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208篇 您的检索式:作者名="Junhui LI"
    题名 作者 年代 出处 被引量
1Human colorectal cancer-specific CCAT1-L IncRNA regulates long-range chromatin interactions at the MYC locus显示文摘人的 8q24 基因沙漠包含多重 enhancers 形式织物特定的远程的染色质与 MYC oncogene 循环,但是染色质在 MYC 地点循环怎么被调整,仍然保持糟糕理解。这里,我们表明那长 noncoding RNA (lncRNA ) , CCAT1-L,从一个地点在人的 colorectal 癌症明确地被抄录 MYC 在上游的 515 kb。这 lncRNA 在 MYC transcriptional 规定起一个作用并且支持远程的染色质循环。重要地, CCAT1-L 地点位于强壮的超级提高以内并且离 MYC 空间地靠近。CCAT1-L 击倒在 MYC 倡导者和它的 enhancers 之间的减少的远程的相互作用。另外, CCAT1-L 与 CTCF 交往并且在这些环区域调制染色质符合构造。这些结果揭示一个重要角色一以前在在 MYC 地点的基因规定的 unannotated lncRNA。Jian-Feng Xiang Qing-Fei Yin Tian Chen Yang Zhang Xiao-Ou Zhang Zheng Wu Shaofeng Zhang Hai-Bin Wang Junhui Ge Xutiua Lu Li Yang Ling-Ling Chen 2014Cell Research2014,24,5:67
2Characterization and assessment of volatile organic compounds (VOCs) emissions from typical industries显示文摘VOCs play an increasingly important role in affecting air quality and threatening human health in China in recent years,where industry activities show a significant contribution to VOCs emission.In this article we report our long term study of industrial VOCs emissions of six major industries (vehicle manufacturing,printing,equipment coating,electronic manufacturing,furniture manufacturing and bio-pharming) on the aspects of emission characteristics,environmental impact and health risk assessment,and control challenge analysis with the purpose to obtain in-depth understanding of industry VOCs emissions and offer some original basements for national control and management of industry VOCs emissions.This study shows that all these industries give middle or low emission with total VOCs concentration less than 1000 mg/m3 at each exhaust pipe.Benzenes,esters,alcohols,ketones,alkanes,chloroalkanes and alkenes were detected as the major emission components and the most frequently monitored VOCs were benzenes,which varied obviously with different processes and industries.The environmental impact assessments indicate that vehicle manufacturing and benzenes should be prior controlled with the purpose to reduce air pollution.While,health risk assessments suggest that furniture manufacturing and chloroalkanes should be firstly controlled.Control analysis indicates that developing technologies with low cost and high efficiency and establishing and completing specific industry emission standards/regulations are the two key issues in VOCs emission management at present stage.WANG HaiLin NIE Lie LI Jing WANG YuFei WANG Gang WANG JunHui HAO ZhengPing 2013Science China(Technological Sciences)2013,56,3:60
3Shortened Basal Internodes Encodes a Gibberellin 2-Oxidase and Contributes to Lodging Resistance in Rice显示文摘改进住宿抵抗的繁殖半矮子变化被证明了在自从绿 revolution.?However 的来临,增加谷物产量极其成功,在亚洲繁殖半矮子米饭变化的多数主要依赖于 SD1 的变异的等位基因的基因介绍,它编码赤霉素( GA ) 20-oxidase , OsGA20ox2 ,为催化 GA 生合成。这里,我们报导新米饭住宿抵抗基因,弄短的基础 Internodes (SBI ) ,它编码赤霉素 ? 2-oxidase 并且明确地控制灰煤杆的延伸通过撤销的基础 internodes GA 活动。SBI 主要在灰煤杆被表示基础 internodes。基因分析显示 SBI 是影响米饭高度和住宿抵抗的半主导的基因。SBI 突变而产生之遗传的变体显示不同活动并且与米饭变化的高度被联系。与 SBI 等位基因的更高的活动繁殖与改进住宿抵抗和增加的产量产生新米饭变化。SBI 的发现为生产半矮子米饭显型提供一个理想的基因资源并且为与提高的住宿抵抗和高产量引起米饭变化提供有效策略。Chang Liu Jinshan Gui Chenjian Fu Hasi Yu Dongliang Song Junhui Shen Peng Qin Xuanming Liu Bin Han Yuanzhu Yang Laigeng Li 2018Molecular Plant2018,11,2:33
4Structural insights of phosphorylated into the recognition FUNDC1 by LC3B in mitophagy显示文摘Mengqi Lv Chongyuan Wang Fudong Li Junhui Peng Bin Wen Qingguo Gong Yunyu Shi Yajun-Tang 2017Protein & Cell2017,8,1:21
