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| 1 | Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats显示文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. | Yuan Yiping Zhai Huaqiang Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 2 | Purification and characterization of a thermostable cellulase-free xylanase from the newly isolated Paecilomyces themophila显示文摘 | LI Lite TIAN Hongmei CHENG Yongqiang | 2006 | Enzyme and Microbial Technology2006，38，： | 1 |
| 3 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Science2009，48，9： | 1 |
| 4 | Hydrodynamics and heat transfer characteristics of a novel heat exchanger with delta-winglet vortex generators 显示文摘 | Yonggang Lei Yaling He Liting Tian | 2010 | Chemical Engineering Science2010，65，5： | 1 |
| 5 | A Com- parative Study on the Air-Side Performance of Wavy Fin- and-~be Heat Exchanger With Punched Delta Winglets in Staggered and in-Line Arrangements 显示文摘 | TIAN Liting HE Yaling TAO Yubing | 2009 | International Journal of Thermal Sciences2009，48，17： | 1 |
| 6 | Hydrodynamics and heat transfer characteristics of a novel heat exchanger with delta-winglet vortex generators显示文摘 | LEI Yonggang HE Yaling TIAN Liting | 2010 | Chemical Engineering Science2010，65，5： | 1 |
| 7 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements显示文摘 | Liting Tian Yaling He Yubing Tao Wenquan Tao | 2009 | International Journal of Thermal Sciences2009，，9： | 1 |
| 8 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements 显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Sciences2009，48，9： | 1 |
| 9 | Numerical study of fluid flow and heat transfer in a flatplate channel with longitudinal vortex generators by applying filed synergy principle analysis显示文摘 | Tian Liting He Yaling Lei Yonggang | 2009 | International Communications in Heat Mass Transfer2009，36，2： | 1 |
| 10 | A polymorphism in metallothionein 1A ( MT1A ) is associated with cadmium-related excretion of urinary beta 2‐microglobulin显示文摘 | Lijian Lei Xiuli Chang Gerda Rentschler Liting Tian Guoying Zhu Xiao Chen Taiyi Jin Karin Broberg | 2012 | Toxicology and Applied Pharmacology2012，，3： | 1 |
| 11 | Numerical study of fluid flow and heat transfer in a fiat-plate channel with longitudinal vortex generators by applying field synergy principle analysis 显示文摘 | Tian Liting He Yaling Lei Yonggang | 2009 | International Communication in Heat and Mass Transfer2009，36，2： | 1 |
| 12 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Sciences2009，48，9： | 1 |
| 13 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements 显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Sciences2009，48，9： | 1 |
| 14 | Hydrodynamics and heat transfer characteristics of a novel heat exchanger with delta-winglet vortex generators显示文摘 | Lei Yonggang He Yaling Tian Liting | 2010 | Chemical EngineeringScience2010，65，5： | 1 |
| 15 | Numerical study of fluid flow and heat transfer in a flat-plate channel with longitudinal vortex generators by applying field synergy principle analysis显示文摘 | Tian Liting He Yaling Lei Yonggang | 2009 | International Communications in Heat and Mass Transfer2009，36，2： | 1 |
| 16 | A homozygous frameshift mutation in ADAD2 causes male infertility with spermatogenic impairments显示文摘Male infertility is a complex reproductive disorder that impedes a huge number of couples from having children naturally in the world(Agarwal et al.,2021).As an important pathogenic factor of male infertility,spermatogenic impairments are mainly characterized by impaired male gamete production,reduced sperm quality,or function(Tournaye et al.,2017).Spermatogenesis is a delicate and complex biological process that requires the collaboration of a large number of proteins performing different biological functions(Liu et al.,2021). | Shixiong Tian Ziqi Wang Liting Liu Yiling Zhou Yue Lv Dongdong Tang Jiaxiong Wang Jing Jiang Huan Wu Shuyan Tang Guanxiong Wang Hao Geng Fangbiao Tao Hongbin Liu Xiaojin He Feng Zhang Jinsong Li Li Jin Tao Huang Chunyu Liu Yunxia Cao | 2023 | Journal of Genetics and Genomics2023，50，4： | 0 |
