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| 1 | Simulation study of coal mine safety investment based on system dynamics显示文摘To generate dynamic planning for coal mine safety investment, this study applies system dynamics to decision-making, classifying safety investments by accident type. It validates the relationship between safety investments and accident cost, by structurally analyzing the causality between safety investments and their influence factors. Our simulation model, based on Vensim software, conducts simulation analysis on a series of actual data from a coalmine in Shanxi Province. Our results indicate a lag phase in safety investments, and that increasing pre-phase safety investment reduces accident costs. We found that a 24% increase in initial safety investment could help reach the target accident costs level 14 months earlier. Our simulation test included nine kinds of variation trends of accident costs brought by different investment ratios on accident prevention. We found an optimized ratio of accident prevention investments allowing a mine to reach accident cost goals 4 months earlier, without changing its total investment. | Tong Lei Dou Yuanyuan | 2014 | International Journal of Mining Science and Technology2014，24，2： | 11 |
| 2 | Graphitic carbon nitride (g-C3N4)-based nanosized heteroarrays: Promising materials for photoelectrochemical water splitting显示文摘Photoelectrochemical(PEC)water splitting is recognized as a sustainable strategy for hydrogen generation due to its abundant hydrogen source,utilization of inexhaustible solar energy,high-purity product,and environment-friendly process.To actualize a practical PEC water splitting,it is paramount to develop efficient,stable,safe,and low-cost photoelectrode materials.Recently,graphitic carbon nitride(g-C3N4)has aroused a great interest in the new generation photoelectrode materials because of its unique features,such as suitable band structure for water splitting,a certain range of visible light absorption,nontoxicity,and good stability.Some inherent defects of g-C3N4,however,seriously impair further improvement on PEC performance,including low electronic conductivity,high recombination rate of photogenerated charges,and limited visible light absorption at long wavelength range.Construction of g-C3N4-based nanosized heteroarrays as photoelectrodes has been regarded as a promising strategy to circumvent these inherent limitations and achieve the high-performance PEC water splitting due to the accelerated exciton separation and the reduced combination of photogenerated electrons/holes.Herein,we summarize in detail the latest progress of g-C3N4-based nanosized heteroarrays in PEC water-splitting photoelectrodes.Firstly,the unique advantages of this type of photoelectrodes,including the highly ordered nanoarray architectures and the heterojunctions,are highlighted.Then,different g-C3N4-based nanosized heteroarrays are comprehensively discussed,in terms of their fabrication methods,PEC capacities,and mechanisms,etc.To conclude,the key challenges and possible solutions for future development on g-C3N4-based nanosized heteroarray photoelectrodes are discussed. | Liqun Wang Wenping Si Yueyu Tong Feng Hou Daniele Pergolesi Jungang Hou Thomas Lippert Shi Xue Dou Ji Liang | 2020 | Carbon Energy2020，2，2： | 10 |
| 3 | The design and performance analysis of optical wireless ACO-MC-CDMA system in the presence of clipping noise显示文摘Dear editor,With rapidly growing wireless data demand and the saturation of radio frequency(RF)spectrum,optical wireless communications(OWC)has become a viable candidate for indoor and medium range data transmission[1].In general,the perfor- | Peng DOU Guojie SONG Tong ZHAO Kejun JIA Li HAO | 2018 | Science China(Information Sciences)2018，61，2： | 8 |
