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| 1 | Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。 | Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu | 2017 | Nano Research2017，10，4： | 16 |
| 2 | Single crystalline CH_3NH_3PbI_3 self-grown on FTO/TiO_2 substrate for high efficiency perovskite solar cells显示文摘Since its first report in 2009,CH_3NH_3PbI_3-based perovskite solar cells(PSCs)have emerged as one of the most exciting developments in the next generation photovoltaic(PV)technologies[1],with its PV conversion efficiency(PCE)rising spectacularly from3.81% to 22.1% in just 7 years.Such rapid advance is | Jinjin Zhao Guoli Kong Shulin Chen Qian Li Boyuan Huang Zhenghao Liu Xingyuan San Yujia Wang Chen Wang Yunce Zhen Haidan Wen Peng Gao Jiangyu Li | 2017 | Science Bulletin2017，62，17： | 12 |
| 3 | NEW EQUATIONS OF SEDIMENT TRANSPORT RATE显示文摘NEWEQUATIONSOFSEDIMENTTRANSPORTRATEWANGShiqiang;ZHANGRenandHUIYujia(ProfDept.ofHydraulicEngrg.TsinghuaUniversity,Beijing,Chin... | WANG Shiqiang ZHANG Ren and HUI Yujia( Dept.of Hydraulic Engrg.Tsinghua University,Beijing,China)( Dept of Hydraulic Engrg..Tsinghua University, Beijing, China)( Dept.of Hydraulic Engrg.Tsinghua University, Beijing, China) | 1995 | International Journal of Sediment Research1995，10，3： | 10 |
| 4 | Removal of Pb(Ⅱ) from aqueous solution by hydrous manganese dioxide:Adsorption behavior and mechanism显示文摘Hydrous manganese dioxide (HMO) synthesized by redox of potassium permanganate and hydrogen peroxide was used as an adsorbent for Pb(Ⅱ) removal.The specific surface area,pore volume and BJH pore diameter of the HMO were 79.31m2/g,0.07cm3/g and 3.38 nm,respectively.The adsorption equilibrium at 298K could be well described by the Langmuir isotherm equation with q max value of 352.55mg/g.The negative values of G and the positive values of H and S indicated the adsorption process was spontaneous and endothermic.The pseudo second-order equation could best fit the adsorption data.The value of the calculated activation energy for Pb(Ⅱ) adsorption onto the HMO was 38.23 kJ/mol.The uptake of Pb(Ⅱ) by HMO was correlated with increasing surface hydroxyl group content and the main adsorbed speciation was PbOH+.The final chemical state of Pb(Ⅱ) on the surface of HMO was similar to PbO.HMO was a promising candidate for Pb(Ⅱ) removal from aqueous solution. | Meng Xu Hongjie Wang Di Lei Dan Qu Yujia Zhai Yili Wang | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 5 | Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning显示文摘Parasitic infections constitute a major global public health issue.Existing screening methods that are based on manual microscopic examination often struggle to provide sufficient volumetric throughput and sensitivity to facilitate early diagnosis.Here,we demonstrate a motility-based label-free computational imaging platform to rapidly detect motile parasites in optically dense bodily fluids by utilizing the locomotion of the parasites as a specific biomarker and endogenous contrast mechanism.Based on this principle,a cost-effective and mobile instrument,which rapidly screens~3.2 mL of fluid sample in three dimensions,was built to automatically detect and count motile microorganisms using their holographic time-lapse speckle patterns.We demonstrate the capabilities of our platform by detecting trypanosomes,which are motile protozoan parasites,with various species that cause deadly diseases affecting millions of people worldwide.Using a holographic speckle analysis algorithm combined with deep learningbased classification,we demonstrate sensitive and label-free detection of trypanosomes within spiked whole blood and artificial cerebrospinal fluid(CSF)samples,achieving a limit of detection of ten trypanosomes per mL of whole blood(~five-fold better than the current state-of-the-art parasitological method)and three trypanosomes per mL of CSF.We further demonstrate that this platform can be applied to detect other motile parasites by imaging Trichomonas vaginalis,the causative agent