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| 1 | Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells显示文摘人的表皮的生长因素受体 2 (HER2/neu,也作为 ErbB2 知道) overexpression 在癌症与差的预后和 chemoresistance 被相关。乳癌抵抗蛋白质(BCRP 和 ABCG2 ) 在许多癌症房间是为 multidrug 抵抗(MDR ) 负责的药流出泵。HER2 和 BCRP 在乳癌病人与差的治疗反应被联系,尽管在 HER2 和 BCRP 表示之间的关系不是清楚的。这里,我们证明进 MCF7 乳癌房间(MCF7/HER2 ) 的 HER2 的 transfection 经由 phosphatidylinositol 3-kinase (PI3K ) 导致了 BCRP 的一条起来规定 /Akt 和发信号的原子 factor-kappa B (NF-B ) 。有 PI3K 禁止者 LY294002, IB phosphorylation 禁止者 Bay11-7082,和 IB 的主导的否定异种的 MCF/HER2 房间的治疗禁止了导致 HER2 的 BCRP 倡导者活动。而且,我们发现 HER2 overexpression 导致了 MCF7 房间的一个增加的电阻到多重 antitumor 药象 paclitaxel (Taxol ) 那样, cisplatin (DDP ) , etoposide (VP-16 ) , adriamycin (ADM ) , mitoxantrone (MX ) ,和 5 氟尿嘧啶(5-FU ) 。而且, silencing BCRP 或有选择地的表示禁止 Akt 或 NF-B 的活动部分地至少敏化 MCF7/HER2 房间到这些化疗代理人。一起拿,通过表明小径的 PI3K/AKT/NF-B 的 BCRP 的起来规定在 MCF7 的调停 HER2 的 chemoresistance 起了一个重要作用房间,和 AKT, NF-B,和 BCRP 小径可能为治疗学的干预用作潜在的目标。 | Weijia Zhang Wei Ding Ye Chen Meilin Feng Yongmei Ouyang Yanhui Yu Zhimin He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 8 |
| 2 | A wave of Foxp3^(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance显示文摘Newborn animals require tightly regulated local and systemic immune environments to govern the development and maturation of multiple organs/tissues even though the immune system itself is far from mature during the neonatal period.Regulatory T cells(Tregs)are essential for maintaining immune tolerance/homeostasis and modulating inflammatory responses.The features of Tregs in the neonatal liver under steady-state conditions are not well understood.The present study aimed to investigate the phenotype,functions,and significance of neonatal Tregs in the liver.We found a wave of thymus-derived Treg influx into the liver during 1–2 weeks of age.Depletion of these Tregs between days 7 and 11 after birth rapidly resulted in Th1-type liver inflammation and metabolic disorder.More Tregs in the neonatal liver than in the spleen underwent MHC II-dependent activation and proliferation,and the liver Tregs acquired stronger suppressive functions.The transcriptomic profile of these neonatal liver Tregs showed elevated expression of PPARγand T-bet and features of Tregs that utilize lipid metabolic machinery and are capable of regulating Th1 responses.The accumulation of Tregs with unique features in the neonatal liver is critical to ensure self-tolerance and liver maturation. | Mingyang Li Weijia Zhao Yifan Wang Lixue Jin Gaowen Jin Xiuyuan Sun Wei Wang Ke Wang Xi Xu Jie Hao Rong Jin Wenxian Fu Ying Sun Yingjun Chang Xiaojun Huang Xuyu Zhou Hounan Wu Kunshan Zhang Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 3 | Connectivity in finite ad-hoc networks显示文摘Research on ad-hoc network connectivity has mainly focused on asymptotic results in the number of nodes in the network. For a one-dimensional ad-hoc network G1, assuming all the nodes are independently uniform distributed in a closed interval [0,Z](z ∈ R+), we derive a generic formula for the probability that the network is connected. The finite connected ad-hoc networks is analyzed. And we separately suggest necessary conditions to make the ad-hoc network to be connected in one and two dimensional cases, facing possible failed nodes (f-nodes). Based on the necessary condition and unit-disk assumption for the node transmission, we prove that the nodes of the connected two-dimensional ad-hoc networks (G2) can be divided into at most five different groups. For an f-node n0 in either of the five groups, we derive a close formula for the probability that there is at least one route between a pair of nodes in G2 - {n0}. | WANG HanXing LU GuiLin JIA WeiJia ZHAO Wei | 2008 | Science in China(Series F)2008，51，4： | 3 |
