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| 1 | Fault diagnosis of an intelligent hydraulic pump based on a nonlinear unknown input observer显示文摘Hydraulic piston pumps are commonly used in aircraft. In order to improve the viability of aircraft and energy efficiency, intelligent variable pressure pump systems have been used in aircraft hydraulic systems more and more widely. Efficient fault diagnosis plays an important role in improving the reliability and performance of hydraulic systems. In this paper, a fault diagnosis method of an intelligent hydraulic pump system(IHPS) based on a nonlinear unknown input observer(NUIO) is proposed. Different from factors of a full-order Luenberger-type unknown input observer, nonlinear factors of the IHPS are considered in the NUIO. Firstly, a new type of intelligent pump is presented, the mathematical model of which is established to describe the IHPS. Taking into account the real-time requirements of the IHPS and the special structure of the pump, the mechanism of the intelligent pump and failure modes are analyzed and two typical failure modes are obtained. Furthermore, a NUIO of the IHPS is performed based on the output pressure and swashplate angle signals. With the residual error signals produced by the NUIO, online intelligent pump failure occurring in real-time can be detected. Lastly, through analysis and simulation, it is confirmed that this diagnostic method could accurately diagnose and isolate those typical failure modes of the nonlinear IHPS. The method proposed in this paper is of great significance in improving the reliability of the IHPS. | Zhonghai MA Shaoping WANG Jian SHI Tongyang LI Xingjian WANG | 2018 | Chinese Journal of Aeronautics2018，31，2： | 13 |
| 2 | An adaptive-order particle filter for remaining useful life prediction of aviation piston pumps显示文摘An accurate estimation of the remaining useful life(RUL) not only contributes to an effective application of an aviation piston pump, but also meets the necessity of condition based maintenance(CBM). For the current RUL evaluation methods, a model-based method is inappropriate for the degradation process of an aviation piston pump due to difficulties of modeling, while a data-based method rarely presents high-accuracy prediction in a long period of time. In this work,an adaptive-order particle filter(AOPF) prognostic process is proposed aiming at improving long-term prediction accuracy of RUL by combining both kinds of methods. A dynamic model is initialized by a data-driven or empirical method. When a new observation comes, the prior state distribution is approximated by a current model. The order of the current model is updated adaptively by fusing the information of the observation. Monte Carlo simulation is employed for estimating the posterior probability density function of future states of the pump's degradation.With updating the order number adaptively, the method presents a higher precision in contrast with those of traditional methods. In a case study, the proposed AOPF method is adopted to forecast the degradation status of an aviation piston pump with experimental return oil flow data, and the analytical results show the effectiveness of the proposed AOPF method. | Tongyang LI Shaoping WANG Jian SHI Zhonghai MA | 2018 | Chinese Journal of Aeronautics2018，31，5： | 7 |
| 3 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 4 | First Report of Zircon U-Pb Ages from Lubei Cu-Ni Sulfide Deposit in East Tianshan of Central Asian Orogenic Belt, NW China显示文摘Objective The East Tianshan mafic-ultramafic rocks belt mainly produced in the eastern Jueluotage belt is an important part of the Central Asia Orogenic Belt(CAOB).The wellknown deposits including Huangshan,Huangshandong,Tulaergen,Hulu,Xiangshan were have been consecutively discovered in this belt(Duan Xingxing et al.,2016).The new discovery of the Lubei Cu-Ni sulfide deposit in | LI Ping ZHAO Tongyang ZHU Zhixin TIAN Jiangtao LI Dahai | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 3 |
