|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Xanthogranulomatous cholecystitis:Difficulty in differentiating from gallbladder cancer显示文摘AIM: To compare cases of xanthogranulomatous cholecystitis(XGC) and advanced gallbladder cancer and discuss the differential diagnoses and surgical options.METHODS: From April 2000 to December 2013, 6 XGC patients received extended surgical resections. During the same period, 16 patients were proven to have gallbladder(GB) cancer, according to extended surgical resection. Subjects chosen for analysis in this study were restricted to cases of XGC with indistinct borders with the liver as it is often difficult to distinguish these patients from those with advanced GB cancer. We compared the clinical features and computed tomography findings between XGC and advanced GB cancer. The following clinical features were retrospectively assessed: age, gender, symptoms, and tumor markers. As albumin and the neutrophil/lymphocyte ratio(NLR) are prognostic in several cancers, we compared serum albumin levels and the NLR between the two groups. The computerized tomography findings were used to compare the two diseases, determine the coexistence of gallstones, the pattern of GB thickening(focal or diffuse), the presence of a hypoattenuated intramural nodule, and continuity of the mucosal line.RESULTS: Based on the preoperative image findings, we suspected GB carcinoma in all cases includingXGC in this series. In addition, by pathological examination, we found that the group of patients with XGC developed inflammatory disease after surgery. Patients with XGC tended to have abdominal pain(4/6, 67%). However, there was no significant difference in clinical symptoms, including fever, between the two groups. Serum albumin and NLR were also similar in the two groups. Serum tumor markers, such as carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9), tended to increase in patients with GB cancer. However, no significant differences in tumor markers were identified. On the other hand, gallstones were more frequently observed in patients with XGC(5/6, 83%) than in patients with GB cancer(4/16, 33%)(P = 0.0116). A hypoattenuated intramural nodule was found in 3 patients with XGC(3/6, 50%), but in only 1 patient with GB cancer(1/16, 6%)(P = 0.0024). The GB thickness, continuous mucosal line, and bile duct dilatation showed no significant differences between XGC and GB cancer.CONCLUSION: Although XGC is often difficult to differentiate from GB carcinoma, it is possible to obtain an accurate diagnosis by careful intraoperative gross observation, and several intraoperative frozen sections. | Hideki Suzuki Satoshi Wada Kenichiro Araki Norio Kubo Akira Watanabe Mariko Tsukagoshi Hiroyuki Kuwano | 2015 | World Journal of Gastroenterology2015，21，35： | 18 |
| 2 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 3 | Dopaminergic neuronal loss in transgenic mice expressing the Parkinson’s disease-associated UCH-L1 I93M mutant显示文摘 | Rieko Setsuie Yu-Lai Wang Hideki Mochizuki Hitoshi Osaka Hideki Hayakawa Nobutsune Ichihara Hang Li Akiko Furuta Yae Sano Ying-Jie Sun Jungkee Kwon Tomohiro Kabuta Kenji Yoshimi Shunsuke Aoki Yoshikuni Mizuno Mami Noda Keiji Wada | 2006 | Neurochemistry International2006，，1： | 1 |
| 4 | Influence of Corn Oil and Diet on Reproduction and the Kidney in Female Sprague-Dawley Rats 显示文摘 | Masako Sato Kazuyoshi Wada Hideki Marumo | 2000 | Toxicological Sciences2000，56，1： | 1 |
| 5 | Biliary strictures as a cause of primary intrahepatic bile duct stones显示文摘 | Yoshiro Matsumoto Hideki Fujii Masakazu Yoshioka Takayoshi Sekikawa Toshisue Wada Masayuki Yamamoto Hideo Eguchi Katsuhiko Sugahara | 1986 | World Journal of Surgery1986，，： | 1 |
| 6 | Significance of consecutive bilateral surgeries for patients with acute subdural hematoma who develop contralateral acute epi- or subdural hematoma显示文摘 | Akira Matsuno Haruko Katayama Hiromi Wada Kentaro Morikawa Kotaro Tanaka Hideki Tanaka Mineko Murakami Nobuo Fuke Tadashi Nagashima | 2003 | Surgical Neurology2003，，1： | 1 |
| 7 | Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines显示文摘 | Toshio Tsuyuguchi Tadahiro Takada Yoshifumi Kawarada Yuji Nimura Keita Wada Masato Nagino Toshihiko Mayumi Masahiro Yoshida Fumihiko Miura Atsushi Tanaka Yuichi Yamashita Masahiko Hirota Koichi Hirata Hideki Yasuda Yasutoshi Kimura Steven Strasberg Henry | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，1： | 1 |
| 8 | Highly Sensitive UV Photodetectors Fabricated Using High- Quality Single-Crystalline CVD Diamond Films显示文摘 | Tokuyuki Teraji Satoshi Yoshizaki Hideki Wada | 2004 | Diamond and Related Materials2004，13，5： | 1 |
