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| 1 | Diagnostic value of 5 serum biomarkers for hepatocellular carcinoma with different epidemiological backgrounds:A large-scale,retrospective study显示文摘Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this retrospective study,we measured the serum levels of each biomarker using ELISAs in 921 participants,including 298 patients with HCC,154 patients with chronic hepatitis(CH),122 patients with liver cirrhosis(LC),and 347 healthy controls from 3 hospitals.Patients negative for hepatitis B surface antigen and hepatitis C antibody(called'NBNC-HCC')and patients positive for the above indices(called'HBV-HCC and HCV-HCC')were enrolled.The selected diagnostic model was constructed using a training cohort(n=468),and a validation cohort(n=453)was used to validate our results.Receiver operating characteristic analysis was used to evaluate the diagnostic accuracy.Results:Theα-L-fucosidase(AFU)/α-fetoprotein(AFP)combination was best able to distinguish NBNC-HCC[area under the curve:0.986(95%confidence interval:0.958–0.997),sensitivity:92.6%,specificity:98.9%]from healthy controls in the test cohort.For screening populations at risk of developing HCC(CH and LC),the AFP/AFU combination improved the diagnostic specificity for early-stage HCC[area under the curve:0.776(0.712–0.831),sensitivity:52.5%,specificity:91.6%in the test group].In all-stage HBV-HCC and HCV-HCC,AFU was also the best candidate biomarker combined with AFP[area under the curve:0.835(0.784–0.877),sensitivity 69.1%,specificity:87.4%in the test group].All results were verified in the validation group.Conclusions:The AFP/AFU combination could be used to identify NBNC-HCC from healthy controls and hepatitis-related HCC from at-risk patients. | Dongming Liu Yi Luo Lu Chen Liwei Chen Duo Zuo Yueguo Li Xiaofang Zhang Jing Wu Qing Xi Guangtao Li Lisha Qi Xiaofen Yue Xiehua Zhang Zhuoyu Sun Ning Zhang Tianqiang Song Wei Lu Hua Guo | 2021 | Cancer Biology & Medicine2021，18，1： | 10 |
| 2 | Aromatization over nanosized Ga-containing ZSM-5 zeolites prepared by different methods:Effect of acidity of active Ga species on the catalytic performance显示文摘Nanosized Ga-containing ZSM-5 zeolites were prepared via isomorphous substitution and impregnation followed by characterized using various techniques. The catalytic performance of the zeolites for the aromatization of 1-hexene was investigated. The results indicate that isomorphous substitution promotes the incorporation of Ga heteroatoms into the framework along with the formation of extra-framework GaO^+species([GaO^+]a) that have stronger interactions with the negative potential of the framework. In addition, based on the Py-IR results and catalytic performance, the [GaO^+]aspecies with stronger Lewis acid sites produced a better synergism with moderate Br?nsted acid sites and thus improved the selectivity to aromatic compounds. However, the impregnation results in the formation of Ga_2O_3 phase and small amounts of GaO^+species that are mainly located on the external surface([GaO^+]~b), which contribute to weaker Lewis acid sites due to weaker interactions with the zeolite framework. During 1-hexene aromatization, the nanosized Ga isomorphously substituted ZSM-5 zeolite samples(Gax-NZ5) exhibited better catalytic performance compared to the impregnated samples, and the highest aromatic yield(i.e.,65.4 wt%) was achieved over the Ga4.2-NZ5 sample, which contained with the highest Ga content. | Yujun Fang Xiaofang Su Xuefeng Bai Wei Wu Gaoliang Wang Linfei Xiao Anran Yu | 2017 | Journal of Energy Chemistry2017，26，4： | 8 |
