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| 1 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 2 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 3 | Modeling of radionickel sorption on MX-80 bentonite as a function of pH and ionic strength显示文摘MX-80 bentonite was detected using acid-based titration, XRD and FTIR in detail. The sorption behavior of 63Ni(Ⅱ) from aqueous solution to MX-80 bentonite was investigated as a function of solid content, ionic strength and pH by using batch technique. The experimental data of 63Ni(Ⅱ) sorption on MX-80 bentonite was obtained using the diffuse layer model (DLM) with the aid of FITEQL 3.1 program. The results indicated that the sorption of 63Ni(Ⅱ) on MX-80 bentonite was mainly dominated by surface complexation, and cation exchange also contributed partly to 63Ni(Ⅱ) sorption at low pH values. The sorption isotherms were simulated by Langmuir and Freundlich models, and the results indicated that Freundlich isotherm model fitted the sorption data better than the Langmuir isotherm model. The results are crucial to evaluate the sorption and migration of radionickel in MX-80 bentonite. | SHAO DaDong XU Di WANG SuoWei FANG QiaoHui WU WangSuo DONG YunHui WANG XiangKe | 2009 | Science China Chemistry2009，52，3： | 13 |
| 4 | Using the nematode Caenorhabditis elegans as a model animal for assessing the toxicity induced by microcystin-LR显示文摘Among more than 75 variants of microcystin(MC),microcystin-LR(MC-LR) is one of the most common toxins.In this study,the feasibility of using Caenorhabditis elegans to evaluate MC-LR toxicity was studied.C.elegans was treated with MC-LR at different concentrations ranging from 0.1 to 80 μg/L.The results showed that MC-LR could reduce lifespan,delay development,lengthen generation time,decrease brood size,suppress locomotion behavior,and decreases hsp-16-2-gfp expression.The endpoints of generation time,brood size,and percentage of the population expressing hsp-16-2-gfp were very sensitive to 1.0 μg/L of MC-LR,and would be more useful for the evaluation of MC-LR toxicity.Furthermore,the tissue-specific hsp-16-2-gfp expressions were investigated in MC-LR-exposed animals,and the nervous system and intestine were primarily affected by MC-LR.Therefore,the generation time,brood size,and hsp-16-2-gfp expression in C.elegans can be explored to serve as valuable endpoints for evaluating the potential toxicity from MC-LR exposure. | LI Yunhui WANG Yang YIN Lihong PU Yuepu WANG Dayong | 2009 | Journal of Environmental Sciences2009，21，3： | 9 |
| 5 | Is graphite lithiophobic or lithiophilic?显示文摘Graphite and lithium metal are two classic anode materials and their composite has shown promising performance for rechargeable batteries.However,it is generally accepted that Li metal wets graphite poorly,causing its spreading and infiltration difficult.Here we show that graphite can either appear superlithiophilic or lithiophobic,depending on the local redox potential.By comparing the wetting performance of highly ordered pyrolytic graphite,porous carbon paper(PCP),lithiated PCP and graphite powder,we demonstrate that the surface contaminants that pin the contact-line motion and cause contact-angle hysteresis have their own electrochemical-stability windows.The surface contaminants can be either removed or reinforced in a time-dependent manner,depending on whether the reducing agents(C6→Li C6)or the oxidizing agents(air,moisture)dominate in the ambient environment,leading to bifurcating dynamics of either superfast or superslow wetting.Our findings enable new fabrication technology for Li–graphite composite with a controllable Li-metal/graphite ratio and present great promise for the mass production of Li-based anodes for use in high-energy-density batteries. | Jian Duan Yuheng Zheng Wei Luo Wangyan Wu Tengrui Wang Yong Xie Sa Li Ju Li Yunhui Huang | 2020 | National Science Review2020，7，7： | 8 |
