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| 1 | miR-146a-5p acts as a negative regulator of TGF-β signaling in skeletal muscle after acute contusion显示文摘成长证据在表明小径的应力建议 microRNAs (miRNAs ) 的重要性。转变生长因素 --(TGF-) 是在尖锐殴打以后支持骨胳的肌肉纤维变性的发展的有势力 cytokine。然而, miRNAs 怎么涉及 TGF- 发信号并且授与 TGF 的坚韧性 -- 导致的 fibrotic 反应尚待充分被阐明。这里,我们证明 miR-146a-5p (miR-146 ) 层次在尖锐肌肉殴打以后在一个 fibrotic 老鼠模型被减少。它也被发现那个 TGF- 处理减少在在一个剂量依赖者和时间依赖者举止的 vitro 的 miR-146 的表示。另外, Smad3 和 Samd4 的 overexpression,在 TGF- 发信号的二个关键播放器,在肌肉房间压制了 miR-146 的表达式。miR-146 的 Overexpression 在 vitro 并且在 vivo 禁止了纤维变性标记的表情。而且,在肌肉房间的 miR-146 的表示的增加能在纤维变性标记的表情上稀释 TGF- 的效果。机械学的分析表明 Smad4 是在肌肉房间的 miR-146 的一个直接目标。而且, miR-146 的 anti-fibrotic 效果能被 Smad4 的 overexpression 在 vivo 堵住。这些结果建议 Smad4 由在骨胳的肌肉的 miR-146 是下面调整的。一起拿,我们的结果显示 anti-fibrotic miR-146 是 TGF- 发信号的一个部件。它由 Smad 蛋白质是下面调整的,并且能禁止 Smad4 的表示。我们的学习建议 miR-146 可能有一个治疗学的潜力在损害以后减少骨胳的肌肉纤维变性。 | Yaying Sun Yan Li Hui Wang Hongyun Li Shaohua Liu Jiwu Chen Hao Ying | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 5 |
| 2 | Mantle Source Components and Magmatic Evolution for the Comei Large Igneous Province:Evidence from the Early Cretaceous Niangzhong Mafic Magmatism in Tethyan Himalaya显示文摘The Niangzhong diabase dikes,dated at 138.1±0.4 Ma,are located within the outcrop area of the Comei large igneous province(LIP).These diabase samples can be divided into two groups:samples in Group 1 show varying MgO(1.50 wt.%-10.25 wt.%)and TiO_(2)(0.85 wt.%-4.63 wt.%)contents,and enriched initial isotope compositions(^(87)Sr/^(86)Sr(t)=0.7056-0.7112,ε_(Nd)(t)=-0.3-+3.8),with OIB-like REEs and trace elements patterns,resulting from low degree melting of garnet-bearing lherzolite mantle sources;in contrast,samples in Group 2 show limited MgO(4.14 wt.%-7.75 wt.%)and TiO_(2)(0.98 wt.%-1.69 wt.%)contents,and depleted initial isotope compositions(^(87)Sr/^(86)Sr(t)=0.7075-0.7112,ε_(Nd)(t)=+5.5-+6.2),with N-MORB-like REEs and trace elements patterns,resulting from relatively high degree melting of spinel-bearing lherzolite mantle source.Combined with the published representative data about Comei LIP,we summarize that the source components for Comei LIP products include OIB end-member,enriched OIB end-member,and N-MORB end-member,respectively.Melts modeling suggests that magmas in the Comei LIP evolve in a relatively high oxygen fugacity condition,which influenced their fractionation sequences and led to systematic changes of TiO_(2)contents,Ti/Y and Ti/Ti*ratios.From the spatial and temporal distribution of above three end-member samples,deep process of Kerguelen plume during the Comei LIP formation can be interpreted as the interaction among the Kerguelen plume,the overlying lithospheric mantle,and the upwelling asthenosphere.The magmatism of Comei LIP began at~140 Ma and then lasted and peaked at~132 Ma with the progressively lithospheric thinning of eastern Gondwana upon the impact of Kerguelen plume. | Yaying Wang Lingsen Zeng Kejun Hou Li'e Gao Qian Wang Linghao Zhao Jiahao Gao Guangxu Li | 2022 | Journal of Earth Science2022，33，1： | 3 |
| 3 | Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation显示文摘Radiotherapy is one of the most effective treatment methods for various solid tumors.Bidirectional signal transduction between cancer cells and stromal cells within the irradiated microenvironment is important in cancer development and treatment responsiveness.Exosomes,initially considered as'garbage bins'for unwanted from cells,are now understood to perform a variety of functions in interactions within the tumor microenvironment.Exosome-mediated regulation processes are rebuilt under the irradiation stimuli,because the exosome production,uptake,and contents are markedly modified by irradiation.In turn,irradiation-modified exosomes may modulate the cell response to irradiation through feedback regulation.Here,we review current knowledge and discuss the roles of exosome-mediated interactions between cells under radiotherapy conditions. | Chuanshi He Ling Li Linlin Wang Wanrong Meng Yaying Hao Guiquan Zhu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 4 | The effect of regeneration conditions on the selectivity of NO x reduction in a fully formulated lean NO x trap catalyst显示文摘 | Jin Wang Yaying Ji Vencon Easterling Mark Crocker Mark Dearth Robert W. McCabe | 2011 | Catalysis Today2011，，1： | 2 |
