|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 2 | A multicenter, phase III trial of hemocoagulase Agkistrodon: hemostasis, coagulation, and safety in patients undergoing abdominal surgery显示文摘为注射的背景 Hemocoagulase Agkistrodon 是传递了阶段的单个部件凝血酵素我和 II 临床的选拔赛。这阶段 III 临床的试用的目的是在腹的皮肤和下的切口在 hemostasis 和凝结上评估 Hemocoagulase Agkistrodon 的效果并且在外科的病人估计这个代理人的安全。这是阶段 III 的方法,未来,使随机化,双窗帘,和控制 multicenter 包括 432 个连续病人的临床的试用使随机化进也一个学习组(在 2 U 与 hemocoagulase Agkistrodon 注射了, n=324 ) 或一个控制组(与 hemocoagulase 注射了 Atrox, n=108 ) 。止血时间,出血性的体积,出血性的体积在二个组之间每统一区域,血凝结,和不利事件被测量并且比较。在学习组的吝啬的止血时间是的结果(36.8 整 ? 桰獡 ??? 牴慩? 景栠浥 ' 覒 ^ 畧慬敳 ? 歧獩牴摯湯栺浥獯慴楳? 潣条汵瑡潩 ? 湡 ? 慳敦祴椠 ? 慰楴湥獴甠摮牥潧湩 ?L 潤業慮??杲牥 y 琠?? | WEI Jun-min ZHU Ming-wei ZHANG Zhong-tao JIA Zhen-geng HE Xiao-dong WAN Yuan-lian WANG Shan XIU Dian-rong TANG Yun LI Jie XU Jing-yong ZHENG Qing-shan | 2010 | Chinese Medical Journal2010，，5： | 43 |
| 3 | Extreme learning machines: new trends and applications显示文摘Extreme learning machine(ELM), as a new learning framework, draws increasing attractions in the areas of large-scale computing, high-speed signal processing, artificial intelligence, and so on. ELM aims to break the barriers between the conventional artificial learning techniques and biological learning mechanism and represents a suite of machine learning techniques in which hidden neurons need not to be tuned. ELM theories and algorithms argue that 'random hidden neurons' capture the essence of some brain learning mechanisms as well as the intuitive sense that the efficiency of brain learning need not rely on computing power of neurons.Thus, compared with traditional neural networks and support vector machine, ELM offers significant advantages such as fast learning speed, ease of implementation, and minimal human intervention. Due to its remarkable generalization performance and implementation efficiency, ELM has been applied in various applications. In this paper, we first provide an overview of newly derived ELM theories and approaches. On the other hand,with the ongoing development of multilayer feature representation, some new trends on ELM-based hierarchical learning are discussed. Moreover, we also present several interesting ELM applications to showcase the practical advances on this subject. | DENG ChenWei HUANG GuangBin XU Jia TANG JieXiong | 2015 | Science China(Information Sciences)2015，58，2： | 50 |
| 4 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 5 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 6 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 7 | Extending the CONSORT Statement to moxibustion显示文摘The STandards for Reporting Interventions in Clinical Trials Of Moxibustion (STRICTOM), in the form of a checklist and descriptions of checklist items, were designed to improve reporting of moxibustion trials, and thereby facilitating their interpretation and replication. The STRICTOM checklist included 7 items and 16 sub-items. These set out reporting guidelines for the moxibustion rationale, details of moxibustion, treatment regimen, other components of treatment, treatment provider background, control and comparator interventions, and precaution measures. In addition, there were descriptions of each item and examples of good reporting. It is intended that the STRICTOM can be used in conjunction with the main CONSORT Statement, extensions for nonpharmacologic treatment and pragmatic trials, and thereby raise the quality of reporting of clinical trials of moxibustion. Further comments will be solicited from the experts of the CONSORT Group, the STRICTA Group, acupuncture and moxibustion societies, and clinical trial authors for optimizing the STRICTOM. | Chung-wah Cheng Shu-fei Fu Qing-hui Zhou Tai-xiang Wu Hong-cai Shang Xu-dong Tang Zhi-shun Liu Jia Liu Zhi-xiu Lin Lixing Lao Ai-ping Lü Bo-li Zhang Bao-yan Liu Zhao-xiang Bian | 2013 | Journal of Integrative Medicine2013，11，1： | 27 |