| 6 | The application of nanostructured transition metal sulfides as anodes for lithium ion batteries显示文摘With wide application of electric vehicles and large-scale in energy storage systems, the requirement of secondary batteries with higher power density and better safety gets urgent. Owing to the merits of high theoretical capacity, relatively low cost and suitable discharge voltage, much attention has been paid to the transition metal sulfides. Recently, a large amount of research papers have reported about the application of transition metal sulfides in lithium ion batteries. However, the practical application of transition metal sulfides is still impeded by their fast capacity fading and poor rate performance. More well-focused researches should be operated towards the commercialization of transition metal sulfides in lithium ion batteries. In this review, recent development of using transition metal sulfides such as copper sulfides,molybdenum sulfides, cobalt sulfides, and iron sulfides as electrode materials for lithium ion batteries is presented. In addition, the electrochemical reaction mechanisms and synthetic strategy of transition metal sulfides are briefly summarized. The critical issues, challenges, and perspectives providing a further understanding of the associated electrochemical processes are also discussed. | Jinbao Zhao Yiyong Zhang Yunhui Wang He Li Yueying Peng | 2018 | Journal of Energy Chemistry2018，27，6： | 7 |
| 7 | Cooperative localization method for multi-robot based on PF-EKF显示文摘A method of cooperative localization for multi-robot in an unknown environment is described.They share information and perform localization by using relative ob-servations and necessary communication.At initial time,robots do not know their positions.Once the robot that can obtain the absolute position information has its position,other robots use particle filter to fuse relative observations and maintain a set of samples respectively representing their positions.When the particles are close to a Gaussian distribution after a number of steps,we switch to an EKF to track the pose of the robots.Simulation results and real experiment show that PF-EKF method combines the robustness of PF and the efficiency of EKF.Robots can share the absolute position information and effectively localize themselves in an unknown environment. | WANG Ling WAN JianWei LIU YunHui SHAO JinXin | 2008 | Science in China(Series F)2008，51，8： | 7 |
| 8 | Influence of different inoculation methods on the evaluation of the resistance to rice sheath blight(Rhizoctonia solani Kuhn)显示文摘To establish a standard system for genetic studies on sheath blight resistance. a field test was conducted at the experimental farm of Yangzhou University to compare several procedures for inoculating rice plants with R. | PAN Xuebiao CHEN Zongxiang XU Jingyou TONG Yunhui WANG Zibin PAN Xingyuan Dept of Agro of Agri Coll,Yangzhou Univ,Yangzhou 225009,China | 1998 | Chinese Rice Research Newsletter1998，6，2： | 6 |
| 9 | Spatial Correlation and Ecological Characteristics Analysis of Man-agement Area for Biodiversity Conservation and Relevant Regionalization显示文摘Formulation of different ecological zone plans according to the corresponding protection targets and the necessity of proper conservation policy is one of the measures to achieve the goal of ecological conservation in China.In order to clarify the interrelation among key ecological zone plans,this paper carried out the research on spatial relation of priority areas of biodiversity conservation and three key ecological areas(key ecological function areas,key regions of ecological service function,national nature reserves)and the research on ecological conditions,based on multi-scale ecological spatial theme information,which incorporates elements like ecological quality and type,and by the aid of spatial information analysis and GIS modeling.The results showed a contrastively fine spatial consistency with 68.8%of priority areas of biodiversity conservation overlapping with three key ecological areas.Although the environment in priority areas of biodiversity conservation were in good conditions,protection pressure is also increasing,powerful supervision and protection should not be ignored.The environmental conditions in the overlapping areas,as a whole,were superior to those in the non-overlapping areas.Since two areas have different characteristics,targeted protection measures should be formulated based on this difference,which will be very important for biodiversity conservation in priority areas of biodiversity conservation. | WANG Wenjie ZHENG Hua XU Chao JIANG Weiguo DU Yunhui WANG Wei ZHANG Zhe LIU Xiaofu | 2014 | Chinese Geographical Science2014，24，1： | 5 |