| 5 | Shadow–highlight feature matching automatic small crater recognition using high-resolution digital orthophoto map from Chang’E Missions显示文摘This paper introduces a new method of small lunar craters’ automatic identification, using digital orthophoto map(DOM) data. The core of the approach is the fact that the lunar exploration DOM data reveal contrasting highlight and shadow characteristics of small craters under sunlight irradiation. This research effort combines image processing and mathematical modeling. Overall it proposes a new planetary data processing approach, to segment and extract the highlight and shadow regions of small craters,using the image gray frequency(IGF) statistical method.IGF can also be applied to identify the coupling relationships between small craters’ shape and their relative features. This paper presents the highlight and shadow pair matching(HSPM) model which manages to perform highprecision automatic recognition of small lunar craters.Testing was performed using the DOM data of Chang’E-2(CE-2). The results have shown that the proposed method has a high level of successful detection rate. The proposed methodology that uses DOM data can complement the drawbacks of the digital elevation model(DEM) that has a relatively high false detection rate. A hybrid fusion model(FUM) that combines both DOM and DEM data, was carried out to simultaneously identify small, medium, and large-sized craters. It has been proven that the FUM generally shows stronger recognition ability compared to previous approaches and it can be adapted for high precision identification of craters on the whole lunar surface.The results meet the requirements for a reliable and accurate exploration of the Moon and the planets. | Wei Zuo Chunlai Li Lingjie Yu Zhoubin Zhang Rongwu Wang Xingguo Zeng Yuxuan Liu Yaying Xiong | 2019 | Acta Geochimica2019，38，4： | 1 |
| 6 | QNE1 is a key flowering regulator determining the length of the vegetative period in soybean cultivars显示文摘The soybean E1 gene is a major regulator that plays an important role in flowering time and maturity.However,it remains unclear how cultivars carrying the dominant E1 allele adapt to the higher latitudinal areas of northern China.We mapped the novel quantitative trait locus QNE1(QTL near E1) for flowering time to the region proximal to E1 on chromosome 6 in two mapping populations.Positional cloning revealed Glyma.06G204300,encoding a TCP-type transcription factor,as a strong candidate gene for QNE1.Association analysis further confirmed that functional single nucleotide polymorphisms(SNPs) at nucleotides 686 and 1,063 in the coding region of Glyma.06G204300 were significantly associated with flowering time.The protein encoded by the candidate gene is localized primarily to the nucleus.Furthermore,soybean and Brassica napus plants overexpressing Glyma.06G204300 exhibited early flowering.We conclude that despite their similar effects on flowering time,QNE1 and E4 may control flowering time through different regulatory mechanisms,based on expression studies and weighted gene co-expression network analysis of flowering time-related genes.Deciphering the molecular basis of QNE1 control of flowering time enriches our knowledge of flowering gene networks in soybean and will facilitate breeding soybean cultivars with broader latitudinal adaptation. | Zhengjun Xia Hong Zhai Yanfeng Zhang Yaying Wang Lu Wang Kun Xu Hongyan Wu Jinglong Zhu Shuang Jiao Zhao Wan Xiaobin Zhu Yi Gao Yingxiang Liu Rong Fan Shihao Wu Xin Chen Jinyu Liu Jiayin Yang Qijian Song Zhixi Tian | 2022 | Science China(Life Sciences)2022，65，12： | 1 |
