|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | 一种仿生水下机器人的设计与动力学分析(英文)显示文摘A biomimetic underwater vehicle propelled by two undulating long-fins is introduced in this paper. The concerned vehicle is propelled by two symmetrical undulating long-fins installed on both sides. Ten servo motors are employed to drive the long-fins and cosine wave function is employed for motor control. A real-time control system is designed for controlling the long-fins by adjusting its oscillating frequency and oscillating amplitude. An inertial measurement unit is installed to collect the accelerations and angular velocity. To obtain the relationship between oscillating frequency/amplitude and swimming performance, kinematic analysis and hydromechanic analysis are given. By dividing the long-fin into many small elements and computing the hydrodynamic force acting on each element, the instantaneous thrust generated by the long-fin is obtained. Then the average thrust of the long-fin is obtained by summing up the forces acted on the elements in one undulating period. Then swimming experiments are carried out to validate the vehicle design and kinematic analysis and hydromechanic analysis. And two swimming motion modes including marching and rotating locomotion are chosen. Finally, discussions between the swimming performance and the oscillating parameters are given. | WEI Qing-Ping WANG Shuo DONG Xiang SHANG Liu-Ji TAN Min | 2013 | 自动化学报2013，39，8： | 11 |
| 3 | Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital显示文摘 | CUI Wei WU Wei WANG Xin WANG Geng HAO Ying-ying CHEN Yu LUO Dan SHOU Wei-ling ZHANG Shuo XIANG Xue-fang SI Yong-zhen CHEN Qian CAI Hao LI Tan SHEN Han SHANG Kun ZHANG Yong-qiang | 2010 | Chinese Medical Journal2010，，22： | 10 |
| 4 | Evaluation of Cloud Top Height Retrievals from China’s Next-Generation Geostationary Meteorological Satellite FY-4A显示文摘To evaluate the validity of cloud top height (CTH) retrievals from FY-4A, the first of China's next-generation geostationary meteorological satellite series, the retrievals are compared to those from Himawari-8, CloudSat, Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO), and Moderate Resolution Imaging Spectroradiometer (MODIS) operational products from August to October 2017. Regarding CTHs from CloudSat, CALIPSO, and MODIS as truth, the results show that the performance of FY-4A CTH retrievals is similar to that of Himawari-8. Both FY-4A and Himawari-8 retrieve reasonable CTH values for single-layer clouds, but perform poorly for multi-layer clouds. The mean bias error (MBE) shows that the mean value of FY-4A CTH retrievals is smaller than that of Himawari-8 for single-layer clouds but larger for multi-layer clouds. For ice crystal clouds, both FY-4A and Himawari-8 obtain the underestimated CTHs. However, there is a tendency for FY-4A and Himawari-8 to overestimate the CTH values of CloudSat and CALIPSO mainly for low level liquid water clouds. The temperature inversion near the tops of water clouds may result in an overestimation of CTHs. According to the MBE change with altitude, FY-4A and Himawari-8 overestimate the CTHs mainly for clouds below 3 km, and the overestimation is slightly more apparent in Himawari-8 data than that in FY-4A values. As the cloud optical thickness (COT) increases, the CTH bias of FY-4A CTH retrievals gradually decreases. Two typical cases are analyzed to illustrate the differences between different satellites' CTH retrievals in detail. | Zhonghui TAN Shuo MA Xianbin ZHAO Wei YAN Wen LU | 2019 | Journal of Meteorological Research2019，33，3： | 8 |
| 5 | VECTOR VALUED RATIONAL INTERPOLANTS BY TRIPLE BRANCHED CONTINUED FRACTIONS显示文摘VECTORVALUEDRATIONALINTERPOLANTSBYTRIPLEBRANCHEDCONTINUEDFRACTIONSTANJIEQINGANDTANGSHUOAbstract.Triplebranchedcontinuedfract... | TAN JIEQING AND TANG SHUO | 1997 | Applied Mathematics(A Journal of Chinese Universities)1997，12，1： | 8 |