| 4 | Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients显示文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)is a serious threat to global public health,and is imposing severe burdens on human society.Several candidate vaccines against SARS-CoV-2 are now undergoing clinical trials.The Spike(S)protein of SARS-CoV-2 is widely considered as a promising antigen.However. | Bao-zhong Zhang Ye-fan Hu Lin-lei Chen Thomas Yau Yi-gang Tong Jing-chu Hu Jian-piao Cai Kwok-Hung Chan Ying Dou Jian Deng Xiao-lei Wang Ivan Fan-Ngai Hung Kelvin Kai-Wang To Kwok Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，8： | 5 |
| 5 | Estimating the Health and Economic Outcomes of the Prevention of Mother-to-child Transmission of HIV Using a Decision Tree Model显示文摘In 2016, there were 17.8 million (15.4-20.3 million) women living with HIV/AIDS across the world and the prevalence of reproductive desire among this group was 26%-49%[1]. If pregnant women living with HIV/AIDS are left untreated, the rates of HIV transmission from mother-to-child would range from 14% to 48%, depending on the presence and duration of breastfeeding[2]. | QU Shui Ling WANG Ai Ling PAN Xiao Ping WANG Qian DOU Li Xia ZHANG Tong | 2019 | Biomedical and Environmental Sciences2019，32，1： | 4 |
| 6 | Generalized two-dimensional correlation spectroscopy——Theory and applications in analytical field显示文摘Since the theory of generalized two-dimensional (2-D) correlation spectroscopy was proposed, it has been keenly concerned in scientific research and its analytical method has been widely applied in various analytical fields. The mathematical process to construct generalized 2-D correlation spectroscopy and the physical meaning of 2-D correlation spectral map are described, and three examples in the fields of chemical analysis and molecular biology are provided, such as the component analysis of organic solvent, the analysis of biological molecules in the solvent with different pH values and structural analysis of protein. The theory and analytical method of generalized 2-D correlation spectroscopy are also detailedly commented. | DOU Xiaoming1, YUAN Bo1, ZHAO Haiying1, YIN Guangzhong2 & Yukihiro Ozaki3 1. Molecular and Photonics Laboratory, Physical Department, Shanghai Jiao Tong University, Shanghai 200030, China 2. Suzhou No.2 People抯 Hospital, Suzhou 215000, China 3. Chemical Department, School of Science and Technology, Kwansei-Gakuin University, Sanda 669-1337, Japan | 2004 | Science China Chemistry2004，47，3： | 2 |
| 7 | β-Elemene-loaded polymeric micelles intensify anti-carcinoma efficacy and alleviate side effects显示文摘β-Elemene is a volatile oil used for the treatment of cancer,but poor solubility,low bioavailability,and various adverse reactions limit its application.For amelio rating risks of the venous toxicity ofβ-elemene,intravenously injectable micelle ofβ-elemene was prepared using the thin-film hydration method.The results pointed out the micelles were uniformly spherical with about 20.96±0.1966 nm in average diameter and exhibited high entrapment efficiency(99.02%±0.88%).As revealed by drug release studies in vitro,β-elemene micelles had sustained drug release.Compared with freeβ-elemene,the micelles increased the drug cellular uptake and enhanced the anti-tumor effect in vitro through retarding cell cycle and inducing apoptosis.Meanwhile,the elevated se rum stability o fβ-elemene micelles implied less drug leakage and reduced toxicity.The wound healing and tube formation assay in vitro demonstrated the anti-metastasis and anti-angiogenesis effects ofβ-elemene micelles.Moreover,the pharmacokinetics study showed the AUC and T1/2 ofβ-elemene in micelle group were 1.79 and 1.62 times of that in free fi-elemene group,suggesting the circulation time ofβ-elemene in the blood had been prolonged.In addition,β-elemene micelles showed a favorable antitumor response compared with theβ-elemene solution on C26 colon cance r-bearing mice model.Local irritation study investigated in rabbits indicated that theβ-elemene micelles strikingly mitigated the irritation to the injection sites compared with freeβ-elemene.These results proved that the micelle could be a good candidate as an auspicious drug delivery system ofβ-elemene for the prospective clinical treatment of carcinoma. | Qiaoqiao Hu Lan Bai Zejiang Zhu Zhengying Su Peng Bai Minghai Tang Caixia Dou Junfeng Yan Rongsheng Tong Wuyu Zhang Lijuan Chen Lulu Cai | 2020 | Chinese Chemical Letters2020，31，3： | 2 |
