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1Micro-structural evolution and their effects on physical properties in different types of tectonically deformed coals显示文摘The macromolecular structure of tectonically deformed coals(TDC)may be determined by the deformation mechanisms of coal.Alterations of the macromolecular structure change the pore structure of TDC and thereby impact physical properties such as porosity and permeability.This study focuses on structure and properties of TDC from the Huaibei and Huainan coal mining areas of southern North China.Relationships between the macromolecular structure and the pore structure of TDC were analyzed using techniques such as X-ray diffraction,high-resolution transmission electron microcopy,and the low-temperature nitrogen adsorption.The results indicated that the directional stress condition can cause the arrangement of basic structural units(BSU)more serious and closer.And,the orientation is stronger in ductile deformed coal than in brittle deformed coal.Tectonic deformation directly influences the macromolecular structure of coal and consequently results in dynamic metamorphism.Because the size of BSU in brittle deformed coal increases more slowly than in ductile deformed coal,frictional heating and stress-chemistry of shearing areas might play a more important role,locally altering coal structure under stress,in brittle deformed coal.Strain energy is more significant in increasing the ductile deformation of coal.Furthermore,mesopores account for larger percentage of the nano-scale pore volume in brittle deformed coals,while mesopores volume in ductile deformed coal diminishes rapidly along with an increase in the proportion of micropores and sub-micropores.This research also approved that the deformations of macromolecular structures change nano-scale pore structures,which are very important for gas adsorption and pervasion space for gas.Therefore,the exploration and development potential of coal bed methane is promising for reservoirs that are subjected to a certain degree of brittle deformation(such as schistose structure coal,mortar structure coal and cataclastic structure coal).It also holds promise for TDC resulting from wrinkle structure coal of low ductile deformation and later superimposed by brittle deformation.Other kinds of TDC suffering from strong brittle-ductile and ductile deformation,such as scale structure coal and mylonitic structure coal,are difficult problems to resolve.Yiwen Ju Kray Luxbacher Xiaoshi Li Guochang Wang Zhifeng Yan Mingming Wei Liye Yu 2014International Journal of Coal Science & Technology2014,1,3:43
2Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin显示文摘Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model establishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang's regulation of Ghrelin-Ghrelin receptors.Liye Wang Yuehan Song Feng Li Yan Liu Jie Ma Meng Mao Fengzhi Wu Ying Wu Sinai Li Binghe Guan Xiaolan Liu 2014Neural Regeneration Research2014,9,2:16
3Analysis on the hourly spatiotemporal complementarities between China's solar and wind energy resources spreading in a wide area显示文摘China is rich in solar and wind energy resources,of which the proportion of China's power sources has been rapidly increasing.Such fluctuating and intermittent energy sources will bring significant challenges to the safe and stable operation power system.However,making use of the spatiotemporal complementarities between different renewable energy resources is a feasible way to level fluctuating power especially when they have a widely geographical dispersion.Based on the data provided by China Meteorological Administration(CMA),this research explores the spatiotemporal complementarities between wind and solar energy resources.This paper nondimensionalizes hourly wind speed and global solar radiation data and employs several indexes to compare the smoothing effect with various combining scenarios.The results show that combining wind and solar powers within a certain area can cause a fall of zero-power or very-full power hours.Besides,combining different resources improves 'smoothness' in power output when compared with that from each individual resource.However,under hourly time scale,when the dispersion of sites is large enough,the smoothing effect of combining the dispersed wind power is very close to the combination of those two different resources.Nevertheless,this complementary effect is much better than that of just combining solar energy resources.LIU Yi XIAO LiYe WANG HaiFeng DAI ShaoTao QI ZhiPing 2013Chinese Science Bulletin2013,58,7:14
