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| 1 | Efficacy and Safety of Quxie Capsule(祛邪胶囊) in Metastatic Colorectal Cancer:A Double-Blind Randomized Placebo Controlled Trial显示文摘Objective:To verify the efficacy and safety of Quxie Capsule(祛邪胶囊) in patients with metastatic colorectal cancer(mC RC).Methods:The present study was a randomized,double-blind,placebo-controlled trial.Sixty patients with mC RC were randomized into two groups at a 1:1 ratio by sealed envelope.The treatment group received conventional therapy combined with Quxie Capsule for 3 months.The control group was treated with conventional therapy combined with placebo for 3 months.Main outcome measures were overall survival(OS) and progression-free survival(PFS).Subgroup analysis was performed according to age,right or left-sided disease,and second-line therapy to determine the differences in PFS and OS between the two groups.Patients were followed up every 3 months until Dec 31 st 2016.Results:The median OS was 23 months in the treatment group [95% confidence interval(CI):15–not calculated] vs.14 months in the control group(95% CI:11–22,P=0.060).The OS of the treatment group tended to be longer than that of the control group(P>0.05).In the subgroups of patients <65 years old,left-sided colon,and 2 nd-line therapy,the treatment group showed a significant survival benefit compared with the control group(P=0.006,0.038,0.013,respectively).There were no significant differences between the two groups in PFS(P>0.05).Safety analysis showed no severe hematological toxicity or liver and renal function injury in the treatment group.Conclusions:Quxie Capsule showed good safety and efficacy,and could prolong the OS of patients with mC RC. | ZHANG Tong YANG Yu-fei HE Bin YI Dan-hui HAO Jie ZHANG Da | 2018 | Chinese Journal of Integrative Medicine2018，24，3： | 20 |
| 2 | Influence of high energy ball milling on Al-30Si powder and ceramic particulate显示文摘The influence of high energy ball milling on Al 30Si powder and ceramic particulate SiC was studied by means of SEM, XRD and DSC. The results show that Al 30Si powder and their microstructure are obviously refined after high energy ball milling process. The alloy powder and SiC p stick closely to each other without interfacial reaction. DSC results detect no reaction but relaxation of the samples. So high energy ball milling can be used as an effective method for ceramic particulate pre treatment in the fabrication of MMC. | LI Yuan yuan(李元元) ZHANG Da tong(张大童) XIAO Zhi yu(肖志宇) | 2000 | 中国有色金属学会会刊:英文版2000，10，3： | 12 |
| 3 | Two new secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora显示文摘从 Picrorhiza scrophulariiflora 的根,二新 secoiridoid glycosides,命名 picrosecosides 我和 II (1, 2 ) 被孤立。他们的结构根据化学药品和 spectropic 证据被阐明。 | Lian Chun Zou Tong Fei Zhu Shu Cai Gan Da Cheng Wang Yu Zhang Xu Ming Deng | 2008 | Chinese Chemical Letters2008，19，10： | 8 |
| 4 | Strain Softening and Hardening Behavior in AZ61 Magnesium Alloy显示文摘The deformation behavior of AZ61 Mg alloy during hot deformation has been investigated in wide temperature and strain rate range by a Gleeble simulator. Specimens are deformed in compression in the temperature range of 523~673 K and at strain rates of 0.001~1 s-1. It is found that the flow curves exhibit a peak and then decrease towards steady-state of classical DRX, which decrease with rising temperature and decreasing strain rate. The deformation behavior of the specimens can be attributed to the occurrence of strain hardening and softening. As stress decreases, the strain hardening rate declines at a fast rate when temperature rises or strain rate decreases. The shapes of θ-σ curves indicate some important features such as subgrain formation, the critical stress, the peak stress and steady stress. The onset of DRX can be determined by the point of inflection on θ-σ or Inθ-σ curves. | Haitao ZHOU, Liufa LIU, Qudong WANG, Da LU, Xiaoqin ZENG and Wenjiang DINGNational Engineering Research Center of Light Alloys Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200030, China | 2004 | Journal of Materials Science & Technology2004，20，6： | 7 |
| 5 | Two new phenylethanoid glycosides and a new secoiridoid glycoside from the roots of Picrorhiza scrophulariiflora显示文摘二新 phenylethanoid glycosides,命名 scroside H (1 ) , scroside 我(2 ) ,并且新 secoiridoid glycoside,命名 picrogentioside 我(3 ) ,从地下被孤立 Picrorhiza scrophulariiflora 的部分。他们的结构根据分光镜的证据被阐明。 | Lian Chun Zou Zhi Hui Yan Tong Fei Zhu Hua Xiang Da Cheng Wang Xu Ming Deng | 2010 | Chinese Chemical Letters2010，21，9： | 7 |
