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| 1 | The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas显示文摘 | Ken Tamai Takashi Koyama Tsuneo Saga Nobuko Morisawa Koji Fujimoto Yoshiki Mikami Kaori Togashi | 2008 | European Radiology2008，，4： | 6 |
| 2 | Treatment of colorectal carcinoids:A new paradigm显示文摘It is often difficult to evaluate the grade of malignancy and choose an appropriate treatment for colorectal carcinoids in clinical settings. Although tumor size and depth of invasion are evidently not enough to stratify the risk of this rare tumor, the present guidelines or staging systems do not mention other clinicopathological variables. Recent studies, however, have shed light on the impact of lymphovascular invasion on the outcome of colorectal carcinoids. It has been revealed that the presence of lymphovascular invasion was among the strongest risk factors for metastasis along with tumor size and depth of invasion. Furthermore, tumors smaller than 1 cm, within submucosal invasion and without lymphovascular invasion, carry minimal risk for metastasis with 100% 5-year survival in the studies from Japan as well as from the USA. This would suggest that these tumors could be curatively treated by endoscopic resection or transanal local excision. On the other hand, colorectal carcinoids with either lymphovascular invasion or tumor size larger than 1 cm carry the risk for metastasis equivalent to adenocarcinomas. Therefore, it should be emphasized that histological examination of lymphovascular invasion is mandatory in the specimens obtained by endoscopic resection or transanal local excision, as this would provide useful information for determining the need for additional radical surgery with regional lymph node dissection. Although the present guidelines or TNM staging system do not mention the impact of lymphovascular invasion, this would be among the next promising targets in order to establish better guidelines and staging systems, particularly in early-stage colorectal carcinoids. | Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya Masashi Ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 5 |
| 3 | Preoperative chemoradiation and extended pelvic lymphadenectomy for rectal cancer:Two distinct principles显示文摘Extended pelvic lymphadenectomy(EPL) with total mesorectal excision(TME) has been reported to provide oncological benefit in lower rectal cancer in Japan.In Western countries EPL is not widely accepted because of frequent morbidity but instead preoperative chemoradiation(CRT) followed by TME has been established as a standard treatment for decreasing local recurrence.Recently,several studies have focused on the comparison between these two distinct therapeutic approaches in Western countries and Japan.A study comparing Dutch trial data and Japanese data revealed that EPL and RT are almost equivalent in decreasing local recurrence in lower rectal cancer as compared with TME alone.Considering that almost 45 survival can be achieved by EPL even in the presence of metastatic lateral lymph nodes(LLNs),EPL performed by experienced surgeons definitely contributes to decrease local recurrence.On the other hand,a randomized controlled trial in Japan that compared EPL with conventional TME following preoperative RT revealed that EPL is associated with a higher frequency of sexual and urinary dysfunction without oncological benefits in the presence of preoperative RT.On this point,preoperative CRT followed by conventional TME without EPL would be a better therapeutic approach in patients without evident metastatic LLNs.For future treatment,it would be desirable to have a narrower indication for EPL using full advantage of recent improvement in image diagnosis.Although objective comparison of these two principles between Japan and the West is difficult due to differences in patient groups,further studies would lead to the next great step towards future improvement in treating lower rectal cancer. | Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya Masashi Ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 4 | Changes in portal venous pressure in the early phase after living donor liver transplantation: pathogenesis and clinical implications1,2显示文摘 | Takashi Ito Tetsuya Kiuchi Hidekazu Yamamoto Fumitaka Oike Yasuhiro Ogura Yasuhiro Fujimoto Kazuhiro Hirohashi and Koichi Tanaka | 2003 | Transplantation2003，，8： | 3 |
| 5 | The Cellulose Synthases Are Cargo of the TPLATE Adaptor Complex显示文摘 | Clara Sanchez-Rodriguez Yanyun Shi Christopher Kesten Dongmei Zhang Gloria Sancho-Andres Alexander Ivakov Edwin R. Lampugnani Kamil Sklodowski Masaru Fujimoto Akihiko Nakano Antony Bacic Ian S. Wallace Takashi Ueda Daniel Van Damme Yihua Zhou Staffan Persson | 2018 | Molecular Plant2018，11，2： | 3 |
