|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 2 | Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity显示文摘 | Shinichi Takayama Takaaki Sato Stanislaw Krajewski Kristine Kochel Shinji Irie Juan A Milian John C Reed | 1995 | Cell1995，，2： | 2 |
| 3 | Application of hyperthermophiles and their enzymes 显示文摘 | Haruyuki A Takaaki S Tamotsu K | 2011 | Current Opinion in Biotechnology2011，22，5： | 1 |
| 4 | Application of hyperthermophiles and their enzymes 显示文摘 | Haruyuki A Takaaki S Tamotsu K | 2011 | Current Opinion in Biotecbnology2011，22，5： | 1 |
| 5 | A ntiemetic priciples of Poria cocos显示文摘 | Takaaki T Yasuhiko A Kaoru K | 1995 | Planta Med1995，61，6： | 1 |
| 6 | Immunoglobulin E oligomers iden- tified in blood components activate mast cells: rele- vance to anaphylactic transfusion reaction显示文摘 | TAKAAKI A B E CHIEKO MATSUMOTO EIKO SHIMADA | 2011 | Trans- fusion2011，51，： | 1 |
| 7 | Discovery of unique African Helicobacter pylori CagAmultimerization motif in the Dominican Republic显示文摘BACKGROUND Helicobacter pylori(H.pylori)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric cancer.However,although the prevalence of H.pylori is high in Africa,the incidence of gastric cancer is low,and this phenomenon is called to be African enigma.The CagA protein produced by H.pylori is the most studied virulence factor.The carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala(EPIYA)patterns and CagAmultimerization(CM)motifs.AIM To better understand the EPIYA patterns and CM motifs of the cagA gene.METHODS Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic,from which 120 H.pylori strains were cultured.After the bacterial DNA extraction,the EPIYA pattern and CM motif genotypes were determined using a polymerase chain reaction-based sequencing.The population structure of the Dominican Republic strains was analyzed using multilocus sequence typing(MLST).Peptic ulcer disease and gastric cancer were identified via endoscopy,and gastric cancer was confirmed by histopathology.Histological scores of the gastric mucosa were evaluated using the updated Sydney system.RESULTS All CagA-positive strains carried the Western-type CagA according to the identified EPIYA patterns.Twenty-seven kinds of CM motifs were observed.Although the typical Western CM motif(FPLKRHDKVDDLSKVG)was observed most frequently,the typical East Asian CM motif(FPLRRSAAVNDLSKVG)was not observed.However,“FPLRRSAKVEDLSKVG”,similar to the typical East Asian CM motif,was found in 21 strains.Since this type was significantly more frequent in strains classified as hpAfrica1 using MLST analysis(P=0.034),we termed it Africa1-CM(Af1-CM).A few hpEurope strains carried the Af1-CM motif,but they had a significantly higher ancestral Africa1 component than that of those without the Af1-CM motif(P=0.030).In 30 cagA-positive strains,the'GKDKGPE'motif was observed immediately upstream of the EPIYA motif in the EPIYA-A segment,and there was a significant association between strains with the hpAfrica1 population and those containing the“GKDKGPE”motif(P=0.018).In contrast,there was no significant association between the CM motif patterns and histological scores and clinical outcomes.CONCLUSION We found the unique African CM motif in Western-type CagA and termed it Africa1-CM.The less toxicity of this motif could be one reason to explain the African enigma. | Takaaki Ono Modesto Cruz Hiroyuki Nagashima Phawinee Subsomwong Junko Akada Takashi Matsumoto Tomohisa Uchida Rumiko Suzuki Celso Hosking Jose A Jimenez Abreu Yoshio Yamaoka | 2020 | World Journal of Gastroenterology2020，26，45： | 1 |
| 8 | Adsorption of polyvinylpyrrolidone on titanium dioxide from binary solvents (methanol/water) and its effect on dispersion stability显示文摘 | Atsushi S Takaaki A | 1998 | Colloids and Surface1998，142，： | 1 |
| 9 | Triterpenes of Poria cocos 显示文摘 | Takaaki T Akira A Tetsuro S | 1993 | Phytochemistry1993，32，5： | 1 |
| 10 | Clinical and neuroradiological features of intracranial vertebrobasilar artery dissection 显示文摘 | Takaaki H Michito A Koichi Y | 1999 | Stroke1999，30，： | 1 |
| 11 | Self-organizing feature maps with asymmetric neigh- borhood function 显示文摘 | TAKAAKI A | 2007 | Neural Computation2007，19，9： | 1 |
| 12 | Low-temperature epitaxial growth of conductive LaNiO3 thin films by RF magnetron sputtering显示文摘 | NAOKI W TAKAAKI A KAZUO S | 2002 | Thin Solid Films2002，410，12： | 1 |
| 13 | Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis 显示文摘 | Takaaki A Yoshikazu U Munetsugu H | 2010 | J Surg Oncal2010，102，7： | 1 |
| 14 | Design of highly stable,ordered cage mesostructured monoliths with controllable pore geometries and sizes显示文摘 | SHERIF A E S TAKAAKI H FUJIO M | 2005 | Chem Mater2005，17，： | 1 |
| 15 | A closed form formula for magnetic dipole localization by measurement of its magnetic field and spatial gradients 显示文摘 | TAKAAKI N SATOSHI S SHIGERU A | 2006 | IEEE Transac- tions on Magnetics2006，42，10： | 1 |
| 16 | Hydrogen evolution fromchemically etched titanium aluminides显示文摘 | FURUYA Y | 1996 | Journal of Alloys and Compounds1996，243，12： | 1 |
| 17 | New phase forma tion in titanium aluminide during chemical etching显示文摘 | OJIMA K TANEDA Y | 1994 | Scripta Metallurgica et Materlalia1994，30，9： | 1 |
| 18 | Clinnical and neuro- radiological features of intracranial vertebrobasilar artery dissection 显示文摘 | Takaaki H Michito A Koichi Y | 1999 | Stroke1999，30，： | 1 |
| 19 | Polymerizable cationic gemini surfactant显示文摘 | MASAHIKO A KAZUYUKI T TAKAAKI K | 2006 | Langmuir2006，22，20： | 1 |
| 20 | Elastatinal, a new elastase inhibitor produced by actinomycetes 显示文摘 | Hamao U Takaaki A Akira O | 1973 | J Antibiot1973，26，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员