of trichomoniasis,which affects 275 million people worldwide.With its costeffective,portable design and rapid screening time,this unique platform has the potential to be applied for sensitive and timely diagnosis of neglected tropical diseases caused by motile parasites and other parasitic infections in resource-limited regions. | Yibo Zhang Hatice Ceylan Koydemir Michelle M.Shimogawa Sener Yalcin Alexander Guziak Tairan Liu Ilker Oguz Yujia Huang Bijie Bai Yilin Luo Yi Luo Zhensong Wei Hongda Wang Vittorio Bianco Bohan Zhang Rohan Nadkarni Kent Hill Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 6 | Impacts of Uncertainty in AVOC Emissions on the Summer RO_x Budget and Ozone Production Rate in the Three Most Rapidly-Developing Economic Growth Regions of China显示文摘High levels of uncertainty in non-methane volatile organic compound(NMVOC) emissions in China could lead to significant variation in the budget of the sum of hydroxyl(OH) and peroxy(HO2, RO2) radicals(ROx= OH + HO2+ RO2)and the ozone production rate [P(O3)], but few studies have investigated this possibility, particularly with three-dimensional air quality models. We added diagnostic variables into the WRF-Chem model to assess the impact of the uncertainty in anthropogenic NMVOC(AVOC) emissions on the ROxbudget and P(O3) in the Beijing–Tianjin–Hebei region, Yangtze River Delta, and Pearl River Delta of China. The WRF-Chem simulations were compared with satellite and ground observations,and previous observation-based model studies. Results indicated that 68% increases(decreases) in AVOC emissions produced4%–280% increases(2%–80% decreases) in the concentrations of OH, HO2, and RO2 in the three regions, and resulted in35%–48% enhancements(26%–39% reductions) in the primary ROxproduction and ~ 65% decreases(68%–73% increases)of the P(O3) in Beijing, Shanghai, and Guangzhou. For the three cities, the two largest contributors to the ROxproduction rate were the reaction of O1 D + H2 O and photolysis of HCHO, ALD2, and others; the reaction of OH + NO2(71%–85%)was the major ROxsink; and the major contributor to P(O3) was the reaction of HO2+ NO(~ 65%). Our results showed that AVOC emissions in 2006 from Zhang et al.(2009) have been underestimated by ~ 68% in suburban areas and by > 68%in urban areas, implying that daily and hourly concentrations of secondary organic aerosols and inorganic aerosols could be substantially underestimated, and cloud condensation nuclei could be underestimated, whereas local and regional radiation was overestimated. | WANG Feng AN Junling LI Ying TANG Yujia LIN Jian QU Yu CHEN Yong ZHANG Bing ZHAI Jing | 2014 | Advances in Atmospheric Sciences2014，31，6： | 5 |
| 7 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 8 | Response of the sensorimotor cortex of cerebral palsy rats receiving transplantation of vascular endothelial growth factor 165-transfected neural stem cells显示文摘Neural stem cells are characterized by the ability to differentiate and stably express exogenous genes. Vascular endothelial growth factor plays a role in protecting local blood vessels and neurons of newborn rats with hypoxic-ischemic encephalopathy. Transplantation of vascular endothelial growth factor-transfected neural stem cells may be neuroprotective in rats with cerebral palsy. In this study, 7-day-old Sprague-Dawley rats were divided into five groups:(1) sham operation(control),(2) cerebral palsy model alone or with(3) phosphate-buffered saline,(4) vascular endothelial growth factor 165 + neural stem cells, or(5) neural stem cells alone. The cerebral palsy model was established by ligating the left common carotid artery followed by exposure to hypoxia. Phosphate-buffered saline, vascular endothelial growth factor + neural stem cells, and neural stem cells alone were administered into the sensorimotor cortex using the stereotaxic instrument and microsyringe. After transplantation, the radial-arm water maze test and holding test were performed. Immunohistochemistry for vascular endothelial growth factor and