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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Abrogation of bleomycin- induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor显示文摘 | Wang R Ibarra - Sunga O Verlinski L | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，： | 2 |
| 4 | Dispersal in the Glanville fritillary butterfly in fragmented versus continuous landscapes:comparison between three methods 显示文摘 | Wang R Ovaskainen O Cao Y D | 2011 | Ecological Entomology2011，36，： | 1 |
| 5 | Multi-frequency measurements of the effects of soil moisture,soil texture,and surface roughness显示文摘 | Wang J R O'Neill P E Jackson T J | 1983 | IEEE Transactions on Geoscience and Remote Sensing1983，21，1： | 1 |
| 6 | Effects of blood collection tubes, iucluding pediatric devices on 16 common immunoassays 显示文摘 | Wang S Virginia H O Altheia R | 2006 | Clin Chem2006，52，5： | 1 |
| 7 | Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay显示文摘 | Sun H Shen O X Wang X R | 2009 | Toxicology In Vitro2009，23，5： | 1 |
| 8 | Multiple functional groups of varying ratios in metal-organic frameworks显示文摘 | Deng H Doonan C J Furukawa H Ferreira R B Towne J Knobler C B Wang B Yaghi O M | | 0，，： | 1 |
| 9 | Fast, Realistic Lighting and Material Design Using Nonlinear Cut Approximation显示文摘 | Cheslack-postava E Wang R Akerlund O | 2008 | ACM Transactions on Graphics2008，27，5： | 1 |
| 10 | Genetic composition and diploid hybrid speciation of a high mountain pine,Pinus densata,native to the Tibetan Plateau显示文摘 | WANG X R SZM1DT A E SAVOLAINEN O | | 0，，01： | 1 |
| 11 | Large area growth and electrical properties of p-type WSe2 atomic layers显示文摘 | Zhou H Wang C Shaw J C Cheng R Chen Y Huang X Liu Y Weiss N O Lin Z Huang Y Duan X | 2015 | Nano Letters2015，15，1： | 1 |
| 12 | The NPI-1/NPI-3(karyopherinα)binding site on the influenza A virus nucleoprotein NP is a nonconventional nuclear localization singal显示文摘 | Wang P Palese P O'Neill R E | 1997 | J Virol1997，71，： | 1 |
| 13 | Bistatic point target reference spectrum in the presence of trai-- ectory deviations显示文摘 | WANG R LOFFELD O NIES H | 2009 | IET Radar Sonar Navig2009，3，2： | 1 |
| 14 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 15 | A Functional Data Analysis of the Pinch Force of Human Fingers 显示文摘 | Ramsay J O Wang X Flanagan R | 1995 | Journal of the Royal Statistical Society1995，44，1： | 1 |
| 16 | Population balance modeling of aggregation and breakage in turbulent Taylor - Cou- ette flow 显示文摘 | Soos M Wang L Fox R O | 2007 | Journal of Colloid and Interface Science2007，307，2： | 1 |
| 17 | Processing the azimuth-variant bistatic sat data by using monosta- tie imaging algorithms based on two-dimensional prin- ciple of stationary phase显示文摘 | WANG R DENG Y LOFFELD O | 2011 | IEEE Trans Geosci Re- mote Sens2011，49，10： | 1 |
| 18 | Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies显示文摘 | Sullivan B P Wang R Tawfik O | | 0，，01： | 1 |
| 19 | Time-resolved flroroimmunoassay of plasma daidzein and genistein 显示文摘 | Wang GJ Lapcik O Hampl R | 2000 | Steroids2000，65，6： | 1 |
| 20 | Extending Loffeld's bistatic formula for the general bistatic SAR configuration显示文摘 | WANG R LOFFELD O NEO Y | 2010 | IET Radar Sonar Navigation2010，4，1： | 1 |
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