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| 1 | Morrey Spaces for Non-doubling Measures显示文摘作者为可能非加倍,但是满足某些生长条件的氡措施给 Morrey 空格的一个自然定义,并且在泛音分析和他们的珍视向量的扩展在一些古典操作符的这些空格调查围住的海角。 | Yoshihiro SAWANO Hitoshi TANAKA | 2005 | Acta Mathematica Sinica,English Series2005，21，6： | 25 |
| 2 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 3 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 4 | Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium显示文摘AIM:To investigate the possible biological outcome and effect of glutamine depletion in neonatal mice and rodent intestinal epithelial cells.METHODS:We developed three kinds of artificial milk with different amounts of glutamine;Complete amino acid milk (CAM),which is based on maternal mouse milk,glutamine-depleted milk (GDM),and glutaminerich milk (GRM).GRM contains three-fold more glutamine than CAM.Eighty-seven newborn mice were divided into three groups and were fed with either of CAM,GDM,or GRM via a recently improved nipple-bottle system for seven days.After the feeding period,the mice were subjected to macroscopic and microscopic observations by immunohistochemistry for 5-bromo-2'deoxyuridine (BrdU) and Ki-67 as markers of cell proliferation,and for cleaved-caspase-3 as a marker of apoptosis.Moreover,IEC6 rat intestinal epithelial cells were cultured in different concentrations of glutamine and were subject to a 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)2H-5-tetrazolio]-1,3-benzene disulfonate cell proliferation assay,flow cytometry,and western blotting to examine the biological effect of glutamine on cell growth and apoptosis.RESULTS:During the feeding period,we found colonic hemorrhage in six of 28 GDM-fed mice (21.4%),but not in the GRM-fed mice,with no differences in body weight gain between each group.Microscopic examination showed destruction of microvilli and the disappearance of glycocalyx of the intestinal wall in the colon epithelial tissues taken from GDM-fed mice.Intake of GDM reduced BrdU incorporation (the average percentage of BrdU-positive staining;GRM:13.8%,CAM:10.7%,GDM:1.14%,GRM vs GDM:P < 0.001,CAM vs GDM:P < 0.001) and Ki-67 labeling index (the average percentage of Ki67-positive staining;GRM:24.5%,CAM:22.4% GDM:19.4%,GRM vs GDM:P=0.001,CAM vs GDM:P =0.049),suggesting that glutamine depletion inhibited cell proliferation of intestinal epithelial cells.Glutamine deprivation further caused the deformation of the nuclear membrane and the plasma membrane,accompanied by chromatin degeneration and an absence of fat droplets from the colonic epithelia,indicating that the cells underwent apoptosis.Moreover,immunohistochemical analysis revealed the appearance of cleaved caspase-3 in colonic epithelial cells of GDM-fed mice.Finally,when IEC6 rat intestinal epithelial cells were cultured without glutamine,cell proliferation was significantly suppressed after 24 h (relative cell growth;4 mmol/L:100.0% ± 36.1%,0 mmol/L:25.3% ± 25.0%,P < 0.05),with severe cellular damage.The cells underwent apoptosis,accompanied by increased cell population in sub-G0 phase (4 mmol/L:1.68%,0.4 mmol/L:1.35%,0 mmol/L:5.21%),where dying cells are supposed to accumulate.CONCLUSION:Glutamine is an important alimentary component for the maintenance of intestinal mucosa.Glutamine deprivation can cause instability of the intestinal epithelial alignment by increased apoptosis. | Takayuki Motoki Yoshio Naomoto Junji Hoshiba Yasuhiro Shirakawa Tomoki Yamatsuji Junji Matsuoka Munenori Takaoka Yasuko Tomono Yasuhiro Fujiwara Hiroshi Tsuchita Mehmet Gunduz Hitoshi Nagatsuka Noriaki Tanaka Toshiyoshi Fujiwara | 2011 | World Journal of Gastroenterology2011，17，6： | 4 |
| 5 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 6 | Multilinear Fractional Integrals on Morrey Spaces显示文摘In the present paper we obtain and extend the boundedness property of the Adams type for multilinear fractional integral operators. Also, we deal with the Olsen type inequality. | Takeshi IIDA Enji SATO Yoshihiro SAWANO Hitoshi TANAKA | 2012 | Acta Mathematica Sinica,English Series2012，28，7： | 3 |