| 5 | An energy-based coupling degradation propagation model and its application to aviation actuation system显示文摘The degradation of components in complex mechatronic systems involves multiple physical processes which will cause coupling interactions among nodes in the system.The interaction of nodes may be carried out not only by physical connections but also by the environment which cannot be described by single network using the traditional methods.In order to give out a unified model to quantitatively describe the coupling degradation spreading by both physical connections and environment,a novel Energy-Flow-Field Network(EFFN)and a coupling degradation model based on EFFN are proposed in this paper.The EFFN is driven by energy flow and the state transition of spatially related nodes is triggered by the dissipation energy.An application is conducted on aviation actuation system in which the degradation spreading by fluid-thermal-solid interaction is considered.The degradation path and the most probable fault reason can be obtained by combining the state transition and energy output of nodes,which is consistent with the given scenario. | Tongyang LI Shaoping WANG Jian SHI Enrico ZIO Xiaoyu CUI | 2020 | Chinese Journal of Aeronautics2020，33，4： | 1 |
| 6 | Performance of smoke elimination and confinement with modi-fied hybrid ventilation for subway station 显示文摘 | Na Luo Angui Li Ran GAO Tongyang Song Wei Zhang ZhipeiHu | 2014 | Tunnelling and Un-derground Space Technology2014，43，： | 1 |
| 7 | Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2显示文摘The Coronavirus Disease 2019(COVID-19)caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a global pandemic that seriously threatens health and socioeconomic development,but the existed antiviral drugs and vaccines still cannot yet halt the spread of the epidemic.Therefore,a comprehensive and profound understanding of the pathogenesis of SARS-CoV-2 is urgently needed to explore effective therapeutic targets.Here,we conducted a multiomics study of SARS-CoV-2-infected lung epithelial cells,including transcriptomic,proteomic,and ubiquitinomic.Multiomics analysis showed that SARS-CoV-2-infected lung epithelial cells activated strong innate immune response,including interferon and inflammatory responses.Ubiquitinomic further reveals the underlying mechanism of SARS-CoV-2 disrupting the host innate immune response.In addition,SARS-CoV-2 proteins were found to be ubiquitinated during infection despite the fact that SARS-CoV-2 itself didn’t code any E3 ligase,and that ubiquitination at three sites on the Spike protein could significantly enhance viral infection.Further screening of the E3 ubiquitin ligases and deubiquitinating enzymes(DUBs)library revealed four E3 ligases influencing SARS-CoV-2 infection,thus providing several new antiviral targets.This multiomics combined with high-throughput screening study reveals that SARS-CoV-2 not only modulates innate immunity,but also promotes viral infection,by hijacking ubiquitination-specific processes,highlighting potential antiviral and anti-inflammation targets. | Gang Xu Yezi Wu Tongyang Xiao Furong Qi Lujie Fan Shengyuan Zhang Jian Zhou Yanhua He Xiang Gao Hongxiang Zeng Yunfei Li Zheng Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 8 | A review of occluded objects detection in real complex scenarios for autonomous driving显示文摘Autonomous driving is a promising way to future safe,efficient,and low-carbon transportation.Real-time ac-curate target detection is an essential precondition for the generation of proper following decision and control signals.However,considering the complex practical scenarios,accurate recognition of occluded targets is a major challenge of target detection for autonomous driving with limited computational capability.To reveal the overlap and difference between various occluded object detection by sharing the same available sensors,this paper presents a review of detection methods for occluded objects in complex real-driving scenarios.Considering the rapid development of autonomous driving technologies,the research analyzed in this study is limited to the recent five years.The study of occluded object detection is divided into three parts,namely occluded vehicles,pedes-trians and traffic signs.This paper provided a detailed summary of the target detection methods used in these three parts according to the differences in detection methods and ideas,which is followed by the comparison of advantages and disadvantages of different detection methods for the same object.Finally,the shortcomings and limitations of the existing detection methods are summarized,and the challenges and future development prospects in this field are discussed. | Jiageng Ruan Hanghang Cui Yuhan Huang Tongyang Li Changcheng Wu Kaixuan Zhang | 2023 | Green Energy and Intelligent Transportation2023，2，3： | 0 |
