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| 1 | 三氧化二砷对慢性粒细胞白血病细胞系的作用(英文)显示文摘本研究探讨三氧化二砷 (As2 O3)对两种慢性粒细胞白血病 (CML)细胞系有无作用及作用机制。实验选用了两种不同的CML细胞系KU81 2和MEG 0 1及两种其它白血病细胞系U937和PL2 1 ,加入不同浓度的As2 O3(0 .2 ,2和 1 0 μmol/L) ,在不同时间计数活细胞数 ,观察细胞形态 ,并以TUNEL法和DNA凝胶电泳检测细胞有无凋亡的发生 ;同时检测 0 .2 μmol/LAs2 O3作用时细胞表面CD34 ,CD1 3 ,CD33 ,CD1 9,CD1 1b ,CD1 4和CD7的变化 ,并通过RT PCR检测细胞bcr abl水平及caspase 3的变化。研究结果发现 ,不同浓度的As2 O3对 4种细胞系的作用不同 ,1 0 μmol/L时 4种细胞系均会发生细胞凋亡 ,2 μmol/L时则仅CML细胞系KU81 2和MEG 0 1会产生凋亡 ,0 .2μmol/L时 4种细胞系均不发生凋亡。在培养 2 4小时后 ,4种细胞系表面的CD34 ,CD1 3 ,CD33 ,CD1 9,CD1 1b ,CD1 4和CD7等均无明显改变。RT PCR检测bcr abl的水平发现在 2种CML细胞系中无明显改变 ,其caspase 3的活性较对照细胞均有所增加。结论 :As2 O3在较高浓度下可诱导 4种白血病细胞系产生凋亡 ,在 2 μmol/L仅可诱导CML来源的两种细胞系产生凋亡 ,CML细胞系对As2 O3较其它两种细胞系敏感 ,其作用机制与caspase | 景红梅 Shimizu Yukihiro 克晓燕 Kashii Yoshiro Watanabe Akiharu | 2002 | 中国实验血液学杂志2002，10，5： | 3 |
| 2 | Potential role of transient receptor potential (TRP) channels in bladder cancer cells显示文摘 | Hideki Mizuno Yoshiro Suzuki Masaki Watanabe Takaaki Sokabe Tokunori Yamamoto Ryohei Hattori Momokazu Gotoh Makoto Tominaga | 2014 | The Journal of Physiological Sciences2014，，4： | 1 |
| 3 | Larval parameters determining preschooling juvenile production of Pacific saury in the northwestern Pacific显示文摘 | Yoshiro Watanabe | 1997 | Can J Fish Aquat Sci Vol1997，54，： | 1 |
| 4 | Effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells显示文摘 | Megumi Miyamoto Yukihiro Shimizu Kazuhiko Okada Yoshiro Kashii Kiyohiro Higuchi Akiharu Watanabe | 1998 | Cancer Immunology Immunotherapy1998，，1： | 1 |
| 5 | Catalytic dehydrohalogenation of 1,2-dichloroethane over polyacrylonitrile-based active carbon fiber(PAN-ACF)显示文摘 | Isao Mochida Yoshiro Watanabe | | 0，，： | 1 |
| 6 | Growth and Survival of Pacific Saury Cololabis saira in the Kuroshio-Oyashio Transitional Waters显示文摘 | Yoshiro Watanabe Yutaka Kurita Masayuki Noto Yoshioki Oozeki Daiji Kitagawa | 2003 | Journal of Oceanography2003，，4： | 1 |
| 7 | Promoter polymorphism in the CD14 gene and concentration of soluble CD14 in patients with in-stent restenosis after elective coronary stenting显示文摘 | Kazunori Shimada Katsumi Miyauchi Hiroshi Mokuno Yoshiro Watanabe Yoshitaka Iwama Mariko Shigekiyo Megumi Matsumoto Shinya Okazaki Kosei Tanimoto Takeshi Kurata Hitoshi Sato Hiroyuki Daida | 2003 | International Journal of Cardiology2003，，： | 1 |
| 8 | Transport-determined early growth and development of jack mackerel Trachurus japonicus juveniles immigrating into Sagami Bay, Japan 显示文摘 | Xie S G Yoshiro Watanabe B | 2007 | Marine and Freshwater Research2007，58，： | 1 |
| 9 | Characterization of tumor-necrosis-factor-gene-transduced tumor-infiltrating lymphocytes from ascitic fluid of cancer patients: analysis of cytolytic activity, growth rate, adhesion molecule expression and cytokine production显示文摘 | Yoshinori Itoh Yoshikazu Koshita Minoru Takahashi Naoki Watanabe Yutaka Kohgo Yoshiro Niitsu | 1995 | Cancer Immunology Immunotherapy1995，，2： | 1 |
| 10 | Otolith Microstructure Analysis Reveals Different Growth Histories of Japanese Sardine (Sardinops melanostictus) in the Oyashio Waters显示文摘After decades of low year classes,the stock of Japanese sardine(Sardinops melanostictus)has begun to recover since the mid-2000s.The hatch dates and otolith growth rates of age-0 juvenile sardine,which were collected in the subarctic Oyashio waters in autumn 2018,were determined from an otolith microstructure analysis.The sardines were hatched from late January to late April,while mostly in February and March.The otolith growth rate increased continuously up to 60 d after hatching and thereafter de-creased.The revealed growth rate in a crucial growth period is faster than that reported for juvenile sardines collected in the 1990s,which is coincided with the recent recovery trend of the sardine stock.Two groups with different hatch dates,growth histories,and migration routes were identified using unsupervised random forest clustering analysis.They were considered inshore and offshore migration individuals in accordance with recent researches.In the offshore group,a high proportion of sardine juveniles hatched late and grew faster in the Kuroshio-Oyashio transitional waters,a finding consistent with the hypothesis of growth-rate-dependent re-cruitment.This finding on the population composition and growth rate of juvenile sardine in the Oyashio waters can be a basis for an improved prediction of their survival and provides us with valuable information on the recruitment processes of this stock during the period of stock recovery. | LIU Chunlin ZHANG Chi TIAN Yongjun WANG Liangming LIN Longshan LI Yuan WATANABE Yoshiro | 2022 | Journal of Ocean University of China2022，21，1： | 0 |