5Energy-Efficient Computation Offloading and Resource Allocation in Fog Computing for Internet of Everything显示文摘With the dawning of the Internet of Everything(IoE) era, more and more novel applications are being deployed. However, resource constrained devices cannot fulfill the resource-requirements of these applications. This paper investigates the computation offloading problem of the coexistence and synergy between fog computing and cloud computing in IoE by jointly optimizing the offloading decisions, the allocation of computation resource and transmit power. Specifically, we propose an energy-efficient computation offloading and resource allocation(ECORA) scheme to minimize the system cost. The simulation results verify the proposed scheme can effectively decrease the system cost by up to 50% compared with the existing schemes, especially for the scenario that the computation resource of fog computing is relatively small or the number of devices increases.Qiuping Li Junhui Zhao Yi Gong Qingmiao Zhang 2019China Communications2019,16,3:19
6Effect of N and P addition on soil organic C potential mineralization in forest soils in South China显示文摘Atmospheric nitrogen deposition is at a high level in some forests of South China. The effects of addition of exogenous N and P on soil organic carbon mineralization were studied to address: (1) if the atmospheric N deposition promotes soil C storage through decreasing mineralization; (2) if the soil available P is a limitation to organic carbon mineralization. Soils (0-10 cm) was sampled from monsoon evergreen broad-leaved forest (MEBF), coniferous and broad-leaved mixed forest (CBMF), and Pinus massoniana forest (PMF) in Dinghushan Biosphere Reserve (located in Guangdong Province, China). The soils were incubated at 25°C for 45 weeks, with addition of N (NH4NO3 solution) or P (KH2PO4 solution). CO2-C emission and the inorganic N (NH4+-N and NO3?-N) of the soils were determined during the incubation. The results showed that CO2-C emission decreased with the N addition. The addition of P led to a short-term sharp increase in CO2 emission after P application, and the responses of CO2-C evolution to P addition in the later period of incubation related to forest types. Strong P inhibition to CO2 emission occurred in both PMF and CBMF soils in the later incubation. The two-pool kinetic model was fitted well to the data for C turnover in this experiment. The model analysis demonstrated that the addition of N and P changed the distribution of soil organic C between the labile and recalcitrant pool, as well as their mineralization rates. In our experiment, soil pH can not completely explain the negative effect of N addition on CO2-C emission. The changes of soil inorganic N during incubation seemed to support the hypothesis that the polymerization of added nitrogen with soil organic compound by abiotic reactions during incubation made the added nitrogen retard the soil organic carbon mineralization. We conclude that atmospheric N deposition contributes to soil C accretion in the three subtropical forest ecosystems, however, the shortage of soil available P in CBMF and PMF may also retard soil organic C mineralization.OUYANG, Xuejun ZHOU, Guoyi HUANG, Zhongliang ZHOU, Cunyu LI, Jiong SHI, Junhui ZHANG, Deqiang 2008Journal of Environmental Sciences2008,20,9:17
7Designer TAL Effectors Induce Disease Susceptibility and Resistance to Xanthomonas oryzae pv. Oryzae in Rice显示文摘TAL (抄写像使活跃之物) 从 Xanthomonas 细菌的受动器激活血缘的主人基因,在主人目标基因的基因上下文上导致疾病危险性或抵抗依赖者。模块化的性质和 TAL 受动器的 DNA 识别代码启用为基因激活的设计者 TAL 受动器(dTALE ) 特定工程。然而, dTALEs 的可行性作为为基因的抄写使活跃之物,功能的分析没被表明。这里,我们报导 dTALEs 的使用,由病原的 Xanthomonas oryzae pv 表示了并且交付。oryzae (Xoo ) ,在揭示,二的新功能以前在 rice/Xoo 相互作用为疾病危险性识别了疾病相关的基因和一发展基因的潜力。dTALE 基因 dTALE-xa27,设计了指向抵抗基因 Xa27 的易受影响的等位基因,在不那样易受影响的米饭栽培变种 IR24 得到了抵抗反应。四 dTALE 基因被做导致四四导致的象 Xa27 一样基因的在米饭栽培变种 Nipponbare 的注解 Xa27 相应基因,而是没有授与抵抗到包含 dTALE Xoo 种类。dTALE 基因也被产生激活后退的抵抗基因 xa13,疾病危险性基因 Os8N3 的等位基因(也命名的 Xa13 或 OsSWEET11,蔗糖流出 transporter 的一个成员香甜的基因家庭) 。由 dTALE 的 xa13 的正式就职显示了抵抗米饭 IRBB13 (xa13/xa13 ) 产生 Xoo。最后, OsSWEET12,到 Xoo 的当还,没有相应自然地发生的 TAL 受动器的 uncharacterized 糖果基因识别的、授与的危险性尽力表示相应 dTALE 基因。我们的结果证明 dTALEs 能通过细菌的分泌物系统被交付在植物为功能的分析激活兴趣的基因。Ting Li Sheng Huang Junhui Zhou Bing Yang 2013Molecular Plant2013,6,3:14
