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| 1 | Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer显示文摘AIM:To evaluate the agreement between transrectal ultrasound(TRUS) and magnetic resonance imaging(MRI) in classification of ≥ T3 rectal tumors.METHODS:From January 2010 to January 2012,86 consecutive patients with ≥ T3 tumors were included in this study.The mean age of the patients was 66.4 years(range:26-91 years).The tumors were all ≥ T3 on TRUS.The sub-classification was defined by the penetration of the rectal wall:a:0 to 1 mm;b:1-5 mm;c:6-15;d:> 15 mm.Early tumors as ab(≤ 5 mm) and advanced tumors as cd(> 5 mm).All patients underwent TRUS using a 6.5 MHz transrectal transducer.The MRI was performed with a 1.5 T Philips unit.The TRUS findings were blinded to the radiologist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread.RESULTS:TRUS found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor,whereas MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors.No patients with tumors classified as advanced by TRUS were found to be early on MRI.The kappa value in classifying early versus advanced T3 rectal tumors was 0.93(95% CI:0.85-1.00).We found a kappa value of 0.74(95% CI:0.63-0.86) for the total sub-classification between the two methods.The mean maximal tumor outgrowth measured by TRUS,5.5 mm ± 5.63 mm and on MRI,6.3 mm ± 6.18 mm,P = 0.004.In 19 of the 86 patients the following CT scan or surgery revealed distant metastases;of the 51 patients in the ultrasound ab group three(5.9%) had metastases,whereas 16(45.7%) of 35 in the cd group harbored distant metastases,P = 0.00002.The odds ratio of having distant metastases in the ultrasound cd group compared to the ab group was 13.5(95% CI:3.5-51.6),P = 0.00002.The mean maximal ultrasound measured outgrowth was 4.3 mm(95% CI:3.2-5.5 mm) in patients without distant metastases,while the mean maximal outgrowth was 9.5 mm(95% CI:6.2-12.8 mm) in the patients with metastases,P = 0.00004.Using the MRI classification three(6.3%) of 48 in the MRI ab group had distant metastases,while 16(42.1%) of the 38 in the MRI cd group,P = 0.00004.The MRI odds ratio was 10.9(95% CI:2.9-41.4),P = 0.00008.The mean maximal MRI measured outgrowth was 4.9 mm(95% CI:3.7-6.1 mm) in patients without distant metastases,while the mean maximal outgrowth was 11.5 mm(95% CI:7.8-15.2 mm) in the patients with metastases,P = 0.000006.CONCLUSION:There is good agreement between TRUS and MRI in the pretreatment sub-classification of ≥ T3 tumors.Distant metastases are more frequent in the advanced group. | Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John Plφen Anders Jakobsen | 2012 | World Journal of Gastroenterology2012，18，36： | 14 |
| 2 | High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer显示文摘 | Mads H. Rasmussen Niels F. Jensen Line S. Tarpgaard Camilla Qvortrup Maria U. R?mer Jan Stenvang Tine P. Hansen Lise L. Christensen Jan Lindebjerg Flemming Hansen Benny V. Jensen Torben F. Hansen Per Pfeiffer Nils Brünner Torben F. ?rntoft Claus L. Anders | 2013 | Molecular Oncology2013，，3： | 2 |