| 6 | Adaptive backtracking search optimization algorithm with pattern search for numerical optimization显示文摘The backtracking search optimization algorithm(BSA) is one of the most recently proposed population-based evolutionary algorithms for global optimization. Due to its memory ability and simple structure, BSA has powerful capability to find global optimal solutions. However, the algorithm is still insufficient in balancing the exploration and the exploitation. Therefore, an improved adaptive backtracking search optimization algorithm combined with modified Hooke-Jeeves pattern search is proposed for numerical global optimization. It has two main parts: the BSA is used for the exploration phase and the modified pattern search method completes the exploitation phase. In particular, a simple but effective strategy of adapting one of BSA's important control parameters is introduced. The proposed algorithm is compared with standard BSA, three state-of-the-art evolutionary algorithms and three superior algorithms in IEEE Congress on Evolutionary Computation 2014(IEEE CEC2014) over six widely-used benchmarks and 22 real-parameter single objective numerical optimization benchmarks in IEEE CEC2014. The results of experiment and statistical analysis demonstrate the effectiveness and efficiency of the proposed algorithm. | Shu Wang Xinyu Da Mudong Li Tong Han | 2016 | Journal of Systems Engineering and Electronics2016，27，2： | 5 |
| 7 | Bubble Strategy—A Practical Solution to Return to Regular Life in the Intertwined Era of Vaccine Rollouts and Virus Mutation显示文摘For a long time,vaccination and herd immunity were considered to be the magic solution for controlling coronavirus disease 2019(COVID-19).However,the emergence of new variants altered people’s expectations and prolonged the pandemic duration,especially the Omicron strain with substantially increased transmissibility and decreased vaccine efficacy.Therefore,we are in urgent need of a practical solution to resume regular life to some extent,while mitigating COVID-19 risks in the tight race between vaccine rollouts and virus variation.This commentary proposed that bubble strategy(or closed loop management),utilized in Tokyo 2020 Olympic Games and to be implemented in Beijing 2022 Winter Games,could serve as a novel technique of nonpharmaceutical interventions in coping with such a situation. | Ying Shen Da Huo Tong Yu Quanyi Wang | 2022 | China CDC weekly2022，4，4： | 4 |
| 8 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 9 | Lipopolysaccharide(LPS)-induced dopamine cell loss in culture : roles of tumor necrosis factor-alpha, interleukin-l beta, and nitric oxide 显示文摘 | Gayle DA Ling Z Tong C | 2002 | Brain Res Dev Brain Res2002，133，： | 1 |
| 10 | Effects of extracellular matrix components on axonal outgrowth from peripheral nerves of adult animals in vitro显示文摘 | Tonge DA Golding JP Edbladh M | | 0，，： | 1 |
| 11 | Serum concentrations of macro- phage inhibitory cytokine 1 (MIC-1) as a predictor of miscarriage 显示文摘 | Tong S Marjono B Brown DA | 2004 | Lancet2004，363，9403： | 1 |
| 12 | Phase III, randomized, open‐label, first‐line study in Asia of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non‐small‐cell lung cancer: evaluation of patients recruited from mainland China显示文摘 | Yi‐Long WU Da‐Tong CHU Baohui HAN Xuyi LIU Li ZHANG Caicum ZHOU Meilin LIAO Tony MOK Haiyi JIANG Emma DUFFIELD Masahiro FUKUOKA | 2012 | Asia‐Pacific Journal of Clinical Oncology2012，，3： | 1 |
| 13 | An efficient all-zero-block detection method for general orthogonal transformations显示文摘 | Zhu Bingqiang Tong Xin An Da | | 0，，04： | 1 |
| 14 | Pancreatic Encephalopathy显示文摘 | Johnson DA Tong NT | 1977 | South Med J1977，70，2： | 1 |
| 15 | Differential display cloning of a novel human histone deacetylase(HDAC3)cDNA from PHA-activated immune cells显示文摘 | Dangond F Hafler DA Tong JK | 1998 | Biochem Biophys Res Commun1998，242，3： | 1 |
| 16 | WO3 thin film prepared by PECVD technique and its gas sensing properties to NO2 显示文摘 | TONG M S DA G R WU Y D | 2001 | J Mater Sci2001，36，10： | 1 |
| 17 | WO3 thin film prepared by PECVD technique and its gas sensing properties to NO2 显示文摘 | Tong Maosong Da Guorui Wu Yuanda | 2001 | Journal of Materials Science2001，36，10： | 1 |
| 18 | A study of factors influencing synapse formation by a foreign nerve in skeletal muscle of Rana pipiens显示文摘 | Sayers H Tonge DA | 1986 | Physiol1986，375，： | 1 |
| 19 | Geodetic spectra of graphs 显示文摘 | Chang Gerard J Tong Li Da Wang Hong Tsu | 2004 | Europ J Combinatorics2004，，25： | 1 |
| 20 | High rate and changing molecular epidemiology pattern of norovirus infections in sporadic cases and outbreaks of gastroenteritis in Hong Kong显示文摘 | Lau CS Wong DA Tong LK | 2004 | J Med Virol2004，76，1： | 1 |
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