4Recursive modeling and online identification of lithium-ion batteries for electric vehicle applications显示文摘For safe and reliable operation of lithium-ion batteries in electric vehicles,the real-time monitoring of their internal states is important.The purpose of our study is to find an easily implementable,online identification method for lithium-ion batteries in electric vehicles.In this article,we propose an equivalent circuit model structure.Based on the model structure we derive the recursive mathematical description.The recursive extended least square algorithm is introduced to estimate the model parameters online.The accuracy and robustness are validated through experiments and simulations.Real-road driving cycle experiment shows that the proposed online identification method can achieve acceptable accuracy with the maximum error of less than 5.52%.In addition,it is proved that the proposed method can also be used to estimate the real-time SOH and SOC of the batteries.LI Yong WANG LiFang LIAO ChengLin WANG LiYe XU DongPin 2014Science China(Technological Sciences)2014,57,2:10
5Different contribution of SBP and DBP variability to vascular events in patients with stroke显示文摘Background High blood pressure variability(BPV)is a novel risk factor for cardiovascular disease.However,the heterogeneity of systolic blood pressure variability(SBPV)and diastolic blood pressure variability(DBPV)for different vascular events remains unclear.This study aims to investigate whether SBPV or DBPV has different contribution to vascular events in patients with acute ischaemic stroke(IS)or transient ischaemic attack(TIA).Methods Data from the BOSS(blood pressure and clinical outcome in TIA or IS)study were examined for vascular events at 3-month and 1-year follow-up.BPV was defined as the SD and coefficient of variation(CV)of day-to day measurements within 3 months after IS/TIA.Vascular events include cardiovascular events(myocardial infarction,unstable angina,cardiac death and congestive heart failure)and cerebrovascular events(ischaemic or haemorrhagic stroke).Logistic regression model was used to test the associations between BPV and vascular events.results Of 2325 patients with IS or TIA,103(4.43%)experienced a recurrent stroke and 64(2.75%)had cardiovascular events within 3 months.Day-to day SBPV was only associated with stroke recurrence(BPVSD:OR,1.72,95%CI 1.09 to 2.71;BPVCV:1.86,95%CI 1.19 to 2.92),but not cardiovascular events(BPVSD:1.67,95%CI 0.94 to 2.94;BPVCV:1.51,95%CI 0.86 to 2.64).However,DBPV seems to be related to both stroke(BPVSD:1.60,95%CI 1.02 to 2.49;BPVCV:1.53,95%CI 0.99 to 2.37)and cardiovascular events(BPVSD:2.48,95%CI 1.37 to 4.48;BPVCV:1.92,95%CI 1.09 to 3.36).Similar results were found at 1 year.Conclusions For patients with IS/TIA,stroke recurrence was associated with both SBPV and DBPV;however,cardiovascular events seem to be only related to DBPV.Liye Dai Aichun Cheng Xiwa Hao Jie Xu Yingting Zuo Anxin Wang Xia Meng Hao Li Yilong Wang Xingquan Zhao Yongjun Wang 2020Stroke & Vascular Neurology2020,5,2:6
6Multidisciplinary co-design optimization of structural and control parameters for bucket wheel reclaimer显示文摘Bucket wheel reclaimer(BWR)is an extremely complex engineering machine that involves multiple disciplines,such as structure,dynamics,and electromechanics.The conventional design strategy,namely,sequential strategy,is structural design followed by control optimization.However,the global optimal solution is difficult to achieve because of the discoordination of structural and control parameters.The co-design strategy is explored to address the aforementioned problem by combining the structural and control system design based on simultaneous dynamic optimization approach.The radial basis function model is applied for the planning of the rotation speed considering the relationships of subsystems to minimize the energy consumption per volume.Co-design strategy is implemented to resolve the optimization problem,and numerical results are compared with those of sequential strategy.The dynamic response of the BWR is also analyzed with different optimization strategies to evaluate the advantages of the strategies.Results indicate that co-design strategy not only can reduce the energy consumption of the BWR but also can achieve a smaller vibration amplitude than the sequential strategy.Yongliang YUAN Liye LV Shuo WANG Xueguan SONG 2020Frontiers of Mechanical Engineering2020,15,3:4