| 8 | Risk factors related to female breast cancer in regions of Northeast China: a 1:3 matched case-control population-based study显示文摘在那里的背景是在中国的乳癌的发生的增加,但是为乳癌的明确的风险和保护的因素都没在中国 females.This 学习被识别被设计在 A 1:3 匹配的诺思和东方 China.Methods 为女乳癌识别风险因素,盒子控制学习是在情况中的题目的 conducted.All ,控制组 25~70 years.Single 从 122 058 女性的以前的流行病学的调查被选择并且多重逻辑良性的胸疾病历史, 2.672 (0.848-8.416, P=0.093 ) ;乳癌的家庭历史, 7.080 (1.758-28.551, P=0.006 ) ;流产的数字, 1.738 (1.014-2.978, P=0.044 ) ;生活满足的全球质量, 3.044 (1.804-5.136, P=0.000 ) ;健康行为和预防, 3.294 (1.692-6.412, P=0.000 ) 与乳癌有关的因素的一个全面范围是的 .Conclusions identified.Women 应该关于一种健康生活方式被教育,特别那些与乳癌的家庭历史或良性的胸的个人历史疾病。 | YU Zhi-gang JIA Cun-xian GENG Cui-zhi TANG Jin-hai ZHANG Jin LIU Li-yuan | 2012 | Chinese Medical Journal2012，，5： | 26 |
| 9 | Diagnosis and treatment of hepatic angiomyolipoma in 26 cases显示文摘AIM: To summarize the experience of the diagnosis and treatment of hepatic angiomyolipoma (HAML).METHODS: The clinical, imaging and pathological features,and treatment strategies of 26 patients with HAML treated at the authors′institute between October 1998 and January 2003 were retrospectively analyzed. All the patients received liver resection and were followed up till the study.Immunohistochemical assays were performed with a panel of antibodies.RESULTS: There was an obvious female predominance (21:5), and most of the patients (18/26) had no symptoms.Heterogeneous high echo was found in ultrasonography and punctiform or filiform vascular distribution pattern was found in color Doppler-sonography in most of the lesions (21/26).All of the 5 lesions further enhanced with Levovist showed early and prolonged enhancement. At contrast-enhanced spiral CT, the soft-tissue components of 24 lesions were markedly enhanced in the arterial phase and 18 lesions remained enhanced in the portal venous phase. MRI was performed in 9 patients, and showed hypointensity or hyperintensity on T1-weighted images and heterogeneous hyperintensity on T2-weighted images. Histopathologically,all lesions were composed of adipose tissues, smooth muscle and blood vessels with different proportions. Most lesions showed positive immunohistochemical staining for HMB45(26/26), A103 (24/26) and SMA (24/26). All of the 26 patients showed a benign course with no sign of recurrence.CONCLUSION: Preoperative radiological diagnosis of HAML is possible. The demonstration of intratumoral fat and central vessels is helpful in the diagnosis. HMB45, A103 and SMA are promising markers for pathologic diagnosis of HAML,and surgical resection is effective for the treatment of HAML. | Ning Ren Lun-Xiu Qin Zhao-You Tang Zhi-Quan Wu Jia Fan, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China | 2003 | World Journal of Gastroenterology2003，9，8： | 25 |
| 10 | Perspective of Chinese GF-1 high-resolution satellite data in agricultural remote sensing monitoring显示文摘High-resolution satellite data have been playing an important role in agricultural remote sensing monitoring. However,the major data sources of high-resolution images are not owned by China. The cost of large scale use of high resolution imagery data becomes prohibitive. In pace of the launch of the Chinese 'High Resolution Earth Observation Systems',China is able to receive superb high-resolution remotely sensed images(GF series) that equalizes or even surpasses foreign similar satellites in respect of spatial resolution,scanning width and revisit period. This paper provides a perspective of using high resolution remote sensing data from satellite GF-1 for agriculture monitoring. It also assesses the applicability of GF-1 data for agricultural monitoring,and identifies potential applications from regional to national scales. GF-1's high resolution(i.e.,2 m/8 m),high revisit cycle(i.e.,4 days),and its visible and near-infrared(VNIR) spectral bands enable a continuous,efficient and effective agricultural dynamics monitoring. Thus,it has gradually substituted the foreign data sources for mapping crop planting areas,monitoring crop growth,estimating crop yield,monitoring natural disasters,and supporting precision and facility agriculture in China agricultural