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| 1 | Detecting and monitoring of water inrush in tunnels and coal mines using direct current resistivity method:A review显示文摘Detecting, real-time monitoring and early warning of underground water-bearing structures are critically important issues in prevention and mitigation of water inrush hazards in underground engineering.Direct current(DC) resistivity method is a widely used method for routine detection, advanced detection and real-time monitoring of water-bearing structures, due to its high sensitivity to groundwater. In this study, the DC resistivity method applied to underground engineering is reviewed and discussed,including the observation mode, multiple inversions, and real-time monitoring. It is shown that a priori information constrained inversion is desirable to reduce the non-uniqueness of inversion, with which the accuracy of detection can be significantly improved. The focused resistivity method is prospective for advanced detection; with this method, the flanking interference can be reduced and the detection distance is increased subsequently. The time-lapse resistivity inversion method is suitable for the regions with continuous conductivity changes, and it can be used to monitor water inrush in those regions. Based on above-mentioned features of various methods in terms of benefits and limitations, we propose a three-dimensional(3D) induced polarization method characterized with multi-electrode array, and introduce it into tunnels and mines combining with real-time monitoring with time-lapse inversion and cross-hole resistivity method. At last, the prospective applications of DC resistivity method are discussed as follows:(1) available advanced detection technology and instrument in tunnel excavated by tunnel boring machine(TBM),(2) high-resolution detection method in holes,(3) four-dimensional(4D)monitoring technology for water inrush sources, and(4) estimation of water volume in water-bearing structures. | Shucai Li Bin Liu Lichao Nie Zhengyu Liu Mingzhen Tian Shirui Wang Maoxin Su Qian Guo | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，4： | 12 |
| 2 | High performance and stability of double perovskite-type oxide NdBa0.5Ca0.5Co1.5Fe0.5O5+δas an oxygen electrode for reversible solid oxide electrochemical cell显示文摘In this study,we successfully synthesized double perovskite-type oxide NdBa0.5Ca0.5Co1.5Fe0.5O5+δ(NBCCF)using a conventional wet chemical method as the oxygen electrode for reversible solid oxide electrochemical cells(RSOCs).The polarization resistance(Rp)of the composite electrode NBCCFGd0.1Ce0.9O2(GDC)is only 0.079Ωcm^2 at 800℃under air.The single cell based on NBCCF-GDC electrode displays a peak power density of 0.941 W/cm^2 in fuel cell mode and a low Rp value of 0.134Ωcm^2.In electrolysis cell mode,the cell displays an outstanding oxygen evolution reaction(OER)activity and shows current density as high as 0.92 A/cm^2 with 50 vol%AH(Absolute Humidity)at 800℃and applied voltage of 1.3 V.Most importantly,the cell exhibits admirable durability of 60 h both in electrolysis mode and fuel cell mode with distinguished reversibility.All these results suggest that NBCCF is a promising candidate electrode for RSOC. | Yunfeng Tian Yun Liu Wenjie Wang Lichao Jia Jian Pu Bo Chi Jian Li | 2020 | Journal of Energy Chemistry2020，29，4： | 4 |
| 3 | Study on the imaging ability of the 2D neutron detector based on MWPC显示文摘A 2D neutron detector based on 3 He convertor and MWPC with an active area of 200 mm×200 mm has been successfully designed and fabricated.The detector has been tested with Am/Be neutron source and with collimated neutron beam with the wavelength of =1.37.The best spatial resolution of 1.18 mm(FWHM) and good linearity were obtained.This is in good agreement with theoretical calculations. | TIAN LiChao CHEN YuanBo TANG Bin ZHOU JianRong QI HuiRong LIU RongGuang ZHANG Jian YANG GuiAn XU Hong CHEN DongFeng SUN ZhiJia | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 3 |
| 4 | Prototype of a large neutron detector based on MWPC显示文摘A prototype of large-area position sensitive neutron detector was designed and constructed according to the requirements of the Small-Angle Scattering spectrometer of China Spallation Neutron Source(CSNS).The detector was based on the 3He neutron convertor and MWPC with an effective area of 650 mm×650 mm.A prototype was completed and tested with 55Fe X-ray.The high-pressure vessel was designed and constructed with high-strength aluminum alloy.A position resolution of about 4.6mm×2.3 mm(FWHM)and efficiency>65%for neutrons with wavelength of 1.8?was determined after the operational gas filled. | TIAN LiChao QI HuiRong SUN ZhiJia WANG YanFeng ZHANG Jian LIU RongGuang ZHAO YuBin ZHANG HongYu ZHAO DongXu DONG Jing XIE Wan YANG GuiAn OUYANG Qun CHEN YuanBo | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 1 |
| 5 | Effect of aging on islet beta-cell function and its mechanisms in Wistar rats显示文摘 | Zhaoyan Gu Yingzhen Du Yu Liu Lichao Ma Lin Li Yanping Gong Hui Tian Chunlin Li | 2012 | AGE2012，，6： | 1 |
