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| 1 | Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential显示文摘Metastatic human HCC model is needed for the studies on mechanism and intervention of metastatic recurrence. By using orthotopic implantation of histologically intact tissues of 30 surgical specimens, a patient like metastatic model of human HCC in nude mice (LCI-D20)and a Iow metastatic model of human HCC in nude mice LCI-D35 ) have been established. All mice with transplanted LCI-D20 tumors exhibited extremely high metastatic ability including spontaneous metastasis to liver, lungs, lymph nodes and peritoneal seeding.Remarkable difference was also found in expression of some of the invasiveness related genes and growth factors between the LCI-D20 and LCI-D35 tumors. PAI-Iincreased gradually following tumor progression in LCID20 model, and correlated with tumor size and AFP level,Phasic expression of tissue intercellular adhesion molecule-I in this model was also observed. Using corneal micropocket model, it was demonstrated that the vascular response induced by LCI-D20 tumor was stronger than that induced by LCI-D35 tumor. Similar report on metastatic human HCC model in nude mice and human HCC cell line with metastatic potential was rarely found in the literature. This LCI-D20 model has been widely used for the studies on intervention of metastasis, including antiangiogenesis, antisense approach, metalloproteinase inhibitor, differentiation inducer, etc. It is concluded that the establishment of metastatic human HCC model in nude mice and human HCC cell line with metastatic potential will provide important models for the in vivo and in vitro study of HCC invasiveness, angiogenesis as well as intervention of HCC recurrence. | Zhao-You Tang Fan-Xian Sun Jian Tian Sheng-Long Ye Yin-Kun Liu Kang-Da Liu Qiong Xue Jie Chen Jing-Lin Xia Lun-Xiu Qin Hui-Chuan Sun Lu Wang Jian Zhou Yan Li Zeng-Chen Ma Xin-Da Zhou Zhi-Quan Wu Zhi-Ying Lin Bing-Hui Yang Liver Cancer Institute of Fudan University and Zhongshan Hospital,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 34 |
| 2 | Changes in China’s lakes: climate and human impacts显示文摘Lakes have played a critical role in providing water and ecosystem services for people and other organisms in China for millennia.However,accelerating climate change and economic boom have resulted in unprecedented changes in these valuable lakes.Using Landsat images covering the entity of the country,we explored the changes in China’s lakes and the associated driving forces over the last 30 years(i.e.mid-1980 s to 2015).We discovered that China’s lakes have changed with divergent regional trends:in the sparsely populated Tibetan Plateau,lakes are abundant and the lake area has increased dramatically from 38596 to46831 km^2(i.e.increased by 8235 km^2,or 21.3%),whereas,in the densely populated northern and eastern regions,lakes are relatively scarce and the lake area has decreased from 36659 to 33657 km^2(i.e.decreased by 3002 km^2,or 8.2%).In particular,severe lake decreases occurred in the Mongolia-Xinjiang Plateau and the Eastern Plain(-2151 km^2).Statistical analyses indicated that climate was the most important factor controlling lake changes in the Tibetan Plateau,the Yun-Gui Plateau and the Northeast Plain.However,the strength of climatic control on lake changes was low in the Eastern Plain and the Mongolia-Xinjiang Plateau,where human activities,e.g.impoldering,irrigation and mining,have caused serious impacts on lakes.Further lake changes will exacerbate regional imbalances between lake resources and population distribution,and thus may increase the risk of water-resource crises in China. | Shengli Tao Jingyun Fang Suhui Ma Qiong Cai Xinyu Xiong Di Tian Xia Zhao Leqi Fang Heng Zhang Jiangling Zhu Shuqing Zhao | 2020 | National Science Review2020，7，1： | 14 |