| 6 | Simplified propulsive model for biomimetic robot fish and its experimental validation显示文摘As a combination of bio-mechanism and engineering technology, robot fish has become a multidisciplinary research that mainly involves both hydrodynamics-based control and actuation technology. This paper presents a simplified propulsive model for carangiform propulsion, which is a swimming mode suitable for high speed and high efficiency. The carangiform motion is modeled as an N-joint oscillating mechanism that is composed of two basic components: the streamlined fish body represented by a planar spline curve and its lunate caudal tail by an oscillating foil. The speed of fish's straight swimming is adjusted by modulating the joint's oscillating frequency, and its orientation is tuned by different joint's deflection. The results from actual experiment showed that the proposed simplified propulsive model could be a viable candidate for application in aquatic swimming vehicles. | 喻俊志 Wang Shuo Tan Min | 2005 | High Technology Letters2005，11，4： | 6 |
| 7 | A marsupial robotic fish team: Design, motion and cooperation显示文摘A bio-inspired marsupial robotic fish system composed of heterogeneous robotic fish is proposed in this paper. A miniature robotic fish, as the daughter robotic fish, can adapt to some narrow space, while the mother robotic fish, with a cabin to transport the daughter, possesses a powerful movement ability to improve the mobility and endurance of the team. The structures for mimicking bio-motion and the method for fishlike-motion are presented. A typical task of daughter-mother following is given to show the cooperation of the team. A motion model of free swimming is built based on the Lagrangian function, and the coupled dynamic and kinematic functions are calculated based on the relation between the generalized force and fluid force. Then, a neural network is trained through the data generated from this model to get a predictive yaw controller, which can control the orientation by a different offset of each link. The daughter robotic fish adopts a dynamic light source tracking approach to follow the mother, and a heterogeneous communication-based finite state machine is presented for task modeling. Experiments are carried out to verify the system. | ZHOU Chao*, CAO ZhiQiang, WANG Shuo & TAN Min Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China(Technological Sciences)2010，53，11： | 6 |
| 8 | Pain threshold, anxiety and other factors affect intensity of postoperative pain in gastric cancer patients: A prospective cohort study显示文摘Objective: This prospective cohort study explored factors related to postoperative pain in gastric cancer patients.Methods: A total of 236 patients who underwent gastrectomy were enrolled. All patients enrolled in the study completed the Hospital Anxiety and Depression Scale(HADS) questionnaire and Life Orientation Test-Revised(LOT-R) questionnaire on the day before surgery. Heat pain threshold(HPT), cold pain threshold(CPT) and pressure pain threshold(PPT) were measured for all patients one day prior to surgery and demographic details were collected. All patients were connected to a patient-controlled intravenous analgesia(PCIA) pump at the end of the surgery. The occurrence of postoperative pain was used as a dependent variable, and multivariate logistic regression analyses were conducted to screen for factors affecting postoperative pain.Results: In total, 83 patients(35.2%) had postoperative pain. Body mass index(BMI) ≥28 kg/m^(2) [odds ratio(OR): 2.67;95% confidence interval(95% CI): 1.07-6.67], total gastrectomy(OR: 2.64;95% CI: 1.42-4.91),preoperative anxiety score ≥8(OR: 2.37;95% CI: 1.12-5.02), heat pain threshold ≤4.9 s(OR: 2.14;95% CI:1.06-4.32), pressure pain threshold ≤4 g(OR: 2.05;95% CI: 1.05-4.03), and female gender(OR: 1.99;95% CI:1.04-3.83) were risk factors for postoperative pain.Conclusions: Obesity, wide range of gastrectomy, high preoperative anxiety, low HPT and PPT, and female gender are associated with increased risk for postoperative pain. | Hongyu Tan Jin Wei Shuo Li Ling Yu Hongwei Sun Ke Ji Yinkui Wang Changlong Li | 2021 | Chinese Journal of Cancer Research2021，33，3： | 5 |
| 9 | FGF/FGFR signaling in health and disease显示文摘Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of cells.In this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems. | Yangli Xie Nan Su Jing Yang Qiaoyan Tan Shuo Huang Min Jin Zhenhong Ni Bin Zhang Dali Zhang Fengtao Luo Hangang Chen Xianding Sun Jian Q.Feng Huabing Qi Lin Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 10 | Mobility in China,2020:a tale of four phases显示文摘2020 was an unprecedented year;with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun),to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements;which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55%city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others. | Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu | 2021 | National Science Review2021，8，11： | 3 |