| 8 | A modified laser-induced choroidal neovascularization animal model with intravitreal oxidized low-density lipoprotein显示文摘AIM: To investigate whether intravitreal injection of oxidized low-density lipoprotein(OxLDL) can promote laserinduced choroidal neovascularization(CNV) formation in mice and the mechanism involved, thereby to develop a better animal model.METHODS: C57BL6/J mice were randomized into three groups. Immediately after CNV induction with 532 nm laser photocoagulation, 1.0 μL of OxLDL [100 μg/m L in phosphate-buffered saline(PBS)] was intravitreally injected, whereas PBS and the same volume low-density lipoprotein(LDL;100 μg/m L in PBS) were injected into the vitreous as controls. Angiogenic and inflammatory cytokines were measured by quantitative real-time polymerase chain reaction(q RT-PCR) and Western blotting(WB) after 5 d, and CNV severity was analyzed by choroid flat mount and immunofluorescence staining after 1wk. In vitro, retinal pigment epithelial(RPE) cell line(ARPE19) were treated with OxLDL(LDL as control) for 8 h. Angiogenic and inflammatory cytokine levels were measured. A specific inhibitor of lectin-like oxidized low-density lipoprotein receptor 1(LOX1) was used to evaluate the role of LOX1 in this process.RESULTS: At 7 d after intravitreal injection of 1 μL(100 μg/mL) OxLDL, T15-labeled OxLDL was mainly deposited around the CNV area, and the F4/80-labeled macrophages, the CD31-labeled vascular endothelial cells number and CNV area were increased. Meanwhile, WB and qR T-PCR results showed that vascular endothelial growth factor(VEGF), CC chemokine receptor 2(CCR2), interleukin-6(IL-6), IL-1β, and matrix metalloproteinase 9(MMP9) expressions were increased, which was supported by in vitro experiments in RPE cells. LOX1 inhibitors significantly reduced expressions of inflammatory factors IL-1β and VEGF. CONCLUSION: A modified laser-induced CNV animal model is established with intravitreal injection of 1 μL(100 μg/mL) of OxLDL at 7 d, which at least partially through LOX1. This animal model can be used as a simple model for studying the role of OxLDL in age-related macular degeneration. | Tong Wu Kuan-Rong Dang Ya-Fen Wang Bao-Zhen Lyu Wen-Qin Xu Guo-Rui Dou Jian Zhou Yan-Nian Hui Hong-Jun Du | 2020 | International Journal of Ophthalmology(English edition)2020，13，8： | 2 |
| 9 | A simulation study of 630 nm and 557.7 nm airglow variations due to dissociative recombination and thermal electrons by high-power HF heating显示文摘One of the important effects of the ionospheric modification by high-power waves is the airglow enhancement. Both the thermal electrons and the dissociation recombination contribute to generate the airglow emissions during HF heating. However, the relative importance of the airglow emission induced by dissociative recombination and thermal electrons has been rarely investigated. In this study, we carry out a simulation study on the airglow produced by high-power HF heating at nighttime associated with dissociative recombination and thermal electrons. SAMI2(Sami2 is Another Model of the Ionosphere) is employed to simulate the ionospheric variations during the HF heating. The main conclusions from this study are as follows:(1) For the airglow induced by dissociative recombination, both 630.0 nm and 557.7 nm emissions show a decrease at the heating wave reflection height during the heating period,while when the heating is turned off, an increase is shown at lower altitudes. The reduction of airglow during the heating is caused by the rapid increase of electron temperature and the diffusion of plasmas dominates the after-heating airglow enhancement.