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| 1 | Co-encapsulation of curcumin and doxorubicin in albumin nanoparticles blocks the adaptive treatment tolerance of cancer cells显示文摘The adaptive treatment tolerance (ATT) of cancer cells is the main encumbrance to cancer chemotherapy. A potential solution to this problem is to treat cancer cells with multiple drugs using nanoparticles (NPs). In this study, we tested the co-administration of curcumin (Cur) and doxorubicin (Dox) to MCF-7 resistant breast cancer cells to block the ATTand elicit efficient cell killing. Drugs were co-administered to cells both sequentially and simultaneously. Sequential drug co-administration was carried out by pre-treating the cells with albumin nanoparticles (ANPs) loaded w让h Cur (Cur@ANPs) followed by treatment with Dox-loaded ANPs (Dox@ANPs). Simultaneous drug co-administration was carried out by treating the cells with ANPs loaded with both the drugs (Cur/Dox@ANPs). We found that the simultaneous drug co-administration led to a greater intra-cellular accumulation of Dox and cell killing with respect to the sequential drug co-administration. However;the simultaneous drug co-administration led to a lower intracellular accumulation of Cur with respect to the sequential drug co-administration. We showed that this result was due to the aggregation and entrapment of Cur in the lysosomes as soon as it was released from Cur@ANPs, a phenomenon called lysosomotropism. In contrast, the simultaneous release of Dox and Cur from Cur/Dox@ANPs into the lysosomes led to lysosomal pH elevation, which, in turn, avoided Cur aggregation, led to lysosome swelling and drug release in the cytosol, and finally provoked efficient cell killing. Our study shed the light on the molecular processes driving the therapeutic effects of anti-cancer drugs co-administered to cancer cells in different manners. | Seyed Mohammad Motevalli Ahmed Shaker Eltahan Lu Liu Andrea Magrini Nicola Rosato Weisheng Guo Massimo Bottini Xing-Jie Liang | 2019 | Biophysics Reports2019，5，1： | 3 |
| 2 | Integration of high-performance spin-orbit torque MRAM devices by 200-mm-wafer manufacturing platform显示文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future. | Hongchao Zhang Xiangyue Ma Chuanpeng Jiang Jialiang Yin Shuqin Lyu Shiyang Lu Xiantao Shang Bowen Man Cong Zhang Dandan Li Shuhui Li Wenjing Chen Hongxi Liu Gefei Wang Kaihua Cao Zhaohao Wang Weisheng Zhao | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 3 | Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase gene from Ginkgo biloba显示文摘 | Lu Jie Wu Weisheng Cao Shuwen | 2008 | Mol Biol Rep2008，35，3： | 1 |
| 4 | Scenarios for applying RFID technology in construction project management 显示文摘 | LU WEISHENG HUANG GEORGE Q LI HENG | 2011 | Automation in construction2011，，： | 1 |
| 5 | Engineered nanoparticles circumvent the adaptive treatment tolerance to immune-checkpoint blockade therapy显示文摘The fight against cancer has witnessed the rapid develop・ment of various therapeutic methodologies,including chemotherapy,surgery,radiotherapy,phototherapy,and the emerging immunotherapy[1].However,malignancies evolve adaptive tolerance under the threatening conditions upon therapies because of some potential biological or genetic mutations,which may cause serious adverse events,compromised therapeutic efficacy and even treatment failure.For instance,following the standard chemotherapy with paclitaxel,primary breast cancer can release exosomes that facilitate the seeding and growth of metastatic cancer cells in distant organs[2].Therefore,the term'adaptive treatment tolerance'(ATT),rather than'drug resistance',has been employed to better describe the dynamic evolution of this phenomenon during/post cancer therapy. | Weisheng Guo Lu Liu Chenyang Xiang Jingqi Chen Xing-Jie Liang | 2019 | Science China Chemistry2019，62，12： | 1 |
| 6 | Exploring critical success factors for waste management in construction projects of China显示文摘 | WEISHENG LU HONGPING YUAN | 2010 | Resources Conservation and Recycling2010，55，2： | 1 |
| 7 | An empirical investigation of construction and demolition waste generation rates in Shenzhen city, South China 显示文摘 | Weisheng Lu Hongping Yuan Jingru Li | 2011 | Waste Management2011，31，4： | 1 |
