|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Room temperature liquid metal:its melting point,dominating mechanism and applications显示文摘The room temperature liquid metal(LM)is recently emerging as a new class of versatile materials with fascinating characteristics mostly originated from its simultaneous metallic and liquid natures.The melting point is a typical parameter to describe the peculiarity of LM,and a pivotal factor to consider concerning its practical applications such as phase change materials(PCMs)and advanced thermal management.Therefore,the theoretical exploration into the melting point of LM is an essential issue,which can be of special value for the design of new LM materials with desired properties.So far,some available strategies such as molecular dynamics(MD)simulation and classical thermodynamic theory have been applied to perform correlative analysis.This paper is primarily dedicated to performing a comprehensive overview regarding typical theoretical strategies on analyzing the melting points.It,then,presents evaluations on several factors like components,pressure,size and supercooling that may be critical for melting processes of liquid metal.After that,it discusses applications associated with the characteristic of low melting points of LM.It is expected that a great many fundamental and practical works are to be conducted in the coming future. | Junheng FU Chenglin ZHANG Tianying LIU Jing LIU | 2020 | Frontiers in Energy2020，14，1： | 3 |
| 2 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 3 | Concept design of a new non-ship-shaped FPSO显示文摘 | WANG Tianying ZHANG Jian LIU Jinkun | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 4 | Effect of surface morphology on apatite formation 显示文摘 | Zhao Ying Xiong Tianying Liu Yuliang | 2006 | Materials Science Forum2006，，： | 1 |
| 5 | Microstructure and Mechanical Properties of Ti–Ta Composites Prepared Through Cold Spray Additive Manufacturing显示文摘In this study, an innovative approach was used to fabricate Ti–Ta composite biomaterials through cold spray additive manufacturing followed by a diff usion treatment. The microstructure and mechanical properties of the composites were investigated in detail using field emission scanning electron microscopy, electron backscatter diff raction, 3D X-ray computed tomography, tensile test, nanohardness test and resonance vibration test. The obtained results indicated that the prepared composites have inhomogeneity in their microstructure and composition. A unique microstructure, composed of Ti-rich, Ta-rich and diff usion regions, was evolved in the composites due to incomplete diff usion between Ti and Ta splats. Further, Kirkendall pores were formed in the composites due to uneven diff usion of the two phases(of Ti and Ta) during high-temperature heat treatment. The prepared composites simultaneously showed low elastic modulus and high tensile strength which is required for a good biomaterial. Low elastic modulus was associated with the residual pores and the alloying eff ect of Ta in Ti, while high tensile strength was related to the solid solution strengthening eff ects. The obtained results indicated that the prepared Ti–Ta composites have a great potential to become a new candidate for biomedical applications. | Junrong Tang Naeem ul Haq Tariq Zhipo Zhao Mingxiao Guo Hanhui Liu Yupeng Ren Xinyu Cui Yanfang Shen Jiqiang Wang Tianying Xiong | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，9： | 1 |
| 6 | A Novel Turn-on Fluorescent Probe for Highly Selective Detection of Phosphate Ion in Living Cell显示文摘A novel fluorescent probe was synthesized and studied.Fluorescent probe 1 undergoes a unique Pi induced hydrolytic reaction in DMSO-HEPES at physiological pH that produces a colorimetric change associated with a 76nm red-shift in the UV-vis absorption maximum and up to a 210-fold enhancement in the fluorescence intensity.It has successfully been used to stain and record microscopy images of HeLa cells.Moreover,the mechanistic proposal that these spectroscopic changes are associated with the reaction of Pi and probe 1 to form 2-(2-hydroxyphenyl)benzothiazole gains support from the results of mass spectrometry studied. | Jin Zhang Si Wang Changhui Liu Guowen He Tianying Peng | 2018 | Chinese Journal of Chemistry2018，36，12： | 1 |