8Fabrication,microstructures,and properties of copper matrix composites reinforced by molybdenum-coated carbon nanotubes显示文摘Multiwalled carbon nanotubes(CNTs) were coated by a molybdenum layer using carbonyl thermal decomposition process with a precursor of molybdenum hexacarbonyl.The Mo-coated CNTs(Mo-CNTs) were added into copper powders to fabricate Mo-CNT/Cu composites by means of mechanical milling followed by spark plasma sintering.The Mo-CNTs were uniform dispersion in the Cu matrix when their contents were 2.5 vol.%-7.5 vol.%,while some Mo-CNT clusters were clearly observed at additions of 10.0 vol.%-15.0 vol.% Mo-CNTs in the mixture.The mechanical,electrical,and thermal properties of the Mo-CNT/Cu composites were characterized,and the results showed that the tensile strength and hardness were 2.0 and 2.2 times higher than those of CNT-free specimens,respectively.Moreover,the Mo-CNT/Cu composites exhibited an enhanced thermal conductivity but inferior electrical conductivity compared with sintered pure Cu.The uncoated CNT/Cu composites were fabricated by the similar processes,and the measured tensile strength,hardness,thermal conductivity,and electrical conductivity of the CNT/Cu composites were lower than those of the Mo-CNT/Cu composites.NIE Junhui JIA Chengchang JIA Xian ZHANG Yafeng SHI Na LI Yi 2011Rare Metals2011,30,4:12
9LncRNA Nron regulates osteoclastogenesis during orthodontic bone resorption显示文摘Activation of osteoclasts during orthodontic tooth treatment is a prerequisite for alveolar bone resorption and tooth movement.However,the key regulatory molecules involved in osteoclastogenesis during this process remain unclear.Long noncoding RNAs(lnc RNAs)are a newly identified class of functional RNAs that regulate cellular processes,such as gene expression and translation regulation.Recently,lnc RNAs have been reported to be involved in osteogenesis and bone formation.However,as the most abundant noncoding RNAs in vivo,the potential regulatory role of lnc RNAs in osteoclast formation and bone resorption urgently needs to be clarified.We recently found that the lnc RNA Nron(long noncoding RNA repressor of the nuclear factor of activated T cells)is highly expressed in osteoclast precursors.Nron is downregulated during osteoclastogenesis and bone ageing.To further determine whether Nron regulates osteoclast activity during orthodontic treatment,osteoclastic Nron transgenic(Nron c TG)and osteoclastic knockout(Nron CKO)mouse models were generated.When Nron was overexpressed,the orthodontic tooth movement rate was reduced.In addition,the number of osteoclasts decreased,and the activity of osteoclasts was inhibited.Mechanistically,Nron controlled the maturation of osteoclasts by regulating NFATc1 nuclear translocation.In contrast,by deleting Nron specifically in osteoclasts,tooth movement speed increased in Nron CKO mice.These results indicate that lnc RNAs could be potential targets to regulate osteoclastogenesis and orthodontic tooth movement speed in the clinic in the future.Ruilin Zhang Junhui Li Gongchen Li Fujun Jin Zuolin Wang Rui Yue Yibin Wang Xiaogang Wang Yao Sun 2020International Journal of Oral Science2020,12,2:9
10Experimental study of an insert and its influence on churning losses in a high-speed electro-hydrostatic actuator pump of an aircraft显示文摘The speed of an Electro-Hydrostatic Actuator(EHA) pump can recently reach 20000 r/min, and its churning losses increase obviously with an increasing speed, which results in low efficiency and thus increasing heat in aircraft EHA systems. In order to reduce churning losses at high speeds, more attention should be given to the design of an insert. In this paper, the effect of an insert with different design parameters on churning losses is investigated through Computational Fluid Dynamics(CFD) simulation and experiments by calculating the difference between churning losses torques of the test pump with and without the insert based on a high-speed churning losses test rig.Analytical results show that the gap between the insert and the cylinder is critical for churning losses reduction. It is found that the churning losses of the test pump can be reduced with a decreasing gap between the cylinder block and the insert at high speeds. This is because the insert can decrease the turbulence occurrence at high speeds. The results can be used for flow field analysis and optimization of the high-speed EHA pump and provide a new method for improving efficiency of high-speed EHA pumps.Junhui ZHANG Ying LI Bing XU Min PAN Qun CHAO 2019Chinese Journal of Aeronautics2019,32,8:9
