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| 1 | High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa显示文摘It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-n Cov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas(TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression(FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. | Hao Xu Liang Zhong Jiaxin Deng Jiakuan Peng Hongxia Dan Xin Zeng Taiwen Li Qianming Chen | 2020 | International Journal of Oral Science2020，12，1： | 69 |
| 2 | Relay-intercropping soybean with maize maintains soil fertility and increases nitrogen recovery efficiency by reducing nitrogen input显示文摘Optimized nitrogen(N)management can increase N-use efficiency in intercropping systems.Legume-nonlegume intercropping systems can reduce N input by exploiting biological N fixation by legumes.Measurement of N utilization can help in dissecting the mechanisms underlying N uptake and utilization in legume-nonlegume intercropping systems.An experiment was performed with three planting patterns:monoculture maize(MM),monoculture soybean(SS),and maize-soybean relay intercropping(IMS),and three N application levels:zero N(NN),reduced N(RN),and conventional N(CN)to investigate crop N uptake and utilization characteristics.N recovery efficiency and 15N recovery rate of crops were higher under RN than under CN,and those under RN were higher under intercropping than under the corresponding monocultures.Compared with MM,IMS showed a lower soil N-dependent rate(SNDR)in 2012.However,the SNDR of MM rapidly declined from 86.8%in 2012 to 49.4%in 2014,whereas that of IMS declined slowly from 75.4%in 2012 to 69.4%in 2014.The interspecific N competition rate(NCRms)was higher under RN than under CN,and increased yearly.Soybean nodule dry weight and nitrogenase activities were respectively 34.2%and 12.5%higher under intercropping than in monoculture at the beginning seed stage.The amount(Ndfa)and ratio(%Ndfa)of soybean N2 fixation were significantly greater under IS than under SS.In conclusion,N fertilizer was more efficiently used under RN than under CN;in particular,the relay intercropping system promoted N fertilizer utilization in comparison with the corresponding monocultures.An intercropping system helps to maintain soil fertility because interspecific N competition promotes biological N fixation by soybean by reducing N input.Thus,a maize-soybean relay intercropping system with reduced N application is sustainable and environmentally friendly. | Qing Du Li Zhou Ping Chen Xiaoming Liu Chun Song Feng Yang Xiaochun Wang Weiguo Liu Xin Sun Junbo Du Jiang Liu Kai Shu Wenyu Yang Taiwen Yong | 2020 | The Crop Journal2020，8，1： | 7 |
| 3 | Far-red light: A regulator of plant morphology and photosynthetic capacity显示文摘Plant photosynthetic capacity directly determines crop yield. Light quality regulates photosynthetic capacity. This review discusses plant responses to far-red light from the phenotypic to the molecular level, focusing specifically on the improvement of photosynthetic capacity by adjustment of photosynthetic electron transport and the path of light energy. Far-red light can also regulate leaf angle and increase plant height and leaf area, via expression of associated genes, to capture more light energy.Thus, far-red light regulates plant morphology and photosynthetic capacity. Identifying the mechanism of this regulation may lead to increased crop yields. | Tingting Tan Shenglan Li Yuanfang Fan Zhonglin Wang Muhammad Ali Raza Iram Shafiq Beibei Wang Xiaoling Wu Taiwen Yong Xiaochun Wang Yushan Wu Feng Yang Wenyu Yang | 2022 | The Crop Journal2022，10，2： | 4 |
| 4 | Formation mechanisms and control method for stray grains at melt-back region of Ni-based single crystal seed显示文摘An experimental study together with numerical simulation was conducted to investigate the formation mechanisms and control methods for stray grains at melt-back of seed in this paper.The numerical simulation results showed that the convex solid/liquid(S/L)interface changed very slowly into a concave interface during the initial solidification stage and the undercooling was slightly affected by the S/L curvature change.The formation of stray grains below melt-back interface at seed perimeter could be suppressed with the decrease of clearance between the seed and mold.However when the clearance was further decreased to 0,an orientation deviation layer formed originated from the deformation of un-melted seed caused by different expend coefficient between the seed and mold.The nucleation of stray grains above the melt-back interface at the seed perimeter could be suppressed using the mold with small surface roughness.The isolated un-melted dendrite stem at semi-solid mushy of the seed with the large original primary dendrite spacing transfer to complex network structure,suppressing the formation of the stray grains,when the primary dendrite spacing of seed decreased or the seed underwent solution heat treatment.Then,the formation mechanisms of the stray grains at the melt-back region are discussed based on above results,and a method is proposed to suppress the formation of the stray grains for preparing single crystal components by re-used seed . | Songsong Hu Wenchao Yang Zhuoran Li Hanyuan Xu Taiwen Huang Jun Zhang Haijun Su Lin Liu | 2021 | Progress in Natural Science:Materials International2021，31，4： | 2 |