histology using hematoxylin-eosin were performed on cerebral cortex. Results revealed that the number of vascular endothelial growth factor-positive cells in cerebral palsy rats transplanted with vascular endothelial growth factor-transfected neural stem cells was increased, the time for finding water and the finding repetitions were reduced, the holding time was prolonged, and the degree of cell degeneration or necrosis was reduced. These findings indicate that the transplantation of vascular endothelial growth factor-transfected neural stem cells alleviates brain damage and cognitive deficits, and is neuroprotective in neonatal rats with hypoxia ischemic-mediated cerebral palsy. | Jielu Tan Xiangrong Zheng Shanshan Zhang Yujia Yang Xia Wang Xiaohe Yu Le Zhong | 2014 | Neural Regeneration Research2014，9，19： | 4 |
| 9 | Peniazaphilones A—I,Produced by Co-culturing of Mangrove Endophytic Fungi,Penicillium sclerotiorum THSH-4 and Penicillium sclerotiorum ZJHJJ-18显示文摘Co-culturing the mangrove endophytic fungus Penicillium sclerotiorum THSH-4 with Penicillium sclerotiorum ZJHJJ-18 in PDB medium resulted in the production of nine new azaphilones derivatives,peniazaphilones A—I(1-9),and six known azaphilones derivatives(10-15).Their structures were elucidated by analysis of detailed spectroscopic data,single-crystal X-ray diffraction,ECD spectra,^(13)C NMR calculation and DP4+analysis.It is noteworthy that compound 1 with an isoquinoline quinone moiety,was isolated from natural source for the first time.Besides,compound 2 is the third reported phenylhydrazone derivative from fungi.In the bioactivity assays,compounds 1,12,14 and 15(IC_(50)=4.71-17.64μmol/L)exhibited potent inhibition of LPS-induced NO release from RAW264.7 without obvious cytotoxicity within 50μmol/L compared to the positive control indomethacin(IC_(50)=35.27μmol/L).Moreover,compounds 1 and 13 displayed moderate to strong cytotoxicity to A549 and MDA-MB-435,with IC_(50) values in the range of 6.84-14.63μmol/L.Together compound 1 showed moderate broad-spectrum antibacterial activity. | Wencong Yang Jie Yuan Qi Tan Yan Chen Yujia Zhu Hongming Jiang Ge Zou Zhenming Zang Bo Wang Zhigang She | 2021 | Chinese Journal of Chemistry2021，39，12： | 3 |
| 10 | Identification and characterization of soybean dreg soluble dietary fibre by combination of extrusion pre-treatment and enzymatic modification显示文摘OBJECTIVES:Soybean dreg is a by-product of soy milk processing,which contains high levels of soluble dietary fibre(SDF).In this study,we aimed to provide comprehensive processes of pre-treated extrusion for the improving structure and properties of soybean dreg soluble dietary fibre(SDSDF),which would be a valuable approach to enhance physiological activity.METHODS:Here,we characteristic the functional role of SDSDF employing to extrusion pretreatment.Soybean dregs were pre-treated using the twin screw extrusion method followed by enzymatic modification using neutral protease,α-amylase,glucoamylase,and cellulose to produce SDSDF.The physical properties and antioxidant activity of SDSDF were investigated.RESULTS:The morphology and crystal structure of SDSDF were observed that,through extrusion processing and enzymatic modification,the SDSDF yield increased by 106.28%.Moreover,the surface structure showed block-shaped or reticular formations in the extruded SDSDF,and the size of block-shaped cells was about 10μm.Infrared spectroscopic analysis showed that a characteristic absorption peak of polysaccharide appeared at 1631 cm−1 during extrusion processing.However,after extrusion processing,decreased absorption peaks were observed for the extruded SDSDF.Furthermore,XRD analysis showed that the 2θdiffraction peak changed at 24.16°for the extruded SDSDF.CONCLUSIONS:The overall findings suggest that the water holding capacity(WHC),oil holding capacity(OHC),expansibility,and the water solubility were significantly decreased in extruded SDSDF.In addition,the scavenging ability of 1,1-diphenyl-2-picrylhydrazyl(DPPH),-OH,O_(2)^(-),and the total reducing power were significantly improved,indicating that beneficial changes had taken place in the crystal structure of cellulose or hemicellulose to improve the physiological activity in extruded SDSDF. | Min Qu Yujia Liu Guang Zhang Sophia Jun Xue Hongchen Fan Yan Wang Shiyou Yu | 2017 | Food Quality and Safety2017，1，2： | 3 |