11Power Allocation Based on Genetic Simulated Annealing Algorithm in Cognitive Radio Networks显示文摘ZHAO Junhui GUAN Xin LI Xiuping 2013Chinese Journal of Electronics2013,22,1:7
12Application and future perspective of CRISPR/Cas9 genome editing in fruit crops显示文摘Fruit crops, including apple, orange, grape,banana, strawberry, watermelon, kiwifruit and tomato, not only provide essential nutrients for human life but also contribute to the major agricultural output and economic growth of many countries and regions in the world. Recent advancements in genome editing provides an unprecedented opportunity for the genetic improvement of these agronomically important fruit crops. Here, we summarize recent reports of applying CRISPR/Cas9 to fruit crops,including efforts to reduce disease susceptibility, change plant architecture or flower morphology, improve fruit quality traits, and increase fruit yield. We discuss challenges facing fruit crops as well as new improvements and platforms that could be used to facilitate genome editing in fruit crops, including d Cas9-base-editing to introduce desirable alleles and heat treatment to increase editing efficiency. In addition, we highlight what we see as potentially revolutionary development ranging from transgene-free genome editing to de novo domestication of wild relatives. Without doubt, we now see only the beginning of what will eventually be possible with the use of the CRISPR/Cas9 toolkit. Efforts to communicate with the public and an emphasis on the manipulation of consumerfriendly traits will be critical to facilitate public acceptance of genetically engineered fruits with this new technology.Junhui Zhou Dongdong Li Guoming Wang Fuxi Wang Merixia Kunjal Dirk Joldersma Zhongchi Liu 2020Journal of Integrative Plant Biology2020,62,3:7
13Hollow spherical rare-earth-doped yttrium oxysulfate: A novel structure for upconversion显示文摘锻烧跟随的一条灵巧的 帮助biomolecule 的热水的线路为空范围与另外的稀土元素的离子做了的单斜晶的钇 oxysulfate 的准备被采用了( Yb <啜class=“ a-plus-plus ”>3+和 Eu <啜class=“ a-plus-plus ”>3+或嗯<啜class=“ a-plus-plus ”>3+)。空范围的形成可以包含 Ostwald 成熟。产生混合材料被用于 upconversion 应用。主人水晶结构允许容易没有显著地改变主人格子,二个不同稀土元素的金属离子共同做。光性质被稀土元素的金属离子由于精力转移和水晶的对称回答的掺杂物的比率和集中影响。光中心的类型和样品的 crystallinity 也被显示在同样准备的产品的光性质上有重要影响。Gen Chen Fashen Chen Xiaohe Liu Wei Ma Hongmei Luo Junhui Li Renzhi Ma Guanzhou Qiu 2014Nano Research2014,7,8:6
14Enhancement of precursor amino acid supplies for improving bacitracin production by activation of branched chain amino acid transporter BrnQ and deletion of its regulator gene lrp in Bacillus licheniformis显示文摘Bacitracin,a new type of cyclic peptide antibiotic,is widely used as the feed additive in feed industry.Branched chain amino acids(BCAAs)are the key precursors for bacitracin synthesis.In this research,soybean meal was served as the raw material to supply precursor amino acids for bacitracin synthesis,and enhanced production of bacitracin was attempted by engineering BCAA transporter BrnQ and its regulator Lrp in the bacitracin industrial production strain Bacillus licheniformis DW2.Firstly,our results confirmed that Lrp negatively affected bacitracin synthesis in DW2,and deletion of lrp improved intracellular BCAA accumulations,as well as the expression level of BCAA transporter BrnQ,which further led to a 14.71%increase of bacitracin yield,compared with that of DW2.On the contrary,overexpression of Lrp decreased bacitracin yield by 12.28%.Secondly,it was suggested that BrnQ acted as a BCAA importer in DW2,and overexpression of BrnQ enhanced the intracellular