| 8 | Wind and Photovoltaic Power Time Series Data Aggregation Method Based on an Ensemble Clustering and Markov Chain显示文摘Reducing the input wind and photovoltaic power time series data can improve the efficiency of time sequential simulations.In this paper,a wind and photovoltaic power time series data aggregation method based on an ensemble clustering and Markov chain(ECMC)is proposed.The ECMC method can effectively reduce redundant information in the data.First,the wind and photovoltaic power time series data were divided into scenarios,and ensemble clustering was used to cluster the divided scenarios.At the same time,the Davies-Bouldin Index(DBI)is adopted to select the optimal number of clusters.Then,according to the temporal correlation between wind and photovoltaic scenarios,the wind and photovoltaic clustering results are merged and reduced to form a set of combined typical day scenarios that can reflect the characteristics of historical data within the calculation period.Finally,based on the Markov Chain,the state transition probability matrix of various combined typical day scenarios is constructed,and the aggregation state sequence of random length is generated,and then,the combined typical day scenarios of wind and photovoltaic were sampled in a sequential one-way sequence according to the state sequence and then are built into a representative wind and photovoltaic power time series aggregation sequence.A provincial power grid was chosen as an example to compare the multiple evaluation indexes of different aggregation methods.The results show that the ECMC aggregation method improves the accuracy and efficiency of time sequential simulations. | Jingxin Jin Lin Ye Jiachen Li Yongning Zhao Peng Lu Weisheng Wang Xuebin Wang | 2022 | CSEE Journal of Power and Energy Systems2022，8，3： | 1 |
| 9 | Competi-tiveness in construction:a critical review of research con-struction显示文摘 | ROGER F LU WEISHENG SHEN L | 2007 | Construction Management and Economics2007，，25： | 1 |
| 10 | Competitiveness in construction: a critical review of research显示文摘 | Flanagan R Lu Weisheng Shen Liyin | 2007 | Construction Management and Economics2007，，25： | 1 |
| 11 | Numerical study of liquid coverage in a gas-liquid-solid packed bed显示文摘 | Wei Du Lifeng Zhang Sha Lv Panpan Lu Jian xu Weisheng Wei | 2015 | Particuology2015，13，6： | 1 |
| 12 | Mo-based perpendicularly magnetized thin films with low damping for fast and low-power consumption magnetic memory显示文摘Perpendicular magnetic anisotropy-based magnetic tunnel junctions(p-MTJs) with low Gilbert damping constant(α) are of particular interest for fast and low-power consumption magnetic random-access memory(MRAM). However, obtaining a faster switching speed and lower power consumption is still a big challenge. Herein, we report a Mo-based perpendicular double free layer structure with a low Gilbert damping constant of 0.02 relative to W-based films, as measured by time-resolved magnetooptical Kerr effect equipment. To show the influence of different film structures on the Gilbert damping constant, we measured the Mo-based single free layer. Thereafter, we deposited the full stacks with the Mo-based double free layer and obtained a high tunneling magnetoresistance of 136.3% and high thermal stability. The results of high-resolution transmission electron microscopy(HR-TEM) and energy-dispersive X-ray spectroscopy(EDS) showed that the Mo-based films had better crystallinity,sharper interfaces, and weaker diffusion than the W-based films and thus produced a weaker external contribution of the Gilbert damping constant. As a result of the weak spin-orbit coupling in the Mo-based structure, the intrinsic contribution of the Gilbert damping constant was also weak, thereby leading to the small Gilbert damping constant of the Mo-based stacks. In addition, the macro-spin simulation results demonstrated that the magnetization switching by the spin transfer torque of the Mo-based MTJs was faster than that of the W-based MTJs. These findings help to understand the mechanism behind the good performance of Mo-based p-MTJ films and show the great promise of these structures in low-power consumption MRAM or other spintronic devices. | Houyi Cheng Boyu Zhang Yong Xu Shiyang Lu Yuxuan Yao Rui Xiao Kaihua Cao Yongshan Liu Zilu Wang Renyou Xu Danrong Xiong Yan Wang Helin Ma Sylvain Eimer Chao Zhao Weisheng Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 0 |