| 10 | Highly Enhanced Visible-Light-Driven Photoelectrochemical Performance of ZnO-Modified In_2S_3 Nanosheet Arrays by Atomic Layer Deposition显示文摘Photoanodes based on In_2S_3/ZnO heterojunction nanosheet arrays(NSAs) have been fabricated by atomic layer deposition of ZnO over In_2S_3 NSAs, which were in situ grown on fluorine-doped tin oxide glasses via a facile solvothermal process. The as-prepared photoanodes show dramatically enhanced performance for photoelectrochemical(PEC) water splitting, compared to single semiconductor counterparts. The optical and PEC properties of In_2S_3/ZnO NSAs have been optimized by modulating the thickness of the Zn O overlayer. After pairing with ZnO, the NSAs exhibit a broadened absorption range and an increased light absorptance over a wide wavelength region of 250–850 nm. The optimized sample of In_2S_3/ZnO-50 NSAs shows a photocurrent density of 1.642 m A cm^(-2)(1.5 V vs. RHE) and an incident photonto-current efficiency of 27.64% at 380 nm(1.23 V vs.RHE), which are 70 and 116 times higher than those of the pristine In_2S_3 NSAs, respectively. A detailed energy band edge analysis reveals the type-II band alignment of the In_2S_3/ZnO heterojunction, which enables efficient separation and collection of photogenerated carriers,especially with the assistance of positive bias potential, and then results in the significantly increased PEC activity. | Ming Li Xinglong Tu Yunhui Wang Yanjie Su Jing Hu Baofang Cai Jing Lu Zhi Yang Yafei Zhang | 2018 | Nano-Micro Letters2018，10，3： | 5 |
| 11 | Morphology-controllable solvothermal synthesis of nanoscale LiFePO_4 in a binary solvent显示文摘LiFePO4(LFP) nanobars,microplates and nanorods have been selectively synthesized via a solvothermal method in a water-ethylene glycol(EG) binary solvent with H3PO4,LiOH·H2O,and FeSO4·7H2O as starting materials.The morphology and size of the as-obtained LFP products can be deliberately controlled by varying the volume ratio of EG to water.The formation mechanism and electrochemical properties of different LFP morphologies have been investigated.With carbon coating,the Li-ion diffusion coefficients of LFP nanorods,nanobars and micro-plates are 2.58×10-9,2.91×10-10,and 7.22×10-10 cm2 s-1,respectively.For the carbon-coated nanorods,excellent rate capability and cyclability were attained.At 5 C,the capacity was 141 mAh g-1 for the first cycle and maintained 120 mAh g-1 after 100 cycles;at 10 C,the capacity was still as high as 132 mAh g-1. | WU Miao WANG ZhaoHui YUAN LiXia ZHANG WuXing HU XianLuo HUANG YunHui | 2012 | Chinese Science Bulletin2012，57，32： | 4 |
| 12 | Direct silylation reactions of inert C-H bonds via transition metal catalysis显示文摘In the past thirty years,transition metal catalyzed silylation of inert C–H bonds has attracted intensive attention due to the importance and wide use of organosilicon compounds.In this review,the silylation reactions of inert C–H bonds catalyzed by transition metal complexes of Ir,Rh,Ru,Pt,Pd,Ni,and Sc,and the strategies utilized to access the site-selective C–H silylation products have been summarized.Furthermore,the mechanisms of C–H silylation reactions have been discussed briefly. | Yunhui Yang Congyang Wang | 2015 | Science China Chemistry2015，58，8： | 4 |
| 13 | Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats显示文摘A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) and NG2. Double immunofluorescence staining showed that electroacupuncture markedly increased the numbers of BrdU+/NG2+ cells at spinal cord tissue 15 mm away from the injury center in the rostral and caudal directions. The results suggest that electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in rats with spinal cord injury. | Haiying Wu Min HU Dekai Yuan Yunhui Wang Jing Wang Tao Li Chuanyun Qian Hualin YU | 2012 | Neural Regeneration Research2012，7，15： | 4 |
| 14 | Robot Intelligence for Real World Applications显示文摘This paper presents a brief review on recent work on machine intelligence for real-world applications of robots.To act in a real world environment,a robot should possess a broad sense of intelligence including speech,perception,reasoning,action,etc.In this paper,we particularly deal with the intelligence involving action or body motion.The intelligence related to robot action/motion can be classified into two categories:manipulation intelligence and mobility intelligence.The manipulation intelligence means the skill/intelligence of reliably manipulating objects according to tasks and the mobility intelligence corresponds to the ability of autonomously moving,or flying,and or jumping in a natural environment.Human-robot interaction is another important topic for real-world applications.In addition to reviewing the ma jor approaches,this paper also gives an overview on our efforts in these important topics. | LIU Yunhui ZHENG Fan GUO Ruibin WANG Jiangliu NIE Qiang WANG Xin WANG Zerui | 2018 | Chinese Journal of Electronics2018，27，3： | 3 |
