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| 1 | Paeoniflorin suppresses TGF-β mediated epithelial- mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway显示文摘 | Yu JI Yan-nong DOU Qian-wen ZHAO Ji-zhou ZHANG Yan YANG Ting WANG Yu-feng XIA Yue DAI Zhi-feng WEI | 2016 | Acta Pharmacologica Sinica2016，37，6： | 48 |
| 2 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 3 | Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report显示文摘Fecal microbiota transplantation(FMT)is a promising strategy that involves reconstruction of gut microbiota.Recently,it has been considered as a treatment of Crohn’s disease(CD)and certain neurological diseases.Here,to the best of our knowledge,we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of epilepsy.During the 20 mo of follow-up,FMT has proved its efficacy in preventing relapse of seizures after withdrawing the antiepileptic drugs.Furthermore,this finding highlights the role of microbiota-gut-brain axis and inspires a novel treatment for epilepsy through remodeling gut microbiota. | Zhi He Bo-Ta Cui Ting Zhang Pan Li Chu-Yan Long Guo-Zhong Ji Fa-Ming Zhang | 2017 | World Journal of Gastroenterology2017，23，19： | 37 |
| 4 | Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study显示文摘AIM To assess the efficacy and safety of a Chinese herbal medicine(CHM), Xiangsha Liujunzi granules, in the treatment of patients with functional dyspepsia(FD). METHODS We performed a randomized, double-blind, placebocontrolled trial with patients from three centers. Two hundred and sixteen subjects diagnosed with FD according to ROME Ⅲ criteria and confirmed by upper gastrointestinal endoscopy and spleen-deficiency and Qi-stagnation syndrome were selected to receive Xiangsha Liujunzi granules or placebo for 4 wk in a 2:1 ratio by blocked randomization. The subjects also received follow-up after the 4-wk intervention. Herbal or placebo granules were dissolved in 300 m L of water. Participants in both groups were administered 130 m L(45 ℃) three times a day. Participants were evaluated prior to and following 4 wk of the intervention in terms of changes in the postprandial discomfort severity scale(PDSS) score, clinical global impression(CGI) scale score, hospital anxiety and depression scale(HADS) score, traditional Chinese medicine symptoms score(SS), scores of various domains of the 36-item short form health survey(SF-36), gastric emptying(GE) and any observed adverse effects. RESULTS Compared with the placebo group, patients in the CHM group showed significant improvements in the scores of PDSS, HADS, SS, SF-36 and CGI scale(P < 0.05 or P < 0.01). They also showed the amelioration in the GE rates of the proximal stomach and distal stomach(P < 0.05 or P < 0.01).CONCLUSION Xiangsha Liujunzi granules offered significant symptomatic improvement in patients with FD. | Lin Lv Feng-Yun Wang Xiang-Xue Ma Zhen-Hua Li Sui-Ping Huang Zhao-Hong Shi Hai-Jie Ji Li-Qun Bian Bei-Hua Zhang Ting Chen Xiao-Lan Yin Xu-Dong Tang | 2017 | World Journal of Gastroenterology2017，23，30： | 29 |
| 5 | Cap-assisted endoscopic sclerotherapy for hemorrhoids: Methods, feasibility and efficacy显示文摘AIM: To evaluate the methodology, feasibility, safety and efficacy of a novel method called cap-assisted endoscopic sclerotherapy(CAES) for internal hemorrhoids.METHODS: A pilot study on CAES for grade Ⅰ to Ⅲ internal hemorrhoids was performed. Colon and terminal ileum examination by colonoscopy was performed for all patients before starting CAES. Polypectomy and excision of anal papilla fibroma were performed if polyps or anal papilla fibroma were found and assessed to be suitable for resection under endoscopy. CAES was performed based on the requirement of the cap, endoscope, disposable endoscopic long injection needle, enough insufflated air and sclerosing agent.RESULTS: A total of 30 patients with grade Ⅰ to Ⅲ internal hemorrhoids was included. The follow-up was more than four weeks. No bleeding was observed after