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| 1 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 2 | The single nucleotide polymorphisms of the chicken myostatin gene are associated with skeletal muscle and adipose growth显示文摘Myostatin, a new member of the TGF-β superfamily, is predominantly expressed in skeletal muscle cells and functions as a negative regulator of skeletal muscle growth in animals. Recently, we have reported three single nucleotide polymorphisms (SNPs) in the chicken myostatin gene. Herein, we investigate the association of those SNPs with the production traits in a F2 chicken line derived from Broilers crossing to Silky with the least square analysis. The results show that the BB and AA genotypes are strongly associated with abdominal fat weight (AFW), abdominal fat percentage (AFP), and birth weight (BW) (P < 0.05). Breast muscle percentage (BMP) of the AA type is higher than that of the AB type. The breast muscle weight and breast muscle percentages of F2 individuals have significant difference between CC and DD genotypes (P < 0.05). Breast muscle weight (BMW) of EF birds is higher than that of EE birds (P < 0.05). In this report, we present the first genetic evidence to show that chicken myostatin not only plays an important role in controlling skeletal muscle growth and differentiation, but also may be involved in regulation of adipose growth in chicken. | GU Zhiliang, ZHU Dahai, LI Ming, LI Hui, DENG Xuemei & WU ChangxinMolecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, Harbin 150001, China College of Animal Science & Technology, Northeast Agricultural University, Harbin 150030, China National Laboratories for Agribiotechnology, China Agricultural University, Beijing 100094, China College of Animal Science & Technology, China Agricultural University, Beijing 100094, China Department of Life Science and Technology, Changshu Institute of Technology, Changshu 215500, China Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Peking Union Medical College, Beijing 100005, China | 2004 | Science China(Life Sciences)2004，47，1： | 9 |
| 3 | Calibration method of phase distortions for cross polarization channel of instantaneous polarization radar system显示文摘A novel polarimetric calibration method for new target property measurement radar system is presented.Its application in the real radar system is also discussed.The analysis indicates that instantaneous polarization radar(IPR) has inherent cross-polarization measurement error.The proposed method can effectively eliminate this error,and thus enhance the polarization scattering matrix(PSM) measurement precision.The phase error caused by digital receiver's direct IF sampling and mixing of two orthogonal polarization channels can be removed.Consequently,the inherent error of target polarization scattering measurement of the instantaneous polarization radar system is well revised.It has good reference value for further ploarimetric calibration and high practical application prospect. | Huanyao Dai Yuliang Chang Dahai Dai Yongzhen Li XuesongWang | 2010 | Journal of Systems Engineering and Electronics2010，21，2： | 7 |
| 4 | Research on instantaneous polarization radar system and external experiment显示文摘Instantaneous polarization radar can obtain radar target polarization scattering matrix (PSM) by using single pulse echo.The system overcomes the defects of inter-pulse interval polarization measurement radar and accurately measures the PSM of the moving target.Thus the capabilities of detection,anti-jamming and target identification can be improved.The present paper reports the first international self-developed instantaneous polarization radar experimental system and,by using this system,the measurement experiments of target polarization characteristics are conducted.The results show that the performance of target instantaneous polarization measurement by different waveforms is good.The basic and common problems in polarization scattering feature extraction and recognition domain are solved. | WANG XueSong LI YongZhen DAI HuanYao CHANG YuLiang DAI DaHai MA Liang LIU Yong | 2010 | Chinese Science Bulletin2010，55，15： | 5 |
