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| 1 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 2 | Selectivity regulation of CO2 electroreduction through contact interface engineering on superwetting Cu nanoarray electrodes显示文摘Electrocatalytic CO2 reduction is a promising way to mitigate the urgent energy and environmental issues, but how to increase the selectivity for desired product among multiple competi ng reaction pathways remains a bottle neck. Here, we demonstrate that engineering the gas-liquid-solid contact interface on the electrode surface could tailor the selectivity of CO2 reducti on and meanwhile suppress H2 production through regulated reacti on kin etics. Specifically, polytetrafl uoroethyle ne (PTFE) was utilized to modify a Cu nano array electrode as an example, which is able to cha nge the electrode surface from aerophobic to aerophilic state. The en riched nano-tunnels of the Cu nano array electrode can facilitate CO2 transportation and pin gaseous products on the electrode surface. The latter is believed to be the reason that boosts the Faradaic efficie ncy of liquid products by 67% and limits the H2 producti on to less than half of before. This in terface engin eeri ng strategy also lowered H2O (proton) affinity, therefore promoting CO and HCOOH production. Engineering the electrode contact interface controls the reaction kinetics and the selectivity of products, which should be inspiring for other electrochemical reactions. | Zhao Cai Yusheng Zhang Yuxin Zhao Yueshen Wu Wenwen Xu Xuemei Wen Yang Zhong Ying Zhang Wen Liu Hailiang Wang Yun Kuang Xiaoming Sun | 2019 | Nano Research2019，12，2： | 5 |
| 3 | The Kangding earthquake swarm of November, 2014显示文摘There was an earthquake swarm of two major events of MS6.3 and MS5.8 on the Xianshuihe fault in November, 2014. The two major earthquakes are both strike-slip events with aftershock zone along NW direction.We have analyzed the characteristics of this earthquake sequence. The b value and the h value show the significant variations in different periods before and after the MS5.8earthquake. Based on the data of historical earthquakes, we also illustrated the moderate-strong seismic activity on the Xianshuihe fault. The Kangding earthquake swarm manifests the seismic activity on Xianshuihe fault may be in the late seismic active period. The occurrence of the Kangding earthquake may be an adjustment of the strong earthquakes on the Xianshuihe fault. The Coulomb failure stress changes caused by the historical earthquakes were also given in this article. The results indicate that the earthquake swarm was encouraged by the historical earthquakes since1893, especially by the MS7.5 Kangding earthquake in1955. The Coulomb failure stress changes also shows the subsequent MS5.8 earthquake was triggered by the MS6.3earthquake. | Wen Yang Jia Cheng Jie Liu Xuemei Zhang | 2015 | Earthquake Science2015，28，3： | 5 |
| 4 | On the founder effect in COVID-19 outbreaks:how many infected travelers may have started them all?显示文摘How many incoming travelers(I0 at time 0,equivalent to the‘founders’in evolutionary genetics)infected with SARS-CoV-2 who visit or return to a region could have started the epidemic of that region?I0 would be informative about the initiation and progression of epidemics.To obtain I0,we analyze the genetic divergence among viral populations of different regions.By applying the‘individual-output’model of genetic drift to the SARS-CoV-2 diversities,we obtain I0<10,which could have been achieved by one infected traveler in a long-distance flight.The conclusion is robust regardless of the source population,the continuation of inputs(It for t>0)or the fitness of the variants.With such a tiny trickle of human movement igniting many outbreaks,the crucial stage of repressing an epidemic in any region should,therefore,be the very first sign of local contagion when positive cases first become identifiable.The implications of the highly‘portable’epidemics,including their early evolution prior to any outbreak,are explored in the companion study(Ruan et al.,personal communication). | Yongsen Ruan Zhida Luo Xiaolu Tang Guanghao Li Haijun Wen Xionglei He Xuemei Lu Jian Lu Chung-I Wu | 2021 | National Science Review2021，8，1： | 3 |