| 11 | Tensile properties of a composite–metal single-lap hybrid bonded/bolted joint显示文摘Hybrid bonded/bolted(HBB) joint has been widely used in engineering practice because it can overcome the potential weakness of pure bonded and pure bolted joints. However, studies on HBB joint are still at the initial stage. In this paper, tensile properties of a composite–metal singlelap HBB joint was investigated experimentally. And a detailed finite element model(FEM) was established to simulate the tensile behavior of the joint. The model was verified by the experimental results. Then the damage propagation and load transfer mechanism were explored based on the FEM. The results show that the HBB joint can provide multi-load transmission paths and resist damage propagation in the adhesive. The HBB joint has higher strength and energy absorption capacity than the pure bonded joint. And the HBB joint has greater initial damage load and tensile stiffness than pure bolted joint. Adhesive fillets can obviously improve the tensile performances of the HBB joint. Lateral stiffness of the joint boundary and testing machine show obvious effects on tensile performances of single-lap hybrid joints. | Xiaoqi LI Xiaoquan CHENG Yujia CHENG Zhiyong WANG Wenjun HUANG | 2021 | Chinese Journal of Aeronautics2021，34，2： | 3 |
| 12 | Recent advances on the circadian gene PER2 and metabolic rhythm of lactation of mammary gland显示文摘Due to regulation by circadian rhythm, the lactation of the mammary gland has rhythmicity. As one of prominent members of period protein family which regulates biological rhythms, PER2 plays an important role in developing the milk duct and maintaining the polarity and the morphology of the mammary epithelium; at the same time, it is also closely related with the metabolism of milk protein and milk fat. This paper summarized recent researches on PER2 gene and related researches on mammary gland development and metabolism to provide some information for the studies of the theory and technology on physiological functions of the mammary gland and milk quality control. | Mengzhi Wang Yujia Jing Liangyu Hu Jian Gao Luyang Ding Jun Zhang | 2015 | Animal Nutrition2015，，4： | 2 |
| 13 | Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine显示文摘Dear Editor,Urine passes through the entire kidney and urinary tract system starting from the glomerulus and ending to the urethra.Cells in the kidney and urinary tract could be exfoliated from the epithelium into the urine,while leukocyte could infiltrate from the local tissue into the urine,which makes the urine a useful subject for clinical evaluation of relevant diseases. | Yujia Wang Yu Zhao Zixian Zhao Dandan Li Hao Nie Yufen Sun Xiaobei Feng Ting Zhang Yu Ma Jing Nie Guangyan Cai Xiangmei Chen Wei Zuo | 2021 | Protein & Cell2021，12，4： | 2 |
| 14 | The neutrophil-to-lymphocyte ratio as a predictor for recurrence of colorectal liver metastases following radiofrequency ablation显示文摘 | Zhihui Chang Jiahe Zheng Yujia Ma Jian Zhao Chuanzhuo Wang Zhaoyu Liu | 2014 | Medical Oncology2014，，3： | 2 |
| 15 | Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque显示文摘The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis(MRSE) strains isolated from the dental plaque of a healthy human population. Broth microdilution minimum inhibitory concentrations(MICs) revealed that all the isolates were nonsusceptible to oxacillin and penicillin G. Most of them were also resistant to trimethoprim(65.7%) and erythromycin(54.3%). The resistance to multiple antibiotics was found to be largely due to the acquisition of plasmid-borne genes. The mec A and dfr A genes were found in all the isolates, mostly dfr G(80%), aac A-aph