CAES. One(3.33%) patient claimed mild tenesmus within four days after CAES in that an endoscopist performed this procedure for the first time. One hundred percent of patients were satisfied with this novel procedure, especially for those patients who underwent CAES in conjunction with polypectomy or excision of anal papilla fibroma.CONCLUSION: CAES as a novel endoscopic sclerotherapy should be a convenient, safe and effective flexible endoscopic therapy for internal hemorrhoids. | Ting Zhang Li-Juan Xu Jie Xiang Zhi He Zhao-Yuan Peng Guang-Ming Huang Guo-Zhong Ji Fa-Ming Zhang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 22 |
| 6 | Structure and photocatalytic properties of TiO_2-Graphene Oxide intercalated composite显示文摘TiO2-Graphene Oxide intercalated composite (TiO2-Graphene Oxide) has been successfully prepared at low temperature (80°C) with graphite oxide (GO) and titanium sulfate (Ti(SO4)2) as initial reactants.GO was firstly exfoliated by NaOH and formed single and multi-layered graphite oxide mixture which can be defined as graphene oxide,[TiO]2+ induced by the hydrolysis of Ti(SO4)2 diffused into graphene oxide interlayer by electrostatic attraction.The nucleation and growth of TiO2 crystallites took place at low temperature and TiO2-Graphene Oxide composite was successfully synthesized.Furthermore,the photocatalytic properties of TiO2-Graphene Oxide under the irradiation of UV light were also studied.The results show that the degradation rate of methyl orange is 1.16 mg min-1 g-1(refer to the efficiency of the initial 15 min).Compared with P25 powder,this kind of intercalation composite owns much better efficiency.On the other hand,the reusable properties and stable properties of TiO2-Graphene Oxide intercalated composite are also discussed in this paper.At last,crystalline structure,interface status,thermal properties and microscopic structure of TiO2-Graphene Oxide were characterized by X-ray diffraction (XRD),X-ray photoelectron spectroscopy (XPS),thermogravimetric analysis (TGA),field emission scanning electron microscopy (FESEM) and high-resolution Transmission Electron Microscopy (HRTEM).Also,we have analyzed major influencing factors and mechanism of the composite structures which evidently improve the photocatalytic properties. | ZHANG Qiong HE YunQiu CHEN XiaoGang HU DongHu LI LinJiang YIN Ting JI LingLi | 2011 | Chinese Science Bulletin2011，56，3： | 14 |
| 7 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 8 | Association between CYP2C19*2/*3Polymorphisms and Coronary Heart Disease显示文摘This study sought to explore the relationship between cytochrome P450 2C19(CYP2C19)*2/*3 polymorphisms and the development of coronary heart disease(CHD),and to evaluate the influence of the single nucleotide polymorphisms(SNPs)on the occurrence of adverse clinical events in CHD patients.A total of 231 consecutive patients candidate for percutaneous coronary intervention genotyped for CYP2C19*2(681G>A)and*3(636G>A)polymorphisms were enrolled.The adverse clinical events were recorded during a follow-up period of 14 months.The incidence of CHD,according to coronary angiography,was significantly higher(P=0.025)in CYP2C19*2 carriers group.Stepwise binary logistic regression analysis revealed that among factors that potentially influenced the presence of CHD(age>60 years,gender,BMI,etc.),CYP2C19*2 carriers(OR 1.94,95%CI:1.08-3.50,P=0.028)and male gender(OR 2.74,95%CI:1.58-4.76,P=0.001)were independent predictors,which were associated with the presence of CHD.The follow-up results showed that the incidence of adverse cardiovascular events within 14 months of discharge was significantly higher in the CYP2C 19*2 carriers than in the non-carriers(21.6%vs.6.3%,P=0.019).The results of the multivariate Cox proportional hazards model showed that CYP2C19*2 loss-of-flinction was the only independent factor which predicted the coronary events during the follow-up period of 14 months(OR=3.65,95%CI:1.09-12.25,P=0.036).The adverse impact of CYP2C19*2 polymorphisms was found not only in the risk of the presence of CHD,but also in the adverse cardiovascular events in CHD patients during the follow-up period of 14 months.However the same influence was not found in CYP2C19*3 mutation in Chinese Han population. | Ying-ying ZHANG Xin ZHOU Wen-jie JI Ting LIU Jing MA Ying ZHANG Yu-ming LI | 2019 | Current Medical Science2019，39，1： | 11 |