| 15 | Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis defects by microcystin-LR exposure in nematode Caenorhabditis elegans显示文摘Apart from the liver disruption, embryotoxicity and genotoxicity, microcystin (MC)-LR also could cause neurotoxicity. Nematode Caenorhabditis elegans was explored as a model to study the neurotoxicity. In the present study, we provided evidence to indicate the neurotoxicity on chemotaxis to NaCl and diacetyl, and thermotaxis from MC-LR exposure to C. elegans. As a result, higher concentrations of MC-LR caused significantly severe defects of chemotaxis to NaCl and diacetyl, and thermotaxis. The neurotoxicity on chemotaxis to NaCl and diacetyl, and thermotaxis from MC-LR exposure might be largely mediated by the damage on the corresponding sensory neurons (ASE, AWA, and AFD) and interneuron AIY. The expression levels of che-1 and odr-7 were significantly decreased (P < 0.01) in animals exposed to MC-LR at concentrations lower than 10 μg/L, whereas the expression levels of ttx-1 and ttx-3 could be significantly (P < 0.01) lowered in animals even exposed to 1 μg/L of MC-LR. Moreover, both the chemotaxis to NaCl and diacetyl and the thermotaxis were more significantly reduced in MC-LR exposed mutants of che-1(p674), odr-7(ky4), ttx-1(p767), and ttx-3(ks5) than those in exposed wild-type N2 animals at the same concentrations. | LI Yunhui YE Huayue DU Min ZHANG Yanfen YE Boping PU Yuepu WANG Dayong | 2009 | Journal of Environmental Sciences2009，21，7： | 2 |
| 16 | Atom elimination strategy for MoS_(2) nanosheets to enhance photocatalytic hydrogen evolution显示文摘The regulation of the basic properties of atom-economic catalysts at the atomic scale and atomic-level insights into the underlying mechanism of catalysis are less explored. We engineer the surface of vertical immobilized MoS_(2) on dispersible TiO_(2) nanofibers via atomic subtraction to precisely manipulate active sites at the atomic level. The photocatalytic performances of TiO_(2) @MoS_(2) after H_(2) reduction towards the hydrogen production under visible light irradiation(>420 nm) are about 4 times that of TiO_(2) @MoS_(2) before H_(2) reduction. Importantly, the enhanced stability of TiO_(2) @MoS_(2) lasts for at least 30 h. Promising catalytic activity that is attributed to omnidirectional exposed active sites located defects, edges, corners that are transformed from the subtractive atomic sites could be exhumed comprehensively. This work will provide an intriguing and effective approach on tuning electronic structures for optimizing the catalytic activity at the atomic level by atom elimination strategy. To get rid of a few atomics on the surface of atomically-thin MoS_(2) nanosheet could be a prudent avenue for enabling the basal plane of MoS_(2) catalytically active. | Xia Liu Yunhui Hou Meng Tang Longlu Wang | 2023 | Chinese Chemical Letters2023，34，3： | 2 |
| 17 | A writable lithium metal ink显示文摘The recent revival of Li metal anodes(LMA)leads to a renewed interest in LMA as the ultimate choice for rechargeable lithium batteries towards high energy density.However,multiple challenges stand in the way of using LMA,of which high reactivity,dendrite growth,the difficulty of fabricating Li thin foils,and the flammability of organic liquid electrolytes are typical.Here,a writable Li metal ink(LMI)prepared by introducing biomass-derived carbon particles into molten Li is presented.Due to the significantly decreased surface tension,LMI is able to directly write on copper foils or other substrates that ultrathin Li foils with a remarkably small thickness(<10μm)can be achieved.The versatility of LMI is further demonstrated in addressing the interface issue between LMA and garnet-type solid-state electrolytes,where directly writing LMI on the garnet offers a perfect contact and enables an extremely low interfacial resistance of 6Ωcm^2,in sharp contrast to 939Ωcm^2 between the pure Li and the garnet.Due to the successful partnership with non-flammable solid-state electrolytes,ink-based technology may have a chance to bring us very close to the use of solid-state lithium metal batteries(SSLMBs)with high safety and high energy density. | Wangyan Wu Jian Duan Jiayun Wen Yuwei Chen Xuyang Liu Liqiang Huang Zhengfeng Wang Shengyuan Deng Yunhui Huang Wei Luo | 2020 | Science China Chemistry2020，63，10： | 2 |