| 9 | The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3显示文摘Dear Editor,Esophageal carcinoma(EC)is the 6th leading cause of cancer death worldwide.In China,esophageal squamous cell carcinoma(ESCC)is the predominant histological subtype of EC and the 4th leading cause of death from cancer.1,2 While esophagectomy has been central to the standard of care for localized ESCC,relapse often occurs rapidly.For advanced ESCC,multimodality therapies incorporating systemic chemotherapies and/or radiotherapy have yielded limited clinical benefit.Despite extensive research efforts,no targeted therapies have yet been approved for the treatment of advanced ESCC.Interestingly,ESCC is strongly characterized by a male-predominant propensity,as both incidence and mortality rate are 2–3-fold higher in males than in females.1 Previous studies have revealed a possible association between androgen receptor(AR)signaling and male ESCC.3,4 AR is a ligand-dependent transcription factor that regulates target gene expression through binding to androgen-responsive elements(AREs)in the presence of androgens.Conversely,AR antagonists(e.g.,enzalutamide)compete with androgens to bind AR and inhibit its binding to AREs.5,6 To date,while the genomic function of AR has been extensively studied in prostate cancer,5,7,8 it remains unknown how AR exerts its oncogenic functions in ESCC at a genome-wide scale.Addressing this question is of high clinical relevance as it will establish a mechanistic basis for a promising therapeutic strategy targeting the AR transcription axis for ESCC patients. | Furong Huang Hongyan Chen Xiaolin Zhu Tongyang Gong Xukun Li William Hankey Hongyan Wang Zhong Chen Qianben Wang Zhihua Liu | 2021 | Cell Research2021，31，3： | 0 |
| 10 | Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice显示文摘Behavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease(AD).However,the molecular mechanism remains poorly understood due to a lack of sufficient pertinent biochemical evidence.We investigated the potential effect of long-term physical exercise on cognition and hippocampal gene and protein expression changes in a transgenic AD mouse model.Following twenty weeks of treadmill exercise,transgenic AD mice showed improvement in cognitive functions and downregulation of Nod-like receptor protein 3(NLRP3)(p<0.01),interleukin-1beta(IL-1β)(p<0.05),and amyloid-β1-42(Aβ1-42)(p<0.05)expression levels.In addition,we observed significant reductions of microglial activation and hippocampal neuronal damage in the exercised AD mice(p<0.01),which might be a result of the downregulation of NLRP3-mediated signaling and neuroinflammatory responses.As neuronal damage due to inflammation might be a likely cause of AD-associated cognitive dysfunction.Our results suggested that the anti-inflammatory effects of exercise training involved downregulating the expression of key inflammatory factors and might play an important role in protecting hippocampal neurons against damage during the course of AD. | Xue Li Yu Jin Xianyi Ding Tongyang Zhu Changling Wei Li Yao | 2023 | Sports Medicine and Health Science2023，5，4： | 0 |
| 11 | Effectiveness of Mind-Body Exercise on Burnout and Stress in Female Undergraduate Students显示文摘This study was to investigate the effects of mind-body exercise on burnout and perceived stress among female undergraduate students.A sample of 146 female undergraduate students took part in this study.They were assigned to mind-body exercise group(n=91)and control group(n=55).Mind-body exercise group received three 90-min sessions of Baduanjin exercise per week lasting for 12-weeks.There was no intervention in the control group.The Maslach Burnout Inventory-Student Survey was used to assess burnout level,and the 10-item perceived stress scale was used to assess stress level.Significant decreases in emotional exhaustion(p<0.001),cynicism(p<0.001)and perceived stress(p<0.001)were found in the mind-body exercise group compared with control group.Furthermore after 12-week mind-body exercise,emotional exhaustion,cynicism and perceived stress had greater reduction.Mind-body exercise(Baduanjin)may be considered an alternative strategy to reduce burnout and perceived stress in female undergraduate students. | Xiaohong Zhu Tongyang Chu Qian Yu Jinming Li Xingyu Zhang Yanjie Zhang Liye Zou | 2021 | International Journal of Mental Health Promotion2021，23，3： | 0 |
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