| 3 | Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats显示文摘Shenfu injection(SFI), a Chinese medicinal product, shows potent efficacy in treating sepsis. The aim of the present study was to clarify the protective effects of SFI against lipopolysaccharide(LPS)-induced myocardial inflammation and apoptosis.Experiments were carried out in Sprague-Dawley(SD) rats treated with LPS or LPS + SFI, and in H9 C2 cardiomyocytes. The sepsisassociated myocardial inflammation and apoptosis was induced by the intraperitoneal injection of LPS(20 mg·kg–1). SFI attenuated the increased expression of tumor necrosis factor(TNF)-α and interleukin(IL)-1β induced by LPS both in serum and heart. In LPS group,cell viability was reduced, and reversed after SFI administration. LPS treatment increased the expression levels of cleaved-caspase 3 and Bax, and those of Bcl2 and Bcl2/Bax. These two trends were reversed by SFI administration. The expression levels of phosphorylated mitogen-activated protein kinase kinase(p-MEK) and phosphorylated extracellular regulated protein kinases(p-ERK) were increased by LPS, and reversed by SFI. MEK inhibitor U0126 attenuated the apoptosis induced by LPS. These results indicate that SFI could treat LPS-induced cardiac dysfunction. In conclusion, SFI attenuates the inflammation and apoptosis induced by LPS via downregulating the MEK and ERK signaling pathways. | CHEN Rui-Juan RUI Qing-Lin WANG Qiong TIAN Fang WU Jian KONG Xiang-Qing | 2020 | Chinese Journal of Natural Medicines2020，18，3： | 12 |
| 4 | Shrubs proliferated within a six-year exclosure in a temperate grassland—Spatiotemporal relationships between vegetation and soil variables显示文摘Overgrazing has been considered one of the major causes that trigger shrub encroachment of grassland.Proliferation of shrubs in grassland is recognized as an important indicator of grassland degradation and desertification.In China,various conservation measures,including enclosures to reduce livestock grazing,have been taken to reverse the trend of grassland desertification,yet shrubs have been reported to increase in the grasslands over the past decades.In late 2007,we set up a 400-m-by-50-m exclosure in a long-term overgrazed temperate grassland in Inner Mongolia,with the objective to quantify the spatiotemporal relationship between vegetation dynamics,soil variables,and grazing exclusion.Soil moisture was continuously monitored within the exclosure,and cover and aboveground biomass of the shrubs were measured inside the exclosure in 2007,2009,2010,2012,and 2013,and outside the exclosure in 2012 and 2013.We found the average shrub cover and biomass significantly increased in the six years by 103% and 120%,respectively.The result supported the hypothesis that releasing grazing pressure following long-term overgrazing tends to trigger shrub invasion into grassland.Our results,limited to a single gradient,suggest that any conservation measures with quick release of overgrazing pressure by enclosure or other similar means might do just the opposite to accelerate shrub encroachment in grassland.The changes in vegetation cover and biomass were regressed on the temporal average of the soil moisture content by means of the generalized least square technique to quantify the effect of the spatial autocorrelation.The result indicates that the grass cover and biomass significantly increased with the top,but decreased with the bottom layer soil moisture.The shrub cover and biomass,on the other hand,decreased with the top,but increased with bottom soil moisture,although the regression coefficients for the shrubs were not statistically significant.Hence this study supports the two-layered soil model which assumes grasses and shrubs use belowground resources in different depths. | Yong Zhang Qiong Gao Li Xu Mei Yu YuQiang Tian | 2014 | Research in Cold and Arid Regions2014，6，2： | 11 |
| 5 | Recombinant human bone morphogenetic protein-2 promotes the proliferation of mesenchymal stem cells in vivo and in vitro显示文摘背景骨头形态基因的蛋白质( BMP )是更好转变它是在 hematopoiesis.To 的一个不可缺少的因素的生长 factor-.Recent 研究表演的总科的一个成员在造血作用描绘 recombinant 人 BMP ( rhBMP ) -2 的效果,我们开始决定 rhBMP-2 是否能支持间充质的干细胞( MSC )的增长并且在 MSCs.Methods 2,3二度( 2-methoxy-4-nitro-5-sulfophenyl )增加造血的 cytokines 的层次-5-((phenylamino)羰基) | LIU Shui-bing HU Pei-zhen HOU Ying LI Peng CAO Wei TIAN Qiong | 2009 | Chinese Medical Journal2009，，7： | 8 |