| 18 | Reproductive toxicity and underlying mechanisms of di(2-ethylhexyl) phthalate in nematode Caenorhabditis elegans显示文摘DEHP(di(2-ethylhexyl) phthalate) is an endocrine disruptor commonly found in plastic products that has been associated with reproduction alterations, but the effect of DEHP on toxicity is still widely unknown. Using DEHP concentrations of 10, 1, and 0.1 mg/L, we showed that DEHP reduced the reproductive capacity of Caenorhabditis elegans after 72 hr. of exposure. DEHP exposure reduced the reproductive capacity in terms of decreased brood sizes, egg hatchability(0.1, 1 and 10 mg/L), and egg-laying rate(1 and 10 mg/L), and increased numbers of fertilized eggs in the uterus(1 and 10 mg/L). DEHP also caused damage to gonad development. DEHP decreased the total number of germline cells, and decreased the relative area of the gonad arm of all exposure groups, with worms in the 1 mg/L DEHP exposure group having the minimum gonad arm area. Additionally, DEHP caused a significant concentration-dependent increase in the expression of unc-86. Autophagy and ROS contributed to the enhancement of DEHP toxicity in reducing reproductive capacity, and glutathione peroxidase and superoxide dismutase were activated as the antioxidant defense in this study. Hence, we found that DEHP has a dual effect on nematodes. Higher concentration(10 mg/L) DEHP can inhibit the expression of autophagy genes( atg-18, atg-7, bec-1, lgg-1 and unc-51), and lower concentrations(0.1 and 1 mg/L) can promote the expression of autophagy genes. Our data highlight the potential environmental risk of DEHP in inducing reproductive toxicity toward the gonad development and reproductive capacity of environmental organisms. | Jingjing Li Man Qu Mei Wang Ying Yue Zhaofang Chen Ran Liu Yuanqing Bu Yunhui Li | 2021 | Journal of Environmental Sciences2021，33，7： | 2 |
| 19 | The Uniform Distribution of SiC Particles in an A356-SiC_p Composite Produced by the Tilt-blade Mechanical Stirring显示文摘The tilt-blade mechanical stirring of A356-2.5vol.%SiCp liquid was conducted in a cylindrical crucible to solve the problem of nonhomogeneous radial distribution of SiC particles in conventional straight-blade mechanical stirring. The radial distribution of SiC particles in A356 liquid was studied under the conditions of 25° for horizontal tilt angle α of the blade, 200 r/min for rotating speed of stirrer and 10 mm/s for speed of moving up and down of stirrer. The results show that there exists a nonlinear relationship between circumferential tilt angle β of the blade and radial relative deviation d of SiCp content in A356 liquid. When β is smaller than 26°, the d of SiCp content in A356 liquid between the center and the periphery of crucible decreases with increasing β. Conversely, when β is bigger than 26 , d increases with increasing β. Only when β is about 26°, d can be equal to nought i.e. uniform radial distribution of SiC particles can be realized. It can be seen that the nonhomogeneous radial distribution of SiC particles in conventional straight-blade mechanical stirring can be eliminated in this tilt-blade mechanical stirring of A356-SiCp liquid. | Yunhui DU Peng ZHANG Yujie WANG Jun ZHANG Shasha YAO Chengyu LI | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，1： | 2 |
| 20 | Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms显示文摘Heart failure is the leading cause of death worldwide.Compound Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in China.However,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is unknown.We constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart failure.CDDP or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and anti-fibrosis.Mechanistically,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart injury.Conversely,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt inhibitors.While the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and activity.In addition,CDDP attenuated simvastatin-induced myolysis in skeletal muscle.Taken together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure. | Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
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