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| 1 | A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong显示文摘We conducted a six-year epidemiological study on human coronaviruses(HCoVs) circulating in Hong Kong, using 8275 nasopharyngeal samples from patients with acute respiratory tract infections. HCoVs were detected in 77(0.93%) of the samples by a pan-HCoV RT-PCR assay. The most frequently detected HCoV species was HCoV-OC43(0.58%), followed by HCoV-229E(0.15%),HCoV-HKU1(0.13%) and HCoV-NL63(0.07%). HCoVs were detected throughout the study period(September 2008–August 2014), with the highest detection rate from September 2010 to August2011(22/1500, 1.47%). Different seasonal patterns of each HCoV species in Hong Kong were noted.HCoV-OC43 was predominant in the fall and winter, whereas HCoV-HKU1 showed peak activity in winter, with a few cases occurred in spring and summer. HCoV-229 E mainly occurred in winter and spring, while HCoV-NL63 was predominant in summer and autumn. HCoVs most commonly infect the elderly and young children, with median age of 79.5 years(range, 22 days to 95 years).Intriguingly, the detection rate of HCoV-OC43 in the age group of > 80 years(26/2380, 1.09%) was significantly higher than that in the age group of 0–10 years(12/2529, 0.47%)(P < 0.05). These data provides new insight into the epidemiology of coronaviruses. | Cyril C.Y.Yip Carol S.F.Lam Hayes K.H.Luk Emily Y.M.Wong Rodney A.Lee Lok-Yee So Kwok-Hung Chan Vincent C.C.Cheng Kwok-Yung Yuen Patrick C.Y.Woo Susanna K.P.Lau | 2016 | Virologica Sinica2016，31，1： | 9 |
| 2 | Serum Hepatitis B Surface Antigen Quantitation Can Reflect Hepatitis B Virus in the Liver and Predict Treatment Response显示文摘 | Henry Lik–Yuen Chan Vincent Wai–Sun Wong Ada Mei–Ling Tse Chi–Hang Tse Angel Mei–Ling Chim Hoi–Yun Chan Grace Lai–Hung Wong Joseph Jao–Yiu Sung | 2007 | Clinical Gastroenterology and Hepatology2007，，12： | 7 |
| 3 | Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score显示文摘 | Hwai-I Yang Man-Fung Yuen Henry Lik-Yuen Chan Kwang-Hyub Han Pei-Jer Chen Do-Young Kim Sang-Hoon Ahn Chien-Jen Chen Vincent Wai-Sun Wong Wai-Kay Seto | 2011 | Lancet Oncology2011，，6： | 5 |
| 4 | Hepatitis B virus infection and fatty liver in the general population显示文摘 | Vincent Wai-Sun Wong Grace Lai-Hung Wong Winnie Chiu-Wing Chu Angel Mei-Ling Chim Arlinking Ong David Ka-Wai Yeung Karen Kar-Lum Yiu Shirley Ho-Ting Chu Hoi-Yun Chan Jean Woo Francis Ka-Leung Chan Henry Lik-Yuen Chan | 2011 | Journal of Hepatology2011，，3： | 3 |
| 5 | Polymorphisms Near IL28B and Serologic Response to Peginterferon in HBeAg-Positive Patients With Chronic Hepatitis B显示文摘 | Milan J. Sonneveld Vincent W.–S. Wong Andrea M. Woltman Grace L.H. Wong Yilmaz Cakaloglu Stefan Zeuzem Erik H.C.J. Buster Andre G. Uitterlinden Bettina E. Hansen Henry L.Y. Chan Harry L.A. Janssen | 2012 | Gastroenterology2012，，3： | 3 |
| 6 | 国际卒中遗传学联盟的推荐意见(第1部分):标准化表型数据收集显示文摘与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟( International Stroke Genetics Consortium, ISGC; http://www. strokegenetics.org),其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000~200000个样本。为了达到这个样本量,需要进行更为广泛的协作。 | Jennifer J. Majersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan M. Edip Gurol Ame G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kamal Paul Bentley Joanna M. Wardlaw Ynte M. Ruigrok Thomas W.K Battey Reinhold Schmidt Joan Montaner Anne-Katrin Giese Jaume Roquer Jordi Jimenez-Conde Chaeyoung Lee Hakan Ay Juan Jose Martin 李海峰 岳耀先 徐军 | 2015 | 国际脑血管病杂志2015，23，9： | 3 |
| 7 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 8 | Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial显示文摘 | Vincent Wai-Sun Wong Ruth Suk-Mei Chan Grace Lai-Hung Wong Bernice Ho-Ki Cheung Winnie Chiu-Wing Chu David Ka-Wai Yeung Angel Mei-Ling Chim Jennifer Wing-Yan Lai Liz Sin Li Mandy Man-Mei Sea Francis Ka-Leung Chan Joseph Jao-Yiu Sung Jean Woo Henry Lik-Yue | 2013 | Journal of Hepatology2013，，3： | 2 |