| 5 | Application of Principal Component Analysis(PCA)to the Evaluation and Screening of Multiactivity Fungi显示文摘Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs. | YANG Zonglin SHI Yaqi LI Pinglin PAN Kanghong LI Guoqiang LI Xianguo YAO Shuo ZHANG Dahai | 2022 | Journal of Ocean University of China2022，21，3： | 4 |
| 6 | miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice显示文摘骨胳的肌肉质量和动态平衡大部分在出生后的肌肉开发和新生期间取决于成年肌肉干细胞(卫星房间) 。我们最近证明 miR-378 的全球 overexpression 显著地在老鼠减少了骨胳的肌肉质量。在当前的学习,我们使用了 miR-378 转基因(Tg ) 估计的老鼠在里面 vivo 骨胳的肌肉生长和新生上的 miR-378 的功能的效果。骨胳的肌肉纸巾的代表性的分析证明 myofibers 的数字和尺寸比在野类型的老鼠在 miR-378 Tg 老鼠是显著地更低的。在 miR-378 Tg 老鼠的稀释导致 cardiotoxin 的肌肉新生被发现与推迟的卫星房间激活和区别被联系。机械学地, miR-378 被发现直接在 vitro 并且在 vivo 在肌肉房间指向 Igf1r。这些 miR-378 Tg 老鼠可以为在人在联系肌肉的疾病调查骨胳的肌肉的生理、病理学的角色提供一个模型,特别地在 sarcopenia。 | Ping Zeng Wanhong Han Changyin Li Hu Li Dahai Zhu Yong Zhang Xiaohong Liu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 7 | Protecting healthcare personnel from 2019-nCoV infection risks:lessons and suggestions显示文摘The outbreak of a novel coronavirus disease(COVID-19,caused by the 2019-nCoV infection)in December 2019 is one of the most severe public health emergencies since the founding of People’s Republic of China in 1949.Healthcare personnel(HCP)nationwide are facing heavy workloads and high risk of infection,especially those who care for patients in Hubei Province.Sadly,as of February 20,2020,over two thousand COVID-19 cases are confirmed among HCP from 476 hospitals nationwide,with nearly 90%of them from Hubei Province.Based on literature search and interviews with some HCP working at Wuhan,capital city of Hubei,we have summarized some of the effective measures taken to reduce infection among HCP,and also made suggestions for improving occupational safety during an infectious disease outbreak.The experience and lessons learned should be a valuable asset for international health community to contain the ongoing COVID-19 epidemic around the world. | Zhiruo Zhang Shelan Liu Mi Xiang Shijian Li Dahai Zhao Chaolin Huang Saijuan Chen | 2020 | Frontiers of Medicine2020，14，2： | 4 |
| 8 | Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts显示文摘Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various diseases.However,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains unknown.Methods:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro conditions.We also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 targets.We utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in vivo.Results:We found low expression of miR-101 in HS and HSF compared to NS and NSF.Overexpressing miR-101 decreased Col1,Col3 andα-SMA expression in HSF.We detected high expression of EZH2 in HS and HSF.Knockdown of EZH2 decreased Col1,Col3 andα-SMA in HSF.Mechanistically,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of EZH2.Overexpressing EZH2 rescued miR-101-induced collagen repression.MiR-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse model.Conclusions:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation. | Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao Kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su Huayu Zhu Dahai Hu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 9 | A new coordinated backup protection scheme for distribution network containing distributed generation显示文摘This paper proposes a new backup protection scheme,named coordinated backup protection(CBP)scheme,for distribution networks containing distributed generation.The proposed protection scheme takes into account the issues faced by traditional