| 9 | Current asthma control predicts future risk of asthma exacerbation: a 12-month prospective cohort study显示文摘 | WEI Hua-hua ZHOU Ting WANG Lan ZHANG Hong-ping FU Juan-juan WANG Lei JI Yu-lin WANG Gang | 2012 | Chinese Medical Journal2012，，17： | 9 |
| 10 | A comparative study of dust control practices in Chinese and Australian longwall coal mines显示文摘Mine dust is one of the main hazards in underground longwall mines worldwide.In order to solve the mine dust problem,a significant number of studies have been carried out regarding longwall mine dust control,both in China and Australia.This paper presents a comparative study of dust control practices in Chinese and Australian longwall mines,with particular references to statutory limits,dust monitoring methods and dust management practices,followed by a brief discussion on the research status of longwall mine dust control in both countries.The study shows that water infusion,face ventilation controls,water sprays,and deep and wet cutting in longwall shearer operations are commonly practiced in almost all underground longwall mines and that both Chinese and Australian longwall mine dust control practices have their own advantages and disadvantages.It is concluded that there is a need for further development and innovative design of more effective dust mitigation products or systems despite the development of various dust control technologies.Based on the examinations and discussions,the authors have made some recommendations for further research and development in dust control in longwall mines.It is hoped that this comparative study will provide beneficial guidance for scholars and engineers who are engaging in longwall mine dust control research and practice. | Ji Yinlin Ren Ting Wynne Peter Wan Zhijun Ma Zhaoyang Wang Zhimin | 2016 | International Journal of Mining Science and Technology2016，26，2： | 9 |
| 11 | Clinical Application of Chromosome Microarray Analysis in Han Chinese Children with Neurodevelopmental Disorders显示文摘Chromosome microarray analysis(CMA) is a cost-effective molecular cytogenetic technique that has been used as a first-line diagnostic test in neurodevelopmental disorders in the USA since 2011. The impact of CMA results on clinical practice in China is not yet well studied, so we aimed to better evaluate this phenomenon.We analyzed the CMA results from 434 patients in our clinic, and characterized their molecular diagnoses, clinical features, and follow-up clinical actions based on these results. The overall diagnostic yield for our patients was 13.6%(59 out of 434). This gave a detection rate of 14.7%for developmental delay/intellectual disability(DD/ID,38/259) and 12% for autism spectrum disorders(ASDs,21/175). Thirty-three recurrent(n≥2) variants were found, distributed at six chromosomal loci involving known chromosome syndromes(such as DiGeorge, Williams Beuren, and Angelman/Prader-Willi syndromes).The spectrum of positive copy number variants in our study was comparable to that reported in Caucasian populations, but with specific characteristics. Parental origin tests indicated an effect involving a significant maternal transmission bias to sons. The majority of patients with positive results(94.9%) had benefits, allowing earlier diagnosis(36/59), prioritized full clinical management(28/59), medication changes(7/59), a changed prognosis(30/59), and prenatal genetic counseling(15/59). Our results provide information on de novo mutations in Chinese children with DD/ID and/or ASDs. Our data showed that microarray testing provides immediate clinical utility for patients. It is expected that the personalized medical care of children with developmental disabilities will lead to improved outcomes in long-term developmental potential.We advocate using the diagnostic yield of clinically actionable results to evaluate CMA as it provides information of both clinical validity and clinical utility. | Mingyu Xu Yiting Ji Ting Zhang Xiaodong Jiang Yun Fan Juan Geng Fei Li | 2018 | Neuroscience Bulletin2018，34，6： | 8 |