| 7 | Highly efficient Hg2+ removal via a competitive strategy using a Co-based metal organic framework ZIF-67显示文摘The stronger coordination ability of mercury ions with organic ligands than the metal ions in metal organic framework(MOFs) provides an accessible way to separate mercury ions from solution using specific MOFs. In this study, a Co-based MOF(ZIF-67, Co(mIM)) was synthesized. It did not introduce specific functional groups, such as-SH and-NH, into its structure through complicated steps. It separate Hgfrom wastewater with a new strategy, which utilized the stronger coordination ability of Hgwith the nitrogen atom on the imidazole ring of the organic ligand than the Coions. Hgreplaced Conodes from ZIF-67 and formed a more stable precipitate with m IM. The experimental results showed that this new strategy was efficient. ZIF-67 exhibited Hgadsorption capacity of 1740 mg/g, much higher than the known MOFs sorbents. m IMs is the reaction center and ZIF-67 can improve its utilization. The sample color faded from purple to white due to the loss of cobalt ion. It is a great feature of ZIF-67 that allows users to judge whether the sorbent is deactivated intuitively. ZIF-67 can be sustainable recycled by adding organic ligands to the solution after treatment due to its simple synthesis method at room temperature. It’s a high-efficient and sustainable sorbent for Hgseparation from wastewater. | Jiacheng Zhou Hao Zhang Tianying Xie Ye Liu Qicheng Shen Jie Yang Limei Cao Ji Yang | 2022 | Journal of Environmental Sciences2022，34，9： | 1 |
| 8 | Exploring the role of ligand-BSA in the response of BSA-protected gold-nanoclusters to silver(Ⅰ)ions by FTIR and circular dichroism spectra显示文摘 | Yue Yuan Li Hongwei Liu Tianying | 2014 | Vibrational Spectroscopy2014，74，5： | 1 |
| 9 | Pressure-induced fluorescence enhancement of the bsa-protected gold nanoclustersand the corresponding conformational changes of protein显示文摘 | ZHANG Min DANG Yongqiang LIU Tianying | 2013 | The Journal of Physical Chemistry C2013，117，1： | 1 |
| 10 | Changes of pulmonary glucocorticold receptor and phospholipase A sub in sheep with acute lung injury after high dose endotoxin infusion显示文摘 | Liu LY Sun B TianY | 1993 | Am Rev Respir- Dis1993，148，41： | 1 |
| 11 | Microfluidic three-dimensional biomimetic tumor model for studying breast cancer cell migration and invasion in the presence of interstitial flow显示文摘Cell migration and invasion are critical steps in cancer metastasis,which are the major cause of death in cancer patients.Tumor-associated macrophages(TAMs)and interstitial flow(IF)are two important biochemical and biomechanical cues in tumor microenvironment,play essential roles in tumor progression.However,their combined effects on tumor cell migration and invasion as well as molecular mechanism remains largely unknown.In this work,we developed a microfluidic-based 3 D breast cancer model by co-culturing tumor aggregates,macrophages,monocytes and endothelial cells within 3 D extracellular matrix in the presence of IF to study tumor cell migration and invasion.On the established platform,we can precisely control the parameters related to tumor microenvironment and observe cellular responses and interactions in real-time.When co-culture of U937 with human umbilical vein endothelial cells(HUVECs)or MDA-MB-231 cells and tri-culture of U937 with HUVECs and MDA-MB-231 cells,we found that mesenchymal-like MDA-MB-231 aggregates activated the monocytes to TAM-like phenotype macrophages.MDA-MB-231 cells and IF simultaneously enhanced the macrophages activation by the stimulation of colony-stimulating factor 1(CSF-1).The activated macrophages and IF further promoted vascular sprouting via vascular endothelial growth factor(VEGFα)signal and tumor cell invasion.This is the first attempt to study the interaction between macrophages and breast cancer cells under IF condition.Taken together,our results provide a new insight to reveal the important physiological and pathological processes of macrophages-tumor communication.Moreover,our established platform with a more mimetic 3 D breast cancer model has the potential for drug screening with more accurate results. | Chao Song Dan Gao Tianying Yuan Yongli Chen Liping Liu Xiaowu Chen Yuyang jiang | 2019 | Chinese Chemical Letters2019，30，5： | 1 |
| 12 | IoT Security Situational Awareness Based on Q-Learning and Bayesian Game显示文摘IoT security is very crucial to IoT applications,and security situational awareness can assess the overall security status of the IoT.Traditional situational awareness methods only consider the unilateral impact of attack or defense,but lackconsideration of joint actions by both parties.Applying gametheory to security situational awareness can measure the impact of the opposition and interdependence of the offensive and defensive parties.This paper proposes an IoT security situational awareness method based on Q-Learning and Bayesian game.Through Q-Learning update,the long-term benefits of action strategies in specific states were obtained,and static Bayesian game methods were used to solve the Bayesian Nash Equilibrium of participants of different types.The proposed method comprehensively considers offensive and defensive actions,obtains optimal defense decisions in multi-state and multi-type situations,and evaluates security situation.Experimental results prove the effectiveness of this method. | Yang Li Tianying Liu Jianming Zhu Xiuli Wang | 2021 | 国际计算机前沿大会会议论文集2021，，2： | 0 |