| 3 | Effects of rare earth modifying inclusions on the pitting corrosion of 13Cr4Ni martensitic stainless steel显示文摘In this study,the pitting corrosion behavior of 13Cr4Ni martensitic stainless steel(BASE)and that modified with rare earth(REM)in 0.1 mol/L Na Cl solution were characterized.Techniques such as automatic secondary electron microscope(ASPEX PSEM detector),scanning electron microscope(SEM),transmission electron microscope(TEM),scanning Kelvin probe force microscope(SKP),potentiodynamic and potentiostatic polarizations were employed.The results obtained indicate that BASE steel contains Al_(2)O_(3)/Mn S,Al_(2)O_(3) and Mn S inclusions,while REM steels contain(La,Ce,Cr,Fe)-O and(La,Ce,Cr,Fe)-O-S inclusions.Compared with BASE steel,REM steel is more susceptible to induce the metastable pitting nucleation and repassivation,whereas it restrains the transition from metastable pitting to stable pitting.Adding 0.021%rare earth element to BASE steel can reduce the number and area of inclusions,while that of 0.058%can increase the number and enlarged the size of inclusions,which is also the reason that pitting corrosion resistance of 58 REM steel is slightly lower than that of 21 REM steel.In the process of pitting corrosion induced by Al_(2)O_(3)/Mn S inclusions,Mn S is preferentially anodic dissolved,and also the matrix contacted with Al_(2)O_(3) is subsequently anodic dissolved.For REM steels,anodic dissolution preferentially occurs at the boundary between inclusions and matrix,while(La,Ce,Cr,Fe)-O inclusions chemically dissolve in local acidic environment or are separated from steel matrix.The chemically dissolved substance(La^(3+) and Ce^(3+))of(La,Ce,Cr,Fe)-O inclusions are concentrated in pitting pits,which inhibits its continuous growth. | Changgang Wang Rongyao Ma Yangtao Zhou Yang Liu Enobong Felix Daniel Xiaofang Li Pei Wang Junhua Dong Wei Ke | 2021 | Journal of Materials Science & Technology2021，，34： | 8 |
| 4 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 5 | Diversity and redundancy of the ripening regulatory networks revealed by the fruitENCODE and the new CRISPR/Cas9 CNR and NOR mutants显示文摘Tomato is considered as the genetic model for climacteric fruits,in which three major players control the fruit ripening process:ethylene,ripening transcription factors,and DNA methylation.The fruitENCODE project has now shown that there are multiple transcriptional circuits regulating fruit ripening in different species,and H3K27me3,instead of DNA methylation,plays a conserved role in restricting these ripening pathways.In addition,the function of the core tomato ripening transcription factors is now being questioned.We have employed CRISPR/Cas9 genome editing to mutate the SBP-CNR and NAC-NOR transcription factors,both of which are considered as master regulators in the current tomato ripening model.These plants only displayed delayed or partial non-ripening phenotypes,distinct from the original mutant plants,which categorically failed to ripen,suggesting that they might be gain-of-function mutants.Besides increased DNA methylation genome-wide,the original mutants also have hyper-H3K27me3 in ripening gene loci such as ACS2,RIN,and TDR4.It is most likely that multiple genetic and epigenetic factors have contributed to their strong non-ripening phenotypes.Hence,we propose that the field should move beyond these linear and twodimensional models and embrace the fact that important biological processes such as ripening are often regulated by highly redundant network with inputs from multiple levels. | Ying Gao Ning Zhu Xiaofang Zhu Meng Wu Cai-Zhong Jiang Donald Grierson Yunbo Luo Wei Shen Silin Zhong Da-Qi Fu Guiqin Qu | 2019 | Horticulture Research2019，6，1： | 7 |
| 6 | Composition and solution properties of fluorinated block copolymers and their surface structures in the solid state显示文摘A series of diblock copolymers composed of methyl methacrylate and 2-perfluorooctylethyl methacry-late(PMMA144-b-PFMAn) with various PFMA block lengths were prepared by atom transfer radical po-lymerization(ATRP).The surface structures and properties of these polymers in the solid state and in solution were investigated using contact angle measurement,X-ray photoelectron spectroscopy(XPS),sum frequency generation(SFG) vibrational spectroscopy,surface tension and dynamic laser light scattering(DLS).It was found that with increasing PFMA block length,water and oil repellency de-creased,the ratio of F/C increased with increasing film depth,and the degree of ordered packing of the perfluoroalkyl side chains at the surface decreased.When the number of PFMA block units reached 10,PMMA segments were detected at the copolymer surface,which was attributed to the PFMA block length affecting molecular aggregation structure of the copolymer in the solution and the interfacial structure at the air/liquid interface,which in turn affects surface structure formation during solution solidification.The results suggest that copolymer solution properties play an important role in struc-ture formation on the solid surface. | NI HuaGang XUE DongWu WANG XiaoFang ZHANG Wei WANG XinPing SHEN ZhiQuan | 2009 | Science China Chemistry2009，52，2： | 6 |