| 12 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 13 | Bipartite consensus of edge dynamics on coopetition multi-agent systems显示文摘Dear editor,The cooperative control of multi-agent systems has attracted wide attention from scholars in various fields because of its wide applications.The controllability and consensus problem of multi-agent systems are two basic issues,which have been widely studied in recent years[1-4]. | Lei TIAN Zhijian JI Ting HOU Haisheng YU | 2019 | Science China(Information Sciences)2019，62，12： | 8 |
| 14 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 15 | Mining spatiotemporal patterns of urban dwellers from taxi trajectory data显示文摘随 locationaware 技术的普遍采纳,获得个人的长顺序、巨大、高精确性的空间与时间的轨道数据在各种各样的地理研究变得日益普及。出租车的轨道数据,大多数之一广泛地使用了内部城市的旅行模式,关于两道路网络交通和旅客的旅行行为包含富有的信息。如此的数据能被用来象城市的空间结构的宏系统一样学习个人的显微镜的活动模式。这份报纸在为采矿从使 GPS 能的出租车和他们的应用获得的轨道上集中城市的变换模式。一条新奇途径被建议与很多点地点从出租车轨道数据集发现家庭旅行的空间与时间的模式。途径包含三关键步:,识别从 OD 的统计的阀值价值发现潜在地有意义的地方的基于城市的交通格子的出租车起源目的地( OD )的空间聚类聚类提取城市的工作住房结构,并且分析结果到的可视化理解空间分发和揭示城市的结构和暗示家庭变换行为的时间的趋势。有在上海的出租车轨道数据集的案例研究,中国被介绍表明并且评估建议方法。 | FengMAO Minhe JI Ting LIU | 2016 | Frontiers of Earth Science2016，10，2： | 7 |
| 16 | Management of CO_(2) in a tomato greenhouse using WSN and BPNN techniques显示文摘Rational management of CO_(2) can improve the net photosynthetic rate of plants,thereby improving crop yield and quality.In order to precisely manage CO_(2) in a greenhouse,a wireless sensor network(WSN)system was developed to monitor greenhouse environmental parameters in real time,including air temperature,humidity,CO_(2) concentration,soil temperature,soil moisture,and light intensity.The WSN system includes several sensor nodes,a gateway node,and remote management software.The sensor nodes can collect 0-5 V and 4-20 mA analog signals and universal asynchronous receiver/transmitter(UART)data.The gateway node can process and transmit the data and commands between sensor nodes and remote management software.The remote management software provides a friendly interface between user and machine.Users can inquire about real-time data,and set the parameters of the WSN.The photosynthetic rate of tomato plants were studied in the flowering stage.A LI-6400XT portable photosynthesis analyzer was used to measure the photosynthetic rates of the tomato plants,and the environmental parameters of leaves were controlled according to the presetting rule.The photosynthetic rate prediction model of a single leaf was established based on a back propagation neural network(BPNN).The environmental parameters were used as input neurons after being processed by principal component analysis(PCA),and the photosynthetic rate was taken as the output neuron.The performance of the prediction model was evaluated,and the results showed that the correlation coefficient between the simulated and observed data sets was 0.9899,and root-mean-square error(RMSE)was 1.4686.Furthermore,when different CO_(2) concentrations were selected as the input to predict the photosynthetic rate,the simulated and observed data showed the same trend.According to the above analysis,it was concluded that the model can be used for quantitative regulation of CO_(2) for tomato plants in greenhouses. | Li Ting Zhang Man Ji Yuhan Sha Sha Jiang Yiqiong Li Minzan | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 6 |