| 11 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 12 | Single-/fused-band dual-mode mid-infrared imaging with colloidal quantum-dot triple-junctions显示文摘Image data acquired with fused multispectral information can be used for effective identification and navigation owing to additional information beyond human vision,including thermal distribution,night vision,and molecular composition.However,the construction of photodetectors with such capabilities is hindered by the structural complexity arising from the integration of multiple semiconductor junctions with distinct energy gaps and lattice constants.In this work,we develop a colloidal quantum-dot dual-mode detector capable of detecting,separating,and fusing photons from various wavelength ranges.Using three vertically stacked colloidal quantum-dot homojunctions with alternating polarity,single-band short-wave infrared imaging and fused-band imaging(short-wave and mid-wave infrared)can be achieved with the same detector by controlling bias polarity and magnitude.The dual-mode detectors show detectivity up to 8×10^(10)Jones at the fused-band mode and 3.1×10^(11)Jones at the single-band mode,respectively.Without image post-processing algorithms,the dual-mode detectors could provide both night vision and thermal information-enhanced night vision imaging capability.To the best of our knowledge,this is the first colloidal quantum-dot detector that can achieve such functionality.The operation mode can be changed at a high frequency up to 1.7 MHz,making it possible to achieve simultaneously dual-mode imaging and remote temperature sensing. | SHUO ZHANG GE MU JIE CAO YUNING LUO QUN HAO MENGLU CHEN YIMEI TAN PENGFEI ZHAO XIN TANG | 2022 | Photonics Research2022，10，8： | 3 |
| 13 | The Association between the C5263T Mutation in the Mitochondrial ND2 Gene and Coronary Heart Disease among Young Chinese Han People显示文摘Objective This study aimed to investigate the genetic background of mitochondrial genes in young patients with Coronary heart disease(CHD) to provide a foundation for the early prevention of young patients with CHD.Methods 115 cases of young(≤ 45 years) CHD Chinese Han patients(case group),100 cases of older(> 45 years) Chinese Han CHD patients(experimental group) hospitalized and 100 cases of healthy people through physical examination(control group) at the General Hospital of PLA between January 2014 and December 2015 were selected.General information,clinical assessment,pedigree analysis,and mitochondrial full sequence scanning were performed.The pedigrees of one patient harbouring the C5263 T mutation were recruited.Mitochondrial functional analysis including cellular reactive oxygen species(ROS) levels and mitochondrial membrane potential(MMP) were performed on pedigrees with the C5263 T mutation(mutation group) and without the mutation(non-mutation group).Results The differences in biochemical tests(P > 0.05) between the case group and experimental group were not significant.The C5263 T single-nucleotide mutation of the mitochondrial ND2 gene was observed in 2 young CHD patients in the case group.The premature CHD of these 2 patients followed a pattern of maternal inheritance.The mutation group(Ⅰ1,Ⅱ2) had higher ROS levels(4750.82 ± 1045.55 vs.3888.58 ± 487.60,P = 0.022) and lower MMP levels(P = 0.045) than the non-mutation group(Ⅱ1,Ⅲ1,Ⅲ2).Conclusion We speculated that the mitochondrial C5263 T mutation might be associated with the occurrence CHD in Chinese Han young people. | HAN Guo Xin XIA Lei LI Shuo Shuo JIN Qin Hua SONG Yang SHEN Hong WANG Li Li KONG Ling Jie LI Tan Shi ZHU Hai Yan | 2017 | Biomedical and Environmental Sciences2017，30，4： | 2 |
| 14 | Homomorphic encryption experiments on IBM's cloud quantum computing platform显示文摘量计算在最近的年里经历了快速的开发。由于可伸缩性上的限制,个人量计算机在不久的将来仍然似乎稍微不现实。为平常的用户的第一台实际的量计算机是可能的在云上。然而,仅当安全被保证,云计算的采纳是可能的。同构的加密是允许计算没有解密他们,在加密数据上被表现的一个密码的协议,因此遮蔽计算很好被适合。这里,我们首先在 IBM 云量计算机站台上使用了同构的加密。在我们的实验,当保护我们的隐私时,我们成功地为线性方程实现了一个量算法。这示范打开一条可行路径到云量信息技术的开发的下一个阶段。 | He-Liang Huang You-Wei Zhao Tan Li Feng-Guang Li Yu-Tao Du Xiang-Qun Fu Shuo Zhang Xiang Wang Wan-Su Bao | 2017 | Frontiers of physics2017，12，1： | 2 |