| 6 | Effect of rainfall interannual variability on the biomass and soil water distribution in a semiarid shrub community显示文摘The dynamics of biomass and soil moisture in semiarid land is driven by both the current rainfall and the ecosystem memory.Based on a meta-analysis of existing experiments,an ecosystem model was used to calculate the effect of the rainfall interannual variability on the pattern of biomass and soil moisture in a shrub community.It was found that rainfall interannual variability enabled shrubs to be more competitive than grasses,and to maintain the dominant role over a longer time.The rainfall interannual variability resulted in complex soil moisture dynamics.The soil water recharge in wet years alternated with discharge in drought years. | LIU JunShanXU XiaZHANG Yong,TIAN YuQiang & GAO Qiong State Key Laboratory of Earth Surface Processes and Resource Ecology,College of Resources Science & Technology,Beijing Normal University,Beijing 100875,China | 2010 | Science China(Life Sciences)2010，53，6： | 7 |
| 7 | Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects显示文摘 | Wen-Fang Tian Ping Weng Qiong Sheng Jun-Liang Chen Peng Zhang Ji-Ru Zhang Bin Du Min-Chen Wu Qing-Feng Pang Jian-Jun Chu | 2017 | Chinese Medical Journal2017，，7： | 5 |
| 8 | A multijunction of ZnIn2S4 nanosheet/TiO2 film/Si nanowire for significant performance enhancement of water splitting显示文摘有特定的结构和作文的 Photoelectrodes 为改进切开的太阳的水的效率被建议了。这里,新奇 multijunction 结构被制作,与象核心的 Si nanowires, ZnIn 2 作为分支,和 TiO, 2 是夹了层拍摄的 S 4 nanosheets。这个连接与 0.51% 的最大的 photoconversion 效率展出了优异 photoelectrochemical 表演,它分别地比赤裸的 Si 晶片和 nanowires 的高 795 和 64 倍。大改进为在 multijunction/electrolyte 接口便于电子转移在与水氧化还原作用潜力源于他们的有利精力乐队排列的 multijunctions 以内被归因于有效 electronhole 分离和快激动的搬运人运输,并且到扩大接触区域。 | Qiong Liu Fangli Wu Fengren Cao Lei Chen Xinjian Xie Weichao Wang Wei Tian Liang Li | 2015 | Nano Research2015，8，11： | 4 |
| 9 | Peroxynitrite Scavenging Activities of Resveratrol and Piceid显示文摘In vitro antioxidant activities of resveratrol and piceid against peroxynitrite(ONOO-) were examined by the inhibition of 3-nitrotyrosine formation.Trolox was used as a positive control.Resveratrol and piceid exhibited high ONOO--scavenging activities in a concentration dependent manner.The antioxidant activities(the concentration of test compound required to yield a 50% inhibition of tyrosine nitration,IC 50) of resveratrol and piceid against ONOO-were(48.34±0.97) and(74.69±1.49) μmol/L,respectively.Compared with that of trolox[(105.40±1.16) μmol/L],their scavenging activities were 2.2-and 1.5-fold higher for resveratrol and piceid.Formation of nitroresveratrol as shown by UV-Vis spectroscopy and liquid chromatography-tandom mass spectrometry(LC-MS/MS) analysis indicates that resveratrol could directly scavenge ONOO-via nitration reaction.Our results demonstrate that foods and medicinal herbs with resveratrol and piceid as stronger ONOO-scavengers are valuable ingredients and have healthy application in preventing humans from peroxynitrite-mediated oxidative damage by scavenging peroxynitrite efficiently. | ZHAO Guang-rong TIAN Li-li MA Qiong WANG Chang-song QIAO Bin ZHANG Jun-gang JI Xiang-wu | 2012 | Chemical Research in Chinese Universities2012，28，6： | 4 |