7TOOR: A Novel Product Title Optimization Method Based on Online Reviews in E-commerce显示文摘联机产品的标题在吸引消费者并且在电子商务支持产品出售起一个重要作用。然而,当前的联机产品标题仅仅盖住基本特征并且不能确切反映消费者的偏爱。处理这个问题,这研究基于联机评论的分析建议了一个联机标题优化方法,它被称为 TOOR (标题优化基于联机评论) 。在这研究,我们分析了并且比较从消费者的观点从联机产品标题和联机评论提取并且使用了从评论提取到标题优化的特征的产品特征。以便验证建议方法的有效性,二个实验在这篇论文被进行,作为数据资源作为实验样品和 Taobao.com 选择四典型 smartphones。试验性的结果显示从联机评论提取的特征能更好反映消费者担心,并且标题由 TOOR 方法优化了是更多的投消费者所好并且有更高的点按彻底地率。Liye Wang Jin Zhang Wei Yan 2015Frontiers of Business Research in China2015,9,4:3
8Modifed Multifdelity Surrogate Model Based on Radial Basis Function with Adaptive Scale Factor显示文摘Multifdelity surrogates(MFSs)replace computationally intensive models by synergistically combining information from diferent fdelity data with a signifcant improvement in modeling efciency.In this paper,a modifed MFS(MMFS)model based on a radial basis function(RBF)is proposed,in which two fdelities of information can be analyzed by adaptively obtaining the scale factor.In the MMFS,an RBF was employed to establish the low-fdelity model.The correlation matrix of the high-fdelity samples and corresponding low-fdelity responses were integrated into an expansion matrix to determine the scaling function parameters.The shape parameters of the basis function were optimized by minimizing the leave-one-out cross-validation error of the high-fdelity sample points.The performance of the MMFS was compared with those of other MFS models(MFS-RBF and cooperative RBF)and single-fdelity RBF using four benchmark test functions,by which the impacts of diferent high-fdelity sample sizes on the prediction accuracy were also analyzed.The sensitivity of the MMFS model to the randomness of the design of experiments(DoE)was investigated by repeating sampling plans with 20 diferent DoEs.Stress analysis of the steel plate is presented to highlight the prediction ability of the proposed MMFS model.This research proposes a new multifdelity modeling method that can fully use two fdelity sample sets,rapidly calculate model parameters,and exhibit good prediction accuracy and robustness.Yin Liu Shuo Wang Qi Zhou Liye Lv Wei Sun Xueguan Song 2022Chinese Journal of Mechanical Engineering2022,35,4:3
9Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer.Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang 2021Cancer Communications2021,41,2:2
10A model-based driving cycle test procedure of electric vehicle batteries显示文摘The battery test methods are the key issues to investigate the energy-storage characteristics and dynamic characteristics of electric vehicle(EV) batteries.In this paper,the research advances of existing battery test methods as well as driving cycles are reviewed.An electric vehicle model that consists of EV dynamics model,battery model and electric motor model is built.The dynamic characteristics of the battery in frequency domain are analyzed.Based on the EV model and the frequency domain characteristics of the battery,a driving cycle test procedure of EV battery is proposed.The battery test procedure is able to reflect the real-world characteristics of EV batteries,and can be used as a universal EV battery test method.李勇 Wang Lifang Liao Chenglin Wang Liye 2014High Technology Letters2014,20,3:2