| 17 | An improved method for prediction of tomato photosynthetic rate based on WSN in greenhouse显示文摘In order to improve the efficiency of CO2 fertilizer and promote high quality and yield,it is necessary to precisely control CO2 fertilizer by wireless sensor network based on a model of photosynthetic rate prediction in greenhouse.An experiment was carried out on tomato plants in greenhouse for photosynthetic rate prediction modeling combined rough set and BP neural network.In data acquiring phase,plants growth information and greenhouse environmental information that may have influences on photosynthetic rate,including plant height,stem diameter,the number of leaves and chlorophyll content of functional leaves,air temperature,air humidity,light intensity,CO2 concentration and soil moisture,which were measured.And LI-6400XT photosynthetic rate instrument was used for obtaining net photosynthetic rate of functional leaf.After preliminary processing,135 sets of data were obtained.And twelve of them were used for model test of neural network,while the others were used for modeling.All of the data were normalized before modeling.Two models were built to predict photosynthetic rate based on BP neural network.One had total nine input parameters.The other had six input parameters,chlorophyll content,air temperature,air humidity,light intensity,CO2 concentration,and soil moisture,which were reducted from original nine based on attributes reduction theory of rough set.Both two models have one output parameter,the net photosynthetic rate of single leaf.The genetic algorithm was adopted to reduct attributes.Since continuous data cannot be processed by rough set,the K-mean cluster method was used to discretize the data of nine input parameters before attributes reduction.The prediction results of two models showed that the model with six input parameters had a mean absolute error of 0.6958,an average relative error of 7.28%,a root-mean-square error of 0.7428,and a correlation coefficient of 0.9964,while the other model respectively had 0.4026,4.53%,0.3245 and 0.9965,which proved that the model with minimum attributes had higher prediction accuracy.On the other hand,the number of iterations was used to represent the neural network train speed.The result showed that the model with six input parameters had an iteration of 544,while the other had 1038.Hence,the reduction model was applied to controlling CO2 concentration.The net photosynthetic rates at different CO2 concentrations were predicted at a certain condition.The results had the same curve trend with theory analysis,and a high prediction accuracy,which proved that the model was useful for CO2 concentration control. | Ji Yuhan Jiang Yiqiong Li Ting Zhang Man Sha Sha Li Minzan | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 6 |
| 18 | Synthesis,crystal structure and thermal behavior of 4-amino-3,5-dinitropyrazole copper salt显示文摘A novel energetic combustion catalyst,4-amino-3,5-dinitropyrazole copper salt([Cu(adnp)2(H_2O)_2]),was synthesized in a yield of 93.6%for the first time.The single crystal of[Cu(adnp)2(H_2O)_2]was determined by single crystal X-ray diffraction.It crystallizes in a triclinic system,space group P'' with crystal parameters a = 5.541(3) A,b = 7.926(4) A,c= 10.231(5) A,β = 101.372(8),V= 398.3(3) A^3,Z= 1,μ = 1.467 mm^(-1),F(0 0 0) = 243,and Dc = 2.000 g cm^(-3).The thermal behavior and non-isothermal decomposition reaction kinetics of[Cu(adnp)_2(H_2O)_2]were studied by means of different heating rate differential scanning calorimetry(DSC).The kinetic equation of major exothermic decomposition reaction for[Cu(adnp)_2(H_20O_2]was obtained.The entropy of activation(AS*),enthalpy of activation(△H~≠),free energy of activation(AG~≠),the self-accelerating decomposition temperature(T_(SADT)) and the critical temperature of thermal explosion(T_b) are 59.42 J mol^(-1) K^(-1),169.5 kJ mol^(-1),1141.26 kJ mol^(-1),457.3 K and 468.1 K,respectively. | Ying-Lei Wang Feng-Qi Zhao Yue-Ping Ji Jian-Hua Yi Ting An Wei-Xiao Liu | 2014 | Chinese Chemical Letters2014，25，6： | 6 |
