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| 1 | Contamination and health risk assessment of heavy metals in road dust in Bayan Obo Mining Region in Inner Mongolia, North China显示文摘这研究的目的是调查集中和 9 个潜在地有毒的重金属元素的空间分发模式(作为, Cd,公司, Cr, Pb, Cu, Zn, Mn,和 Ni ) 在在在内部蒙古的 Bayan Obo 采矿区域的道路灰尘,中国。污染层次用 geoaccumulation 索引和丰富因素被评估。为每个重金属元素的人的健康风险用一个人的暴露模型被估计。结果证明显著地包含的灰尘与背景土壤相比提高了重金属元素集中。所有的空间分发模式测试了金属除了是当时,与工业区域的地点与一致空间分发是与国内来源被联系。污染评估显示在道路灰尘的 Cd, Pb,和 Mn 主要与一个等级从人为的来源发源重重地弄脏到极其弄脏,而留下的金属与水平从生来、人为的来源发源中等弄脏。非癌症健康风险评价证明摄取是为在道路灰尘和那 Mn 的所有金属的主要暴露线路, Cr, Pb,并且这是到在孩子和成年人的非癌症风险的主要贡献者。更高嗨价值为孩子(HI=1.89 ) 被计算,显示孩子们将多半经历更高的健康与成年人(HI=0.23 ) 相比冒险。癌症风险评价证明 Cr 是主要贡献者,与比为另外的金属的那些高 23 个数量级的癌症风险。收进音乐会,所有学习重金属元素提出的非癌症风险和摆姿势由的癌症风险作为,到在 Bayan Obo 采矿区域的孩子和成年人的公司, Cr, Cd,和 Ni 在可接受的范围以内掉落了。 | LI Kexin LIANG Tao WANG Lingqing YANG Zhiping | 2015 | Journal of Geographical Sciences2015，25，12： | 19 |
| 2 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 3 | A Novel Evolutionary Strategy for Particle Swarm Optimization显示文摘 | HONG Tao HONG Tao PENG Gang PENG Gang LI Zhiping LI Zhiping LIANG Yi LIANG Yi | 2009 | Chinese Journal of Electronics2009，18，4： | 4 |
| 4 | Synthesis, characteristics of hierarchical EU-1 zeolite for xylene isomerization probe reaction显示文摘Introduced a method of synthesizing hierarchical EU-1 zeolite with organosilanes as additive, and studied the influences of following different kinds of organosilanes on the synthesis of hierarchical EU-1 zeolite: γ-glycidoxy propyl trimethoxy silane(GPTMS), N-β-(aminoethyl)-γ-aminopropyl methyl dimethoxyl silane(APAEDMS),and N-(β-aminoethyl)-γ-aminopropyl dimethoxyl(ethyoxyl) silane(TMPED). The hierarchical EU-1 samples were characterized by XRD, SEM, N_2 adsorption, FT-IR and NH_3-TPD to analyze the crystallinity, morphology, surface area, pore size distribution and acidity. The results showed that hierarchical EU-1 zeolites were successfully synthesized; organosilanes have great influence on crystal morphology of EU-1 zeolites; the exterior surface area of hierarchical EU-1 zeolite, which synthesized with organosilanes(APAEDMS) adding into synthesis system, increased by 62.1% and mesopore volume increased by 129.1% compared with conventional EU-1 zeolites, thus can reduce the diffusional restriction markedly in catalytic reaction. The catalytic performance of hierarchical EU-1zeolites were evaluated in m-xylene isomerization on fixed bed reactor. The catalytic data showed that the isomerization activity PX/X of the hierarchical EU-1 zeolites reached around 24.09% in theoretical thermodynamic equilibrium from 23.83%, and the selectivity of C_8 aromatic hydrocarbon increased from 75.16% to 84.87%. The conversion of p-xylene increased from 16.30% to 18.41%. | Xiaofeng Li Pengchao Ren Yanting Zhang Xiaozhen Liu Xiaotao Sun Meng Gao Miaojuan Jia Zhiping Lü Tao Dou | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 4 |
| 5 | Proteomics: addressing the challenges of multiple myeloma显示文摘多重骨髓瘤(公里) 是说明 13% 所有 hematologic 癌症的严重地区分的 B 淋巴细胞的恶意。尽管有在治疗学象重要进展一样描述公里的分子的生物学的很多知识,这疾病仍然保持医不好。因为蛋白质管理细胞的结构和生物功能,大量精选的 proteomic 为增加我们这疾病的理解接近抓住伟人诺言,例如由调查蛋白质表示的动态性质,细胞并且在两个的 subcellular 分发, translational 以后修正,和相互作用细胞并且 subcellular 层次。这评论的目的是介绍在公里的学习有潜在的应用的可得到、新兴的 proteomic 技术并且加亮公里的 proteomic 研究的当前的地位。迄今为止,尽管在公里有一小部分 proteomic 研究,执行的那些关于公里诊断和治疗提供了珍贵信息。proteomic 技术的潜在的未来申请被期望为临床医生在公里诊断,个性化的治疗设计和治疗反应监视提供新大街。 | Feng Ge Shengce Tao Lijun Bi Zhiping Zhang Xian'En Zhang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 4 |