| 6 | A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Hiroshi Ohtani Yutaka Tamamori Kozo Noguchi Takashi Azuma Shunsuke Fujimoto Hiroko Oba Tetsuya Aoki Mieko Minami Kosei Hirakawa | 2010 | Journal of Gastrointestinal Surgery2010，，6： | 3 |
| 7 | Usefulness of Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinoma显示文摘 | Toshimi Kaido Kohei Ogawa Akira Mori Yasuhiro Fujimoto Takashi Ito Koji Tomiyama Yasutsugu Takada Shinji Uemoto | 2013 | Surgery2013，，： | 3 |
| 8 | Safety and Feasibility of Laparoscopic Intersphincteric Resection for Very Low Rectal Cancer显示文摘 | Yoshiya Fujimoto Takashi Akiyoshi Hiroya Kuroyanagi Tsuyoshi Konishi Masashi Ueno Masatoshi Oya Toshiharu Yamaguchi | 2010 | Journal of Gastrointestinal Surgery2010，，4： | 2 |
| 9 | Short-Term Outcomes of Laparoscopic Colectomy for Transverse Colon Cancer显示文摘 | Takashi Akiyoshi Hiroya Kuroyanagi Yoshiya Fujimoto Tsuyoshi Konishi Masashi Ueno Masatoshi Oya Toshiharu Yamaguchi | 2010 | Journal of Gastrointestinal Surgery2010，，5： | 2 |
| 10 | Incidence of and risk factors for anastomotic leakage after laparoscopic anterior resection with intracorporeal rectal transection and double-stapling technique anastomosis for rectal cancer显示文摘 | Takashi Akiyoshi Masashi Ueno Yosuke Fukunaga Satoshi Nagayama Yoshiya Fujimoto Tsuyoshi Konishi Hiroya Kuroyanagi Toshiharu Yamaguchi | 2011 | The American Journal of Surgery2011，，3： | 1 |
| 11 | Studies on the constituents of Artemisia argi Levi et Vant显示文摘 | Aina Lao Yasuo Fujimoto Takashi Tatsuno | 1984 | Chem Pharm Bull1984，32，2： | 1 |
| 12 | Laparoscopic abdominosacral resection for locally advanced primary rectal cancer after treatment with mFOLFOX6 plus bevacizumab, followed by preoperative chemoradiotherapy显示文摘 | Toshiya Nagasaki Takashi Akiyoshi Masashi Ueno Yosuke Fukunaga Satoshi Nagayama Yoshiya Fujimoto Tsuyoshi Konishi Toshiharu Yamaguchi | 2014 | Asian J Endosc Surg2014，，1： | 1 |
| 13 | Short-Term Outcomes of Laparoscopic Rectal Surgery for Primary Rectal Cancer in Elderly Patients: Is it Safe and Beneficial?显示文摘 | Takashi Akiyoshi Hiroya Kuroyanagi Masatoshi Oya Tsuyoshi Konishi Meiki Fukuda Yoshiya Fujimoto Masashi Ueno Toshiharu Yamaguchi | 2009 | Journal of Gastrointestinal Surgery2009，，： | 1 |
| 14 | The prognostic significance of overexpression of the decoy receptor for Fas ligand (DcR3) in patients with gastric carcinomas显示文摘 | Yasushi Takahama Yukishige Yamada Koji Emoto Heisuke Fujimoto Tomoyoshi Takayama Masatoh Ueno Hideki Uchida Shuya Hirao Takashi Mizuno Yoshiyuki Nakajima | 2002 | Gastric Cancer2002，，2： | 1 |
| 15 | Studies on the constituents of Artemisia argi Levi et Vant显示文摘 | Aina Lao Yasuo Fujimoto Takashi Tatsuno | 1954 | Chem Pharm Bull1954，32，2： | 1 |
| 16 | Use of the Model for End-Stage Liver Disease (MELD) score to predict 1-year survival of Japanese patients with cirrhosis and to determine who will benefit from living donor liver transplantation显示文摘 | Masatoshi Ishigami Takashi Honda Akihiko Okumura Tetsuya Ishikawa Makoto Kobayashi Yoshiaki Katano Yasuhiro Fujimoto Tetsuya Kiuchi Hidemi Goto | 2008 | Journal of Gastroenterology2008，，5： | 1 |
| 17 | Safety of Laparoscopic Total Mesorectal Excision for Low Rectal Cancer with Preoperative Chemoradiation Therapy显示文摘 | Takashi Akiyoshi Hiroya Kuroyanagi Masatoshi Oya Tsuyoshi Konishi Meiki Fukuda Yoshiya Fujimoto Masashi Ueno Toshiharu Yamaguchi Tetsuichiro Muto | 2009 | Journal of Gastrointestinal Surgery2009，，3： | 1 |
| 18 | Safety and feasibility of laparoscopic intersphincteric re-section for very low rectal cancer显示文摘 | Yoshiya Fujimoto Takashi Akiyoshi Hiroya Kuroyanagi etal | 2010 | J Gastrointest Surg2010，144，： | 1 |
| 19 | Colon Cancer in the Splenic Flexure: Comparison of Short-term Outcomes of Laparoscopic and Open Colectomy显示文摘 | Masayuki Nakashima Takashi Akiyoshi Masashi Ueno Yosuke Fukunaga Satoshi Nagayama Yoshiya Fujimoto Tsuyoshi Konishi Rota Noaki Keiko Yamakawa Yasutomo Nagasue Hiroya Kuroyanagi Toshiharu Yamaguchi | 2011 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2011，，6： | 1 |
| 20 | Host-Derived MCP-1 and MIP-1α Regulate Protective Anti-Tumor Immunity to Localized and Metastatic B16 Melanoma显示文摘 | Yuko Nakasone Manabu Fujimoto Takashi Matsushita Yasuhito Hamaguchi Doanh Le Huu Mizuki Yanaba Shinichi Sato Kazuhiko Takehara Minoru Hasegawa | 2012 | The American Journal of Pathology2012，，1： | 1 |
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