11Spatiotemporal estimation of hourly 2-km ground-level ozone over China based on Himawari-8 using a self-adaptive geospatially local model显示文摘Ground-level ozone(O_(3))is a primary air pollutant,which can greatly harm human health and ecosystems.At present,data fusion frameworks only provided ground-level O_(3) concentrations at coarse spatial(e.g.,10 km)or temporal(e.g.,daily)resolutions.As photochemical pollution continues increasing over China in the last few years,a high-spatial–temporal-resolution product is required to enhance the comprehension of ground-level O_(3) formation mechanisms.To address this issue,our study creatively explores a brand-new framework for estimating hourly 2-km ground-level O_(3) concentrations across China(except Xinjiang and Tibet)using the brightness temperature at multiple thermal infrared bands.Considering the spatial heterogeneity of ground-level O_(3),a novel Self-adaptive Geospatially Local scheme based on Categorical boosting(SGLboost)is developed to train the estimation models.Validation results show that SGLboost performs well in the study area,with the R2 s/RMSEs of 0.85/19.041 lg/m^(3) and 0.72/25.112 lg/m^(3) for the space-based cross-validation(CV)(2017–2019)and historical space-based CV(2019),respectively.Meanwhile,SGLboost achieves distinctly better metrics than those of some widely used machine learning methods,such as e Xtreme Gradient boosting and Random Forest.Compared to recent related works over China,the performance of SGLboost is also more desired.Regarding the spatial distribution,the estimated results present continuous spatial patterns without a significantly partitioned boundary effect.In addition,accurate hourly and seasonal variations of ground-level O_(3) concentrations can be observed in the estimated results over the study area.It is believed that the hourly 2-km results estimated by SGLboost will help further understand the formation mechanisms of ground-level O_(3) in China.Yuan Wang Qiangqiang Yuan Liye Zhu Liangpei Zhang 2022Geoscience Frontiers2022,13,1:2
12A Comprehensive Interpolation for Medical Slices Based on Combination of Linear and Matching Interpolation显示文摘TANG Xiaoying WANG Liye LIU Weifeng 2011Chinese Journal of Electronics2011,20,1:2
13Effect of low-frequency pulse percutaneous electric stimulation on peripheral nerve injuries at different sites显示文摘BACKGROUND: The postoperative recovery of nerve function in patients with peripheral nerve injury is always an important problem to solve after treatment. The electric stimulation induced electromagnetic field can nourish nerve, postpone muscular atrophy, and help the postoperative neuromuscular function. OBJECTIVE: To observe the effects of low-frequency pulse percutaneous electric stimulation on the functional recovery of postoperative patients with peripheral nerve injury, and quantitatively evaluate the results of electromyogram (EMG) examination before and after treatment. DESIGN: A retrospective case analysis. SETTING: The Sixth People’s Hospital affiliated to Shanghai Jiaotong University. PARTICIPANTS: Nineteen postoperative inpatients with peripheral nerve injury were selected from the Department of Orthopaedics, the Sixth People’s Hospital affiliated to Shanghai Jiaotong University from June 2005 to January 2006, including 13 males and 6 females aged 24-62 years with an average of 36 years old. There were 3 cases of brachial plexus nerve injury, 3 of median nerve injury, 7 of radial nerve injury, 3 of ulnar nerve injury and 3 of common peroneal nerve injury, and all the patients received probing nerve fiber restoration. Their main preoperative manifestations were dennervation, pain in limbs, motor and sensory disturbances. All the 19 patients were informed with the therapeutic program and items for evaluation. METHODS: ① Low-frequency pulse percutaneous electric stimulation apparatus: The patients were given electric stimulation with the TERESA cantata instrument (TERESA-0, Shanghai Teresa Health Technology, Co.,Ltd.). The patients were stimulated with symmetric square waves of 1-111 Hz, and the intensity was 1.2-5.0 mA, and it was gradually adjusted according to the recovered conditions of neural regeneration following the principle that the intensity was strong enough and the patients felt no obvious upset. They were treated for 4-24 weeks, 10-30 minutes for each time, 1-3 times a day, and 6 weeks as a course. ② EMG examination was applied to evaluate the recoveries of recruitment, motor conduction velocity (MCV) and sensory conduction velocity (SCV) before and after treatment. The patients were examined with the EMG apparatus (DISA2000C, Danmark) before and after the treatment of percutaneous electric stimulation. ③ Standards for evaluating the effects