| 10 | Epidemiological and clinical characteristics of COVID-19 patients in Hengyang,Hunan Province,China显示文摘BACKGROUND In December 2019,an ongoing outbreak of coronavirus disease 2019(COVID-19)was first identified in Wuhan,China.The characteristics of COVID-19 patients treated in local hospitals in Wuhan are not fully representative of patients outside Wuhan.Therefore,it is highly essential to analyze the epidemiological and clinical characteristics of COVID-19 in areas outside Wuhan or Hubei Province.To date,a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders,clinical classification,and with or without basic diseases.AIM To study the epidemiological and clinical characteristics of COVID-19 patients in Hengyang(China)and provide a reliable reference for the prevention and control of COVID-19.METHODS From January 16 to March 2,2020,a total of 48 confirmed cases of COVID-19 were reported in Hengyang,and those cases were included in this study.The diagnostic criteria,clinical classification,and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)released by National Health Commission and National Administration of Traditional Chinese Medicine.The presence of SARS-CoV-2 in pharyngeal swab specimens was detected by quantitative reverse transcription polymerase chain reaction.All the data were imported into the excel worksheet and statistically analyzed by using SPSS 25.0 software.RESULTS A total of 48 cases of COVID-19 were collected,of which 1 was mild,38 were moderate,and 9 were severe.It was unveiled that there were 31(64.6%)male patients and 17(35.4%)female patients,with a female-to-male ratio of 1.82:1.The range of age of patients with COVID-19 was dominantly 30-49 years old[25(52.1%)of 48],followed by those aged over 60 years old[11(22.9%)].Besides,29.2%(14 of 48)of patients had basic diseases,and 57.2%(8 of 14)of patients with basic diseases were aged over 60 years old.The occupations of 48 COVID-19 patients were mainly farmers working in agricultural production[15(31.5%)of 48],rural migrant workers from Hengyang to Wuhan[15(31.5%)],and service workers operating in the service sector[8(16.7%)].The mean latent period was 6.86±3.57 d,and the median was 7[interquartile range(IQR):4-9]d.The mean time from onset of symptoms to the first physician visit was 3.38±2.98(95%CI:2.58-9.18)d,with a median of 2(IQR:1-5)d,and the mean time from hospital admission to confirmed diagnosis was 2.29±2.11(95%CI:1.18-6.42)d,with a median of 2(IQR:1-3)d.The main symptoms were fever[43(89.6%)of 48],cough and expectoration[41(85.4%)],fatigue[22(45.8%)],and chills[22(45.8%)].Other symptoms included poor appetite[13(27.1%)],sore throat[9(18.8%)],dyspnea[9(18.8%)],diarrhea[7(14.6%)],dizziness[5(10.4%)],headache[5(10.4%)],muscle pain[5(10.4%)],nausea and vomiting[4(8.3%)],hemoptysis[4(8.3%)],and runny nose[1(2.1%)].The numbers of peripheral blood leukocytes,lymphocytes,and eosinophils were significantly reduced in the majority of the patients.The levels of C-reactive protein,fibrinogen,blood glucose,lactate dehydrogenase,Ddimer,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl transferase(γ-GT),myoglobin(MB),and creatine kinase(CK)were increased in 64.6%,44.7%,43.2%,37.0%,29.5%,22.9%,20.8%,21.6%,13.6%,and 12.8%of patients,respectively.The incidence of ALT elevation in male patients was remarkably higher than that in females(P<0.01),while the incidences of AST,CK,and blood glucose elevations in severe patients were remarkably higher than those in moderate patients(P<0.05,respectively).Except for the mild patients,chest computed tomography showed characteristic pulmonary lesions.All the patients received antiviral drugs,38(79.2%)accepted traditional Chinese medicine,and 2(4.2%)received treatment of human umbilical-cord mesenchymal stem cells.On March 2,2020,48 patients with COVID-19 were all cured and discharged.CONCLUSION Based on our results,patients with COVID-19 often have multiple organ dysfunction or damage.The incidences of ALT elevation in males,and AST,CK,and blood glucose elevations in severe patients are remarkably higher. | Zhe-Feng Zhong Jia Huang Xia Yang Jin-Ling Peng Xiao-Yan Zhang Yang Hu Nian Fu Hai-Lian Lin Bo Jiang Ya-Ying Tian Hong-Yi Yao Li-Pu Deng Xiao-Qing Tang Jie-Can Zhou Jian Tang Xia Xie Qiong Liu Jing Liu Cheng-Yun Dou Rong-Juan Dai Bo Yan Xue-Feng Yang | 2020 | World Journal of Clinical Cases2020，8，12： | 3 |