| 7 | Risk Factors and Management of Bile Leakage after Hepatic Resection显示文摘 | Yasuhiko Nagano M.D. Ph.D. Shinji Togo M.D. Ph.D. Kuniya Tanaka M.D. Ph.D. Hidenori Masui M.D. Ph.D. Itaru Endo M.D. Ph.D. Hitoshi Sekido M.D. Ph.D. Kaoru Nagahori M.D. Ph.D. Hiroshi Shimada M.D. Ph.D | 2003 | World Journal of Surgery2003，，6： | 2 |
| 8 | Longitudinal associations between anaerobic threshold and distance running performance显示文摘 | Kiyoji Tanaka Hitoshi Watanabe Yotaro Konishi Ryoichi Mitsuzono Satoshi Sumida Shinsuke Tanaka Takashi Fukuda Fumio Nakadomo | 1986 | European Journal of Applied Physiology and Occupational Physiology1986，，： | 2 |
| 9 | Epidermal growth factor receptor expression in human pancreatic cancer:Significance for liver metastasis显示文摘 | Kosuke Tobita Hiroshi Kijima Shoichi Dowaki Hiroyuki Kashiwagi Yasuo Ohtani Yasuhisa Oida Hitoshi Yamazaki Masato Nakamura Yoshito Ueyama Makiko Tanaka Sadaki Inokuchi Hiroyasu Makuuchi | 2003 | International Journal of Molecular Medicine2003，，3： | 2 |
| 10 | Longitudinal associations between anaerobic threshold and distance running performance显示文摘 | Kiyoji Tanaka Hitoshi Watanabe Yotaro Konishi Ryoichi Mitsuzono Satoshi Sumida Shinsuke Tanaka Takashi Fukuda Fumio Nakadomo | 1986 | European Journal of Applied Physiology and Occupational Physiology1986，，3： | 2 |
| 11 | Apparent diffusion coefficient value reflects invasive and proliferative potential of bladder cancer显示文摘 | Shuichiro Kobayashi Fumitaka Koga Kohei Kajino Soichiro Yoshita Chikako Ishii Hiroshi Tanaka Kazutaka Saito Hitoshi Masuda Yasuhisa Fujii Tetsuo Yamada Kazunori Kihara | 2014 | Imaging2014，，1： | 2 |
| 12 | Developing a hybrid multi-model for peak flood fore casting显示文摘 | Yupa Chidthong Hitoshi Tanaka Seree Supharatid | 2009 | Hydrological Processes2009，23，： | 1 |
| 13 | Soy food and isoflavone intake and colorectal cancer risk: The Fukuoka Colorectal Cancer Study显示文摘 | Sanjeev Budhathoki Amit Man Joshi Keizo Ohnaka Guang Yin Kengo Toyomura Suminori Kono Ryuichi Mibu Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiy | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 14 | Dynamic Analysis of Imitation and Technology Gap显示文摘 | Tanaka Hitoshi | 2006 | Journal of Economics2006，87，3： | 1 |
| 15 | Seismic Load Tests on Interior and Exterior Beam-Colunm Joints with Substandard Reinforcing Details显示文摘 | Shigeru Hakuto Robert Park Hitoshi Tanaka | 2000 | ACI Structural Journal2000，97，1： | 1 |
| 16 | β‐amyloid in lewy body disease is related to Alzheimer’s disease‐like atrophy显示文摘 | Hitoshi Shimada Hitoshi Shinotoh Shigeki Hirano Michie Miyoshi Koichi Sato Noriko Tanaka Tsuneyoshi Ota Kiyoshi Fukushi Toshiaki Irie Hiroshi Ito Makoto Higuchi Satoshi Kuwabara Tetsuya Suhara | 2012 | Mov Disord2012，，： | 1 |
| 17 | Regional Characteristic of Sulfur and Lead at Several Chinese Urban Sites显示文摘 | Hitoshi Mukai Atsushi Tanaka Toshihiro Fujii | 2001 | Environ Sci Techno2001，，35： | 1 |
| 18 | Outcome after simultaneous colorectal and hepatic resection for colorectal cancer with synchronous metastases显示文摘 | Kuniya Tanaka Hiroshi Shimada Kenichi Matsuo Yasuhiko Nagano Itaru Endo Hitoshi Sekido Shinji Togo | 2004 | Surgery2004，，3： | 1 |
| 19 | Erythrina alkaloid from Erythrina x Bidwillii 显示文摘 | Hitoshi Tanaka Toshihiro Tanaka Hideo Etoh | 1998 | Phytochemistry1998，48，8： | 1 |
| 20 | In vitro sequence-dependent interaction between nedaplatin and paclitaxel in human cancer cell lines显示文摘 | Risa Tanaka Yasushi Takii Yoshihiro Shibata Hiroshi Ariyama Baoli Qin Eishi Baba Hitoshi Kusaba Kenji Mitsugi Mine Harada Shuji Nakano | 2005 | Cancer Chemotherapy and Pharmacology2005，，3： | 1 |
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