(2) 630.0 nm emission due to thermal electrons is greatly enhanced at the wave reflection height, indicating that thermal electrons play a major role in exciting 630.0 nm emission. For the 557.7 nm emission, the excitation threshold(4.17 e V) is too high for thermal electrons.(3) The combined effect of dissociative recombination and thermal electrons could be the possible reason for the observed X-mode(extraordinary mode) suppression of 630.0 nm airglow during O-mode(ordinary mode) enhancement. | Tong Dang JiuHou Lei XianKang Dou WeiXing Wan | 2017 | Earth and Planetary Physics2017，1，1： | 2 |
| 10 | Is oral microbiome of children able to maintain resistance and functional stability in response to short-term interference of ingesta?显示文摘Dear Editor,A series of studies had focused on the ecological stability of human microbiome(Lozupone et al.,2012;Faith et al.,2013;Moya and Ferrer,2016).Despite the continuous perturbation and the highly personalized composition within the human microbiome(Human Microbiome Project,2012),healthy adults stably maintain their microbial communities in terms of space and time(Faith et al.,2013;Moya and Ferrer,2016;Oh et al.,2016).This stability is proved to be critical for the well-being of human body(Lozupone et al.,2012).On the contrary,major shifts in microbial community composition are often related to diseases(Lynch and Pedersen,2016). | Fangqiao Wei Xiangyu Sun Yufeng Gao Haoyu Dou Yang Liu Lili Su Haofei Luo Ce Zhu Qian Zhang Peiyuan Tong Wen Ren Zhe Xun Ruochun Guo Yuanlin Guan Shenghui Li Yijun Qi Junjie Qin Feng Chen Shuguo Zheng | 2021 | Protein & Cell2021，12，6： | 1 |
| 11 | Calibration in non-line-ar NIR spectroscopy using principal component artificialneural networks显示文摘 | Dou Ying Zou Tingting Liu Tong | 2007 | Spectrochimica Acta Part A:Molecu-lar and Biomolecular Spectroscopy2007，68，： | 1 |
| 12 | Porous Silicon@Polythiophene Core–Shell Nanospheres for Lithium‐Ion Batteries显示文摘 | Hao Zheng Shan Fang Zhenkun Tong Hui Dou Xiaogang Zhang | 2016 | Part. Part. Syst. Charact2016，，2： | 1 |
| 13 | High temperature oxidation and ablation behaviors of HfB_(2)-SiC/SiC coatings for carbon/carbon composites fabricated by dipping-carbonization assisted pack cementation显示文摘To improve the uniformity and the content of HfBin Hf B-Si-based ceramic coating and alleviate the damage of substrate,and then enhance the high-temperature(1700°C)oxidation and cyclic ablation resistances of carbon/carbon composites,a close-knit double layer HfB_(2)-SiC/SiC coatings with a mosaic structure and high content of HfBwere prepared by a novel dipping-carbonization assisted pack cementation methods(DPC–HS/S).In contrast,a HfB_(2)-SiC/SiC coatings were also fabricated by pack cementation(PC–HS/S).Results revealed that the oxidation and ablation protective performances of the DPC–HS/S coatings were superior to those of PC–HS/S coatings.After 30 thermal cycles between 1500°C and room temperature,the mass gain of the coated sample was 0.78%,and the mass loss was 1.65%after oxidation at 1700°C for 156 h.Moreover,under an oxyacetylene torch ablation for 180 s(3 cycles),the linear ablation rate of the DPC–HS/S coated specimen was 1.62μm/s,which was much lower than that of PC–HS/S coated specimen(3.08μm/s). | Lei Zhou Jiaping Zhang Dou Hu Qiangang Fu Wuqing Ding Jiaqi Hou Bing Liu Mingde Tong | 2022 | Journal of Materials Science & Technology2022，，16： | 1 |
| 14 | Network topology inference from incomplete observation data显示文摘Introduction and related work.Network inference problem covers lots of fields in real life,such as viral-marketing,stopping rumors and controlling the spread of diseases.It aims to infer the hidden network topology with only the infection time stamps of nodes when various messages | Peng DOU Guojie SONG Tong ZHAO | 2018 | Science China(Information Sciences)2018，61，2： | 1 |