| 19 | MdMYB8 is associated with flavonol biosynthesis via the activation of the MdFLS promoter in the fruits of Malus crabapple显示文摘Flavonols are polyphenolic compounds that play important roles in plant stress resistance and development.They are also valuable components of the human diet.The Malus crabapple cultivar‘Flame’provides an excellent model for studying flavonol biosynthesis due to the high flavonol content of its fruit peel.To obtain a more detailed understanding of the flavonol regulatory network involved in fruit development,the transcriptomes of the fruit of the Malus cv.‘Flame’from five continuous developmental stages were analyzed using RNA sequencing.A flavonol-related gene module was identified through weighted gene coexpression network analysis(WGCNA),and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis indicated that phytohormones are involved in regulating flavonol biosynthesis during fruit development.A putative transcription factor,MdMYB8,was selected for further study through hub gene correlation network analysis and yeast one-hybrid assays.Stable overexpression or RNAi knockdown of MdMYB8 in transgenic‘Orin’apple calli resulted in a higher or lower flavonol content,respectively,suggesting that MdMYB8 is a regulator of flavonol biosynthesis.This transcriptome analysis provides valuable data for future studies of flavonol synthesis and regulation. | Hua Li Yu Li Jiaxuan Yu Ting Wu Jie Zhang Ji Tian Yuncong Yao | 2020 | Horticulture Research2020，7，1： | 6 |
| 20 | Chang'an Ⅱ Decoction(肠安Ⅱ号方)-Containing Serum Ameliorates Tumor Necrosis Factor-α-Induced Intestinal Epithelial Barrier Dysfunction via MLCK-MLC Signaling Pathway in Rats显示文摘Objective To investigate the effect of Chang’an Ⅱ Decoction(肠安Ⅱ号方))-containing serum on intestinal epithelial barrier dysfunction in rats.Methods Tumor necrosis factor(TNF)-α-induced injury of Caco-2 monolayers were established as an inflammatory model of human intestinal epithelium.Caco-2 monolayers were treated with blank serum and Chang’an Ⅱ Decoction-containing serum that obtained from the rats which were treated with distilled water and Chang’an Ⅱ Decoction intragastrically at doses of 0.49,0.98,1.96 g/(kg·d)for 1 week,respectively.After preparation of containing serum,cells were divided into the normal group,the model group,the Chang’an Ⅱ-H,M,and L groups(treated with 30 ng/mL TNF-αand medium plus 10%high,middle-,and low-doses Chang’an Ⅱ serum,respectively).Epithelial barrier function was assessed by transepithelial electrical resistance(TER)and permeability of fluorescein isothiocyanate(FITC)-labeled dextran.Transmission electron microscopy was used to observe the ultrastructure of tight junctions(TJs).Immunofluorescence of zonula occludens-1(ZO-1),claudin-1 and nuclear transcription factor-kappa p65(NF-κBp65)were measured to determine the protein distribution.The mRNA expression of myosin light chain kinase(MLCK)was measured by real-time polymerase chain reaction.The expression levels of MLCK,myosin light chain(MLC)and p-MLC were determined by Western blot.Results Chang’an Ⅱ Decoction-containing serum significantly attenuated the TER and paracellular permeability induced by TNF-α.It alleviated TNF-α-induced morphological alterations in TJ proteins.The increases in MLCK mRNA and MLCK,MLC and p-MLC protein expressions induced by TNF-αwere significantly inhibited in the Chang’an Ⅱ-H group.Additionally,Chang’an Ⅱ Decoction significantly attenuated translocation of NF-κBp65 into the nucleus.Conclusion High-dose Chang’an Ⅱ-containing serum attenuates TNF-α-induced intestinal barrier dysfunction.The underlying mechanism may be involved in inhibiting the MLCK-MLC phosphorylation signaling pathway mediated by NF-κBp65. | CHEN Ting YIN Xiao-Ian KANG Nan WANG Xiao-ge LI Bao-shuang JI Hai-jie ZHANG Yin-qiang BIAN Li-qun ZHANG Bei-hua WANG Feng-yun TANG Xu-dong | 2020 | Chinese Journal of Integrative Medicine2020，26，10： | 5 |
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