| 9 | Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines显示文摘 | Toshio Tsuyuguchi Tadahiro Takada Yoshifumi Kawarada Yuji Nimura Keita Wada Masato Nagino Toshihiko Mayumi Masahiro Yoshida Fumihiko Miura Atsushi Tanaka Yuichi Yamashita Masahiko Hirota Koichi Hirata Hideki Yasuda Yasutoshi Kimura Steven Strasberg Henry | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，1： | 1 |
| 10 | Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines显示文摘 | Toshio Tsuyuguchi Tadahiro Takada Yoshifumi Kawarada Yuji Nimura Keita Wada Masato Nagino Toshihiko Mayumi Masahiro Yoshida Fumihiko Miura Atsushi Tanaka Yuichi Yamashita Masahiko Hirota Koichi Hirata Hideki Yasuda Yasutoshi Kimura Steven Strasberg Henry | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，1： | 1 |
| 11 | A new in-vitro drug sensitivity test (collagen-gel droplet embedded-culture drug sensitivity test) in carcinomas of pancreas and biliary tract: possible clinical utility显示文摘 | Hideki Yasuda Tadahiro Takada Keita Wada Hodaka Amano Takahiro Isaka Masahiro Yoshida Toyohiko Uchida Naoyuki Toyota | 1998 | Journal of Hepato - Biliary - Pancreatic Surgery1998，，3： | 1 |
| 12 | Does 'clonal progression' relate to the development of intraductal papillary mucinous tumors of the pancreas?显示文摘 | Keita Wada M.D. Tadahiro Takada M.D. Hideki Yasuda M.D. Hodaka Amano M.D. Masahiro Yoshida M.D. Maki Sugimoto M.D. Hiroshi Irie M.D | 2004 | Journal of Gastrointestinal Surgery2004，，3： | 1 |
| 13 | Development of Advanced Parking Assistance System显示文摘 | Massaki Wada Kang Sup Yoon Hideki Hashimoto | 2003 | IEEE Transancation on Indrustrial Electronics2003，5，1： | 1 |
| 14 | Geochemistry of Archean carbonaceous cherts deposited at immature island-arc setting in the Pilbara Block, Western Australia 显示文摘 | Sugitani Kenichiro Yamamoto Koshi Wada Hideki | 2002 | Sedimentary Geology2002，151，12： | 1 |
| 15 | Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma显示文摘 | Akira Watanabe Hideki Suzuki Takehiko Yokobori Mariko Tsukagoshi Bolag Altan Norio Kubo Shigemasa Suzuki Kenichiro Araki Satoshi Wada Kenji Kashiwabara Yasuo Hosouchi Hiroyuki Kuwano | 2014 | Cancer Sci2014，，6： | 1 |
| 16 | Biliary strictures as a cause of primary intrahepatic bile duct stones显示文摘 | Yoshiro Matsumoto M.D. Hideki Fujii M.D. Masakazu Yoshioka M.D. Takayoshi Sekikawa M.D. Toshisue Wada M.D. Masayuki Yamamoto M.D. Hideo Eguchi M.D. Katsuhiko Sugahara M.D. F.A.C.S | 1986 | World Journal of Surgery1986，，5： | 1 |
| 17 | Computational model for shape estimation by integration of shading and edge information显示文摘 | Hayakawa Hideki Nishida Shinya Wada Yasuhiro Kawato Mitsuo | 1994 | Neural Networks1994，7，8： | 1 |
| 18 | Temporal Emplacement Sequence of the South Nam Xe Carbonatites (Northwest Vietnam)显示文摘South Nam Xe carbonatites are located in northwest Vietnam and include calcio-and ferro-carbonatite dikes.This investigation on their petrography,mineralogy and whole rock chemistry aims to constrain temporal emplacement sequence of the carbonatites during their evolution.The calciocarbonatites are supposed to be formed in the first or second stage due to massive coarse-grained texture with an assemblage of calcite,typical magmatic alkaline silicates(aegirine,arfvedsonite),biotite,fluorapatite and magnetite.Their calcites show a high CaO/(MgO+Fe_(2)O_(3)+MnO)ratio and a predominance of SrO over MnO(SrO=3.81-3.98 wt.%;MnO=0.66-0.78 wt.%).Rare earth elements(REE)tend to participate in rock-forming minerals rather than in isolated REE minerals.The ferrocarbonatites are composed of magmatic and hydrothermal varieties and assumed to be formed in the third and/or fourth stage.Major minerals of the former include zoned ankerite,Sr-rich calcite,subhedral feldspar crystals,phlogopite and magnetite;fluorapatite,monazite and REE carbonates are minor resulting in a moderate REE concentration of 43,200 ppm.Meanwhile,the latter is predominant by syntax-texture REE fluorcarbonates and(Ba,Sr)sulphates.Further,the highest REE concentration(163,900 ppm)of the rock coupled with abundance of volatile minerals(fluorite,fluorcarbonates,sulphides)and ^(18)O enrichment in the calcites(δ^(18)O_(V-SMOW)=12.01-13.26‰)is probably attributed to hydrothermal subjection in the last stage. | Thuy Nguyen Thi Hideki Wada | 2021 | Journal of Geological Resource and Engineering2021，9，1： | 0 |
| 19 | Novel Fused Taper 1x4 Star Coupler for Full-Band Operation显示文摘A novel fused taper 1×4 coupler for full-band operation is proposed. Wavelength flattened characteristics and excellent branching uniformity less than 0.4 dB have been achieved in wavelength range from 1200 nm to 1700 nm. | Masakazu Ohashi Hideki Sasaki Ryoukichi Matsumoto Daiichiro Tanaka Akira Wada | 2003 | 光学学报2003，23，S1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员