| 7 | Efficient catalytic conversion of carbohydrates into 5-ethoxymethylfurfural over MIL-101-based sulfated porous coordination polymers显示文摘In this work, a series of MIL-101-SO3H(x) polymeric materials were prepared and further used for the first time as efficient heterogeneous catalysts for the conversion of fructose-based carbohydrates into 5-ethoxymethylfurfural(EMF) in a renewable mixed solvent system consisting of ethanol and tetrahydrofuran(THF). The influence of –SO3H content on the acidity as well as on the catalytic activity of the porous coordination polymers in EMF production was also studied. High EMF yields of 67.7% and 54.2% could be successively obtained from fructose and inulin in the presence of MIL-101-SO_3H(100) at 130 °C for 15 h.The catalyst could be reused for five times without significant loss of its activity and the recovery process was facile and simple. This work provides a new platform by application of porous coordination polymers(PCPs) for the production of the potential liquid fuel molecule EMF from biomass in a sustainable solvent system. | Xiaofang Liu Hu Li Hu Pan Heng Zhang Shan Huang Kaili Yang Wei Xue Song Yang | 2016 | Journal of Energy Chemistry2016，25，3： | 6 |
| 8 | A Study of the Characteristics of Microorganisms for Effective Degradation of Marine Oil Spills显示文摘Four microorganism strains were isolated from coastal petroleum-polluted soil and sand samples of Bohai Sea oilfield; they were found to degrade marine oil spills effectively. The experimental results show that the degradation efficiency of crude oil with these four strains (XT-4, SZ-1-25, B-4-9, BS-3-12) is 95.97%, 96.01%, 97.99% and 98.99%, respectively, in their optimum conditions. The characteristics of bacterial biodegradation are investigated. The simulation biotreatment of oil-contaminated beach sand, with an initial oil content of 5,664mg/kg-dry-sand, shows that the residual oil content is 2,700 mg/kg-dry-sand and 2,679 mg/kg-dry-sand after 170 days’ treatment with two bacteria (B-4-9, BS-3-12), respectively. | Zhang Zhongzhi Wei Xiaofang Zong Chang Yu Hongwen Li Chengjian He Ruibing | 2006 | Petroleum Science2006，3，1： | 6 |
| 9 | Solid Acid Used as Highly Efficient Catalyst for Esterification of Free Fatty Acids with Alcohols显示文摘Anovel solid acid catalyst, which was prepared from sodium alginate (SA) and metal chlorides and characterized with XRD and FT-IR spectrometry, was used for the preparation of biodiesel via esterification reaction. The study results showed that the aluminum-alginate complex prepared in a cheap and easy way exhibited high catalytic activity, and a 92.6% conversion of methyl oleate was obtained in the presence of 4m% of catalyst dosage upon refluxing for 3h of methanol and acid mixed in a molar ratio of 10:1. It should be noted that the catalyst can be applied to the esterification reaction of fatty acids with various carbon chain length on methanol or different short chain alcohols, indicating that the catalyst is suitable for the preparation of biodiesel from waste oils with a high acid value. | Zhang Qiuyun Li Hu Qin Wenting Liu Xiaofang Zhang Yuping Xue Wei Yang Song | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 6 |
