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| 1 | Effects of a combination of Japanese Raisin Tree Seed and Flower of Lobed Kudzuvine against acute alcohol-induced liver injury in mice显示文摘Objective:The Flower of Lobed Kudzuvine[Pueraria lobata(Willd.)Ohwi;Gehua in Chinese;GH]and Japanese Raisin Tree Seed(Hovenia dulcis Thunnb.;Zhijuzi in Chinese;ZJZ)are herbs that have been used in China for the treatment of alcohol intoxication and liver diseases.We aimed to evaluate the hepatoprotective potential of a combination of these in mice with acute alcohol-induced liver injury,and to elucidate the mechanisms involved.Methods:Male ICR mice were randomly allocated to six groups:a control group,an alcohol-administered group,and groups that were administered alcohol and one of silibinin,the GH,the ZJZ or a GH-ZJZ combination(at a ratio of 2:1).Animals were orally administered 56%alcohol(Er Guo-tou white spirit,0.12 mL/10 g/d)for 10 days and at the end of this period,hepatic biochemical indicators,antioxidant parameters,alcohol metabolic enzymes,and histopathologic changes were evaluated.Moreover,the expression of the signaling molecules KEAP1,NRF2,and AQP9 were measured by qRT-PCR and western blotting.Results:Compared with the model group,GH-ZJZ(2:1)had lower serum ALT(12.15±0.39,P紏.003),AST(104.07±1.03,P紏.001),and ALP(148.09±2.55,P紏.010)activities,and lower TC(1.97±0.05,P紏.001)and TG(1.54±0.07,P?.002)concentrations.GH-ZJZ(2:1)also significantly increased the hepatic activities of SOD and GSH(4.24±0.25 and 1.57±0.06,respectively;both P<.01),reduced the ROS and MDA concentrations(97.50±3.00 and 2.39±0.19,respectively;both P<.01),and upregulated Nrf2 expression(P<.01).GH-ZJZ(2:1)significantly reduced the expression of KEAP1 and AQP9 in the liver,compared with alcohol-administered mice(P<.01).Importantly,the GH-ZJZ combination caused a more marked improvement in acute liver injury than GH or ZJZ alone.Conclusion:We have demonstrated protective effects of GH-ZJZ(2:1)against acute alcohol-induced hepatic injury,and shown that these effects may be associated with improvements in lipid and alcohol metabolism,antioxidant capacity,and lipid peroxidation. | Wan Xu Shaohong Chen Gansheng Zhong Haiyan Liu Linlin Xiu Xue Yu Feng Chen Na Li Yanmin Lv | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 2 |
| 2 | Thermal protective performance and moisturetransmission of firefighter protective clothing based on orthogonal design 显示文摘 | CUI Zhiying WAN Yanmin ZHANG Weiyuan | 2010 | Journal of Industrial Textiles2010，39，4： | 1 |
| 3 | Pathogenicity and immunogenicity of recombinant Tiantan Vaccinia Virus with deleted C12L and A53R genes显示文摘 | Kaifan Dai Ying Liu Mingjie Liu Jianqing Xu Wei Huang Xianggang Huang Lianxing Liu Yanmin Wan Yanling Hao Yiming Shao | 2008 | Vaccine2008，，39： | 1 |
| 4 | Metagenomics analysis identifies oral Streptococcus as potential biomarkers for nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignancy originating from the nasopharyngeal epithelial cells.Although some studies have identified potential biomarkers for early diagnosis of NPC based on metabolomics data(Chen et al.,2023;Zhou et al.,2023)and Epstein-Barr virus subtypes(Xu et al.,2019),their effectiveness and applicability need further investigation,particularly when consideringthe roles of oral microbiota. | Yanmin Liu Chengtao Wang Lixiang Xie Shuling Du Li Ding Ying Cui Runzhi Chen Jingxiang Zhang Wan Wang Xi Liu Yan Wang Shiyan Chen Tian Tan Qiaochu Zhao Limei Yin Chunwei Li Yong Chen Tao Ding | 2024 | Journal of Genetics and Genomics2024，51，3： | 0 |