included cured (complete recovery of motor functions, muscle strength of grade 5, no abnormality in EMG examination), obviously effective [general recovery of motor function, muscle strength of grade 4, no or a few denervation potentials, motor conduction velocity (MCV) and sensory conduction velocity (SCV)], improved (partial recovery of motor function, muscle strength of grade 3, denervation potentials and reinneration potentials, slowed MCV and SCV, invalid (no obvious changes of motor function). MAIN OUTCOME MEASURES: ① Ameliorated degree of the nerve function of the postoperative patients with peripheral nerve injury treated with percutaneous electric stimulation; ② Changes of EMG examination before and after treatment. RESULTS: All the 19 postoperative patients with peripheral nerve injury were involved in the analysis of results. ① Comparison of nerve function before and after treatment in 19 patients with peripheral nerve injury of different sites: For the patients with radial nerve injury (n=7), the nerve functions all completely recovered after 8-week treatment, and the cured and obvious rate was 100% (7/7); For the patients with brachial plexus nerve injury (n=3), 1 case had no obvious improvement, and the cured and obvious rate was 67% (2/3); For the patients with common peroneal nerve injury (n=3), the extension of foot dorsum generally recovered in 1 case of nerve contusion after 4-week treatment, and the cured and obvious rate was 67% (2/3); For the patients with median nerve injury (n=3), muscle strength was obviously recovered, and the cured and obvious rate was 100% (3/3); For the patients with ulnar nerve injury (n=3), 1 case only had recovery of partial senses, and the cured and obvious rate was 67% (2/3). Totally 9 cases were cured, 7 were obviously effective, 1 was improved, and only 2 were invalid. After 4 courses, the cured rate of damaged nerve function after four courses was 47% (9/19), and effective rate was 89% (17/19). ② Comparison of EMG examination before and after treatment: Before and after percutaneous electric stimulation, he effective rates of recruitment, MCV and SCV were 89% (17/19), 58% (11/19), 47% (9/19) respectively, and there were extremely obvious differences (P < 0.01). CONCLUSION: ① Low-frequency pulse percutaneous electric stimulation can improve the nerve function of postoperative patients with peripheral nerve injury of different sites, especially that the injuries of radial nerve and median nerve recover more obviously. ②Percutaneous electric stimulation can ameliorate the indexes of EMG examination, especially the recruitment, in postoperative patients with peripheral nerve injury.Jinwu Wang Liye Chen Qi Li Weifeng Ni Min Zhang Shangchun Guo Bingfang Zeng 2006Neural Regeneration Research2006,1,3:1
14The draft genome of the fast-growing non-timber forest species moso bamboo (PhyUostachys heterocycla) 显示文摘Peng Z H Lu Y Li L Zhao Q Feng Q Gao Z M Lu H Y Hu T YAO N Liu K Y LiY FanDL GuoYL LiW J LuY Q Weng Q J Zhou C C Zhang L Huang T Zhu C R Liu X G Yang X W Wang T Miao K Zhuang C Y Cao X L Tang W L Liu G S Liu Y L Chen J Liu Z J Yuan L C Liu Z H Huang X H LuT T Fei B H Ning Z M Han B Jiang Z H 2013Nature Genetics2013,45,4:1
15Degradation of acetochlor by consortium of two bacterial strains and cloning of a novel amidase gene involved in acetochlor-degrading pathway显示文摘LiY Chen Q Wang C H Cai S He J Huang X Li S P 2013Bioresource Technology2013,148,:1
16Rapid and simultaneous quantitation of Escherichia coli O157: H7, Salmonella, and Shigella in ground beef by multiplex real-time PCR and immunomagnetic separation显示文摘Wang L LiY Mustaphai A 2007Journal of Food Protection2007,70,6:1
17Microstructure and dielectric properties of Ba x Sr 1? x TiO 3 ceramics显示文摘Chunlin Fu Chuanren Yang Hongwei Chen Yinxin Wang Liye Hu 2005Materials Science & Engineering B2005,,2:1
18Causes of blindness and visual im-pairment in urban and rural areas in Beijing:the Beijing Eye Study显示文摘Xu L Wang Y LiY 2008Ophthalmology2008,113,:1
19A new spectral method on triangles显示文摘LIY Y WANG L L LI H Y 0,,:1
20Monodisperse nanocrystals: general synthesis, assembly, and their applications 显示文摘WANG X LIY D 2007Chem Commun2007,2,:1
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