| 11 | Synthesis,photophysical properties and TD-DFT calculation of four two-photon absorbing triphenylamine derivatives显示文摘In this study,linear absorption,single-photon excited fluorescence,fluorescence quantum yields,fluorescence lifetime and two-photon excited fluorescence of a series of triphenylamine derivatives (L1,L2,L3 and L4) have been measured.L1 and L3 are D--A type dyes,while L2 and L4 are D--D--A type dyes (D=donor,A=acceptor).The investigated compounds consist of triphenylamine-bearing donor-substituted and/or systematically extended-conjugated length,which are designed to gain insight into the effect of the ethoxyl unit and-linkage length on the linear and nonlinear optical properties.The influence of solvent polarity on the photophysical properties was investigated.Employing time-dependent density functional theory (TD-DFT) calculations,the structure-property relationships are discussed. | KONG Lin YANG JiaXiang ZHOU HongPing LI ShengLi HAO FuYing ZHANG Qiong TU YuLong WU JieYing XUE ZhaoMing TIAN YuPeng | 2013 | Science China Chemistry2013，56，1： | 3 |
| 12 | Concepts, processing, and recent developments in encapsulating essential oils显示文摘By the virtue of their olfactory,physicochemical,and biological characteristics,essential oils(EOs)have drawn wide attention as additives in daily chemicals like perfume or personal care products.Nevertheless,they are physicochemically unstable and susceptible to degradation or loss.Microencapsulation offers a feasible strategy to stabilize and prolong release of EO.This review summarizes the recognized benefits and functional properties of various preparation and characterization methods,wherein innovative fabrication strategies and their formation mechanisms are especially emphasized.Progress in combining detecting/measuring technologies with kinetic modelling are discussed,to give an integral approach of controlling the dynamic release of encapsulated EOs.Moreover,new development trends of EOs capsules are also highlighted. | Qirui Tian Weiqing Zhou Qiong Cai Guanghui Ma Guoping Lian | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 3 |
| 13 | Privacy Protection Based Access Control Scheme in Cloud-Based Services显示文摘With the rapid development of computer technology, cloud-based services have become a hot topic. They not only provide users with convenience, but also bring many security issues, such as data sharing and privacy issue. In this paper, we present an access control system with privilege separation based on privacy protection(PS-ACS). In the PS-ACS scheme, we divide users into private domain(PRD) and public domain(PUD) logically. In PRD, to achieve read access permission and write access permission, we adopt the Key-Aggregate Encryption(KAE) and the Improved Attribute-based Signature(IABS) respectively. In PUD, we construct a new multi-authority ciphertext policy attribute-based encryption(CP-ABE) scheme with efficient decryption to avoid the issues of single point of failure and complicated key distribution, and design an efficient attribute revocation method for it. The analysis and simulation result show that our scheme is feasible and superior to protect users' privacy in cloud-based services. | Kai Fan Qiong Tian Junxiong Wang Hui Li Yintang Yang | 2017 | China Communications2017，14，1： | 3 |
| 14 | Zircon U-Pb geochronology and geochemistry of diorite dikes from Nancha ore deposit in Tonghua area of Jilin and its geological significance显示文摘The authors presented geochronology and geochemical data of diorites from Nancha gold deposit in Tonghua region,with the aim to constraining its formation age,magma source and tectonic setting.LA-ICP-MS U-Pb dating results of zircons from the diorites indicate that the rocks were formed in the Middle Jurassic( 171± 2 Ma,MSWD = 1.19).Geochemically,these rocks have Si O_2 concentrations of 52.52%--54.90%,K_2 O of2.14%--3.84%,Na_2 O of 3.17%--3.35%,Mg O of 7.43%--9.34% and high Mg~# of 68.57-72.57.These rocks are characterized by enrichment in large ion lithophile elements( LILE,such as K,Ba,Rb and Sr) and light rare earth elements( LREE),relatively depletion in high field strength elements( HFSE,such as Ta,Nb,Ti and