| 3 | Selective Deactivation of Gibberellins below the Shoot Apex is Critical to Flowering but Not to Stem Elongation of Lolium显示文摘赤霉素(气体) 在 GA1 的合成在植物高度和基因块引起戏剧的增加解释相形见绌 Mendel 的豌豆。为 flowering,是 GA5 重要在长天(LD ) 应答的草, Lolium。当我们这里出现,因为他们被 C-2 hydroxylation 在射击顶下面撤销, GA1 和 GA4 为 flowering 在他们的有效性被限制。相反,因为它的结构的保护, GA5 是有效的。切除植物的射击尖端很快降级[14C ] GA1,[14C ] GA4,并且[14C ] GA20 (>80% 在 6 ? h ) ,然而并非[14C ] GA5。偶然,编码二 2-oxidases 的基因和通常认为的 1617-epoxidase 最就在射击顶下面被表示(< 3 ? 公里) 。进一步击倒不成熟的茎(> 4 ? 公里) ,这些 GA 释放基因的表示被减少,那么允许 GA1 和 GA4 支持接近顶点的茎延伸。随后, GA 降级在花地导致的射击尖端和这些气体衰退能为花的开发变得活跃。稳定 GA4 的结构的变化证实在 florigenicity 和限制 GA 2-hydroxylation 之间的连接(例如 2-hydroxylation 和 C-2 di-methylation ) 。另外,一个 2-oxidase 禁止者(Trinexapac 乙醇) 提高了应用 GA4 的活动,作为做了在 16,17-dihydro 气体或在 C-13 hydroxylation 以后限制 C-16,17 epoxidation。总的来说,就在射击顶下面的 GA1 和 GA4 的释放有效地在 Lolium 限制他们的 florigenicity,相反地,与 GA5,对释放的 C-2 和 C-13 保护允许它的高 florigenicity。思索地,在草的射击顶的 GA 存取的如此的差别可能为把花的正式就职与开花期出现分开是重要的并且能因此在草食动物 predation 的条件下面影响他们的幸存。 | Rod W. King Lewis N. Mander Torben Asp Colleen R MacMillan Cheryl A. Blundell Lloyd T. Evans | 2008 | Molecular Plant2008，1，2： | 2 |
| 4 | First flush effects in an urban catchment area in Aalobrg 显示文摘 | Torben L Kirsten B Margit R A | 1998 | Water Sci Technol1998，37，1： | 1 |
| 5 | Preparation,Structure Determination and Thermal Transformation of a New Lithium Zinc Phosphate,δ-LiZnPO4显示文摘 | Torben R Jenen P N Stein C | 1995 | Journal of Solid State Chemistry1995，，117： | 1 |
| 6 | Antibacterial property of a coral associated bacterium Pseudoalteromonas Luteoviolacea against shrimp patho- genic Vibrio Harveyi 显示文摘 | Oeky K R Torben M Hans-Peter G | 2004 | J Coast Dev2004，7，3： | 1 |
| 7 | Hydrogen Energy显示文摘 | Torben R J Anders A Tejs V | 2006 | 31: 20522006，31，： | 1 |
| 8 | Converting XML DTDs to UML diagrams for conceptual data integration显示文摘 | Mikael R Jensen Thomas H Moller Torben Bach Pedersen | 2003 | Data and Knowledge Engineering2003，44，7： | 1 |
| 9 | Species- specific effects of vascular plants on carbon tumover and methane emissions from wetlands 显示文摘 | Lena Strom Mikhail Mastepanov Torben R Christensen | 2005 | Biogeochemistry2005，75，： | 1 |
| 10 | Guided tour of Chemoff bounds 显示文摘 | TORBEN H CHRISTINE R | 1990 | Information Processing Letters1990，33，6： | 1 |
| 11 | Serum 25(OH)D and Type 2 Diabetes Association in a General Population: A prospective study显示文摘 | Husemoen Lise Lotte N Thuesen Betina H Fenger Mogens J?rgensen Torben Glümer Charlotte Svensson Jannet Ovesen Lars Witte Daniel R Linneberg Allan | 2012 | EN2012，，： | 1 |
| 12 | Characterization and three-dimensional structures of two dis?tinct bacterial xyloglucanases from families GH5 and GH12显示文摘 | TRACEY M G FARID M I KATHERINE M JENS M E SHIRLEY R JOHAN P T MADS E B PER L J STEFFEN D KATJA S J TORBEN V B KEITH S W HARRY B GIDEON J D | 2007 | Journal of Biological Chemistry2007，282，19： | 1 |
| 13 | Specifying OLAP cubes on XML data显示文摘 | Mikael R Jensen Thomas H Moller Torben Bach Pedersen | 2001 | Journal of Intelligent Information System2001，17，23： | 1 |
| 14 | The cycloid permanent magnetic gear显示文摘 | FRANK T J TORBEN O A PETER O R | 2008 | IEEE Transac- tions on Industry Applications2008，44，6： | 1 |
| 15 | Cooperation with public research institutions and success in innovation: evidence from france and germany 显示文摘 | Stephane R Torben S | 2015 | Research Policy2015，42，： | 1 |
| 16 | Guided tour of Chernoff bounds显示文摘 | Torben H Christine R | 1990 | Information Processing Letters1990，33，6： | 1 |
| 17 | Microbial biomass as a fraction of potentially mineralizable nitrogen in soils from long-term field experiments 显示文摘 | Torben A B Johan S Thomas R | 1988 | Soil Biol Biochem1988，20，4： | 1 |
| 18 | Diversity of aerobic methanotrophic bacteria in a permafrostActive layer soil of the lena delta,siberia显示文摘 | Susanne L Katja R Torben S | 2009 | Microb Ecol2009，57，6： | 1 |
| 19 | Optimal Fiscal Policy in Open Economies with Labor Market Distortions显示文摘 | Torben M A Sandemann B R | 1996 | Journal of Public Economics1996，63，1： | 1 |
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