| 6 | Insight into selective removal of copper from high-concentration nickel solutions with XPS and DFT:New technique to prepare 5N-nickel with chelating resin显示文摘An efficient and profitable separation process was proposed to prepare 5N(the purity of the metal solution reaches 99.999%) high-purity nickel from 3N nickel-solutions using Purolite S984. The adsorption performance of this superior resin, especially its selectivity for metal ions,was explored quantitatively. The maximum adsorption capacity for copper was 2.286 mmol/g calculated by the Langmuir model, which was twice as large as that for nickel. In the binary systems, the adsorption capacity for nickel was decreased by 45%, indicating direct competition for the active sites. The infinite separation factor for copper versus nickel exceeded 300, revealing the feasibility of preparing5N-level high-purity nickel solutions, which was further verified using the 800 BV(bed volume) effluent in the column dynamic process.According to the cost–benefit analysis, purification contributed to a profit of approximately 60,000 USD per cycle, and the investment return period was less than 1/3 years. Density functional theory analysis confirmed that four nitrogen atoms would be involved in the coordination complex and thus a structure involving two five-membered rings could be achieved. The X-ray photoelectron spectra confirmed the involvement of nitrogen atoms,implying a coordination ratio of approximately 1:1. | Xuewen Tao Fuqiang Liu Zhiping Bai Dongyang Wei Xiaopeng Zhang Junfei Wang Jie Gao Xiaowen Sun Baohua Li Chenghui Li Aimin Li | 2016 | Journal of Environmental Sciences2016，28，10： | 3 |
| 7 | Spatial learning and memory deficits in young adult mice exposed to a brief intense noise at postnatal age显示文摘Noise pollution is a major hazardous factor to human health and is likely harmful for vulnerable groups such as pre-term infants under lifesupport system in an intensive care unit. Previous studies have suggested that noise exposure impairs children's learning ability and cognitive performance and cognitive functions in animal models in which the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. The potential role of noise induced hearing loss(NIHL), rather than the oxidant stress, has also been indicated by a depression of neurogenesis in the hippocampus long after a brief noise exposure, which produces only a tentative oxidant stress. It is not clear if noise exposure and NIHL during early development exerts a long term impact on cognitive function and neurogenesis towards adulthood. In the present study, a brief noise exposure at high sound level was performed in neonatal C57BL/6J mice(15 days after birth) to produce a significant amount of permanent hearing loss as proved 2 months after the noise. At this age, the noise-exposed animals showed deteriorated spatial learning and memory abilities and a reduction of hippocampal neurogenesis as compared with the control. The averaged hearing threshold was found to be strongly correlated with the scores for spatial learning and memory. We consider the effects observed are largely due to the loss of hearing sensitivity, rather than the oxidant stress, due to the long interval between noise exposure and the observations. | Shan Tao Lijie Liu Lijuan Shi Xiaowei Li Pei Shen Qingying Xun Xiaojing Guo Zhiping Yu Jian Wang | 2015 | Journal of Otology2015，10，1： | 3 |
| 8 | Sea ice thickness analyses for the Bohai Sea using MODIS thermal infrared imagery显示文摘Level ice thickness distribution pattern in the Bohai Sea in the winter of 2009–2010 was investigated in this paper using MODIS night-time thermal infrared imagery.The cloud cover in the imagery was masked out manually.Level ice thickness was calculated using MODIS ice surface temperature and an ice surface heat balance equation.Weather forcing data was from the European Centre for Medium-Range Weather Forecasts(ECMWF) analyses.The retrieved ice thickness agreed reasonable well with in situ observations from two off-shore oil platforms.The overall bias and the root mean square error of the MODIS ice thickness are –1.4 cm and 3.9 cm,respectively.The MODIS results under cold conditions(air temperature < –10°C) also agree with the estimated ice growth from Lebedev and Zubov models.The MODIS ice thickness is sensitive to the changes of the sea ice and air temperature,in particular when the sea ice is relatively thin.It is less sensitive to the wind speed.Our method is feasible for the Bohai Sea operational ice thickness analyses during cold freezing seasons. | ZENG Tao SHI Lijian MARKO Makynen CHENG Bin ZOU Juhong ZHANG Zhiping | 2016 | Acta Oceanologica Sinica2016，35，7： | 3 |