| 13 | Quality evaluation of systematic reviews of the effects of Baduanjin on diabete显示文摘Objective:Recently,the effects of Baduanjin(a traditional Chinese mind-body exercise)on diabetes have attracted increasing attention,and relevant systematic reviews(SRs)have emerged.However,the qualities of these SRs vary markedly,and their conclusions are inconsistent,which is not conducive to guiding decision-making.We sought to assess the quality of these SRs and provide more evidence for diabetes treatment.Methods:A literature search was conducted in 7 databases from inception to December 1st,2021.SRs of randomized controlled trials investigating the effects of Baduanjin were identified.A Measurement Tool to Assess Systematic Reviews 2(AMSTAR-2)checklist,Preferred Reporting Items for Systematic Review and Meta-analysis(PRISMA)statement,and Grading of Recommendations Assessment,Development and Evaluation(GRADE)system were applied to evaluate the quality of the SRs.Results:Ten SRs were identified.All SRs were judged as critically low methodological quality by the AMSTAR-2 checklist.The total PRISMA score of the included SRs ranged from 15 to 21,and the mean score was 18.60(1.90),indicating that all SRs had partial reporting deficits.Sixty outcomes were reported in the included studies,of which 25(41.67%)were judged as low quality,and 34(56.67%)as very low quality according to the GRADE system,indicating that the overall evidence quality of outcomes was not high.Conclusion:Baduanjin seems to be an effective therapy for diabetes in improving glucose and lipid metabolism,mental health,quality of life,and waist-hip ratio(WHR).The overall quality of the SRs was less than optimal.This conclusion should be treated with caution,and researchers should conduct higher-quality clinical studies following AMSTAR-2checklist,PRISMA statement,and GRADE system in the future. | Bei Zhang Zhe Wang Fucong Peng Jiaxin Fang Liqun Guo Chunli Lu Tianying Wu Hongxia Liu | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，1： | 0 |
| 14 | Synthetic and immunological studies on the OCT4 immunodominant motif antigen-based anti-cancer vaccine显示文摘Objective:Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor.However,at present,there is no immune vaccine targeting these cells.Octamer-binding transcription factor 4(OCT4),a marker of embryonic stem cells and germ cells,often highly expresses in the early stages of tumorigenesis and is therefore a good candidate for cancer vaccine development.Methods:To identify the optimal carrier and adjuvant combination,we chemically synthesized and linked three different OCT4 epitope antigens to a carrier protein,keyhole limpet hemocyanin(KLH),combined with Toll-like receptor 9 agonist(TLR9).Results:Immunization with OCT4-3+TLR9 produced the strongest immune response in mice.In prevention assays,significant tumor growth inhibition was achieved in BABL/c mice treated with OCT4-3+TLR9(P<0.01).Importantly,the results showed that cytotoxic T lymphocyte activity and the inhibition of tumor growth were enhanced in mice immunized with OCT4-3 combined with TLR9.Meanwhile,multiple cytokines[such as interferon(IFN)-γ(P<0.05),interleukin(IL)-12(P<0.05),IL-2(P<0.01),and IL-6(P<0.05)]promoting cellular immune responses were shown to be greatly enhanced in mice immunized with OCT4-3+TLR9.Moreover,we considered safety considerations in terms of the composition of the vaccines to help facilitate the development of effective next-generation vaccines.Conclusions:Collectively,these experiments demonstrated that combination therapy with TLR9 agonist induced a tumor-specific adaptive immune response,leading to the suppression of primary tumor growth in testis embryonic carcinoma. | Tingting Chen Kan Liu Jiangyao Xu Tianying Zhan Maixian Liu Li Li Zhiwen Yang Shuping Yuan Wenyi Zou Guimiao Lin Dennis ACarson Christina CNWu Xiaomei Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 0 |