| 13 | Biomimetic nanomedicines for precise atherosclerosis theranostics显示文摘Atherosclerosis(AS)is a leading cause of the life-threatening cardiovascular disease(CVD),creating an urgent need for efficient,biocompatible therapeutics for diagnosis and treatment.Biomimetic nanomedicines(b NMs)are moving closer to fulfilling this need,pushing back the frontier of nano-based drug delivery systems design.This review seeks to outline how these nanomedicines(NMs)might work to diagnose and treat atherosclerosis,to trace the trajectory of their development to date and in the coming years,and to provide a foundation for further discussion about atherosclerotic theranostics. | Ying Tao Xinmiao Lan Yang Zhang Chenxing Fu Lu Liu Feng Cao Weisheng Guo | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 14 | Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques显示文摘Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular event.Early detection and precise intervention of VASP hold great clinical significance,yet remain a major challenge.Photodynamic therapy(PDT)realizes potent ablation efficacy under precise manipulation of laser irradiation.In this study,we constructed theranostic nanoprobes(NPs),which could precisely regress VASPs through a cascade of synergistic events triggered by local irradiation of lasers under the guidance of fluorescence/MR imaging.The NPs were formulated from human serum albumin(HSA)conjugated with a high affinity-peptide targeting osteopontin(OPN)and encapsulated with photosensitizer IR780 and hypoxia-activatable tirapazamine(TPZ).After intravenous injection into atherosclerotic mice,the OPN-targeted NPs demonstrated high specific accumulation in VASPs due to the overexpression of OPN in activated foamy macrophages in the carotid artery.Under the visible guidance of fluorescence and MR dual-model imaging,the precise near-infrared(NIR)laser irradiation generated massive reactive oxygen species(ROS),which resulted in efficient plaque ablation and amplified hypoxia within VASPs.In response to the elevated hypoxia,the initially inactive TPZ was successively boosted to present potent biological suppression of foamy macrophages.After therapeutic administration of the NPs for 2 weeks,the plaque area and the degree of carotid artery stenosis were markedly reduced.Furthermore,the formulated NPs displayed excellent biocompatibility.In conclusion,the developed HSA-based NPs demonstrated appreciable specific identification ability of VASPs and realized precise synergistic regression of atherosclerosis. | Mengqi Xu Cong Mao Haoting Chen Lu Liu Yabin Wang Abid Hussain Sulei Li Xu Zhang Ruslan G.Tuguntaev Xing-Jie Liang Weisheng Guo Feng Cao | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 15 | Spin-orbit torque efficiency enhancement to tungsten-based SOT-MTJs by interface modification with an ultrathin MgO显示文摘Spin-orbital torque (SOT) based three-terminal magnetic tunnel junctions (MTJs) have attracted much interest as the next generation magnetic random-access memory (MRAM)key device both in the academy and the industry.This is because SOT-MTJs feature high endurance and fast switching speed,benefiting tremendously from the separation of read/write current paths and less incubation time during the write in contrast to the spin-transfer torque (STT) MTJs [1]. | Shiyang LU Xiaobai NING Hongchao ZHANG Sixi ZHEN Xiaofei FAN Danrong XIONG Dapeng ZHU Gefei WANG Hong-Xi LIU Kaihua CAO Weisheng ZHAO | 2024 | Science China(Information Sciences)2024，67，1： | 0 |