| 9 | An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells显示文摘 | Yan Chen Zhiping Xia Lifen Wang Yong Yu Pingsheng Liu Eli Song Tao Xu | 2015 | Biophysics Reports2015，1，1： | 2 |
| 10 | Response of microbial biomass and bacterial community composition to fertilization in a salt marsh in China显示文摘The effects of nitrogen(N) addition on microbial biomass, bacterial abundance, and community composition in sediment colonized by Suaeda heteroptera were examined by chloroform fumigation extraction method, real-time quantitative polymerase chain reaction, and denaturing gradient gel electrophoresis(DGGE) in a salt marsh located in Shuangtai Estuary, China. The sediment samples were collected from plots treated with different amounts of a single N fertilizer(urea supplied at 0.1, 0.2, 0.4 and 0.8 g/kg(nitrogen content in sediment) and different forms of N fertilizers(urea,(NH_4)_2SO_4, and NH_4NO_3, each supplied at 0.2 g/kg(calculated by nitrogen).The fertilizers were applied 1–4 times during the plant-growing season in May, July, August, and September of 2013. Untreated plots were included as a control. The results showed that both the amount and form of N positively influenced microbial biomass carbon, microbial biomass nitrogen, and bacterial abundance. The DGGE profiles revealed that the bacterial community composition was also affected by the amount and form of N.Thus, our findings indicate that short-term N amendment increases microbial biomass and bacterial abundance,and alters the structure of bacterial community. | MA Yuexin TAO Wei LIU Changfa LIU Jiao YANG Zhiping LI Jin LIU Jichen | 2017 | Acta Oceanologica Sinica2017，36，6： | 2 |
| 11 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 12 | Pollen-like self-supported FeIr alloy for improved hydrogen evolution reaction in acid electrolyte显示文摘Ir is recognized as efficient catalyst for hydrogen evolution reaction(HER).The high price,however,has hindered its application in the production of hydrogen.In this work,we prepared the self-supported FeIr alloy nanoparticles,taking advantage of solid-state synthesis method.The as-prepared FeIr alloy possesses a novel morphology of pollen,which is consist of smaller FeIr nanoparticles.DFT calculations reveal that the change of the free Gibbs for Ir is negative after the adsorption of active H,while it is positive for the case of Fe.Thus,the alloying of Fe and Ir not only effectively reduces the cost,but also can achieve more adequate adsorption of active H species.Benefitting from this,the as-prepared FeIr alloy nanoparticle exhibits superior HER performance with an overpotential of 19 m V at a current density of 10 m V/cm^(2)and a Tafel slope of 32 m V/dec,when tested in 0.5 M H_(2)SO_(4),better than pure Ir and Pt/C.This work paves the way to the exploration of efficient alloy electrocatalysts for HER. | Shengyu Ma Jun Deng Yaping Xu Weiying Tao Xiaoqi Wang Zhiping Lin Qinghua Zhang Lin Gu Wenwu Zhong | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 13 | microRNA-150 inhibits human CD133-positive liver cancer stem cells throughnegative regulation of the transcription factor c-Myb显示文摘 | Jun Zhang Na Luo Yi Luo Zhiping Peng Tao Zhang Shaolin Li | 2012 | International Journal of Oncology2012，，3： | 1 |
| 14 | Considerable Model-Data Mismatch in Temperature over China during the Mid-Holocene:: Results of PMIP Simulations显示文摘 | Jiang Dabang Lang Xianmei Tian Zhiping Wang Tao | 2012 | EN2012，，12： | 1 |
| 15 | MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2显示文摘 | Qiong Wu Haifeng Jin Zhiping Yang Guanhong Luo Yuanyuan Lu Kai Li Gui Ren Tao Su Yan Pan Bin Feng Zengfu Xue Xin Wang Daiming Fan | 2010 | Biochemical and Biophysical Research Communications2010，，3： | 1 |