| 4 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 5 | Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens显示文摘我们采用了结合的复合聚合酶链反应(PCR ) 指向六的毛状的电气泳动(mPCR-CE ) 在为 toxigenic C 的同时的察觉和描述的 tcdC 的 Clostridium 顽固基因,包括的 tpi, tcdA, tcdB, cdtA, cdtB,和删除。顽固直接从烘便的标本。mPCR-CE 每反应有 10 个形成殖民地的单位的察觉的限制没有与另外的相关细菌的基因跨反应。临床的确认在 354 上被执行连续地与怀疑的 C 从病人收集了凳子标本。顽固感染并且 45 孤立。结果与与 BD 最大 Cdiff,即时房间分析试金(RTCA ) ,和 mPCR-CE 相结合的一个参考标准相比。toxigenic C。顽固种类在 36 被检测孤立并且由 mPCR-CE 的 45 个凳子标本,它提供了 20.3% 的积极的率(81/399 ) 。mPCR-CE 有 97.2% 的特性和 96.0% 的敏感,它比 RTCA 高(x 2= 5.67, P = 0.017 ) 但是比 BD 最大 Cdiff 低(P = 0.245 ) 。在 45 紧张之中,(97.8%) 44 作为 non-ribotype 被决定 027 由 mPCR-CE,它充分被适合于 PCR ribotyping。尽管 ribotypes 017 (n = 8, 17.8%) , 001 (n = 6, 13.3%) ,并且 012 (n = 7, 15.6%) 在这个区域是占优势的, ribotype 027 重要遗传型习惯性地被监视。mPCR-CE 为 toxigenic C 的同时的察觉提供了一个其他的诊断工具。在凳子顽固、在 RT027 和 non-RT027 之间潜在地区分。 | Hanjiang Lai Chen Huang Jian Cai Julian Ye Jun She Yi Zheng Liqian Wang Yelin Wei Weijia Fang Xianjun Wang Yi-Wei Tang Yun Luo Dazhi Jin | 2018 | Frontiers of Medicine2018，12，2： | 2 |
| 6 | 数值模拟火星古发电机湮灭前磁场特征显示文摘火星地壳磁场观测结果表明,该行星目前已经丧失了由其内部发电机作用产生的行星尺度的本征磁场,只在其表面残留不对称分布的剩余磁场.通过MoSST行星液核发电机动力学模式的前期模拟工作发现,在火星古发电机'死亡'之前,很可能处于亚临界发电机状态(此时维持发电机所需能量小于激发发电机所需能量).为了解火星发电机湮灭前的磁场特征,本文选取该亚临界发电机区间内,Rayleigh数(表征驱动发电机能量的无量纲参数)=2480时的火星表面磁场数据,采用自然经验正交函数对其分析,结果表明:在火星古发电机湮灭过程中的亚临界发电机状态下,火星表面磁场形态是非轴向偶极子占优的;并频繁出现磁极倒转和漂移现象,该过程中其磁偶极距随时间呈非单调形态的衰减. | 王天媛 ZiGang WEI WeiYuan JIANG WeiJia KUANG 马石庄 | 2013 | 中国科学:地球科学2013，43，1： | 2 |
| 7 | 2-Diphenylphosphinoyl-acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis ofβ-Glycosides显示文摘Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining the biological functions and activities of carbohydrate molecules.However,their stereochemistry control in glycosylation represents one of the most challenging tasks in carbohydrate chemistry. | Xianglai Liu Yetong Lin Ao Liu Qianhui Sun Huiyong Sun Peng Xu Guolong Li Yingying Song Weijia Xie Haopeng Sun Biao Yu Wei Li | 2022 | Chinese Journal of Chemistry2022，40，4： | 2 |
| 8 | Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins显示文摘 | Kong WeiJia Wei Jing Abidi P | 2004 | Nat Med2004，10，12： | 1 |
| 9 | Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: A Chinese experience显示文摘 | Weiyan Zheng Guoqing Wei Xiujin Ye Jingsong He Li Li Wenjun Wu Jimin Shi Jie Zhang Weijia Huang Wanzhuo Xie Yi Luo Xingkui Xue Maofang Lin He Huang Zhen Cai | 2009 | Leukemia Research2009，，12： | 1 |
| 10 | A shortcut for evaluating activities of TiO2 facets: water dissociative chemisorption on TiO2-B (100) and (001) 显示文摘 | Liu Weijia Wang Jianguo Li Wei Guo Xiaojing Lu Linghong Lu Xiaohua Feng Xin Liu Chang Yang Zhuhong | 2010 | Journal of Physical Chemistry C2010，12，31： | 1 |
| 11 | Dissociation of methanol on hydroxylated TiO2-B(100) surface: insights from first principle DFT calculation 显示文摘 | Liu Weijia Wang Jianguo Guo Xiaojing Fang Wei Wei Mingjie Lu Xiaohua Lu Linghong | 2011 | Catalysis Today2011，165，1： | 1 |
| 12 | Theoretical investigation of CO adsorption on clean and hydroxylated TiO2-B (100) surfaces 显示文摘 | Fang Wei Liu Weijia Guo Xiaojing Lu Xiaohua Lu Linghong | 2011 | Journal of Physical Chemistry C2011，115，1： | 1 |
| 13 | [3+3] Formal Cycloadditions of Nitrones from Isatins and Azaoxyallyl Cations for Construction of Spirooxindoles显示文摘一[3+3 ] 正式 cycloaddition 反应在之间在 situ,从靛红的形成的 azaoxyallyl 阳离子和 nitrones 被开发了,供应 spiro 的一个系列[1,2,4-oxadiazinan-5-one ] oxindoles 在对有优秀 diastereoselectivity 的优秀收益好。这个方法提供直接、有效的存取给潜在地合并六成员的杂环的脚手架的 bioactive spirooxindoles。 | Weijia Lin Gu Zhan Minglin Shi Wei Du Yingchun Chen | 2017 | Chinese Journal of Chemistry2017，35，6： | 1 |
| 14 | Guidelines on the Diagnosis and Management of Primary Biliary Cholangitis (2021)显示文摘In 2015, the Chinese Society of Hepatology and the Chinese Society of Gastroenterology published a consensus on pri-mary biliary cholangitis (PBC). In the past years, numerous clinical studies have been published in the field of PBC. To guide the clinical diagnosis and management of PBC patients, the Chinese Society of Hepatology invited a panel of experts to assess the new clinical evidence and formulate the current guidelines. | Hong You Weijia Duan Shuxiang Li Tingting Lv Sha Chen Lungen Lu Xiong Ma Ying Han Yuemin Nan Xiaoyuan Xu Zhongping Duan Lai Wei Jidong Jia Hui Zhuang Chinese Society of Hepatology,Chinese Medical Association | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 15 | Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins显示文摘 | Weijia Kong Jing Wei Parveen Abidi | 2004 | Nature Medicine2004，10，： | 1 |