| 15 | Inhibition of ERK1/2 pathway suppresses adiponectin secretion via accelerating protein degradation by Ubiquitin–proteasome system: Relevance to obesity-related adiponectin decline显示文摘 | Dongfang Gu Zhigang Wang Xiaobing Dou Ximei Zhang Songtao Li Lyndsey Vu Tong Yao Zhenyuan Song | 2013 | Metabolism2013，，8： | 1 |
| 16 | Randomized, three‐arm study to optimize lamivudine efficacy in hepatitis B e antigen‐positive chronic hepatitis B patients显示文摘 | Xieer Liang Jun Cheng Yongtao Sun Xinyue Chen Tong Li Hao Wang Jianning Jiang Xiaoping Chen Hui Long Hong Tang Yanyan Yu Jifang Sheng Shijun Chen Junqi Niu Hong Ren Junping Shi Xiaoguang Dou Mobin Wan Jiaji Jiang Qing Xie Guangfeng Shi Qin Ning Chengwei C | 2015 | J Gastroenterol Hepatol2015，，4： | 1 |
| 17 | Non-small molecule PROTACs(NSM-PROTACs):Protein degradation kaleidoscope显示文摘The proteolysis targeting chimeras(PROTACs)technology has been rapidly developed since its birth in 2001,attracting rapidly growing attention of scientific institutes and pharmaceutical companies.At present,a variety of small molecule PROTACs have entered the clinical trial.However,as small molecule PROTACs flourish,non-small molecule PROTACs(NSM-PROTACs)such as peptide PROTACs,nucleic acid PROTACs and antibody PROTACs have also advanced considerably over recent years,exhibiting the unique characters beyond the small molecule PROTACs.Here,we briefly introduce the types of NSM-PROTACs,describe the advantages of NSM-PROTACs,and summarize the development of NSM-PROTACs so far in detail.We hope this article could not only provide useful insights into NSM-PROTACs,but also expand the research interest of NSM-PROTACs. | Sinan Ma Jianai Ji Yuanyuan Tong Yuxuan Zhu Junwei Dou Xian Zhang Shicheng Xu Tianbao Zhu Xiaoli Xu Qidong You Zhengyu Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 1 |
| 18 | Tetrandrine ameliorates collagen-induced arthritis in mice by restoring the balance between Thl7 and Treg cells via the aryl hydrocarbon receptor 显示文摘 | YUAN XS TONG B DOU Y | 2016 | Biochem Pharmacol2016，101，： | 1 |
| 19 | Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Thl7 and regulatory T cells in gut-associated lymphoid tissues显示文摘 | Tong B Dou Y Wang T | 2015 | Toxicol Appl Pharmacol2015，282，1： | 1 |
| 20 | Study on Volume Variation and Stability of Riverbed in the Yangtze Estuary显示文摘In recent years,regional floods and typhoons have occurred in the Yangtze Estuary.Changing dynamic conditions and dramatic reduction of sediment discharge in the basin are affecting the dynamic equilibrium pattern of the Yangtze Estuary.Based on the field measurement data and theoretical derivation,this paper analyzed the changing process of runoff-sediment discharge into the sea after the operation of the Three Gorges Project(TGP),and the tidal dynamics and sediment variation characteristics of the Yangtze Estuary.The erosion of South Branch mainly occurs in the channel below-10 m contour,and the riverbed volume below contours 0 m and-10 m has a good correlation with the sediment discharge of Datong Station in the previous year.On this basis,the ratio of the horizontal distance from the starting point to the section centroid below the average water level(B_c)and the water depth at the section centroid(H_c)was proposed to describe the change of the section shape.The relationships between the water-diverting ratio,the sediment-diverting ratio and the water-diverting angle,the conditions of runoff and sediment discharge from the upper reach and the characteristics of the riverway section were established,and the theoretical calculation equations of the water-diverting ratio,the sediment-diverting ratio and the diverting angle of each bifurcation were also established. | DING Lei JIAO Jian TONG Chao-feng WANG Yi-fei CHEN Ben SUN Jie-ying DOU Xi-ping | 2023 | China Ocean Engineering2023，37，3： | 0 |
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