remote sensing monitoring system(CHARMS). However,it is still at the initial stage of GF-1 data application in agricultural remote sensing monitoring. Advanced algorithms for estimating agronomic parameters and soil quality with GF-1 data need to be further investigated,especially for improving the performance of remote sensing monitoring in the fragmented landscapes. In addition,the thematic product series in terms of land cover,crop allocation,crop growth and production are required to be developed in association with other data sources at multiple spatial scales. Despite the advantages,the issues such as low spectrum resolution and image distortion associated with high spatial resolution and wide swath width,might pose challenges for GF-1 data applications and need to be addressed in future agricultural monitoring. | ZHOU Qing-bo YU Qiang-yi LIU Jia WU Wen-bin TANG Hua-jun | 2017 | Journal of Integrative Agriculture2017，16，2： | 22 |
| 11 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 12 | Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma:Report of an initial experience显示文摘瞄准:报导收到了 sirolimus 的 36 个病人的初步的结果的回顾的分析(SRL, Rapamune, rapamycin ) 在 248 肝的一个连续的队紧密相联的接枝接受者。方法:被换到的有肝细胞癌(HCC ) 的 36 个肝 transplant 病人从 tacrolimus 的基于 SRL 的免疫力的抑制治疗在这研究被注册。是在常位的肝移植( OLT )前推进了 HCC 被诊断的病人被划分成组 A ( n = 11 ),在 OLT 被分配组织 B 以后,被发现到的那些有 HCC 复发或转移( n = 18 ),并且 calcineurin 禁止者( CNI )引起的发达肾机能不全被分到谁的那些组织 C ( n = 7 )在 OLT 以后。结果:病人被跟随在上面为一 10.4 瞬间中部(范围, 3.8-19.1 瞬间) 在到 SRL 治疗和 12.3 瞬间的变换以后(范围, 5.1-34.4 瞬间) 在 OLT 以后。开发的三个病人在开始 SRL 治疗以后的 2 wk,它是充分在氢化尼松以后颠倒了的温和尖锐细胞的拒绝搏动治疗。在组 A,仅仅 1 个病人被发现有 HCC 复发和转移在 OLT 以后的 12 瞬间。在组 B, 66.7%(12/18 ) 病人们(2 与进步肿瘤, 7 与稳定的肿瘤并且 3 没有肿瘤) 由于在 6.8 瞬间柱子变换和 10.7 瞬间柱子 transplant 的中部的后续的结束为 HCC 复发交谈到 SRL 或切除术仍然是活着的。在组 C,没有 HCC 复发在 7 个病人被表明,并且肾的功能在 SRL 治疗以后变得正常。血小板减少(n = 2 ) ,贫血症(n = 8 ) ,并且口头的 aphthous (n = 7 ) 在我们的队发现是容易可管理的。结论:到基于 SRL 的免疫力的抑制的变换可以禁止 HCC 的复发和转移并且与 HCC 在 OLT 病人改进导致 CNI 的肾机能不全。 | Jian Zhou Jia Fan Zheng Wang Zhi-Quan Wu Shuang-Jian Qiu Xiao-Wu Huang Yao Yu Jian Sun Yong-Sheng Xiao Yi-Feng He Yu-Qi Wang Zhao-You Tang | 2006 | World Journal of Gastroenterology2006，12，19： | 20 |
| 13 | P53 immunohistochemical scoring:an independent prognostic marker for patients after hepatocellular carcinoma resection显示文摘AIM: To confirm if p53 mutation could be a routinepredictive marker for the prognosis of hepatocellularcarcinoma (HCC) patients.METHODS: Two hundreds and forty-four formalin-fixedparaffin-embedded tumor samples of the patients with HCCreceiving liver resection were detected for nuclearaccumulation of p53. The percent of P53 immunoreactivetumor cells was scored as 0 to 3 + in P53 positive region ( <10% -, 10-30 % +, 31-50 % + +, > 50 % + + + ).Proliferating cell nuclear antigen (PCNA) and someclinicopathological characteristics, including patients' sex,preoperative serum AFP level, tumor size, capsule,vascular invasion (both visual and microscopic ), andEdmondson grade were also evaluated.RESULTS: In univariate COX harzard regression modelanalysis, tumor size, capsule status, vascular invasion,and p53 expression were independent factors that wereclosely related to the overall survival (OS) rates of HCCpatients. The survival rates of patients with 3 + for P53expression were much lower than those with 2 + or + forP53 expression. Only vascular invasion ( P < 0.05 ) andcapsule ( P < 0.01 ) were closely related to the disease-freesurvival (DFS) of HCC patients. In multivariate analysis, p53overexpression (RI 0. 5456, P < 0. 01 ) was the mostsignificant factor associated with the OS rates of patientsafter HCC resection, while tumor size (RI 0.5209, P< 0.01),vascular invasion (RI 0.5271, P < 0.01 ) and capsule (RI-0.8691, P<0.01) were also related to the OS. However, onlytumor capsular status was an independent predictive factor( P< 0.05) for the DFS. No significant prognostic value wasfound in PCNA-LI, Edmondson's grade, patients' sex andpreoperative serum AFP level.CONCLUSION: Accumulation of p53 expression, as well estumor size, capsule and vascular invasion, could bevaluable markers for predicting the prognosis of HCCpatients after resection. The quantitativeimmunohistochemical scoring for P53 nuclear accumulationmight be more valuable for predicting prognosis of patientsafter HCC resection than the common qualitative analysis. | Lun-Xiu Qin Zhao-You Tang Zeng-Chen Ma Zhi-Quan Wu Xin-Da Zhou Qing-Hai Ye Yuan Ji Li-Wen Huang Hu-Liang Jia Hui-Chuan Sun Lu Wang,Liver Cancer Institute and Zhongshan Hospital,Fudan University,Shanghai,China | 2002 | World Journal of Gastroenterology2002，8，3： | 18 |