| 10 | Numerical study of hydrofoil surface jet flow on cavitation suppression显示文摘Cavitation caused vibration and noise of hydraulic machinery. To some extent,cavitation made fatigue damage in advance. Many scholars found that the re-entrant jets were the reasons of the shedding of cavities. To suppress cavitation,based on the idea of blocking the re-entrant jets,a special surface flow structure of 2D hydrofoil was proposed. The through-hole was made in the proper position of the hydrofoil. The incoming flow can outflow from this jet-hole automatically depending on the pressure difference between pressure side and suction side. Re-entrant jet growth can be weakened by optimizing the jet-hole geometry. Based on the standard k-ε turbulence model and Schnerr & Sauer cavitation model,under different cavitation numbers( σ) and jet-angles( β) for NACA0066( 2D) hydrofoil with 8° angles of attack,cavitation field numerical analysis was carried out. The results show that 2D hydrofoil cavitation flow had a strong unsteadiness. Making a jet-hole at the junction between the re-entrant jet and cavity can effectively minimize cloud cavitation. For a certain cavitation condition,optimal jet-angles( β) can be obtained to control cavitation growth. For the same β,the effects of cavitation suppression were changed with different cavitation numbers( σ). Consequently,suitable jet-angle and jet-position could extend the stable operating range of the hydrofoil. | WANG Wei LU Shengpeng XU Ruiduo YI Qi WANG Yayun WANG Xiaofang | 2017 | 排灌机械工程学报2017，35，10： | 5 |
| 11 | Local heat transfer properties in co- and counter-current G-L-S magnetically stabilized fluidized beds显示文摘Heat transfer coefficients were measured by immersed probes in co- and counter-current G-L-S magneti-cally stabilized fluidized beds (MSFBs) using air, water and nickel-alloy particles as the gas, liquid and solid phases. Influences of major factors, including magnetic field intensity, superficial gas and liquid velocities, liquid viscosity and surface tension, on heat-transfer properties were studied experimentally, indicating that both co- and counter-current G-L-S MSFB can provide relatively uniform radial distribution of heat transfer coefficients under appropriate operation conditions, thus controlling operation temperature for highly exothermic multi-phase reaction systems. Two correlations were provided to estimate accurately heat transfer properties in both co- and counter-current G-L-S MSFB systems, with an average error of less than 10%. | Jinli Zhang Ming Zhang Wei Li Xiaofang Li Xiangkun Meng Baoning Zong | 2011 | Particuology2011，9，1： | 5 |
| 12 | Optical property of amorphous semiconductor mercury cadmium telluride from first-principles study显示文摘The structural and optical properties of amorphous semiconductor mercury cadmium telluride (a-MCT) are obtained by the first principles calculations. The total pair distribution functions and the density of states show that the a-MCT has the semiconductor characteristic. The calculated results of dielectric function show that E2 peak of the imaginary of dielectric function for the crystal mercury cadmium telluride abruptly disappears in the amorphous case due to the long-range disorders. And the imaginary of dielectric function of a-MCT shows a large broad peak, which is in agreement with the available results of other amorphous semiconductors. From the linear extrapolation of the curve ωε 2(ω)1/2 versus ω, it can be obtained that the optical energy gap of amorphous semiconductor Hg0.5Cd0.5Te is 0.51±0.05 eV. | WANG Liang CHEN XiaoShuang LU Wei HUANG Yan WANG XiaoFang ZHAO JiJun | 2009 | Science China(Technological Sciences)2009，52，7： | 4 |
| 13 | L-S mass transfer in G-L-S countercurrent magnetically stabilized bed with amorphous alloy SRNA-4 catalyst显示文摘Liquid-solid (L-S) mass transfer coefficients (Ks) were characterized in a gas-liquid-solid (G-L-S) three-phase countercurrent magnetically stabilized bed (MSB) using amorphous alloy SRNA-4 as the solid phase. Effects of superficial liquid velocity, superficial gas velocity, magnetic field strength, liquid viscosity and surface tension were investigated. Experimental results indicated that the external magnetic field increased Ks in three-phase MSB, as compared to those in conventional G-L-S fluidized beds; that Ks increased with magnetic field strength, superficial gas and liquid velocities and decreased with liquid viscosity and surface tension; and that Ks showed uniform axial and radial distributions except for small increases close to the wall. Dimensionless correlations were established to estimate Ks of the G-L-S countercurrent MSB using SRNA-4 catalyst, with an average error of 3.6%. | Wei Li Baoning Zong Xiaofang Li Xiangkun Meng Jinli Zhang | 2007 | China Particuology2007，5，1： | 4 |