| 15 | Biodegradation Behavior of Coated As-Extruded Mg–Sr Alloy in Simulated Body Fluid显示文摘As-extruded Mg-Sr alloy, a kind of promising biodegradable biomedical material, was coated using micro-arc oxidation and also using a phosphate conversion coating. The corrosion behaviors were investigated using Hanks' solution. The corrosion of the as-extruded Mg-Sr alloy became more serious with increasing immersion time;that is, the corrosion pits became more numerous, larger and deeper, The micro-arc oxidation coating and the phosphate conversion coating were effective in improving the corrosion resistance of the as-extruded Mg-Sr alloy. The micro-arc oxidation coating was much more effective. Moreover, the as-extruded Mg-Sr alloy and the coated as-extruded Mg-Sr alloy exhibited lower corrosion rates than the as-cast Mg-Sr alloy and the corresponding coated as-cast Mg-Sr alloy, indicating that the corrosion properties of the coated samples are dependent on their substrates. The finer microstructure of the substrate of the as-extruded condition corroded much slower. The corrosion resistance of the coated Mg-Sr alloy depended on the coating itself and on the microstructure of the substrate. | Ming-Chun Zhao Ying-Chao Zhao Deng-Feng Yin Shuo Wang Yong-Ming Shangguan Chao Liu Li-Li Tan Ci-Jun Shuai Ke Yang Andrej Atrens | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，10： | 2 |
| 16 | Hand-assisted-drawing-needle running suture with a curved needle: an effective technique to create a W-ileal neobladder显示文摘 | FANG Dan-bo CAI Song-liang JIN Xiao-dong CHEN Jun JIN Bai-ye ZHENG Xiang-yi WANG Chao-jun TAN Fu-qing WANG Shuo SHEN Bo-hua ZHU Xuan-wen XIE Li-ping | 2012 | Chinese Medical Journal2012，，12： | 1 |
| 17 | Parameter back-calculation for concrete with two slab layers显示文摘 | Li Shuo Fwa T F Tan Kiang-Hwee | 1998 | Journal of Transportation Engineering1998，124，6： | 1 |
| 18 | Development of a Biomimetic Robotic Fish and Its Control Algorithm显示文摘 | Yu Junzhi Tan Min Wang Shuo | 2004 | IEEE Transaction on systems2004，34，4： | 1 |
| 19 | Back-calculation of parameters for slab on two-layer foundation system显示文摘 | Li Shuo Fwa T F Tan K H | 1997 | Journal of Transportation Engineering1997，123，6： | 1 |
| 20 | Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin-23显示文摘The dendritic cell vaccine is a treatment vaccine with potent clinical applications.Functional cytokines can enhance dendritic cell anti-tumor immune responses.This experiment was conducted to study the effects of bone marrow-derived dendritic cells(BM-DCs)modified with genes encoding murine interleukin-23(IL-23)on murine pancreatic carcinoma,and effects of the treatment of pancreatic carcinoma with β-elemene combined with IL-23-modified dendritic cell vaccine.The murine IL-23 cDNA was sub-cloned into a dual-expression vector.DCs were pulsed with tumor cell lysate after being modified wth IL-23.Mice were divided into groups which were injected with IL-23-transduced DC vaccine,non-transduced DC vaccine and sodium respectively.The preventive immune and immunotherapeutic effects of DC vaccines on mice and cytokine release in vivo were then assessed.Results showed inhibitory effects on tumor cells and increased survival time in the experimental group treated with the vaccine combined with β-elemene.The IL-23 protein apparently increases the antigen presenting ability of DCs.After injection with DC vaccines,IFN-γ production in the treatment group was significantly increased as compared with that in the control group(P<0.01),and IL-4 production was decreased as compared with that in the control group(P<0.05).Tumor size was obviously reduced,and survival time clearly prolonged in the group with β-elemene combined with DC vaccine,in comparison to the other treatment groups and the control(P<0.01).IL-23-modified dendritic cell vaccines enhance specific Th1-type and cytotoxic T lymphocyte(CTL)responses against pancreatic carcinoma cells,and induce not only auto-immune ability but also preventive immunity against pancreatic carcinoma implanted in mice.β-elemene has great anti-tumor collaborative functions. | TAN Guang WANG Zhongyu CHE Luanqing YIN Shuo | 2007 | Frontiers of Medicine2007，1，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员