D(20%), aad D(28.6%), aph A3(22.9%), msr A(5.7%), and the erm C gene(14.3%). Classical mutational mechanisms found in these isolates were mainly efflux pumps such as qac A(31.4%), qac C(25.7%), tet K(17.1%), and nor A(8.6%). Multilocus sequence type analysis revealed that sequence type 59(ST59) strains comprised 71.43% of the typed isolates, and the e BURST algorithm clustered STs into the clonal complex 2-II(CC2-II). The staphyloccoccal cassette chromosome mec(SCCmec) type results showed that 25(71.43%) were assigned to type IV. Moreover, 88.66% of the isolates were found to harbor six or more biofilm-associated genes. The aap, atl E, embp, sdr F, and IS256 genes were detected in all 35 isolates. This research demonstrates that biofilm-positive multipleantibiotic-resistant ST59-SCCmec IV S. epidermidis strains exist in the dental plaque of healthy people and may be a potential risk for the transmission of antibiotic resistance. | Boyu Tang Tao Gong Yujia Cui Lingyun Wang Chao He Miao Lu Jiamin Chen Meiling Jing Anqi Zhang Yuqing Li | 2020 | International Journal of Oral Science2020，12，2： | 2 |
| 16 | Towards suppressing dielectric loss of GO/PVDF nanocomposites with TA-Fe coordination complexes as an interface layer显示文摘In this work, graphene oxide(GO) nanosheets with surface modification by Tannic and Fe coordination complexes(TA-Fe) were incorporated into poly(vinylidene fluoride)(PVDF) to prepare high constant but low loss polymer nanocomposites, and the effect of TA-Fe interlayer on dielectric properties of the GO@TA-Fe/PVDF nanocomposites was investigated. The results indicate that the dosage, mixing ratio, and reaction time of TA-Fe complexes have obvious influences on the dielectric properties of the nanocomposites. Furthermore, the TA-Fe interlayer significantly influences the electrical properties of GO@TA-Fe nanoparticles and their PVDF composites, and the GO@TA-Fe/PVDF composites exhibit superior dielectric properties compared with raw GO/PVDF. Dielectric losses of the GO@TA-Fe/PVDF are significantly suppressed to a rather low level owing to the presence of TA-Fe layer, which serves as an interlayer between the GO sheets, thus preventing them from direct contacting with each other. Additionally, the dynamic dielectric relaxation of the GO/PVDF and GO@TA-Fe/PVDF nanocomposites was investigated in terms of temperature. | Ying Gong Wenying Zhou Zijun Wang Li Xu Yujia Kou Huiwu Cai Xiangrong Liu Qingguo Chen Zhi-Min Dang | 2018 | Journal of Materials Science & Technology2018，34，12： | 2 |
| 17 | Structural characterization of coatomer in its cytosolic state显示文摘上衣蛋白质上的研究(COPI ) 我贡献了上衣蛋白质怎么产生泡开始细胞内部的运输的基本理解。COPI 建筑群的核心部件是 coatomer,它是需要从 cytosol 被招募到膜以便在膜弯曲并且货物排序工作的 multimeric 建筑群。clathrin 适配器上的以前的结构的研究发现了膜招募在在货物排序支持他们的角色导致一个大 conformational 变化。这里,追求否定污点的电子显微镜学结合了单个粒子的分析,和也表现的 CXMS (化学 cross-linking 结合了集体 spectrometry ) 为确认,我们重建了在它的可溶的形式的 coatomer 的结构。当与在它的膜界限形式的 coatomer 的以前阐明的结构相比我们不观察一个大 conformational 变化时。因此,结果揭开 COPI 对 clathrin 怎么覆盖的关键差别被膜招募调整。 | Shengliu Wang Yujia Zhai Xiaoyun Pang Tongxin Niu Yue-He Ding Meng-Qiu Dong Victor W. Hsu Zhe Sun Fei Sun | 2016 | Protein & Cell2016，7，8： | 2 |
| 18 | The targeting expression of the vascular endothelial growth factor gene in endothelial cells regulated by HRE.ppET-1显示文摘The success of gene therapy depends largely on the efficacy of gene delivery vector systems that can deliver genes to target organs or cells selectively and efficiently with minimal toxicity. Here, we show that by using the HRE.ppET-1 regulatory element, we were able to restrict expression of the transgene of vascular endothelial growth factor (VEGF) to endothelial cells exclusively in hypoxic conditions. Eukaryotic expression vectors such as pEGFP-HRE.ppET-1, pcDNA3.1-VEGF+Pa, pcDNA3.1-ppET-1+ EGF+Pa, and pcDNA3.1-HRE.ppET-1+VEGF+Pa were constructed by using a series of nuclear molecule handling methods like PCR, enzyme digestion. The recombinant vectors were transfected into HUVEC cells and HL7702 cells by the lipofectin method. GFP expression was observed