| 7 | Multiple Phases of Mafic Magmatism in Gyangze-Kangma Area: Implications for the Tectonic Evolution of Eastern Tethyan Himalaya显示文摘A number of E-W trending subparallel mafic dikes of diabase composition occurred in Gyangze-Kangma area,eastern Tethyan Himalaya,southern Tibet.They intruded into the Tethyan Himalaya sedimentary sequence.Whether they belong to the^132 Ma Comei LIP(Zhu et al.,2009) | WANG Yaying ZENG Lingsen GAO Li-E ZHAO Linghao GAO Jiahao SHANG Zhen | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 1 |
| 8 | Correction to:MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘CORRECTION TO:PROTEIN CELL(2014)5(11):851-861 http://gffzzd3cc09b8251d45dfow9bx5fbnkxck6f5q.ffgz.tsg.suse.edu.cn/10.1007/S13238-014-0093-5 In the original publication the display of Fig.1 is in correct.The correct Fig.1 is available in this correction. | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaiing Hu Qifeng Wang Shujuan Ni Bojian Fei Weiii Wang Xiang Du Dong Hua Zhaohui Huang | 2021 | Protein & Cell2021，12，8： | 1 |
| 9 | N2O production in anaerobic/anoxic denitrifying phosphorus removal process:the effects of carbon sources shock显示文摘 | WANG Yaying GENG Junjun GUO Gang | 2011 | Chemical Engineering Journal2011，172，2： | 1 |
| 10 | Late Ordovician to Early Silurian Tectonic Events in the Himalayan Terrain显示文摘Objective The Himalaya terrain together with the ribbon terrains(e.g.,Lhasa,Qiangtang,and Sibumasu blocks)of the Gondwana supercontinent has experienced episodic tectonic events since the Neoproterozoic.However,almost not any documentation with regard to the tectonic processes links the peri-Gondwana subduction | GAO Li'e ZENG Lingsen HU Guyue WANG Yuhua GAO Jiahao SHANG Zhen WANG Yaying | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 1 |
| 11 | Plasma from healthy donors protects blood-brain barrier integrity via FGF21 and improves the recovery in a mouse model of cerebral ischaemia显示文摘Background Healthy plasma therapy reverses cognitive deficits and promotes neuroplasticity in ageing brain disease.However,whether healthy plasma therapy improve blood-brain barrier integrity after stroke remains unknown.Methods Here,we intravenously injected healthy female mouse plasma into adult female ischaemic stroke C57BL/6 mouse induced by 90 min transient middle cerebral artery occlusion for eight consecutive days.Infarct volume,brain atrophy and neurobehavioural tests were examined to assess the outcomes of plasma treatment.Cell apoptosis,blood-brain barrier integrity and fibroblast growth factor 21 knockout mice were used to explore the underlying mechanism.Results Plasma injection improved neurobehavioural recovery and decreased infarct volume,brain oedema and atrophy after stroke.Immunostaining showed that the number of transferase dUTP nick end labelling+/NeuN+cells decreased in the plasma-injected group.Meanwhile,plasma injection reduced ZO-1,occluding and claudin-5 tight junction gap formation and IgG extravasation at 3 days after ischaemic stroke.Western blot results showed that the FGF21 expression increased in the plasma-injected mice.However,using FGF21 knockout mouse plasma injecting to the ischaemic wild-type mice diminished the neuroprotective effects.Conclusions Our study demonstrated that healthy adult plasma treatment protected the structural and functional integrity of blood-brain barrier,reduced neuronal apoptosis and improved functional recovery via FGF21,opening a new avenue for ischaemic stroke therapy. | Muyassar Mamtilahun Lu Jiang Yaying Song Xiaojing Shi Chang Liu Yixu Jiang Lidong Deng Haoran Zheng Hui Shen Yongfang Li Zhijun Zhang Yongting Wang Yaohui Tang Guo-Yuan Yang | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 12 | Elusive Cenozoic Metamorphism in Mafic Dike Swarms within the Tethyan Himalaya, Southern Tibet显示文摘Mafic dike swarms are well-developed within the Tethyan Himalaya,southern Tibet,in response to the breakup of Gondwana supercontinent,seafloor spreading of the Tethyan Ocean,and forearc hyperextension during | ZENG Lingsen WANG Yuhua GAO Li'E WANG Yaying | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 1 |
| 13 | Regeneration of plantlets and tetraploidy induction in Pseudostellaria hterophylla显示文摘 | Ye Zuyun Wang Yaying Tian Huiqiao | | 0，，02： | 1 |