| 16 | Molecular Simulation of Competitive Adsorption on Fe(110)Between Gasoline Detergent and Deposit:I.Physical Adsorption显示文摘Using molecular dynamics simulations based on classical mechanic method, the mechanism of competitive adsorption between gasoline detergent and deposit on Fe(110) surface was investigated. The representative simulation relating to the deposit molecule and the gasoline detergent molecule with high market share were selected as the model compound. It was found that when the detergent and deposit molecules exist at the same time, the detergent molecules would compete with the deposit molecules to reduce the adsorption of the deposit on Fe(110) so as to protect the metal surface. In addition, the ESP distribution is further confirmed that the detergent molecule has higher adsorption ability than the deposit molecule with the DFT theory. The essence of competitive adsorption is further revealed in detail, which is very important for the development of new type high-efficiency detergent additives. | Li Na Long Jun Zhao Yi Tao Zhiping Dai Zhenyu | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，3： | 1 |
| 17 | microRNA-150 inhibits human CD133-positive liver cancer stem cells throughnegative regulation of the transcription factor c-Myb显示文摘 | Jun Zhang Na Luo Yi Luo Zhiping Peng Tao Zhang Shaolin Li | 2012 | International Journal of Oncology2012，，3： | 1 |
| 18 | Synthesis, Insecticidal Assay and Molecular Docking Study of Novel Neonicotinoids N-Oxide Analogues显示文摘八新奇 neonicotinoids N 氧化物类似物被设计并且综合。所有混合物被 1H NMR 和 HRMS 识别了。N 氧化物类似物在 250 mg 对豇豆蚜虫(蚜虫属 craccivora ) 展出高杀虫的活动 ? ????? 丠??????貸 吗?? | Zhang,Wenwen Fan,Yefeng Yu,Tao Xu,Zhiping Xu,Xiaoyong Cheng,Jiagao Li,Zhong | 2012 | Chinese Journal of Chemistry2012，30，2： | 1 |
| 19 | Statistical Analysis of Full-Chip Leakage Power for 65nm CMOS Node and Beyond显示文摘 | LI Tao YU Zhiping | 2009 | Chinese Journal of Electronics2009，18，1： | 0 |
| 20 | Baseline radiologic features as predictors of efficacy in patients with pancreatic neuroendocrine tumors with liver metastases receiving surufatinib显示文摘Objective:Currently,pre-treatment prediction of patients with pancreatic neuroendocrine tumors with liver metastases(PNELM)receiving surufatinib treatment was unsatisfying.Our objective was to examine the association between radiological characteristics and efficacy/prognosis.Methods:We enrolled patients with liver metastases in the phase III,SANET-p trial(NCT02589821)and obtained contrast-enhanced computed tomography(CECT)images.Qualitative and quantitative parameters including hepatic tumor margins,lesion volumes,enhancement pattern,localization types,and enhancement ratios were evaluated.The progression-free survival(PFS)and hazard ratio(HR)were calculated using Cox’s proportional hazard model.Efficacy was analyzed by logistic-regression models.Results:Among 152 patients who had baseline CECT assessments and were included in this analysis,the surufatinib group showed statistically superior efficacy in terms of median PFS compared to placebo across various qualitative and quantitative parameters.In the multivariable analysis of patients receiving surufatinib(N=100),those with higher arterial phase standardized enhancement ratio-peri-lesion(ASER-peri)exhibited longer PFS[HR=0.039;95%confidence interval(95%CI):0.003−0.483;P=0.012].Furthermore,patients with a high enhancement pattern experienced an improvement in the objective response ratio[31.3%vs.14.7%,odds ratio(OR)=3.488;95%CI:1.024−11.875;P=0.046],and well-defined tumor margins were associated with a higher disease control rate(DCR)(89.3%vs.68.2%,OR=4.535;95%CI:1.285−16.011;P=0.019)compared to poorlydefined margins.Conclusions:These pre-treatment radiological features,namely high ASER-peri,high enhancement pattern,and well-defined tumor margins,have the potential to serve as predictive markers of efficacy in patients with PNELM receiving surufatinib. | Jianwei Zhang Haibin Zhu Lin Shen Jie Li Xiaoyan Zhang Chunmei Bai Zhiwei Zhou Xianrui Yu Zhiping Li Enxiao Li Xianglin Yuan Wenhui Lou Yihebali Chi Nong Xu Yongmei Yin Yuxian Bai Tao Zhang Dianrong Xiu Jia Chen Shukui Qin Xiuwen Wang Yujie Yang Haoyun Shi Xian Luo Songhua Fan Weiguo Su Ming Lu Jianming Xu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
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