| 5 | Pentatricopeptide repeat protein PHOTOSYSTEM I BIOGENESIS FACTOR2 is required for splicing of ycf3显示文摘To gain a better understanding of the molec-ular mechanisms of photosystem!(PSI)biogenesis,wecharacterized the Arabidopsis thaliana photosystem l bio-genesis factor 2(pbf2)mutant,which lacks PSl complex.PBF2 encodes a P-class pentatricopeptide repeat(PPR)protein.In the pbf2 mutants,we observed a striking de-crease in the transcript level of only one gene,thechloroplast gene ycf3,which is essential for PSl assembly.Further analysis of ycf3 transcripts showed that PBF2 isspecifically required for the splicing of ycf3 intron 1.Computational prediction of binding sequences and elec-trophoretic mobility shift assays reveal that PBF2 specifi-cally binds to a sequence in ycf3 intron 1.Moreover,we found that PBF2 interacted with two general factors forgroup ll intron splicing CHLOROPLAST RNA SPLICING2-AsSOCIATED FACTOR1(CAF1)and CAF2,and facilitated theassociation of these two factors with ycf3 intron 1.Ourresults suggest that PBF2 is specifically required for thesplicing of ycf3 intron 1 through cooperating with CAF1and CAF2.Our results also suggest that additional proteinsare required to contribute to the specificity of CAF-dependent group ll intron splicing. | Xuemei Wang Zhipan Yang Yi Zhang Wen Zhou Aihong Zhang Congming Lu | 2020 | Journal of Integrative Plant Biology2020，62，11： | 2 |
| 6 | Revisiting the role of delta-1-pyrroline-5-carboxylate synthetase in drought-tolerant crop breeding显示文摘The delta-1-pyrroline-5-carboxylate synthetase(P5CS)gene exercises a protective function in stressed plants.However,the relationship between proline accumulation caused by P5CS and abiotic stress tolerance in plants is not always clear,as P5CS overexpression has been reported to repress plant growth under normal conditions in several reports.We re-evaluated the role of P5CS in drought-tolerant rice breeding by expressing the AtP5CS1 and feedback-inhibition-removed AtP5CS1(AtP5CS1^(F128A))genes under the regulation of an ABA-inducible promoter to avoid the potential side effects of P5CS overexpression under normal conditions.ABA-inducible AtP5CS1 and AtP5CS1^(F128A) increased seedling growth in a nutrient solution(under osmotic stress)and grain yield in pot plants.However,the evidently deleterious effects of AtP5CS1 on grain quality,tiller number,and grain yield in the field indicated the unsuitability of P5CS for drought-tolerance breeding. | Xuanjun Feng Yue Hu Weixiao Zhang Rongqian Xie Huarui Guan Hao Xiong Li Jia Xuemei Zhang Hanmei Zhou Dan Zheng Ying Wen Qingjun Wang Fengkai Wu Jie Xu Yanli Lu | 2022 | The Crop Journal2022，10，4： | 2 |
| 7 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 8 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 9 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 10 | Death causes and pathogens analysis of systemic lupus erythematosus during the past 26 years显示文摘 | Yunyun Fei Xiaochun Shi Fengying Gan Xuemei Li Wen Zhang Mengtao Li Yong Hou Xuan Zhang Yan Zhao Xiaofeng Zeng Fengchun Zhang | 2014 | Clinical Rheumatology2014，，1： | 1 |
| 11 | Neural networks-based adaptive control for nonlinear time-varying systems with unknown control direction显示文摘 | Wen Yuntong Ren Xuemei | 2011 | IEEE Trans on Neural Networks2011，22，10： | 1 |