| 15 | Printed flexible thin-film transistors based on different types of modified liquid metal with good mobility显示文摘High-performance logic circuits fabricated on flexible or unconventional substrates have become a necessity for several new applications. Generally, compared to those fabricated on more rigid substrates,printed, large-area, and flexible thin film transistors(TFTs) are prone to under-performance, which severely limits their practical value. The realization of printed flexible macroelectronics requires advancements in material science and novel fabricating techniques. In this study, using a fast printing process, we manufacture liquid metal-carbon nanotube TFTs on a thin polyethylene terephthalate substrate. These flexible TFTs(ptype) exhibit enhance stability and flexibility, carrier mobility(10.61 cm2 V-1s-1), and transconductance(0.88 μS). Furthermore, we realize dependable n-type and ambipolar transistors based on liquid metals with charge transport efficiencies that are comparable to our p-type counterparts, thus providing a foundation for manufacturing integrated circuits and complementary logic gates on flexible substrates. This study shows the positive progress of liquid metal printing-enabled functional devices and discusses the possibility of practical applications;moreover, it sets the foundation for printed high-performance and large-area flexible liquid metal electronics. | Qian LI Ju LIN Tianying LIU Han ZHENG Jing LIU | 2019 | Science China(Information Sciences)2019，62，10： | 0 |
| 16 | Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway显示文摘Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC. | TIANYING CAI JUNJIE BAI PENG TAN ZHIWEI HUANG CHEN LIU ZIMING WU YONGLANG CHENG TONGXI LI YIFAN CHEN JIAN RUAN LIN GAO YICHAO DU WENGUANG FU | 2023 | Oncology Research2023，31，5： | 0 |
| 17 | Molecular multipoles and (hyper) polarizabilities from the Buckingham expansion:revisited显示文摘The Buckingham expansion is important for understanding molecular multipoles and(hyper)polarizabilities.In this study,we give a complete derivation of the Buckingham expansion in the traced form using successive Taylor series.Based on the derivation results,a general Buckingham expansion in the traced form is proposed,from which highly accurate numerical calculations using the finite field method can be achieved.The transformations from the traced multipoles and multipole-multipole polarizabilities to the corresponding traceless counterparts are realized with an auxiliary traced electric field gradient.The applications of thefinite field method in this study show good agreements with previous theoretical calculations and experimental measurements. | Houxian Chen Menglin Liu Tianying Yan | 2020 | Communications in Theoretical Physics2020，72，7： | 0 |
| 18 | GranatumX:A Community-engaging, Modularized, and Flexible Webtool for Single-cell Data Analysis显示文摘We present GranatumX,a next-generation software environment for single-cell RNA sequencing(scRNA-seq)data analysis.GranatumX is inspired by the interactive webtool Granatum.GranatumX enables biologists to access the latest scRNA-seq bioinformatics methods in a web-based graphical environment.It also offers software developers the opportunity to rapidly promote their own tools with others in customizable pipelines.The architecture of GranatumX allows for easy inclusion of plugin modules,named Gboxes,which wrap around bioinformatics tools written in various programming languages and on various platforms.GranatumX can be run on the cloud or private servers and generate reproducible results.It is a community-engaging,flexible,and evolving software ecosystem for scRNA-seq analysis,connecting developers with bench scientists.GranatumX is freely accessible at http://gffzz6e31a05dc69b4ca4h0xnvq5fwnvwn6ncf.ffgz.tsg.suse.edu.cn/granatumx/app. | David G.Garmire Xun Zhu Aravind Mantravadi Qianhui Huang Breck Yunits Yu Liu Thomas Wolfgruber Olivier Poirion Tianying Zhao Cédric Arisdakessian Stefan Stanojevic Lana X.Garmire | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 0 |
| 19 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
| 20 | The wrinkle formation in graphene on transition metal substrate:a molecular dynamics study显示文摘To explore the mechanism of the wrinkle formation in graphene on transition metal substrate,a molecular dynamics(MD)simulation package that allows us to simulate systems of millions of atoms was developed.Via the MD simulation,we reveal the detailed kinetics of wrinkles formation on a Cu substrate under compressive strain,from nucleation to one-dimensional propagation and then the splitting of a large wrinkle to a few smaller ones,which is in good conformity with experimental observation.Further study reveals that both friction and the adhesion between graphene and Cu substrate are critical for the wrinkle formation and wrinkles can be easily formed with a lower frictional force and/or a smaller adhesion.Finally,we have shown that impurities in graphene or substrates can greatly facilitate the nucleation of wrinkles.The systematic exploration of the wrinkle formation in graphene on a substrate is expected to facilitate the experimental designs for the controllable synthesis of high-quality graphene. | Chao Zhao Fengning Liu Xiao Kong Tianying Yan Feng Ding | 2020 | International Journal of Smart and Nano Materials2020，11，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员