| 11 | Stock Structure Analysis of the Japanese Spanish Mackerel Scomberomorus niphonius(Cuvier, 1832) Along the China Coast Based on Truss Network显示文摘The Japanese Spanish mackerel Scomberomorus niphonius(Cuvier,1832)is widely distributed in the subtropical and temperate waters of the northwestern Pacific Ocean,supporting one of the most important commercial fisheries in China.However,ignoring the potential population structure changes induced by fishing pressure and climate change may undermine the population stability under the current management strategy.In this study,the population structure of the Japanese Spanish mackerel was investigated based on a morphometric truss network system.A total of 534 individuals were randomly collected from commercial gill nets spanning eight major spawning grounds in the Bohai,Yellow,and East China Seas during the peak spawning seasons respectively.A total of 17 measurements(including eye diameter)were conducted in each specimen and subjected to principal component analysis(PCA)and discriminant function analysis(DFA).The results of PCA indicated that the first two factors cumulatively caused 78.38%of the total morphometric variation and observable differences,primarily fin the caudal and trunk areas.The results of DFA revealed that the eight spawning groups can be divided into three stocks,i.e.,southern,middle,and northern stocks,with 68.7%of total accuracy.In contrast to previous studies,the spawning groups of the Japanese Spanish mackerel demonstrated a tendency to disperse to northern regions.In conclusion,this study found that to maintain the stability of the population structure and the total production of Japanese Spanish mackerel S.niphonius(Cuvier,1832),a newly revised management method should be developed and implemented. | JIANG Yiqian ZHANG Chi YE Zhenjiang XU Binduo TIAN Yongjun WATANABE Yoshiro | 2020 | Journal of Ocean University of China2020，19，2： | 0 |
| 12 | Age,growth,and mortality rate of the yellow goosefish Lophius litulon(Jordan,1902)in the Yellow Sea显示文摘With the decline in the most fisheries resources in the Yellow Sea,the yellow goosefish Lophius litulon has increased in commercial and ecological importance in recent years.We studied the length distribution,length-weight relationship,age composition,growth pattern,mortality,and exploitation rates of the yellow goosefish in the Yellow Sea.Total length(TL)of females and males ranged from 173 to 582 mm and 178 to 500 mm,respectively.The length-weight relationships were also estimated for females and males.Age classes from 2 to 4 years predominated in the samples.The von Bertalanffy growth function(VBGF),estimated based on non-linear least-squares methodology,showed significant differences between sexes.Females attained a greater estimated asymptotic total length(765 mm TL)compared to males(579 mm TL).The VBGF did not differ significantly between stocks of the northern Yellow Sea and the southern Yellow Sea.Estimated natural instantaneous mortality rate(M)ranged from 0.25/a to 0.33/a based on four age-and length-based methods.Total instantaneous mortality rate(Z)of total samples calculated by the age-based catch curve method was 0.591/a and the average fishing mortality(F)was 0.30/a.Estimated exploitation rate(E)was approximately 0.5,indicating that the population of L.litulon in the Yellow Sea may be sustainable.These results provide a reference for the present status of L.litulon and information for the management. | Yu SUN Chi ZHANG Yongjun TIAN Yoshiro WATANABE | 2021 | Journal of Oceanology and Limnology2021，39，2： | 0 |
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