backup protection,such as difficulty in setting parameters and complex cooperation,and considers the features of distribution networks,such as changeable power flow because of high penetration of distributed generation sources and insufficient measuring quantities.The CBP scheme includes two aspects:coordinated substation protection and regional master substation protection,who also work as nearby backup protection and remote backup protection respectively.The two protections support each other by local information coordination and regional information sharing,in order to improve the reliability of fault identification.The configuration principles and performances of the proposed backup protection scheme are addressed in the paper.Different fault conditions in the IEEE 14-node system have been used to illustrate and verify the feasibility of the CBP scheme. | Jinghan He Lin Liu Fanfan Ding Changcheng Li Dahai Zhang | 2017 | Protection and Control of Modern Power Systems2017，2，1： | 3 |
| 10 | One-step synthesis of dimethyl ether from syngas on ordered mesoporous copper incorporated alumina显示文摘Ordered mesoporous copper incorporated Al_2O_3(Cu/Al_2O_3) with high Cu dispersion were prepared by a facile solution combustion synthesis method using aluminum nitrate and copper nitrate as oxidants and urea as fuel. It is a facile and green route to synthesize catalysts for dimethyl ether directly from syngas. Cu/Al_2O_3 catalysts were characterized by XRD, N_2 adsorption–desorption, SEM-EDS, and H_2-TPR.The results indicate that the catalysts obtain an ordered mesoporous structure and copper is homogenously dispersed. The mesoporous Cu/Al_2O_3 catalysts were utilized as bifunctional catalysts in syngas to dimethyl ether reaction(STD). The copper content affects the catalytic performance in STD reaction. The CO conversion and DME selectivity of Cu/Al_2O_3 with 15% copper molar ratio achieve 52.9% and 66.1%,respectively. Moreover, the mesoporous Cu/Al_2O_3 catalysts show excellent stability in STD reaction. | Yan Wang Yuexian Chen Feng Yu Dahai Pan Binbin Fan Jinghong Ma Ruifeng Li | 2016 | Journal of Energy Chemistry2016，25，5： | 3 |
| 11 | First Report of Zircon U-Pb Ages from Lubei Cu-Ni Sulfide Deposit in East Tianshan of Central Asian Orogenic Belt, NW China显示文摘Objective The East Tianshan mafic-ultramafic rocks belt mainly produced in the eastern Jueluotage belt is an important part of the Central Asia Orogenic Belt(CAOB).The wellknown deposits including Huangshan,Huangshandong,Tulaergen,Hulu,Xiangshan were have been consecutively discovered in this belt(Duan Xingxing et al.,2016).The new discovery of the Lubei Cu-Ni sulfide deposit in | LI Ping ZHAO Tongyang ZHU Zhixin TIAN Jiangtao LI Dahai | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 3 |
| 12 | Polarization-sensitive and wide-spectrum photovoltaic detector based on quasi-1D ZrGeTe_(4)nanoribbon显示文摘Low-dimensional semiconductors with in-plane anisotropy and narrow bandgap have been extensively applied to polarized detection in the near-infrared(NIR)region.However,the narrow bandgap can cause noise owing to the high dark current in photodetectors.This article reports quasi-1D ZrGeTe_(4)nanoribbonbased photodetectors with low dark current and broadband polarization detection.The photodetector was fabricated by evaporating 50-nm-thick Au electrodes on a ZrGeTe_(4)nanoribbon.Benefiting from the photovoltaic characteristics in the ZrGeTe_(4)nanoribbon and Au electrodes,these photodetectors can operate without bias voltage,with decreased dark current,and improved device performance.Furthermore,the quasi-1D ZrGeTe_(4)nanoribbon-based photodetectors demonstrate a polarization sensitivity in a broadband from visible(VIS)to the NIR region,such as a high photoresponsivity of 625.65 mA W1,large external quantum efficiency of 145.9%at 532 nm,and photocurrent anisotropy