| 16 | Demonstration of a manufacturable SOT-MRAM multiplexer array towards industrial applications显示文摘We have successfully demonstrated a 1 Kb spin-orbit torque(SOT)magnetic random-access memory(MRAM)multiplexer(MUX)array with remarkable performance.The 1 Kb MUX array exhibits an in-die function yield of over 99.6%.Additionally,it provides a sufficient readout window,with a TMR/RP_sigma%value of 21.4.Moreover,the SOT magnetic tunnel junctions(MTJs)in the array show write error rates as low as 10^(-6)without any ballooning effects or back-hopping behaviors,ensuring the write stability and reliability.This array achieves write operations in 20 ns and 1.2 V for an industrial-level temperature range from-40 to 125℃.Overall,the demonstrated array shows competitive specifications compared to the state-of-the-art works.Our work paves the way for the industrial-scale production of SOT-MRAM,moving this technology beyond R&D and towards widespread adoption. | Chuanpeng Jiang Jinhao Li Hongchao Zhang Shiyang Lu Pengbin Li Chao Wang Zhongkui Zhang Zhengyi Hou Xu Liu Jiagao Feng He Zhang Hui Jin Gefei Wang Hongxi Liu Kaihua Cao Zhaohao Wang Weisheng Zhao | 2023 | Journal of Semiconductors2023，44，12： | 0 |
| 17 | NVP-BEZ235/Chlorin-e6 co-loaded nanoparticles ablate breast cancer by biochemical and photodynamic synergistic effects显示文摘为三元组否定的乳癌(TNBC ) 寻求有利治疗吸引了强烈研究兴趣。然而,为 TNBC 的有效痊愈在肿瘤学仍然是未解决的挑战。第一次,此处,我们描述与 NVP-BEZ235 和 Chlorin-e6 装载的聚合 nanoparticles 的使用,作为 NVP/Ce6@NPs 表示了,在生物化学、光力学的治疗之间完成由利用 synergistic 克服 TNBC 的适应治疗忍耐。在激光照耀之上, NVP/Ce6@NPs 产生了反应的氧种类(ROS ) 并且高效地通过 DNA 损坏导致了肿瘤房间的 apoptosis。而且,释放 NVP-BEZ235 能阻止 Chk1 导致 phosphorylation 的 DNA 损坏修理,因此提高肿瘤房间的敏感到 ROS。忍受一个 MDA- MB-231 肿瘤的老鼠上的动物研究验证了 NVP/Ce6@NPs 与 monotherapies 的相比有更大的治疗学的功效,与 89.3% 的抑制比率。西方的弄污和房间生存能力分析由 NVP/Ce6@NPs 证实了两 MDA-MB-231 房间增长和 Chk1 phosphorylation 的抑制。这些调查结果提供生物化学 / 光力学的治疗的 synergistic 效果的合理理解并且铺平道路让有效治疗学的途径的发展与 TNBC 斗争。 | Ahmed Shaker Eltahan Lu Liu Chukwunweike Ikechukwu Okeke Min Huang Lu Han Jing Chen Xue Xue Massimo Bottini Weisheng Guo Xing-Jie Liang | 2018 | Nano Research2018，11，9： | 0 |
| 18 | Blockchain-based smart contract for smart payment in construction: A focus on the payment freezing and disbursement cycle显示文摘Late payment,and indeed no payment,is a rampant and chronic problem that has plagued the global construction industry for too long.Recent development in blockchain technology,particularly its smart contract,seems to provide a new opportunity to improve this old problem.However,this opportunity is largely unexploited.This study aims to develop a blockchain-based smart contract(BBSC)system for smart payment in the construction industry by focusing on the fundamental cycle of payment freezing(sometimes also synonymously called payment guarantees)and disbursement application.Firstly,a BBSC framework,containing three processes of(a)initiation and configuration,(b)payment freezing,and(c)disbursement application,is developed.Next,based on the framework,the system architecture of the BBSC system,containing three layers of(1)Infrastructure as a Service(IaaS),(2)Blockchain as a Service(BaaS),and(3)Software as a Service(SaaS)is proposed and elaborated.Finally,based on the system architecture,a BBSC prototype system is developed using a real-life modular construction project as a case study.It was found that the prototype system can improve the certainty and efficiency of the progress payment,thereby enabling smart payment in construction transactions.Without advocating radical changes(e.g.,the contractual relationships or the intermediate role of banks in modem construction projects),the prototype can be developed into a real-life BBSC system that can work compatibly with current advancements in the field.Future works are recommended to fine-tune the findings and translate and implement them in real-life applications. | Liupengfei WU Weisheng LU Jinying XU | 2022 | Frontiers of Engineering Management2022，9，2： | 0 |
| 19 | A Demonstration of Automatically Switched Optical Network显示文摘We build an automatically switched optical network (ASON) testbed with four optical cross-connect nodes. Many fundamental ASON features are demonstrated, which is implemented by control protocols based on generalized multi-protocol label switching (GMPLS) framework. | Weisheng Hu, Yaohui Jin, Chun Jiang, Yue Wang, Xiaodong Wang, Chunlei Zhang, Yang Lu,Buwei Xu, Peigang Hu, Qingji ZengState Key Lab of Advanced Optical Communication Systems and Networks, Shanghai Jiao Tong University, P. R.China, Tel: 86-21-62932029, E-mail: wshu@sjtu.edu.cn | 2003 | 光学学报2003，23，S1： | 0 |
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