| 14 | A leap by the rise of solid-state electrolytes for Li-air batteries显示文摘Li-air batteries have attracted extensive attention because of their ultrahigh theoretical energy density. However, the potential safety hazard of flammable organic liquid electrolytes hinders their practical applications. Replacing liquid electrolytes with solidstate electrolytes(SSEs) is expected to fundamentally overcome the safety issues. In this work, we focus on the development and challenge of solid-state Li-air batteries(SSLABs). The rise of different types of SSEs, interfacial compatibility and verifiability in SSLABs are presented. The corresponding strategies and prospects of SSLABs are also proposed. In particular, combining machine learning method with experiment and in situ(or operando)techniques is imperative to accelerate the development of SSLABs. | Kecheng Pan Minghui Li Weicheng Wang Shuochao Xing Yaying Dou Shasha Gao Zhang Zhang Zhen Zhou | 2023 | Green Energy & Environment2023，8，4： | 0 |
| 15 | 阳离子通道TRPV在醛缩酶和AMPK感知葡萄糖过程中起必须的作用显示文摘文章简介在激活AMPK的溶酶体途径感应葡萄糖供给下降的过程中,果糖-1,6-二磷酸醛缩酶(aldolase)起关键作用。然而,醛缩酶是如何把其与果糖-1,6-二磷酸结合的减少的信息传导引起AMPK活化的机制还尚未清楚。 | Mengqi Li Chen-Song Zhang Yue Zong Jin-Wei Feng Teng Ma Meiqin Hu Zhizhong Lin Xiaotong Li Changchuan Xie Yaying Wu Dong Jiang Ying Li Cixiong Zhang Xiao Tian Wen Wang Yanyan Yang Jie Chen Jiwen Cui Yu-Qing Wu Xin Chen Qing-Feng Liu Jianfeng Wu Shu-Yong Lin Zhiyun Ye Ying Liu Hai-Long Piao Li Yu Zhuan Zhou Xiao-Song Xie D.Grahame Hardie 林圣彩 | 2020 | 科学新闻2020，，2： | 0 |
| 16 | 材料、能源、机械工程中高效的电流变技术——从机理到应用显示文摘电流变(ER)技术是一种基于电流变效应的先进技术。电流变技术中最常见的材料是电流变液(ERF)。电流变液是一种软物质智能材料,其黏度可以通过施加电场来可逆地调节。电流变液的衍生物、一种新型的电响应软物质材料——电流变弹性体(ERE),由于其不沉降、易封装的优点也得到了越来越多的关注。电流变材料由于其可逆可调、快速响应、低能耗等特性在机械工程中有着广泛的应用。除了基础的电流变材料的合成和应用以外,电流变技术还应用在了能源材料制备、石油运输、储能等诸多领域。电流变技术在能源领域的应用为其在其他领域的潜在应用提供了一个很好的范例。本文结合最新的研究成果,从机理到应用,系统地综述了电流变技术在材料、能源和机械工程等领域的研究现状和未来发展前景。 | Yudai Liang Dongyang Huang Xuefeng Zhou Ziqiu Wang Quan Shi Yaying Hong Huayan Pu Mengying Zhang Jinbo Wu Weijia Wen | 2023 | Engineering2023，，5： | 0 |
| 17 | Aldolase is a sensor for both low and high glucose,linking to AMPK and mTORC1显示文摘Dear Editor,As well as glucose being the major carbon nutrient for most cells,its availability also acts as a gate-keeper exerting a switch between anabolic and catabolic metabolism,with the protein kinases mTORC1 and AMP-activated protein kinase(AMPK)being the two master controllers.1 In low glucose,AMPK is activated and phosphorylates a wide range of downstream targets to maintain energy homeostasis,by switching on catabolic pathways while switching off ATP-consuming processes.1 In high glucose,mTORC1 is activated and shifts the metabolic program of the cell towards anabolic metabolism.1 It is already known that low glucose,and hence low levels of the glycolytic intermediate fructose-1,6-bisphosphate(FBP),can be sensed by aldolase to trigger AMPK activation via the lysosomal pathway.2,3 This occurs independently of increases in AMP and ADP,the classical activators of AMPK.2 Although it is clear that mTORC1 is also regulated by glucose availability at multiple levels,the underlying mechanisms have not been fully elucidated. | Mengqi Li Chen-Song Zhang Jin-Wei Feng Xiaoyan Wei Cixiong Zhang Changchuan Xie Yaying Wu Simon A.Hawley Abdelmadjid Atrih Douglas J.Lamont Zhichao Wang Hai-Long Piao D.Grahame Hardie Sheng-Cai Lin | 2021 | Cell Research2021，31，4： | 0 |
| 18 | Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate显示文摘Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals,controlling metabolic states beyond energy metabolism.However,whether glycolytic metabolites also play a role in controlling cell fate remains unexplored.Here,we find that low levels of glycolytic metabolite 3-phosphoglycerate(3-PGA)can switch phosphoglycerate dehydrogenase(PHGDH)from cataplerosis serine synthesis to pro-apoptotic activation of p53.PHGDH is a p53-binding protein,and when unoccupied by 3-PGA interacts with the scaffold protein AXIN in complex with the kinase HIPK2,both of which are also p53-binding proteins.This leads to the formation of a multivalent p53-binding complex that allows HIPK2 to specifically