Zr),and heavy rare earth elements( HREE).These characteristics suggest that primary magma of the rocks were derived from the partial melting of mantle with miner crustal contamination,which may related to partial melting of mantle wedge by addition of sediment melt from subducting oceanic crust.Based on former and present studies,the authors consider that the Nancha ore deposit high-Mg diorites were formed in compressional structural setting which is similar to volcanic arc.It could be related to the subduction of the Paleo-Pacific plate beneath the Eurasian continent. | WU Qiong SUN Fengyue WANG Li LIU Jinlong TIAN Lidan WANG Fei | 2017 | Global Geology2017，20，1： | 2 |
| 15 | The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study显示文摘Tuberculosis (TB) is a formidable global health problem and ranks above HIV as the leading cause of death worldwide. In 2017, a total number of 10.0 million cases of TB were reported, which resulted in 1.3 million TB deaths. Resistance to standard anti-TB drugs poses a major threat to control of TB, and 450, 000 cases of multidrug-resistant TB (MDR-TB) were estimated in 2017, which indicates the severity of the problem[1]. Pneumonia is one of the common infectious diseases that cause morbidity and mortality in China, causing approximately 2.5 million new cases and 125, 000 deaths annually[2]. Particularly, a high risk of pneumonia in TB was observed among patients with TB compared to that in the general population[3]. Regarding patients with MDR-TB, the extensive for the focus of lung[4] and lung dysbacteriosis[5] further increase the risk of secondary pneumonia, and the role of secondary pneumonia in the efficacy of anti-TB treatment needs to be delineated. | TAN Shou Yong LIANG Zhuo Zhi Gift Chiwala KUANG Hao Bin HUANG Zhi Pei QIN Hong Juan LI Yan LI Yan Qiong H.M.Adnan Hameed ZHANG Tian Yu | 2018 | Biomedical and Environmental Sciences2018，31，12： | 2 |
| 16 | Risk-taking path choice behaviors under ATIS in transportation networks with demand uncertainty显示文摘A new travel time reliability-based traffic assignment model is proposed to investigate the effects of an advanced transportation information system (ATIS) on drivers' risk-taking path choice behaviours in transportation networks with demand uncertainty. In the model, drivers are divided into two classes. The first class is not equipped with ATIS, while the second class is equipped with ATIS. Different risk-taking path choice behaviours of the two classes are studied, respectively. A corresponding mixed equilibrium traffic assignment model is formulated as a variational inequality problem in terms of path flows, which is solved by a heuristic solution algorithm. Numerical results indicate that the ATIS can influence the drivers' risk-taking path choice behaviours and the total system travel time in transportation networks with demand uncertainty. It is also found that under higher demand levels, the benefits of ATIS for network performance enhancement may be more obvious. | Shao, Hu Tian, Qiong Yuan, Xiaoming Wang, Guodong | 2008 | Journal of Southeast University(English Edition)2008，24，S1： | 2 |
| 17 | Two novel terpyridine-based chromophores with donor-acceptor structural model containing modified triphenylamine moiety: Synthesis, crystal structures and two-photon absorption properties显示文摘Two novel terpyridine-based chromophores with D-A (D = donor, A = acceptor) structural model containing modified triphenylamine moiety (L1 and L2 ) have been conveniently synthesized via formylation and reduction in satisfactory yields, and fully characterized. The single crystals of them were obtained and determined by X-ray diffraction analysis. The relationships between structure and photophysical properties of the two chromophores were investigated both experimentally and theoretically. The measured maximum TPA cross-sections per molecular weight (δmax /MW) of the chromophores are 0.63 GM/(g mol) (L1) and 0.72 GM/(g mol) (L2), respectively, in DMF as a high polar solvent. The results indicate that the value of δmax/MW could be well tuned by the intramolecular charge transfer (ICT), which could be realized by introducing additional elecron-donor/acceptor groups. | LIU Jie ZHANG Qiong DING HongJuan ZHANG Jun TAN JingYun WANG ChuanKui WU JieYing LI ShengLi ZHOU HongPing YANG JiaXiang TIAN YuPeng | 2013 | Science China Chemistry2013，56，9： | 2 |
