|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Budd-Chiari syndrome:A single-center experience显示文摘AIM:To investigate challenges,risk factors,prognostic indicators,and treatment outcomes associated with Budd-Chiari syndrome(BCS)at a tertiary care center.METHODS:A retrospective cohort study was conducted at the University of Pennsylvania in patients with a diagnosis of BCS or hepatic vein thrombosis.All patients receiving care at the University of Pennsylvania,and who had at least 2 clinical encounters in the University of Pennsylvania Health system from January1,2008 to September 10,2013 were eligible for study inclusion.Data were extracted from the electronic medical record of each patient,and recorded in a secure Research Electronic Data Capture database.Logistic regression analyses were applied to identify predictors of outcome of liver transplant(LT)or death.RESULTS:Between January 1,2008 and September10,2013,forty-seven patients were identified.Median age was 42.4 years.Thirty-one(66.0%)were women.A majority were Caucasian(68.1%).At diagnosis,43(91.5%)patients had ascites,27(57.4%)patients had a hematologic disorder associated with a hypercoagulable state and 26(55.3%)had cirrhosis.Forty(85.1%)patients were on anticoagulation(AC),30(63.8%)of whom were maintained on warfarin.Two patients(4.3%)underwent thrombolytic therapy.A transjugular intrahepatic portosystemic shunt(TIPS)was placed in21(44.7%)patients,19(90.5%)of whom were also on AC.Twenty-one(44.7%)received AC alone.Over a median of 974 d,8(17.0%)patients received LT,and10(21.3%)died.The median time from listing to death was 26 mo[interquartile range(IQR)=16,65)].TIPS with AC was utilized more frequently in younger patients(P=0.02).Age,cirrhosis and chronic kidney disease(CKD)were significant predictors of LT or death.CONCLUSION:AC alone was employed as frequently as TIPS with AC,though the latter was used more frequently in younger patients with polycythemia vera.There were no significant differences in treatment outcome regardless of the therapeutic intervention employed.Significant predictors of poor prognosis included age,cirrhosis and CKD. | Tanya M Pavri Alan Herbst Rajender Reddy Kimberly A Forde | 2014 | World Journal of Gastroenterology2014，20，43： | 2 |
| 2 | Large artery stiffness predicts ischemic threshold in patients with coronary artery disease显示文摘 | Bronwyn A Kingwell Tamara K Waddell Tanya L Medley James D Cameron Anthony M Dart | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 3 | Problematic clinical isolates of Pseudomonas aeruginosa from the university hospitals in Sofia,Bulgaria: current status of antimicrobial resistance and prevailing resistance mechanisms显示文摘 | Tanya S Vessela OR Boyka M | 2007 | J Med Microbiol2007，56，： | 1 |
| 4 | Polychlorinated biphenyl profiles in ringed seals (Pusa Hispida) reveal historical contamination by a military radar station in Labrador, Canada显示文摘 | Tanya M B Aaron T F Caren C H | 2014 | Environmental Toxicology and Chemistry2014，33，3： | 1 |
| 5 | The impacts of radio frequency identification (RFID) technology on supply chain costs显示文摘 | Ustundag A Tanyas M | 2009 | Transportation Research Part E:Logistics and Transportation Review2009，45，1： | 1 |
| 6 | Design and function of a closed,recirculating seawater system with denitrification for the culture of black tiger shrimp broodstock显示文摘 | Piamsk M Tanya P Pakitsin S | 2001 | Aquacultural Engineering2001，，25： | 1 |
| 7 | Human gut microbiome viewed across age and geography显示文摘 | Tanya Y Rey F E Manary M J | 2012 | Nature2012，486，7402： | 1 |
| 8 | Design and function of a closed, recirculating seawater with denitrification for the culture of black tiger shrimp broodstock显示文摘 | Piamsk M Tanya P Pakitsin S | 2001 | Aquacultural Engineering2001，，25： | 1 |
| 9 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 10 | Self-similar evolution of self- written waveguides 显示文摘 | TANYA M M PETER D M | 1998 | Opt Lett1998，23，4： | 1 |
| 11 | Synthesis and char- acterization of polyimides based on new fluorinated 3,3' -diamin - obiphenyls显示文摘 | AUMAN B C TANYA L M | 1997 | Journal of Polymer Science Part A: Polym Chem1997，35，： | 1 |
| 12 | Metabolism of the soil and groundwater contaminants,ethylene dibromide and trichloroethylene,by the tropical leguminous tree,Leuceana leucocephala显示文摘 | Sharon Lafferty Doty Tanya Qing Shang Angela M Wilson | 2003 | Water Research2003，37，： | 1 |
| 13 | Modeling the fabrication of hollow fibers: capillary drawing 显示文摘 | ALISTAIR D F KENTARO F TANYA M M | 2001 | Journal of Lightwave Technology2001，19，12： | 1 |
| 14 | Information Leakage in Fuzzy Commitment Schemes 显示文摘 | Tanya I Frans M J W | 2010 | IFEE Transactions on Information Forensics and Security2010，5，2： | 1 |
| 15 | Duration of lipid peroxida- tion after acute spinal cord injury in rats and the effect of methylprednisolone显示文摘 | Sean D C Ben C B Tanya M | 2008 | Neurosurg Focus2008，25，5： | 1 |
| 16 | The effects of a high animal fat diet on the induction of aberrant crypt foci in the colons of male F344/N rats exposed to trihalomethanes in the drinking water显示文摘 | David R Geter Michael H George Tanya M Moore Steve R Kilburn Gloria Huggins-Clark Anthony B DeAngelo | 2003 | Toxicology Letters2003，，： | 1 |
| 17 | The impacts of radio frequency identification (RFID) technology on supply chain costs显示文摘 | Ustundag A Tanyas M | | 0，，1： | 1 |
| 18 | Self-Similar Evolution of SelfWritten Waveguides显示文摘 | Tanya M M Eter D M | 1998 | Optics Letters1998，23，4： | 1 |
| 19 | Impedometric herbicide sensors based-on molecularly imprinted polymers 显示文摘 | Tanya P D Vladimir M M Mathias V | 2001 | Anal Chim Acta2001，，435： | 1 |
| 20 | Dental tissue propor-tions and enamel thickness in Neandertal and modem human mo- lars 显示文摘 | Anthony 3 Olejniczak A Tanya M | 2008 | J Human Evolu2008，55，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员