BCAA accumulations and 10.43%of bacitracin yield.While,the bacitracin yield decreased by 18.27%in the brnQ deletion strain DW2△brnQ.Finally,BrnQ was further overexpressed in lrp deletion strain DW2△lrp,and bacitracin yield produced by the final strain DW2△lrp::BrnQ was 965.34 U/mL,increased by 22.42%compared with that of DW2(788.48 U/mL).Collectively,this research confirmed that Lrp affected bacitracin synthesis via regulating the expression of BCAA transporter BrnQ and BCAA distributions,and provided a promising strain for industrial production of bacitracin.Jiang Zhu Dongbo Cai Haixia Xu Ziwei Liu Bowen Zhang Fei Wu Junhui Li Shouwen Chen 2018Synthetic and Systems Biotechnology2018,3,4:6
15Inspection of reinforced concrete interface delamination using ultrasonic guided wave non-destructive test technique显示文摘An ultrasonic-guided wave(UGW) is a very promising tool in the field of structural health monitoring and non-destructive test.Numerical analysis was used to simulate the propagation in the rebar and explore the characteristics of UGW in the steel rebar waveguide.Two-dimensional fast Fourier transform was used to process the numerical results and to evaluate the damage.Subsequently,different UGW test influence factors were investigated.The results clearly showed that both the group velocity and the amplitude of longitudinal modes were not very sensitive to stress and temperature variations.However,the received UGW signal energy decreased with the increasing concrete strength.Finally,the interface condition between the concrete and the rebar was investigated.Time-domain and frequency-domain analyses were used to process the received signals.Different interface delamination lengths of the UGW energy attenuation were analyzed and a relationship was obtained.This study successfully proved that UGW is an effective tool in the non-destructive test of reinforced concrete interface delamination.LI DongSheng RUAN Tao YUAN JunHui 2012Science China(Technological Sciences)2012,55,10:6
16In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets显示文摘Photoacoustic(PA)computed tomography(PACT)is a noninvasive hybrid imaging technique that combines optical excitation and acoustic detection to realize high contrast,high resolution,and deep penetration in biological tissues.However,the spatial resolution of PACT is limited by acoustic diffraction.Here,we report in vivo superresolution PACT,which breaks the acoustic diffraction limit by localizing the centers of single dyed droplets that are flowing in blood vessels.The droplets were prepared by dissolving hydrophobic absorbing dye in oil,followed by mixing with water.The dyed droplets generate much higher-amplitude PA signals than blood and can flow smoothly in vessels;thus,they are excellent tracers for localization-based superresolution imaging.The in vivo resolution enhancement was demonstrated by continuously imaging the cortical layer of a mouse brain during droplet injection.The droplets that were flowing in the vessels were localized,and their center positions were used to construct a superresolution image that exhibits sharper features and more finely resolved vascular details.An improvement in spatial resolution by a factor of 6 has been realized in vivo by the droplet localization technique.Pengfei Zhang Lei Li Li Lin Junhui Shi Lihong V.Wang 2019Light(Science & Applications)2019,8,1:6
17Microscopic examination of intracellular organisms in bronchoalveolar lavage fluid for the diagnosis of ventilator-associated pneumonia:a prospective multi-center study显示文摘Liu Chang Du Zhaohui Zhou Qing Hu Bo Li Zhifeng Yu Li Xu Tao Fan Xuepeng Yang Junhui Li Jianguo 2014Chinese Medical Journal2014,,10:6