| 18 | Compact CubeSat Gamma-ray detector for GRID mission显示文摘Gamma-Ray Integrated Detectors(GRID)mis-sion is a student project designed to use multiple gamma-ray detectors carried by nanosatellites(CubeSats),forming a full-time all-sky gamma-ray detection network that monitors the transient gamma-ray sky in the multi-mes-senger astronomy era.A compact CubeSat gamma-ray detector,including its hardware and firmware,was designed and implemented for the mission.The detector employs four Gd 2 Al 2 Ga 3 O 12:Ce(GAGG:Ce)scintillators coupled with four silicon photomultiplier(SiPM)arrays to achieve a high gamma-ray detection efficiency between 10 keV and 2 MeV with low power and small dimensions.The first detector designed by the undergraduate student team onboard a commercial CubeSat was launched into a Sun-synchronous orbit on October 29,2018.The detector was in a normal observation state and accumulated data for approximately one month after on-orbit functional and performance tests,which were conducted in 2019. | Jia-Xing Wen Xu-Tao Zheng Jian-Dong Yu Yue-Peng Che Dong-Xin Yang Huai-Zhong Gao Yi-Fei Jin Xiang-Yun Long Yi-Hui Liu Da-Cheng Xu Yu-Chong Zhang Ming Zeng Yang Tian Hua Feng Zhi Zeng Ji-Rong Cang Qiong Wu Zong-Qing Zhao Bin-Bin Zhang Peng An GRID collaboration | 2021 | Nuclear Science and Techniques2021，32，9： | 2 |
| 19 | Urinary concentrations of phenols, oxidative stress biomarkers and thyroid cancer: Exploring associations and mediation effects显示文摘Phenols have been shown to influence the cellular proliferation and function of thyroid in experimental models. However, few human studies have investigated the association between phenol exposure and thyroid cancer, and the underlying mechanisms are also poorly understood. We conducted a case-control study by age- and sex-matching 143 thyroid cancer and 224 controls to investigate the associations between phenol exposures and the risk of thyroid cancer, and further to explore the mediating role of oxidative stress. We found that elevated urinary triclosan (TCS), bisphenol A (BPA) and bisphenol S (BPS) levels were associated with increased risk of thyroid cancer (all P for trends < 0.05), and the adjusted odds ratios (ORs) comparing the extreme exposure groups were 3.52 (95% confidence interval (CI):2.08, 5.95), 2.06 (95% CI: 1.06, 3.97) and 7.15 (95% CI: 3.12, 16.40), respectively. Positive associations were also observed between urinary TCS, BPA and BPS and three oxidative stress biomarkers measured by 8-hydroxy-2 -deoxyguanosine (8-OHdG), 8-iso-prostaglandin F(8-iso PGF) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), as well as between urinary 8-iso PGFand HNE-MA and the risk of thyroid cancer. Mediation analysis showed that urinary 8-iso PGFmediated 28.95%, 47.06% and 31.08% of the associations between TCS, BPA and BPS exposures and the risk of thyroid cancer, respectively (all P < 0.05). Our results suggest that exposure to TCS, BPA and BPS may be associated with increased risk of thyroid cancer and lipid peroxidation may be an intermediate mechanism. Further studies are warranted to confirm the findings. | Pan-Pan Chen Pan Yang Chong Liu Yan-Ling Deng Qiong Luo Yu Miao Min Zhang Fei-Peng Cui Jia-Yue Zeng Tian Shi Ting-Ting Lu Da Chen Long-Qiang Wang Chun-Ping Liu Ming Jiang Qiang Zeng | 2022 | Journal of Environmental Sciences2022，34，10： | 1 |
| 20 | Synthesis and optical and electroluminescent properties of novel conjugated copolymers derived from fluorene and benzoselenadiazole 显示文摘 | Yang Renqiang Tian Renyu Hou Qiong | 2003 | Macromolecules2003，36，20： | 1 |
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