| 5 | 一种用于HIRFL-CSR的超薄真空膜窗研究显示文摘Energetic heavy ion beams from the HIRFL-CSR RIBLL2 will be extracted from the accelerator vacuum through a film vacuum window of thin metal.The transmission efficiency,mechanical strength to sustain the atmospheric pressure,film material(pure titanium),the rise of the film temperature(Because the beam intensity is very low,this issue becomes trivial)and the seal form(filamentary silver and sealing groove)are the main concerns. | Wan Yapeng Meng Jun Luo Cheng Niu Zhiwei Hu Zhenjun Gao Yanmin | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 6 | Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates显示文摘Raising a heterologous tier 2 neutralizing antibody(nAb)response remains a daunting task for HIV vaccine development.In this study,we explored the utility of diverse HIV-1 envelope(Env)immunogens in a sequential immunization scheme as a solution to this task.This exploration stemmed from the rationale that gp145,a membrane-bound truncation form of HIV Env,may facilitate the focusing of induced antibody response on neutralizing epitopes when sequentially combined with the soluble gp140 form as immunogens in a prime-boost mode.We first showed that gp140 DNA prime-gp145 Tiantan vaccinia(TV)boost likely represents a general format for inducing potent nAb response in mice.However,when examined in rhesus macaque,this modality showed little effectiveness.To improve the efficacy,we extended the original modality by adding a strong protein boost,namely native-like SOSIP.664 trimer displayed on ferritin-based nanoparticle(NP),which was generated by a newly developed click approach.The resulting three-immunization regimen succeeded in eliciting tier-2 nAb response with substantial breadth when implemented in rhesus macaque over a short 8-week schedule.Importantly,the elicited nAb response was able to effectively contain viremia upon a heterologous SHIV challenge.Collectively,our studies highlighted that diversification of Env immunogens,in both types and formulations,under the framework of a sequential immunization scheme might open new opportunity toward HIV vaccine development. | Xiangqing Ding Kangli Cao Jing Wang Yanmin Wan Qinyun Chen Yanqin Ren Yongtang Zheng Mingzhao Zhu Renrong Tian Wenjun Wang Chen Zhao Xiaoyan Zhang Jianqing Xu | 2021 | Virologica Sinica2021，36，4： | 0 |
| 7 | Feasible Research on ' Textile · Garment' Supply and Demand Interaction and Optimization Model显示文摘After China entries WTO, China's ‘ textile · garment'industry will confront the difficulties of growth and development. From the view of supply and demand interaction which is common in the social economy, this article analyzes the economic construction and character of China's ‘ textile · garment' industry, represented by Shanghai,Research shows that industrial construction backwardness hinders China's ‘ textile· garment' industry development, which features four bottlenecks in supply and demand interaction in ‘ textile· garment' industry.The key of optimizing the construction and quality of supply and denand interaction in ‘textile· garment'industry is to adjust industrial construction, break the bottlenecks, establish Shanghai as international fashion center, open middle and small size textile processing area with several levels, attach importance to scientific and technology creation and development combined with production, learning and research, and take part in domestic and international maket competition by high added value product, technology and marketing network. | Jiang Zhiwei(蒋智威) Wan Yanmin(万艳敏) | 2001 | Journal of Donghua University(English Edition)2001，18，2： | 0 |
| 8 | HIAF薄壁真空室在线烘烤方案研究显示文摘To keep eddy currents at a tolerable level,thin-walled stainless steel vacuum chambers with wall thickness of 0.3 mm are needed in HAIF BRing magnets.To withstand atmospheric pressure the thin-walled vacuum chambers are supported by ribs which is parallel to the magnetic field lines.In order to obtain the extremely high vacuum(XHV),the chambers have to be bakeable to 220-300℃.According to a given design requirement,the in-situ bake-out scheme of XHV thin-walled chambers with a narrow magnetic gap was studied,where the temperature of surrounding magnetic elements is strictly controlled to below 80℃. | Wan Yapeng Meng Jun Luo Cheng Hu Zhenjun Gao Yanmin Xie Wenju | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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