with a fluorescence microscope to validate the specificity of expression in endothelial cells under the regulation of HRE.ppET-1 element. Cobalt chloride (final concentration 100 μmol/L) was added to the medium to mimic hypoxia in vitro. After transfection of vectors, the expression of VEGF mRNA was detected by RT-PCR, and the expression of VEGF was detected by Western blotting and ELISA methods under normoxia and hypoxia, respectively. The cell proliferation rate was detected by the MTT test. The ex- pression of GFP revealed that the exterior gene was transcripted effectively in endothelial cells regu- lated by the HRE.ppET-1 element, while the expression of GFP was very weak in nonendothelial cells. The results of RT-PCR, Western blotting and ELISA showed that VEGF gene expression in the pcDNA3.1-HRE.ppET-1+VEGF+Pa group and in the pcDNA3.1-ppET-1+VEGF+Pa group was higher in hypoxia than it was in normoxia (P<0.05). The MTT test showed that the proliferation rate of HUVEC transfected with HPVA under hypoxia exceeded that of the control group. We conclude that the HRE.ppET-1 element was expressed specifically in endothelial cells, and can increase the expression of VEGF in hypoxia and stimulate proliferation of endothelial cells. Taking advantage of these facts could greatly improve the efficiency of gene therapy. The vector would be valuable for various gene transfer studies targeting endothelial cells. | ZHENG XiangRong, ZHANG ShangShang, YANG YuJia, WANG Xia, ZHONG Le & YU XiaoHe Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China | 2008 | Science China(Life Sciences)2008，51，11： | 1 |
| 19 | Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer显示文摘Combining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/ RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT. | WU Liting XIN Yujia GUO Zhaoyang GAO Wei ZHU Yanpeng WANG Yinsong RAN Ruixue YANG Xiaoying | 2022 | Chemical Research in Chinese Universities2022，38，2： | 1 |
| 20 | Geochronology, geochemistry, and Sr-Nd isotopes of Early Carboniferous magmatism in southern West Junggar, northwestern China: Implications for Junggar oceanic plate subduction显示文摘West Junggar is a key area for understanding intra-oceanic plate subduction and the final closure of the Junggar Ocean.Knowledge of the Carboniferous tectonic evolution of the Junggar Ocean region is required for understanding the tectonic framework and accretionary processes in West Junggar,Central Asian Orogenic Belt.A series of Early Carboniferous volcanic and intrusive rocks,namely,basaltic andesite,andesite,dacite,and diorite,occur in the Mayile area of southern West Junggar,northwestern China.Our new LA-ICPMS zircon U-Pb geochronological data reveal that diorite intruded at 334(±1)Ma,and that basaltic andesite was erupted at 334(±4)Ma.These intrusive and volcanic rocks are calc-alkaline,display moderate MgO(1.62%-4.18%)contents and Mg#values(40-59),and low Cr(14.5×10-6-47.2×10-6)and Ni(7.5×10-6-34.6×10-6)contents,and are characterized by enrichment in light rare-earth elements and large-ion lithophile elements and depletion in heavy rare-earth elements and high-field-strength elements,meaning that they belong to typical subduction-zone island-arc magma.The samples show low initial 87Sr/86Sr ratios(range of 0.703649-0.705008),positiveεNd(t)values(range of 4.8-6.2 and mean of 5.4),and young TDM Nd model ages ranging from 1016 to 616 Ma,indicating a magmatic origin from depleted mantle involving partial melting of 10%-25%garnet and spinel lherzolite.Combining our results with those of previous studies,we suggest that these rocks were formed as a result of northwestward subduction of the Junggar oceanic plate,which caused partial melting of sub-arc mantle.We conclude that intra-oceanic arc magmatism was extensive in West Junggar during the Early Carboniferous. | LIU Pengde LIU Xijun XIAO Wenjiao ZHANG Zhiguo SONG Yujia XIAO Yao LIU Lei HU Rongguo WANG Baohua | 2021 | Journal of Arid Land2021，13，11： | 1 |
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