| 14 | Meteorological mechanism for a large-scale persistent severe ozone pollution event over eastern China in 2017显示文摘An intensive and persistent regional ozone pollution event occurred over eastern China from 25 June to 5 July 2017.73 out of 96 selected cities,most located in the Beijing-TianjinHebei and the surrounding area(BTHS),suffered severe ozone pollution.A north-south contrast ozone distribution,with higher ozone(199±33μg/m3)in the BTHS and lower ozone(118±25μg/m^3)in the Yangtze River Delta(YRD),was found to be dominated by the position of the West Pacific Subtropical High(WPSH)and mid-high latitude wave activities.In the BTHS,the positive anomalies of geopotential height at 500 hPa and temperature at the surface indicated favorable meteorological conditions for local ozone formation.Prevailing northwesterly winds in the mid-high troposphere and warm advection induced by weak southerly winds in the low troposphere resulted in low-moderate relative humidity(RH),less total cloud cover(TGC),strong solar radiation and high temperatures.Moreover,southerly winds prevailing over the BTHS aggravated the pollution due to regional transportation of O3 and its precursors.On one hand,the deep sinking motion and inversion layer suppressed the dispersion of pollutants.On the other hand,O3-rich air in the upper layer was maintained at night due to temperature inversion,which facilitated O3 vertical transport to the surface in the next-day morning due to elevated convection.Generally,temperature,UV radiation,and RH showed good correlations with O3 in the BTHS,with rates of 8.51(μg/m^3)/℃(within the temperature range of 20-38℃),59.54(μg/m^3)/(MJ/m^2)and-1.93(μg/m^3)/%,respectively. | Jia Mao Lili Wang Chuhan Lu Jingda Liu Mingge Li Guiqian Tang Dongsheng Ji Nan Zhang Yuesi Wang | 2020 | Journal of Environmental Sciences2020，32，6： | 18 |
| 15 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 16 | Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity显示文摘 | Chun-ping WAN Li-xin GAO Li-fei HOU Xiao-qian YANG Pei-lan HE Yi-fu YANG Wei TANG Jian-min YUE Jia LI Jian-ping ZUO | 2013 | Acta Pharmacologica Sinica2013，34，4： | 17 |
| 17 | Hot deformation behavior and constitutive model of TC18 alloy during compression显示文摘The hot deformation behavior of TC18 alloy at strain rates ranging from 1 9 10-4to 1 9 10-2s-1and temperatures ranging from 25 to 800 °C was studied using a WDW-300 electronic universal testing machine. The relationships between true stress and true strain show that flow stress decreases with the increase of temperature and increases as strain rate increases. The effect of strain rate on the flow stress becomes pronounced at higher temperatures. At room temperature, the river pattern characteristic of brittle fracture and the dimple pattern typical of ductile fracture are found to exist in different regions of fracture surfaces of the samples. An improved constitutive relationship is proposed to accurately describe the flow stress of TC18 by considering the effect of strain. And a microscopic model is also deduced which can link the physical mechanisms to the macroscopic experimental results. A good agreement is obtained between the predictions of the microscopic model and the results of the macroscopic experiment. | Bao-Hua Jia Wei-Dong Song Hui-Ping Tang Zhi-Hua Wang Xiao-Nan Mao Jian-Guo Ning | 2014 | Rare Metals2014，33，4： | 16 |
