘 | Louise Baandrup Louise T. Thomsen Tina Bech Olesen Klaus Kaae Andersen Bodil Norrild Susanne K. Kjaer | 2014 | European Journal of Cancer2014，，： | 2 |
| 16 | On hash functions using checksums显示文摘 | Praveen Gauravaram John Kelsey Lars R. Knudsen S?ren S. Thomsen | 2010 | International Journal of Information Security2010，，2： | 2 |
| 17 | Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: Insights from a patient-level pooled analysis of six randomized clinical trials显示文摘 | Vivian A. Fonseca J. Hans DeVries Robert R. Henry Morten Donsmark Henrik F. Thomsen Jorge Plutzky | 2014 | Journal of Diabetes and Its Complications2014，，： | 2 |
| 18 | The warped neutral sheet and plasma sheet in the near-earth geomagnetic tail显示文摘 | Gosling J T McComas D J Thomsen M F | 1986 | J Geophys Res1986，91，： | 1 |
| 19 | Nitrate leaching under spring barley is influenced by the presence of a ryegrass catch crop:Results from a lysimeter experiment显示文摘 | Ingrid K Thomsen | 2004 | Agriculture Ecosystems & Environment2004，111，： | 1 |
| 20 | Vber Konforme Geometrie, Ⅰ : Grundlagen der Konformen Flachentheorie, Abh 显示文摘 | Thomsen G | 1923 | Math Sem Hamburg1923，，3： | 1 |
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