ratio of 2.04 at 1064 nm.They exhibit a novel perpendicular optical reversal of 90in polarization-sensitive photodetection,angle-resolved absorption spectra,and azimuth-dependent reflectance difference microscopy(ADRDM)from VIS to the NIR region,as opposed to other nanoribbon-based polarization-sensitive photodetectors.This work paves the way for utilizing photovoltaic photodetectors based on low-dimensional materials for broad-spectrum polarized photodetection. | Ruixue Bai Tao Xiong Jinshu Zhou Yue-Yang Liu Wanfu Shen Chunguang Hu Faguang Yan Kaiyou Wang Dahai Wei Jingbo Li Juehan Yang Zhongming Wei | 2022 | InfoMat2022，4，3： | 2 |
| 13 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 14 | Functional interplay among the flavivirus NS3 protease, helicase, and cofactors显示文摘Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. Nonstructural protein 2B and 3 of the flaviviruses(NS2BNS3) form an endoplasmic reticulum(ER) membrane-associated hetero-dimeric complex through the NS2B transmembrane region. The NS2BNS3 complex is multifunctional. The N-terminal region of NS3, and its cofactor NS2B fold into a protease that is responsible for viral polyprotein processing, and the C-terminal domain of NS3 possesses NTPase/RNA helicase activities and is involved in viral RNA replication and virus particle formation. In addition, NS2BNS3 complex has also been shown to modulate viral pathogenesis and the host immune response. Because of the essential functions that the NS2BNS3 complex plays in the flavivirus life cycle, it is an attractive target for antiviral development. This review focuses on the recent biochemical and structural advances of NS2BNS3 and provides a brief update on the current status of drug development targeting this viral protein complex. | Kuohan Li Wint Wint Phoo Dahai Luo | 2014 | Virologica Sinica2014，29，2： | 1 |
| 15 | Microwave irradiation-assisted isomerization of glucose to fructose by immobilized glucose isomerase显示文摘 | Dahai Yu Hao Wu Aijun Zhang Li Tian Ludong Liu Chuanming Wang Xuexun Fang | 2010 | Process Biochemistry2010，，2： | 1 |
| 16 | Wave energy in China : Current status and perspectives 显示文摘 | Zhang Dahai Li Wei Lin Yonggang | 2009 | Renewable Energy2009，28，3： | 1 |
| 17 | miR-30e is negatively regulated by myostatin in skeletal muscle and is functionally related to fiber-type composition显示文摘Myostatin (MSTN ) 否定地调整在哪个 microRNAs (miRNAs ) 也起关键作用的骨胳的 myogenesis。用从 MSTN 大美人的骨胳的肌肉的 miRNA microarrays (MSTN /) 老鼠,我们最近证明 miR-431 被 MSTN 发信号调整。为了识别另外的 miRNAs,由 MSTN 调整了,我们重新分析这些 miRNA 数组并且由量的 RT-PCR 验证了他们的表示。此处,我们证明 miR-30e 是显著地在 MSTN / 老鼠的骨胳的肌肉的 upregulated 与野类型的同窝出生的人的相比。重要地, miR-30e 的预言的目标机能上地涉及 myocyte 区别和纤维类型形成。用酶记者基因试金,我们进一步显示出那 peroxisome 激活 proliferator 的受体 gamma,激活剂 1 alpha (Pgc1 ) ,是 miR-30e 的一个直接目标。在 C2C12 房间的 miR-30e 的 Overexpression 显著地减少了 Pgc1 和增加的类型 II 肌浆球蛋白形成重链基因表示,机能上地建议那 miR-30e 把 myofiber 与 glycolytic 联系形成。因此,我们的数据显示在 MSTN / 鼠标的改变的纤维类型作文对 miR-30e 的 deregulated 表示部分地可归因。 | Haixue Jia Yixia Zhao Tingting Li Yong Zhang Dahai Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 1 |
| 18 | Comparison of transcriptomes of chilling- and drought-tolerant and intolerant Nicotiana tabacum varieties and identification of genes associated with stress tolerance显示文摘 | Hao Dahai Ma Wenguang Sheng Yelong Zhang Jianbo Jin Yunfeng Yang Huiqin Li Zhongguang Wang Shasha Gong Ming | 2014 | Plant Omics2014，，6： | 1 |
| 19 | Microwave-assisted fatty acid methyl ester production from soybean oil by Novozym 435 显示文摘 | Dahai Yu Li Tian Dongxiao Ma | 2010 | Green Chem2010，，5： | 1 |
| 20 | Tillage practices effect on root distribution and water use efficiency of winter wheat under rain-fed condition in the North China Plain显示文摘 | Dahai Guan Yushi Zhang Mahdi M. Al-Kaisi Qingyan Wang Mingcai Zhang Zhaohu Li | 2014 | Soil & Tillage Research2014，，： | 1 |
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