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| 1 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 2 | Atomistic molecular simulations of structure and dynamics of crosslinked epoxy resin 显示文摘 | Wu Chaofu Xu Weijian | 2007 | Polymer2007，48，19： | 1 |
| 3 | Atomistic molecular modelling of crosslinked epoxy resin 显示文摘 | WU CHAOFU XU WEIJIAN | 2006 | Polymer2006，47，16： | 1 |
| 4 | Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality:an application of multistate models in a prospective cohort study显示文摘Background and purpose The role of depression in the development and outcome of cardiometabolic diseases remains to be clarified.We aimed to examine the extent to which depressive symptoms affect the transitions from healthy to diabetes,stroke,heart disease and subsequent all-cause mortality in a middle-aged and elderly European population.Methods A total of 78212 individuals aged≥50 years from the Survey of Health Ageing and Retirement in Europe were included.Participants with any baseline cardiometabolic diseases including diabetes,stroke and heart disease were excluded.Depressive symptoms were measured by the Euro-Depression scale at baseline.Participants were followed up to determine the occurrence of cardiometabolic diseases and all-cause mortality.We used multistate models to estimate the transition-specific HRs and 95%CIs after adjustment of confounders.Results During 500711 person-years of follow-up,4742 participants developed diabetes,2173 had stroke,5487 developed heart disease and 7182 died.Depressive symptoms were significantly associated with transitions from healthy to diabetes(HR:1.12,95%CI:1.05 to 1.20),stroke(HR:1.31,95%CI:1.18 to 1.44),heart disease(HR:1.26,95%CI:1.18 to 1.34)and all-cause mortality(HR:1.41,95%CI:1.34 to 1.49).After cardiometabolic diseases,depressive symptoms were associated with the increased risk of all-cause mortality in patients with diabetes(HR:1.54,95%CI:1.25 to 1.89),patients who had stroke(HR:1.29,95%CI:1.03 to 1.61)and patients with heart disease(HR:1.21,95%CI:1.02 to 1.44).Conclusions Depressive symptoms increase the risk of diabetes,stroke and heart disease,and affect the risk of mortality after the onset of these cardiometabolic conditions.Screening and treatment of depressive symptoms may have profound implications for the prevention and prognosis of cardiometabolic diseases. | Yanan Qiao Siyuan Liu Guochen Li Yanqiang Lu Ying Wu Yi Ding Chaofu Ke | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 5 | Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing显示文摘Smart manufacturing still remains critical challenges for pharmaceutical manufacturing.Here,an original data-driven engineering framework was proposed to tackle the challenges.Firstly,from sporadic indicators to five kinds of systematic quality characteristics,nearly 2,000,000 real-world data points were successively characterized from Ginkgo Folium tablet manufacturing.Then,from simplex to the multivariate system,the digital process capability diagnosis strategy was proposed by multivariate C_(pk)integrated Bootstrap-t.The C_(pk)of Ginkgo Folium extracts,granules,and tablets were discovered,which was 0.59,0.42,and 0.78,respectively,indicating a relatively weak process capability,especially in granulating.Furthermore,the quality traceability was discovered from unit to end-to-end analysis,which decreased from 2.17 to 1.73.This further proved that attention should be paid to granulating to improve the quality characteristic.In conclusion,this paper provided a data-driven engineering strategy empowering industrial innovation to face the challenge of smart pharmaceutical manufacturing. | Lijuan Ma Jing Zhang Ling Lin Tuanjie Wang Chaofu Ma Xiaomeng Wang Mingshuang Li Yanjiang Qiao Yongxiang Wang Guimin Zhang Zhisheng Wu | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 1 |
| 6 | Atomistie molecular simulations of struc- ture and dynamics of crosslinked epoxy resin 显示文摘 | Chaofu Wu Weijian Xu | 2007 | Polymer2007，48，19： | 1 |
| 7 | Atomistic simulation study of absorbed water influence on structure and properties of erosslinked epoxy resin显示文摘 | Chaofu Wu Weijian Xu | 2007 | Polymer2007，48，18： | 1 |
| 8 | Competitive absorption of epoxy monomers on carbon nanotube: a molecular simulation study显示文摘 | Chaofu Wu | | Journal of polymer science part B : Polymer physics0，49，15： | 1 |
| 9 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 10 | Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large B-cell lymphoma显示文摘Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed the data on 502 patients with DLBCL treated in our institution from January 2013 to March 2018. Survival functions were estimated using Kaplan Meier method and Cox regression model. The 3-year progression free survival (PFS) and overall survival (OS) rates were 70.2% and 80.9%, respectively, and the complete remission (CR) rate was 78.1%. Among the patients, those with multiple (≥3) abnormal immunologic markers had significantly shorter 3-year PFS (52.7% vs. 77.3%, P < 0.001) and OS (68.5% vs. 85.8%, P=0.001) than those without multiple abnormal immunologic markers.Multivariate analysis revealed that the presence of multiple abnormal immunologic markers and the elevated serum levels of lactate dehydrogenase were the independent adverse prognostic factors for PFS (P= 0.008, P < 0.001) and OS (P = 0.003, P < 0.001). Meanwhile, advanced Ann Arbor stage was an independent adverse prognostic factor for PFS (P= 0.001) and age > 60 years for OS (P= 0.014). In conclusion, the immunologic status was closely related to lymphoma progression, and this study provides new insights into the risk stratification of patients with DLBCL. | Yiwen Cao Zhenhua Liu Wen Wu Ying Qian Qin Shi Rong Shen Binshen Ouyang Pengpeng Xu Shu Cheng Jin Ye Yiming Lu Chaofu Wang Chengde Yang Li Wang Weili Zhao | 2019 | Frontiers of Medicine2019，13，1： | 0 |
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