| 14 | Adaptability research of hydrofoil surface water injection on cavitation suppression显示文摘To study the effectiveness of hydrofoil surface water injection on cavitation suppression,the unsteady cavitation flow field around the NACA0066 hydrofoil at attack angle of 6°was simulated by the modified RNG k-εturbulence model combined with the full-cavitation model.The structure of cavitation flow field and the hydrodynamic performance of hydrofoil were analyzed at the cavitation number of 0.85,0.70,0.55,respectively.The results show that barriered by the jet,the momentum of the reentrant jet was reduced;The development of cavitation and the strength of cavity shedding were weakened to some extent.Cavitation suppression effect was very obvious in the cavitation conditions with the cavitation number of 0.7 and above when the injection position was at 37% chord length from the hydrofoil leading edge and the jet-flow ratio kept 0.3.Time-averaged lift and drag coefficient were reduced,and the lift-drag ratio increased in water injection conditions. | WANG Wei YI Qi WANG Yayun LU Shengpeng WANG Xiaofang | 2017 | 排灌机械工程学报2017，35，6： | 4 |
| 15 | Genetic analysis of fertility restoring genes for AL-type male sterility in wheat显示文摘In order to screen molecular markers linked to fertility restoring genes and further improve the breeding efficiency of restorer lines,in this study,wheat varieties 18A,18B and 99AR144-1 were used as experimental materials to establish F2 fertility-segregating population. Plant quantitative trait'major gene + polygene mixed model'separation analysis method and simple sequence repeat(SSR) molecular markers were adopted for genetic analysis of four generations,including the parents(P1 and P2),and hybrid(Fl and F2) populations. The results show that AL-type fertility restoring gene is controlled by two pairs of additive-dominant-epistatic genes and additive-dominant polygene;two primers linked to fertility restoring genes were selected by SSR molecular markers, including Xgwm95 on chromosome 2A and Barc61 on chromosome 1B,with the linkage distance of 15.0 cM and 18.0 cM,respectively. Based on verification,these two markers are reliable for distinguishing AL-type wheat sterile lines and restorer lines. | Liu Xiaofang Tian Xiaoming Nie Yingbin Mu Peiyuan Han Xinnian Sang Wei Cui Fengjuan Xu Hongjun Xiang Jishan | 2013 | Engineering Sciences2013，11，5： | 4 |
| 16 | The synergic effects of highly selective bimetallic Pt-Pd/SAPO-41 catalysts for the n-hexadecane hydroisomerization显示文摘The hydroisomerization of n-hexadecane over Pt-Pd bimetallic catalysts is an effective way to produce clean fuel oil.This work reports a useful preparation method of bimetallic bifunctional catalysts by a co-impregnation or sequential impregnation process.Furthermore,monometallic catalysts with loading either Pt or Pd are also prepared for comparison.The effects of the metal species and impregnation order on the characteristics and catalytic performance of the catalysts are investigated.The catalytic test results indicate that the maximum iso-hexadecane yield over different catalysts increases as follows:Pt/silicoaluminophosphate SAPO-41 | Guozhi Jia Chunmu Guo Wei Wang Xuefeng Bai Xiaomeng Wei Xiaofang Su Tong Li Linfei Xiao Wei Wu | 2021 | Frontiers of Chemical Science and Engineering2021，15，5： | 4 |
| 17 | Tinea faciei in a newborn due toTrichophyton tonsurans显示文摘We report here the first case of neonatal tinea faciei caused by Trichophyton tonsurans in China's Mainland.The mother of the infant had tinea corpris and tinea capitis while the father had tinea incongnito.The infections in the parents were mycologically confirmed to be due to Trichophyton tonsurans.Ttinea faciei in the infant was cured after two-week topical use of amorolfine cream.The mother ceased breastfeeding and took oral terbinafine for 4 weeks.No recurrence was observed in the infant during 12 months of follow-up. | Meihua Fu Yiping Ge Wei Chen Suying Feng Xiaodong She Xiaofang Li Weida Liu | 2013 | The Journal of Biomedical Research2013，27，1： | 3 |