| 17 | Human RNA Modifications Disease Database(HRMDD):A web resource for the molecular and clinical landscape of RNA modifications in human diseases显示文摘Here,we developed a comprehensive web-searchable database,designated as Human RNA Modifications Disease Database(HRMDD,http://gffzz07111d78e6704980h56vfwpxkqqo56wb9.ffgz.tsg.suse.edu.cn/HRMDD/home.jsp).RNA modification(RM)is an important mechanism of epigenetic regulation.With the evolution of both experimental technologies and computational methods,major progress has been made in identifying the genomic locations and distributions of various RM types throughout the transcriptome.^(1) | Jianjian Wang Lifang Li Hanxiao Zhou Shuang Li Liting Tian Xinyue Wang Danyang Li Yue Yin Shangwei Ning Lihua Wang | 2023 | Genes & Diseases2023，10，4： | 0 |
| 18 | Breeding and Cultivation Techniques of a New Spring Wheat Variety Kechun 140103显示文摘Kechun 140103 is a new spring wheat variety with high and stable yield bred by Keshan Branch of Heilongjiang Academy of Agricultural Sciences.This paper summarizes the breeding process,characteristics,yield performance and cultivation techniques of Kechun 140103,in order to promote the popularization and application of the variety. | Chao TIAN Ligang SHAO Jingyu CHE Yong MA Qichang ZHANG Ningtao LIU Zhikun WANG Xuewei YIN Liting DAI | 2023 | Plant Diseases and Pests2023，14，3： | 0 |
| 19 | Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition显示文摘Metastasis accounts for the majority of cancer deaths in many tumor types including breast cancer.Epithelial-mesenchymal transition(EMT)is the driving force for the occurrence and progression of metastasis,however,no targeted strategies to block the EMT program are currently available to combat metastasis.Diverse engineered nanomaterials(ENMs)have been reported to exert promising anti-cancer effects,however,no ENMs have been designed to target EMT.Palladium(Pd)nanomaterials,a type of ENM,have received substantial attention in nanomedicine due to their favorable photothermal performance for cancer therapeutics.Herein,Pd nanoplates(PdPL)were found to be preferentially biodistributed to both primary tumors and metastatic tumors.Importantly,PdPL showed a significant inhibition of lung metastasis with and without near-infrared(NIR)irradiation.Mechanistic investigations revealed that EMT was significantly compromised in breast cancer cells upon the PdPL treatment,which was partially due to the inhibition of the transforming growth factor-beta(TGF-β)signaling.Strikingly,the PdPL was found to directly interact with TGF-βproteins to diminish TGF-βfunctions in activating its downstream signaling,as evidenced by the reduced phosphorylation of Smad2.Notably,TGF-β-independent pathways were also involved in undermining EMT and other important biological processes that are necessary for metastasis.Additionally,NIR irradiation elicited synergistic effects on PdPL-induced inhibition of primary tumors and metastasis.In summary,these results revealed that the PdPL remarkably curbed metastasis by inhibiting EMT signaling,thereby indicating the promising potential of PdPL as a therapeutic agent for treating breast cancer metastasis. | Shunhao Wang Jingchao Li Mei Chen Liting Ren Wenya Feng Lining Xu Xiaolan Chen Tian Xia Nanfeng Zheng Sijin Liu | 2021 | National Science Review2021，8，7： | 0 |
| 20 | Acupuncture mechanism on oxidative stress in various diseases显示文摘There is compelling evidence to substantiate the notion that oxidative stress,in which the production of reactive oxygen species(ROS)overwhelms antioxidant defense,is a common feature of many acute and chronic disorders.ROS,the antioxidant system,and multiple redox factors underlie the pivotal roles of acupuncture on oxidative stress.Given the complexity of action mechanisms of acupuncture on oxidative stress,additional studies are needed to identify the most crucial mechanism that is applicable not only in animal models but also in patients suffering from oxidative damage. | LIN LiTing LI Hui YANG JingWen ZENG XiangHong HE Tian SHI GuangXia LIU CunZhi | 2015 | Science Foundation in China2015，23，2： | 0 |
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