| 6 | Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas显示文摘Glioblastoma multiforme(GBM),a highly malignant and heterogeneous brain tumor,contains various types of tumor and non-tumor cells.Whether GBM cells can trans-differentiate into non-neural cell types,including mural cells or endothelial cells(ECs),to support tumor growth and invasion remains controversial.Here we generated two genetic GBM models de novo in immunocompetent mouse brains,mimicking essential pathological and molecular features of human GBMs.Lineage-tracing and transplantation studies demonstrated that,although blood vessels in GBM brains underwent drastic remodeling,evidence of trans-differentiation of GBM cells into vascular cells was barely detected.Intriguingly,GBM cells could promiscuously express markers for mural cells during gliomagenesis.Furthermore,single-cell RNA sequencing showed that patterns of copy number variations(CNVs)of mural cells and ECs were distinct from those of GBM cells,indicating discrete origins of GBM cells and vascular components.Importantly,single-cell CNV analysis of human GBM specimens also suggested that GBM cells and vascular cells are likely separate lineages.Rather than expansion owing to trans-differentiation,vascular cell expanded by proliferation during tumorigenesis.Therefore,cross-lineage trans-differentiation of GBM cells is very unlikely to occur during gliomagenesis.Our findings advance understanding of cell lineage dynamics during gliomagenesis,and have implications for targeted treatment of GBMs. | Fangyu Wang Xuan Liu Shaowen Li Chen Zhao Yumei Sun Kuan Tian Junbao Wang Wei Li Lichao Xu Jing Jing Juan Wang Sylvia MEvans Zhiqiang Li Ying Liu Yan Zhou | 2023 | Protein & Cell2023，14，2： | 0 |
| 7 | International Marketing of Taishan Shigandang Based on STP Strategy显示文摘Taishan Shigandang is a widely-spread subculture and an important part of Taishan subculture. Today, there is a great challenge to its protection and development. This paper analyzed the necessity and feasibility of its international marketing based on Segmenting, Targeting and Positioning strategy(STP strategy) | TIAN Lichao | 2017 | Journal of Landscape Research2017，9，3： | 0 |
| 8 | KCNH2 regulates the growth and metastasis of pancreatic cancer显示文摘Objective:Due to the characteristics of insidious onset and early metastasis of pancreatic cancer(PC),patients are often diag-nosed at an advanced stage and often delayed in completing surgical resection timely,resulting in poor prognosis.Therefore,this study aims to explore the expression of potassium voltage-gated channel subfamily H member 2(KCNH2)in PC and its relation-ship with clinicopathological parameters and the related mechanisms.Methods:GEPIA database and immunohistochemical staining were used to analyze the difference in KCNH2 expression be-tween PC and adjacent tissue in RNA and protein levels.Chi-squared test was used to evaluate the relationship between KCNH2 expression and clinicopathological features.The Cox regression model was used for multivariate analysis and univariate analysis.Histological diagnosis was performed according to World Health Organization(WHO)criteria to evaluate the relationship between KCNH2 expression and clinicopathological features.Results:KCNH2 expression was upregulated in PC compared with normal pancreatic tissue.In addition,the knockdown of KCNH2 inhibits PC cell proliferation,migration,invasion,and epithelial-mesenchymal transformation and promotes their apopto-sis.In addition,clinical data showed that the abnormal expression of KCNH2 in PC was related to the tumor stage.Patients with high expression of KCNH2 had a poor prognosis.Conclusions:KCNH2 is expected to be a novel targeted molecule in treating PC. | Jinghao Lei Qiang Wang Tengfei Qu Lichao Cha Hanxiang Zhan Jianwei Xu Shanglong Liu Lantian Tian Chuandong Sun Jingyu Cao Fabo Qiu Weidong Guo Bin Zhou | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 9 | A facile process to optimize performance of regenerated Nd-Fe-B sintered magnets:Chemo-selective dissolution washing显示文摘In this work,the recycled Nd-Fe-B powders and regenerated Nd-Fe-B sintered magnets with low impurity content were successfully prepared from Nd-Fe-B magnet sludge via reduction diffusion(RD)method followed by a chemo-selective dissolution washing proc ess.The chemo-selective dissolution effect of various solution(deionized water,dilute acetic acid solution,NH_(4)Cl-methanol solution) was evaluated by impurity content and magnetic properties of the recycled Nd-Fe-B powder.The NH_(4)Cl-methanol solution can selectively remove impurities with minimal damage to the magnetic phase.Besides,the optimal NH_(4)Cl concentration and liquid-to-solid ratio were investigated.As a consequence,the contents of Ca,O,and H after optimal washing process are reduced to 0.07 wt%,0.31 wt% and 0.22 wt%,respectively.Hence,M_(3) Tis increased to 146.72 emu/g,which is 33% higher than that of the initial sludge.Then,the regenerated Nd-Fe-B sintered magnets with properties of B_(r)=11.66 kG,H_(cj)=16.49 kOe,and(BH)_(m)=31.78 MGOe were successfully prepared by mixing with 40 wt% Nd4Fe14B alloy powders.Compared with the corresponding regenerated magnets washed with deionized water,the remanence and coercivity are increased by 18% and 59%,respectively. | Haibo Xu Qingmei Lu Lichao Yu Liying Cong Haowen Tian Weiqiang Liu Youhao Liu Yunqiao Wang Jingwu Chen Xiaofei Yi Qiong Wu Ming Yue | 2023 | Journal of Rare Earths2023，41，12： | 0 |
| 10 | The roles of traditional Chinese herbal medications in regulating mitochondrial activity to reverse cancer显示文摘Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which might become promising target for cancer chemotherapy.According to western pharmacology,a known target was needed for drug development.Unfortunately,the number of therapeutic agents relating to the mitochondrion are severely limited because of lacking of knowledge about mitochondrial biology.Unlike the“Western Medicine”,some traditional Chinese herbal medicine(TCHM)might be prone to targeting mitochondria despite the lack of precise molecular mechanisms.If it is the case,we might be able to screen and identify active anti-cancer drugs from traditional Chinese therapeutics by using mitochondrial functional assay.In this review,we would give an overview of the effect of TCHM on the mitochondrion,and the challenges and breakthroughs remaining in cancer treatment. | Lichao Sun Guihua Tian Hongcai Shang | 2020 | TMR Modern Herbal Medicine2020，3，2： | 0 |
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