| 18 | Fabrication of superstable gold nanorod-carbon nanocapsule as a molecule loading material显示文摘In this work, we fabricated a monodisperse nanocomposite by coating gold nanorods(Au NRs) with a layer of biocompatible, stable carbon, obtaining Au NR@Carbon core–shell nanocapsules, which without any functionalization could be used as a molecule loading material due to its high surface areas. In this system, the Au NR core had a high-absorption cross section for conversion of near-infrared light to heat, which could be explored for local hyperthermia. The carbon shell, which was biocompatible and stable even under concentrated acidic and alkaline conditions, was able to adsorb molecules with p–p interactions or electrostatic interactions. In comparison with Au NR@Si O2, Au NR@Carbon nanocapsules demonstrate the following merits:(1) simple and green synthesis method,(2) far more stable with respect to high-temperature stability and(3) larger molecule loading capacity,which indicate great potential in the biomedical applications. | Wei Gao Xuewei Wang Huanhuan Fan Zhiling Song Xiaofang Lai Zhuo Chen Weihong Tan | 2015 | Science Bulletin2015，60，12： | 3 |
| 19 | The metabolic role of LncZBTB39-1:2 in the trophoblast mobility of preeclampsia显示文摘Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks’gestation and is a leading cause of maternal and neonatal morbidity and mortality.The pathogenesis of preeclampsia is often associated with aberrant trophoblast function that leads to shallow placental implantation.However,the exact underlying mechanisms remain unclear.Placental LncZBTB39-1:2 expression level was investigated in 20 healthy placentae and 20 placentae with preeclampsia using qRT-PCR,and the metabolic profile of trophoblasts overexpressing LncZBTB39-1:2 in vitro was analysed using gas chromatography-mass spectrometry(GCeMS).In this study,we found that the expression of LncZBTB39-1:2 was significantly higher in preeclamptic placentae than in healthy placentae.Our metabolomics results have shown that tricarboxylic acid cycle intermediates and metabolites related to carbohydrate metabolism were decreased with the overexpression of LncZBTB39-1:2 in HTR8/SVneo cells.These findings were validated by detecting a lower level of intracellular ATP in HTR8/Vneo cells.Furthermore,the migration of HTR8/SVneo cells was compromised when cells were transfected with a plasmid encompassing LncZBTB39-1:2 overexpression.From these results,we conclude that abnormal levels of LncZBTB39-1:2 expression might lead to aberrant conditions in HTR-8/SVneo trophoblast cells.Aberrant conditions might be associated with dysregulated trophoblast migration and subsequent failure of uterine spiral artery remodelling,a pathogenesis recognised as a contributing factor in the aetiology of preeclampsia. | Yamin Liu Ting-Li Han Xiaofang Luo Yuxiang Bai Xuehai Chen Wei Peng Xi Xiong Philip N.Baker Chao Tong Hongbo Qi | 2018 | Genes & Diseases2018，5，3： | 3 |
| 20 | Improved bias proportional navigation with multiple constraints for guide ammunition显示文摘According to the infrared guidance ammunition(GA)attacking non-maneuvering targets on the ground or sea level,an improved bias proportional navigation(IBPN) is put forward,which can meet the constraints of the impact angle and the angle of attack(AOA). The motion equations and the collision triangle for the GA and the target are established in the two-dimensional plane. In accordance with the collision triangle, the integral value of the bias term is solved and BPN is designed on the basis of the relative velocity. To ensure the new method can be solved, closedloop equation of the IBPN is deduced. Considering the limitation of the AOA and the seeker angle, a four-phase IBPN is improved by setting different phases of the bias term. At the same time, the guidance law will make the impact angle achieve the desired angle and the normal acceleration also converges to zero. The simulation results show that the improved guidance law can be applied to various flight tasks and has great potential for engineering applications. | Wei Pang Xiaofang Xie Tao Sun | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 3 |
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