| 18 | Advanced energy materials for flexible batteries in energy storage:A review显示文摘Smart energy storage has revolutionized portable electronics and electrical vehicles.The current smart energy storage devices have penetrated into flexible electronic markets at an unprecedented rate.Flexible batteries are key power sources to enable vast flexible devices,which put forward additional requirements,such as bendable,twistable,stretchable,and ultrathin,to adapt mechanical deformation under the working conditions.This review summarizes the recent advances in construction and configuration of flexible batteries and discusses the general metrics to benchmark various flexible batteries with different materials and chemistries.Moreover,we present advanced prototype flexible batteries developed by some companies to afford general envision of the technological status.Lastly,the critical points are summarized in the development of flexible batteries and remaining challenges are also presented for the future design of flexible batteries in practical perspectives. | Long Kong Cheng Tang Hong‐Jie Peng Jia‐Qi Huang Qiang Zhang | 2020 | SmartMat2020，1，1： | 16 |
| 19 | Downstaging followed by resection plays a role in improving prognosis of unresectable hepatocellular carcinoma显示文摘BACKGROUND: Curable outcome of unresectable hepato- cellular carcinoma ( HCC) was seldom encountered in the past. This study was designed to assess the role of down- staging followed by resection ( downstaging-resection) in the improvement of prognosis of unresectable HCC. METHODS: During the period of 1958-2003 , a total of 1085 patients were verified surgically to be unresectable. Of these patients, 139 received downstaging-resection, with a rate of 84.2% for coexisting cirrhosis and a median tumor diame- ter of 11.1 cm. Resection of the right lobe, hepatic hilum and bilateral cancer accounted for 97. 8% of the patients. Downstaging including hepatic artery ligation ( HAL) + he- patic artery chemo-infusion ( HAI ) was performed in 65.5% of the patients, HAL + HAI + radiotherapy/radioim- munotherapy in 29. 5%, and HAL or HAI alone in 5.0%. Retrospective analysis was made of the survival of patients with unresectable HCC, downstaging-resection rate and treatment pattern. RESULTS: In the 139 patients with downstaging-resection, the median interval between the first and second operation was 7.2 months and the 5-year survival rate calculated from the first operation was 48. 7%. In the 1085 patients with un- resectable HCC, their 5-year survival was 0% in the period of 1958-1973, 11.5% in the period of 1974-1988 and 19.3% in the period of 1989-2003. These figures were correlated with the increasing downstaging-resection rate from 0%, 9.0% to 15.6%, and the increasing percentage of triple or double combination treatment from 32.2%, 60.4% to 69.7%. The 5-year survival in triple treatment group was 24. 9%, double treatment 15.2%, and single treatment only 10.9%, which was also correlated with the downstaging-re- section rate of 34.6%, 16.2% and 1.8% respectively. CONCLUSIONS: Downstaging-resection plays a role in improving prognosis of unresectable HCC. Triple and double treatments provide a higher downstaging-resection rate and may result in better prognosis. | Zhao-You Tang,Xin-Da Zhou, Zeng-Chen Ma, Zhi-Quan Wu, Jia Fan, Lun-Xiu Qin and Yao Yu Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 16 |
| 20 | Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines显示文摘Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout(omentin-1^(-/-)) mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α(TNF-α), we determined that recombinant omentin-1 reduces the production of proinflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the proinflammatory cytokines. | Shan-Shan Rao Yin Hu Ping-Li Xie Jia Cao Zhen-Xing Wang Jiang-Hua Liu Hao Yin Jie Huang Yi-Juan Tan Juan Luo Ming-Jie Luo Si-Yuan Tang Tuan-Hui Chen Ling-Qing Yuan Er-Yuan Liao Ran Xu Zheng-Zhao Liu Chun-Yuan Chen Hui Xie | 2018 | Bone Research2018，6，2： | 16 |
您所在的机构暂未开通此部分的功能，请联系管理员