18A quasi-automated generation control strategy for multiple energy storage systems to optimize low-carbon benefits显示文摘Integrating a battery energy storage system(ESS)with a large wind farm can smooth the intermittent power obtained from the wind farm,but the smoothing function will not be achieved if multiple ESSs are used to smooth the fluctuations in individual wind power plants in a distributed pattern.Therefore,this study focuses on the development of a control strategy to optimize the use of multiple ESSs to accelerate the adoption of wind energy resources.This paper proposes a quasi-automated generation control(QAGC)strategy to coordinate multiple ESSs,which responds to the grid dispatch demand rather than smoothing out the intermittent power from individual wind farms.The aims of QAGC are to ensure that multiple ESSs provide a service that is as balanced as possible,so more wind power systems at various scales can be accepted by the grid,as well maximizing the low-carbon benefits of ESSs.The effectiveness of QAGC is demonstrated by using data from an actual gigawatt scale cluster of wind plants.Gangui YAN Xudong ZHENG Gang MU Junhui LI Yang CUI Yue WANG 2015Journal of Modern Power Systems and Clean Energy2015,3,1:6
19Analysis of the efficacy of transcatheter arterial infusion chemotherapy in the treatment of pancreatic carcinoma显示文摘Objective:To evaluate the clinical efficacy of infusion of gemcitabine(GEM) and fluorouracil(5-FU)through the celiac artery and superior mesenteric artery in the treatment of pancreatic carcinoma(PC).Methods:We analyzed 20 patients diagnosed clinically or pathologically with PC,without metastases,who had an estimated survival duration of>3 months in our department from May 2009 to December 2014.Nine patients were treated directly without surgical resection of the tumor,while the other 11 patients were treated after surgery.In all patients,the femoral artery was punctured using the Seldinger technique,and a catheter was placed in the opening of the celiac artery or the superior mesenteric artery.We administered 500 mg/m2 GEM and 500 mg/m2 5-FU.Observational data included data on clinical efficacy and survival rates during the follow-up period of 3-72 months.Results:Twenty patients were treated 85 times with transcatheter arterial infusion chemotherapy(TAI).The survival rates were 80%,40%,35%,20%,10%,and 5% at 3,6,12,24,and 72 months,respectively.Conclusion: TAI chemotherapy with GEM and 5-FU may be a therapeutic option for the treatment of PC.Chunhui Nie Yuelin Zhang Guanhui Zhou Tanyang Zhou Tongyin Zhu Baoquan Wang Shengqun Chen Hongliang Wang Ziniu Yu Li Jing Junhui Sun 2021Journal of Interventional Medicine2021,4,1:4
20Locomotor activity and anxiety status, but not spatial working memory,are affected in mice after brief exposure to cuprizone显示文摘Chronic long-term exposure to cuprizone causes severe brain demyelination in mice,which leads to changes in locomotion,working memory and anxiety.These findings suggest the importance of intact myelin for these behaviors.This study aimed to investigate the possible behavioral changes in mice with mild oligodendrocyte/myelin damage that parallels the white matter changes seen in the brains of patients with psychiatric disporders.We used the cuprizonetreated mouse model to test both tissue changes and behavioral functions(locomotor activity,anxiety status,and spatial working memory).The results showed that mice given cuprizone in their diet for 7 days had no significant myelin breakdown as evaluated by immunohistochemical staining for myelin basic protein,while the number of mature oligodendrocytes was reduced.The number and length of Caspr protein clusters,a structural marker of the node of Ranvier,did not change.The locomotor activity of the cuprizonetreated mice increased whereas their anxiety levels were lower than in normal controls;spatial working memory,however,did not change.These results,for the first time,link emotion-related behavior with mild white matter damage in cuprizone-treated mice.Handi Zhang Yanbo Zhang Haiyun Xu Lingyan Wang Jinsong Zhao Junhui Wang Zhijun Zhang Qingrong Tan Jiming Kong Qingjun Huang Xin-Min Li 2013Neuroscience Bulletin2013,29,5:4
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