| 5 | How to reduce energy intensity in China: A regional comparison perspective显示文摘 | Yi Li Linyan Sun Taiwen Feng Chunyan Zhu | 2013 | Energy Policy2013，，： | 1 |
| 6 | Enhanced comprehensive properties of stereolithography 3D printed alumina ceramic cores with high porosities by a powder gradation design显示文摘Ceramic cores with complex structures and optimized properties are critical for hollow turbine blades applied in aeroengines.Compared to traditional methods,additive manufacturing(AM)presents great advantages in forming complex ceramic cores,but how to balance the porosity and strength is an enormous challenge.In this work,alumina ceramic cores with high porosity,moderate strength,and low high-temperature deflection were prepared using stereolithography(SLA)3D printing by a novel powder gradation design strategy.The contradiction between porosity and flexural strength is well adjusted when the mass ratio of the coarse,medium,and fine particles is 2:1:1 and the sintering temperature is 1600℃.The fracture mode of coarse particles in sintered SLA 3D printing ceramic transforms from intergranular fracture to transgranular fracture with the increase of sintering temperature and the proportion of fine powders in powder system.The sintered porosity has a greater influence on the high-temperature deflection of SLA 3D printed ceramic cores than grain size.On this basis,a'non-skeleton'microstructure model of SLA 3D printed alumina ceramic cores is created to explain the relationship between the sintering process and properties.As a result,high porosity(36.4%),appropriate strength(50.1 MPa),and low high-temperature deflection(2.27 mm)were achieved by optimizing particle size gradation and sintering process,which provides an insight into the important enhancement of the comprehensive properties of SLA 3D printed ceramic cores. | Xiang Li Haijun Su Dong Dong Di Zhao Yuan Liu Zhonglin Shen Hao Jiang Yinuo Guo Haifang Liu Guangrao Fan Wenchao Yang Taiwen Huang Jun Zhang Lin Liu Hengzhi Fu | 2022 | Journal of Materials Science & Technology2022，，36： | 1 |
| 7 | Maize-soybean relay cropping increases soybean yield synergistically by extending the post-anthesis leaf stay-green period and accelerating grain filling显示文摘Relay cropping of Poaceae and Fabaceae promotes high yield and land-use efficiency by allowing a double harvest.However,it is difficult to increase yield synergistically because of the reduced photosynthetic abilities of legume leaves under the shade of graminoids.Leaf photosynthetic capacity in relay cropping systems is associated with ecological niche differentiation and photosynthetic compensation after restoration of normal light.We conducted a field experiment in southwest China in 2020–2021 to evaluate the effects of three cropping patterns:maize–soybean relay cropping(IMS),monoculture maize(MM),and monoculture soybean(SS),and N application levels:no N application(NN:0 kg N ha^(−1)),reduced N(RN:180 kg N ha^(−1)),and conventional N(CN:240 kg N ha^(−1)).Compared to monocropping,relay cropping increased the stay-green traits of maize and soybean by 13%and 89%,respectively.Relay cropping prolonged the leaf stay-green duration in the maize and soybean lag phase by almost 4 and 8 days,respectively.Relay cropping maize(IM)increased the leaf area index(LAI)by 79.4%to 88.5%under NN and 55.5%to 148%under RN.Relay cropping soybean(IS)increased the LAI from 115%to 437%at days 40 to 50 after anthesis.IM increased yield by 65.6%.IS increased yield by 9.7%.HI and system yield were at their highest values under RN.In the relay cropping system,reduced N application extended green leaf duration,increased photosynthesis inside the canopy at multiple levels,ultimately increases soybean yield synergistically. | Yiling Li Ping Chen Zhidan Fu Kai Luo Ping Lin Chao Gao Shanshan Liu Tian Pu Taiwen Yong Wenyu Yang | 2023 | The Crop Journal2023，11，6： | 0 |
| 8 | Discovery of novel heteroaryl alkynes for highly potent KIT^(D816V) cells inhibition to treat gastrointestinal stromal tumors显示文摘To the Editor:Gastrointestinal stromal tumors(GIST)is the most popular mesenchymal tumor in the gastrointestinal tract with approximately 80%of GIST harboring gain-of-function mutations at either the extracellular region(exon 9)or the juxtamembrane domain(JMD,exon 11)of KIT,resulting in uncontrolled proliferation and resistance to apotosis1. | Zhicheng Xie Lin Li Yihao Guo Mi Zhang Taiwen Chen Yongpeng Li Xin Li Xi Zhu Yu Zhang Liguang Lou Youhong Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 0 |
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