phosphorylate p53-Ser46 and thereby promote apoptosis.Furthermore,we show that PHGDH mutants(R135W and V261M)that are constitutively bound to 3-PGA abolish p53 activation even under low glucose conditions,while the mutants(T57A and T78A)unable to bind 3-PGA cause constitutive p53 activation and apoptosis in hepatocellular carcinoma(HCC)cells,even in the presence of high glucose.In vivo,PHGDH-T57A induces apoptosis and inhibits the growth of diethylnitrosamine-induced mouse HCC,whereas PHGDH-R135W prevents apoptosis and promotes HCC growth,and knockout of Trp53 abolishes these effects above.Importantly,caloric restriction that lowers whole-body glucose levels can impede HCC growth dependent on PHGDH.Together,these results unveil a mechanism by which glucose availability autonomously controls p53 activity,providing a new paradigm of cell fate control by metabolic substrate availability. | Yu-Qing Wu Chen-Song Zhang Jinye Xiong Dong-Qi Cai Chen-Zhe Wang Yu Wang Yan-Hui Liu Yu Wang Yiming Li Jian Wu Jianfeng Wu Bin Lan Xuefeng Wang Siwei Chen Xianglei Cao Xiaoyan Wei Hui-Hui Hu Huiling Guo Yaxin Yu Abdul Ghafoor Changchuan Xie Yaying Wu Zheni Xu Cixiong Zhang Mingxia Zhu Xi Huang Xiufeng Sun Shu-Yong Lin Hai-Long Piao Jianyin Zhou Sheng-Cai Lin | 2023 | Cell Research2023，33，11： | 0 |
| 19 | Modification of Cre Gene by PCR Method显示文摘Cre/LoxP site-specified recombination system is mainly used for excision,inversion and integration of target gene.Therefore,this system can be used for plant marker free genetic transformation,site-specific transgene expression and so on.However,the application of this system was limited due to its low expression and excision efficiency.In this study,an intron,which can enhance gene expression in plants,was inserted into Cre by using PCR method.And a modified Cre gene,named Crein,was obtained.This gene was composed of three parts: ATG,intron,Cre gene without ATG.This gene can be used for further research to provide the good system for plant marker free transformation. | WANG Yong,LUO Hong,XU Yaying,LV Tao,and CHEN Dian College of Horticulture,Northeast Agricultural University,Harbin 150030,China | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，2： | 0 |
| 20 | Prediction of Lifespan of Tropical Cyclones Landing at China in Spring:A Case Study of Northward-moving-cluster Tracks显示文摘The recurving cluster of tropical cyclones(TCs)landing at China in spring has the characteristics of high frequency,strong intensity,severe influence and long lifespan,a better understanding of tropical cyclone tracks and their underlying mechanisms and more accurate prediction are thus of great value for the prevention and mitigation of TC-related disasters.Based on the best track dataset of typhoon during 1951-2018 from Shanghai Typhoon Institute(STI)of Chinese Meteorological Administration,the tracks of tropical cyclones landfalling over the Chinese coast during 1951-2018 are grouped into three clusters through finite mixture model.The ENSO index,PDO index and the 74 circulation indices of the National Climate Center are analyzed by the classification and regression tree(CART)algorithm for the first TC cluster(the northward-moving cluster).The prediction model based on the results of CART for spring track lifespan is built by a random sampling of the data during the 50 years(about 75%)as a model of the training set,and the training accuracy is 82.46%.The 17-year(about 25%)remaining data are used for testing,with a prediction accuracy of 75%.This study suggests that the finite mixture model algorithm produces a better classification of the northward-going-cluster tracks of TC landfalling over China.In addition,the CART algorithm,which is used for the classification of track lifespan prediction model,not only shows high accuracy,but also the results are easily explained and understood.It provides a novel idea for forecasting the lifespan of tropical cyclones landing at China. | Junhui LI Dawei SHI Yaying PAN Wei WANG | 2020 | Meteorological and Environmental Research2020，11，2： | 0 |
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