| 16 | Embedding wasted hairs in Ti/PbO_(2) anode for efficient and sustainable electrochemical oxidation of organic wastewater显示文摘Despite of the hazardous risk of Pb^(2+) leakage, lead dioxide has been attributed as a quasi-ideal anode material with high oxygen evolution potential, excellent conductivity, good stability and low cost in electrochemical oxidation wastewater treatment technique. In this study, a novel Ti/PbO_(2) anode was fabricated by embedding raw materials that are readily and cheaply available, i.e., hairs. The structure-activity relationship of the new electrode was firstly revealed by material and electrochemical characterizations. Then different levels of pollutants (azo dye, phenol and maleic acid) were used to investigate the electrochemical oxidation performance of the new electrode. Finally, the accelerated electrode lifetime and Pb^(2+) leakage tests were carried out. Results showed that the embedded hairs changed the preferential crystallographic orientation of PbO_(2) and decreased the grain size. Hairs introduced additional roughness and active sites, and decreased the electrode impedance, especially under 5 mg/cm^(2) of embedding amount. The removal efficiencies of different target pollutants were enhanced more or less by embedding appropriate amount of hairs, depending on the current density, but loading excessive hairs had a negative effect. The accumulation of intermediate products during phenol degradation was also changed by the hairs. The new electrode could undergo ~550 h of harsh electrolysis. It is also relieved that the Pb^(2+) leakage was found to be suppressed during this long-term electrolysis process. | Dan Shao Zekang Wang Cuiping Zhang Weijia Li Hao Xu Guoqiang Tan Wei Yan | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 17 | Integrated routing algorithms for Anycast messages显示文摘 | JIA Weijia XUAN Dong ZHAO Wei | 2000 | IEEE Communication Magazine2000，38，1： | 1 |
| 18 | Coupling the Xinanjiang model with geomorphologic instantaneous unit hydrograph for flood forecasting in northeast China显示文摘The Xinanjiang(XAJ)model has been successfully applied in humid and semi-humid regions.Considering the geomorphologic factors to accurately estimate floods,this study adopted the geomorphologic instantaneous unit hydrograph(GIUH)method to calculate the surface runoff instead of the experience unit hydrograph(EUH)in the original model.The geomorphologic factors of the case study basin were obtained by using a digital elevation model(DEM)and the Terrain analysis using Digital Elevation Models(TauDEM).Furthermore,the dynamic Muskingum model was used for the channel flood routing.This study focused on the simulation of heavy precipitation and floods over the Chong River,which is a tributary river to the Songhua River on the right bank in northeast China.The detailed steps of the method were shown,up to the estimated value of flood runoff discharges and flood peaks and their comparison with observed values.The average deterministic coefficients(DCs)of model calibration and validation were 0.89 and 0.83,respectively.The results show that the model precision is high and the model is feasible for flood forecasting.Lastly,some methodological perspectives to enhance the method are presented. | Fanghua Hao Mingze Sun Xiaojun Geng Weijia Huang Wei Ouyangn | 2015 | International Soil and Water Conservation Research2015，3，1： | 1 |
| 19 | Integrated muting algorithms for anycast messages显示文摘 | Jia Weijia Xuan Dong Zhao Wei | 2000 | IEEE Communications Magazine2000，，1： | 1 |
| 20 | Effect of thermal annealing on the optical properties of CdGeAs 2 wafers显示文摘 | Wei Huang Beijun Zhao Shifu Zhu Zhiyu He Baojun Chen Jiawei Li You Yu Jingjing Tang Weijia Liu | 2013 | Journal of Crystal Growth2013，，： | 1 |
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