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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Centrifugal model test on a riverine landslide in the Three Gorges Reservoir induced by rainfall and water level fluctuation显示文摘Frequent soil landslide events are recorded in the Three Gorges Reservoir area,China,making it necessary to investigate the failure mode of such riverside landslides.Geotechnical centrifugal test is considered to be the most realistic laboratory model,which can reconstruct the required geo-stress.In this study,the Liangshuijing landslide in the Three Gorgers Reservoir area is selected for a scaled centrifugal model experiment,and a water pump system is employed to retain the rainfall condition.Using the techniques of digital photography and pore water pressure transducers,water level fluctuation is controlled,and multi-physical data are thus obtained,including the pore water pressure,earth pressure,surface displacement and deep displacement.The analysis results indicate that:Three stages were set in the test(waterflooding stage,rainfall stage and drainage stage).Seven transverse cracks with wide of 1–5 mm appeared during the model test,of which 3 cracks at the toe landslide were caused by reservoir water fluctuation,and the cracks at the middle and rear part were caused by rainfall.During rainfall process,the maximum displacement of landslide model reaches 3 cm.And the maximum deformation of the model exceeds 12 cm at the drainage stage.The failure process of the slope model can be divided into four stages:microcracks appearance and propagation stage,thrust-type failure stage,retrogressive failure stage,and holistic failure stage.When the thrust-type zone caused by rainfall was connected or even overlapped with the retrogressive failure zone caused by the drainage,the landslide would start,which displayed a typical composite failure pattern.The failure mode and deformation mechanism under the coupling actions of water level fluctuation and rainfall are revealed in the model test,which could appropriately guide for the analysis and evaluation of riverside landslides. | Fasheng Miao Yiping Wu Ákos Török Linwei Li Yang Xue | 2022 | Geoscience Frontiers2022，13，3： | 3 |
| 5 | An Awareness-Adoption Matrix for Strategic Decision Making in Agricultural Development Projects: A Case Study in Yunnan Province, China显示文摘Significant achievements have been made in generating sustainable agricultural technologies in developing countries. Usually, these new technologies have been more effective in increasing production and productivity than existing technologies. However, many new technologies considered ‘effective’ have not been successful in alleviating the associated sustainability problems, due to poor adoption by targeted users. Success of any novel technical intervention should be judged on the basis of how widespread adoption is in the target area by targeted users. In this context, a case study identified the factors affecting farmers’ adoption of improved technologies extended by an agricultural development project in a rural Village in Yunnan Province, China. Initial adoption/adaptation of project technologies was influenced by farmers’ awareness of the technology. Farmers were more aware of polythene mulch, contour cultivation, intercropping and tree planting technologies than others. This led to a comparatively high initial uptake of polythene mulch, contour cultivation, sweet chestnut, and intercropping technologies. Farmers had inadequate knowledge about some Project technologies, the adoption of which was particularly low. This reveals the need for increasing farmers’ awareness about the rationale for Project technologies to achieve greater adoption/adaptation of project technologies by farmers over wider areas. Farmers’ testing of the technology leads to better adoption/adaptation compared to mere awareness. However, considerable time and resources are required for testing/trying technologies. This justifies the usefulness of comparatively quick and less resource demanding options for awareness creation. Development of effective cropping technologies is important for sustainable agricultural development. The success of any agricultural development project, especially in terms of improving sustainability, depends on how widely those improved technologies are adopted/adapted by farmers in the targeted region. Therefore, farmers’ adoption of technologies should be a key criterion for judging the success of any project. The awareness-adoption matrix is a useful tool to guide research and development projects to achieve expected adoption/adaptation of technologies. Use of the matrix helps identification of weak and strong aspects of research and development projects and thus assists strategic decision-making. | M Subedi T J Hocking M A Fullen A R McCrea E Milne WU Bo-zhi D J Mitche | 2009 | Agricultural Sciences in China2009，8，9： | 2 |
| 6 | Coefficient of restitution and rotational motions of rockfall impacts显示文摘 | CHAU K T WONG R H C WU J J | 2002 | International Journal of Rock Mechanics & Mining Sciences2002，39，： | 1 |
| 7 | Novel baculovirus DNA elements strongly stimulate activities of exogenous and endogenous promoters 显示文摘 | LO H R CHOU C C WU T Y | 2002 | The Journal of Biological Chemistry2002，277，7： | 1 |
| 8 | Analysis of Clay Deformation as a Rate Process显示文摘 | Christensen R W Wu T H | 1964 | Journal of the Soil Mechanics and Foundations Division ASCE1964，90，6： | 1 |
| 9 | Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters显示文摘 | Wu L F Hughes T R Davierwala A P | 2002 | Nat Genet2002，31，7： | 1 |
| 10 | Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs 显示文摘 | Krieg A M Wu T Weeratna R | 1998 | Proc Natl Acad Sci USA1998，95，12： | 1 |
| 11 | An improved formalism for FDTD analysis of thin-slot problems by conformal mapping technique显示文摘 | Wu C T Pang Y H Wu R B | 2003 | IEEE Trans Antennas Propagation2003，51，9： | 1 |
| 12 | Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippecampal neurons显示文摘 | Zhao L Wu T Brinton R D | 2004 | Brain Res2004，1010，12： | 1 |
| 13 | KILLER/DR5is a DNA damage-inducible p53-regulatcd death receptor gene显示文摘 | Wu G S Burns T F McDonald E R | | 0，，： | 1 |
| 14 | Multiphoton magneto opticaltrap显示文摘 | Wu S Plisson T Brown R C | 2009 | Phys Rev Lett2009，103，17： | 1 |
| 15 | Pharmacokinetic interactions of concomitant administration of febuxostat and NSAIDs显示文摘 | Khosravan R Wu J T Joseph Ridge N | | 0，，08： | 1 |
| 16 | 查看详情显示文摘 | Zhang Y H Fu S Y Li R K Y Wu J T Li L F Ji J H | | 0，，11： | 1 |
| 17 | A multidomain boundary element solution for silencer and muffler performance prediction显示文摘 | Cheng C Y R Seybert A F Wu T W | | 0，，1： | 1 |
| 18 | Oscillation criteria for certain even order nonlinear functional differential equa-tions 显示文摘 | WU H W WANG Q R XU Y T | 2004 | Dynamic Systems and Applications2004，13，： | 1 |
| 19 | Probabilistic methods for design assessment of reliability with in- spect ion 显示文摘 | Wu Y T Enright M P Millwater H R | 2002 | AIAA Journal2002，40，5： | 1 |
| 20 | Relation between ligament of marshall and adrenergic atrial tachyarrhythmia显示文摘 | Doshi R N Wu T J Yashima M | 1999 | Circulation1999，100，8： | 1 |
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