| 9 | Liver fibrosis progression in chronic hepatitis B patients positive for hepatitis B e antigen: A prospective cohort study with paired transient elastography examination显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Zhuo Yu Hoi‐Yun Chan Chi‐Hang Tse Vincent Wai‐Sun Wong | 2013 | J Gastroenterol Hepatol2013，，11： | 2 |
| 10 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 11 | Intrahepatic Hepatitis B Virus Covalently Closed Circular DNA Can Be a Predictor of Sustained Response to Therapy显示文摘 | Joseph J.Y. Sung May-Ling Wong Scott Bowden Choong-Tsek Liew Alex Y. Hui Vincent W.S. Wong Nancy W.Y. Leung Stephen Locarnini Henry L.Y. Chan | 2005 | Gastroenterology2005，，7： | 2 |
| 12 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 13 | Dexamethasone Added to Mepivacaine Prolongs the Duration of Analgesia After Supraclavicular Brachial Plexus Blockade显示文摘 | Simon J. Parrington Dermot O’Donnell Vincent W.S. Chan Danielle Brown-Shreves Rajeev Subramanyam Melody Qu Richard Brull | 2010 | Regional Anesthesia and Pain Medicine2010，，5： | 2 |
| 14 | Liver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B显示文摘 | Grace Lai-Hung Wong Henry Lik-Yuen Chan Catherine Ka-Yan Wong Calvin Leung Candace Yim Chan Patricia Po-Lai Ho Vivian Chi-Yee Chung Zhan Cham-Yan Chan Yee-Kit Tse Angel Mei-Ling Chim Tina Kit-Ting Lau Vincent Wai-Sun Wong | 2014 | Journal of Hepatology2014，，2： | 2 |
| 15 | 深部脑刺激治疗帕金森病:下丘脑核团靶点定位的解剖与生理对比研究显示文摘目的 探讨脑深部STN刺激靶点时MRI直接定位法和MER术中导引定位法的解剖学偏差。方法 本组5例帕金森病患者,分别表现为运动迟缓、步态不稳及躯干症状,共安放6例次微电极。结果 采用MRI直接定位法和MER术中导引定位法,其定位靶点的平均偏差距离是1.25mm,尽管该偏差值较小,但是,基于影像学的立体定向法只能将刺激电极定位于距离靶点几毫米的范围内。结论 电生理学方法(MER)对于调整和确定靶点位置至关重要。MER术中导引定位法有助于手术的完全成功。 | Wai.S Poon Danny TM Chan XL Zhu Vincent CT Mok YL Chan | 2002 | 中华神经外科疾病研究杂志2002，1，2： | 2 |
| 16 | CFETR α粒子在纵场波纹扰动下的损失模拟显示文摘托卡马克燃烧等离子体中高能α粒子的损失和输运是聚变实验和模拟研究中的关键问题,纵场磁体分立性导致的磁场波纹扰动可能引起显著的α粒子损失.本文利用粒子导心轨道跟踪程序ORBIT和等离子体输运程序TRANSP/NUBEAM针对中国聚变工程实验堆(CFETR)920 MW混杂运行模式参数进行波纹损失相关的数值模拟,分别考虑了α粒子初始分布、稳态慢化分布、不同碰撞率和不同分布剖面模型,得到了损失份额、损失位置以及局域热负荷等信息,结果显示CFETR混杂运行模式下α粒子波纹损失引起的局域热负荷约为0.13 MW/m2,在聚变堆第一壁安全阈值0.5 MW/m2允许范围内,本文还分别从物理和工程角度讨论了降低波纹损失的途径. | 郝保龙 陈伟 蔡辉山 李国强 王丰 吴斌 王进芳 陈佳乐 王兆亮 高翔 CHAN Vincent CFETR TEAM | 2020 | 中国科学:物理学、力学、天文学2020，50，6： | 2 |
| 17 | Extensive contact tracing and screening to control the spread of vancomycin-resistant Enterococcus faecium ST414 in Hong Kong显示文摘 | CHENG Vincent Chi-chung TAI Josepha Wai-ming NG Modissa Lai-ming CHAN Jasper Fuk-woo WONG Sally Cheuk-ying LI Iris Wai-sum CHUNG Hon-ping LO Wai-kei YUEN Kwok-yung HO Pak-leung | 2012 | Chinese Medical Journal2012，，19： | 2 |
| 18 | Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers显示文摘 | Jiayun Shen Henry Lik-Yuen Chan Grace Lai-Hung Wong Paul Cheung-Lung Choi Anthony Wing-Hung Chan Hoi-Yun Chan Angel Mei-Ling Chim David Ka-Wai Yeung Francis Ka-Leung Chan Jean Woo Jun Yu Winnie Chiu-Wing Chu Vincent Wai-Sun Wong | 2012 | Journal of Hepatology2012，，6： | 2 |
| 19 | Liver fibrosis progression is uncommon in patients with inactive chronic hepatitis B : A prospective cohort study with paired transient elastography examination显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Zhuo Yu Hoi‐Yun Chan Chi‐Hang Tse Vincent Wai‐Sun Wong | 2013 | J Gastroenterol Hepatol2013，，12： | 2 |
| 20 | Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score显示文摘 | Hwai-I Yang Man-Fung Yuen Henry Lik-Yuen Chan Kwang-Hyub Han Pei-Jer Chen Do-Young Kim Sang-Hoon Ahn Chien-Jen Chen Vincent Wai-Sun Wong Wai-Kay Seto | 2011 | Lancet Oncology2011，，6： | 1 |
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