| 12 | The Improved Simulated Annealing Algorithm and Application in the Surface Wave Dispersion Inversion显示文摘The velocity distribution of layers from surface wave dispersion curve is a severely nonlinear program. Base on the Metropolis rule,we improved the simulated annealing algorithm to simultaneously inverse the velocities and thicknesses using the dispersion data and identified the Moho and the bottom of lithosphere. The application to the numerical examples with 5% noise shows the velocity RMS is 1. 56% between the non-linear results and the original models when the condition of selecting method for temperature parameters and initial temperature are satisfied. Using the pure dispersions of Rayleigh wave,the nonlinear inversion has been carried out for S-wave velocities and thicknesses of the vertical profile crossing the Indian Plate,the Qinghai-Tibetan Plateau,and the Tarim Basin. It indicated that the crustal thickness is about 70 km in the Qiangtang block,while in the hinterland of the Qinghai-Tibetan Plateau the lithosphere is relatively thin(~ 130 km)from the velocity values and their offsets. | ZHANG Xuemei YANG Zhigao SHI Haixia DU Guangbao YANG Wen WEI Xing HAN Yanyan LI Fei HUANG Zhibin LIU Jie | 2019 | Earthquake Research in China2019，33，3： | 1 |
| 13 | Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer显示文摘 | Wen Tan Jianxiong Wu Xuemei Zhang | 2007 | Carcinogenesis2007，28，6： | 1 |
| 14 | Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies显示文摘 | Baoan Chen Feng Gao Jing Chen Jun Wang Wei Hulai Jian Cheng Xia Guohua Baoan Chen Liu Lijie Chuanlu Xu Wu Weiwei Bao wen Zhang Yi Ding Jiahua Yang Liya Shen Huiling Yang Mimgming Xu Wenlin Xuemei Wang | 2010 | 2010 (defa)2010，，： | 1 |
| 15 | Homocysteine-related hTERT DNA demethylation contributes to shortened leukocyte telomere length in atherosclerosis显示文摘 | Donghong Zhang Xuemei Wen Wei Wu Ermu Xu Yujuan Zhang Wei Cui | 2013 | Atherosclerosis2013，，： | 1 |
| 16 | Ultra-high general and special color rendering index white organic light-emitting device based on a deep red phosphorescent dye显示文摘 | Yang Li Wei Zhang Letian Zhang Xuemei Wen Yongming Yin Shihao Liu Wenfa Xie Hongyu Zhao Silu Tao | 2013 | Organic Electronics2013，，12： | 1 |
| 17 | On the origin of SARS-CoV-2——The blind watchmaker argument显示文摘In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive.By the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection. | Chung-I Wu Haijun Wen Jian Lu Xiao-dong Su Alice CHughes Weiwei Zhai Chen Chen Hua Chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang Bingjie Chen Zixiao Guo Yongsen Ruan Xuemei Lu Fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang | 2021 | Science China(Life Sciences)2021，64，9： | 1 |
| 18 | Identification of Functional Genetic Variants in Cyclooxygenase -2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Z Xiaoping M Wen T | 2005 | Gastroenterology2005，129，2： | 1 |
| 19 | Terahertz metalens of hyper-dispersion显示文摘Chromatic optical lenses have promising applications in three-dimensional imaging, which allows fast spectral tomography without mechanical moving parts. The scanning range of current chromatic optical lenses is limited by their dispersion ability. The recent development in metasurfaces provides ideal blocks for optical wavefront manipulation and dispersion engineering of artificial materials at sub-wavelength scales. Hyper-dispersive metalenses can be realized by utilizing dispersive meta-atoms, which have enhanced dispersion compared to regular diffractive lenses. This is critical for increasing the imaging depth of fast spectral tomography. In this work, a hyper-dispersive metalens is realized with a chromatic dispersion 1.76 times greater than that of a regular diffractive metalens in the THz frequency range of 2.40–2.61 THz by simultaneously controlling the frequencydependent phase, group delay(GD), and GD dispersion of the metalens. This approach can also be extended to other optical spectra and improve the performance of spectral tomography. | Fen Zhao Ziping Li Sheng Li Xuemei Dai Yi Zhou Xiaoyu Liao JCCao Gaofeng Liang Zhengguo Shang Zhihai Zhang Zhongquan Wen Hua Li Gang Chen | 2022 | Photonics Research2022，10，4： | 1 |
| 20 | Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer显示文摘 | Zhang Xuemei Miao Xiaoping Tan Wen | 2005 | Gastroenterology2005，129，： | 1 |
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