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| 1 | Influence of refined hierarchical martensitic microstructures on yield strength and impact toughness of ultra-high strength stainless steel显示文摘The hierarchical martensitic features in ultra-high strength stainless steel(UHSSS),including the prior austenite grains,martensite packets,blocks and laths with the descending size,were refined to various extents by employing different thermomechanical processes and then carefully characterized.Their relation to yield strength and impact toughness was analyzed.We conclude that the refinement of martensitic structures could lead to the significant increase of yield strength,which follows the Hall-Petch relation with the effect grain size defined by high angle boundaries(HABs).Impact toughness of UHSSS depends on the frequency and capability for retained austenite(RA)grains at both HABs and martensite lath boundaries to trap the propagating cracks via strain-induced transformation,in which the film-like RA grains at lath boundaries appear to make the greater contribution. | Haiwen Luo Xiaohui Wang Zhenbao Liu Zhiyong Yang | 2020 | Journal of Materials Science & Technology2020，47，16： | 12 |
| 2 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 3 | A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants显示文摘Zinc(Zn)alloy porous scaffolds produced by additive manufacturing own customizable structures and biodegradable functions,having a great application potential for repairing bone defect.In this work,a hydroxyapatite(HA)/polydopamine(PDA)composite coating was constructed on the surface of Zn-1Mg porous scaffolds fabricated by laser powder bed fusion,and was loaded with a bioactive factor BMP2 and an antibacterial drug vancomycin.The microstructure,degradation behavior,biocompatibility,antibacterial performance and osteogenic activities were systematically investigated.Compared with as-built Zn-1Mg scaffolds,the rapid increase of Zn2+,which resulted to the deteriorated cell viability and osteogenic differentiation,was inhibited due to the physical barrier of the composite coating.In vitro cellular and bacterial assay indicated that the loaded BMP2 and vancomycin considerably enhanced the cytocompatibility and antibacterial performance.Significantly improved osteogenic and antibacterial functions were also observed according to in vivo implantation in the lateral femoral condyle of rats.The design,influence and mechanism of the composite coating were discussed accordingly.It was concluded that the additively manufactured Zn-1Mg porous scaffolds together with the composite coating could modulate biodegradable performance and contribute to effective promotion of bone recovery and antibacterial function. | Zhenbao Zhang Aobo Liu Jiadong Fan Menglin Wang Jiabao Dai Xiang Jin Huanze Deng Xuan Wang Yijie Liang Haixia Li Yantao Zhao Peng Wen Yanfeng Li | 2023 | Bioactive Materials2023，，9： | 2 |
| 4 | Living cell for drug delivery显示文摘The living cells have been emerged as useful platforms for drug delivery due to their advantages of good liquidity,stability,and low immunogenicity.In this review,we summarized the development of living cells-based drug delivery systems.The drug loading methods,applications,and advantages of living cell drug delivery systems were summarized.Different living cells for drug delivery,the mechanisms of action,therapeutic applications,as well as main features were summarized and highlighted.The recent research progress and challenges were discussed.The future directions and prospects were proposed. | Yuwei Wu Yanfei Liu Ting Wang Qiao Jiang Feng Xu Zhenbao Liu | 2022 | Engineered Regeneration2022，3，2： | 1 |
| 5 | Recombinant Human Endostatin Endostar Inhibits Tumor Growth and Metastasis in a Mouse Xenograft Model of Colon Cancer显示文摘 | Yitao Jia Min Liu Wangang Huang Zhenbao Wang Yutong He Jianhua Wu Shuguang Ren Yingchao Ju Ruichao Geng Zhongxin Li | 2012 | Pathology & Oncology Research2012，，2： | 1 |
| 6 | In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy显示文摘The therapeutic efficiency of active targeting nanoparticulate drug delivery systems(nano-DDS)is highly compromised by the plasma proteins adsorption on nanoparticles(NPs)surface,which significantly hinders cell membrane receptors to recognize the designed ligands,and provokes the off-target toxicity and rapid clearance of NPs in vivo.Herein,we report a novel dihydroartemisinin(DHA)-decorating nano-DDS that in situ specifically recruits endogenous apolipoprotein E(apoE)on the NPs surface.The apoE-anchored corona is able to prolong PLGA-PEG2000-DHA(PPD)NPs circulation capability in blood,facilitate NPs accumulating in tumor cells by the passive enhanced permeability and retention(EPR)effect and low-density lipoprotein receptor(LDLr)-mediated target transport,and ultimately improve the in vivo antitumor activity.Our findings demonstrate that the strategy of in situ regulated apoE-enriched corona ensures NPs an efficient LDLr-mediated tumor-homing chemotherapy. | Zhenbao Li Jiaojiao Zhu Yongqi Wang Mei Zhou Dan Li Shunzhe Zheng LiLi Yin Cong Luo Huicong Zhang Lu Zhong Wei Li JianWang Shuangying Gui Biao Cai Yongjun Wang Jin Sun | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 1 |
| 7 | Effect of Matrix Modification on Durability of Cementitious Composites in an Acid Rain Environment显示文摘The durability of silane-modifi ed mortar, a cementitious composite, in acid rain environment was investigated given its extensive usage as a structural material. The results indicated that the addition of silane decreased the compressive strength of the cementitious composite. Wetting angle was increased by incorporating silane into the matrix. Decrease in both water absorption ability and coefficient of capillary suction confi rmed hydrophobicity as induced by silane addition. Results of mechanical testing, scanning electron microscopy and X-ray diffraction showed that the sulfuric acid resistance of mortar was enhanced by silane. Based on these results, it is revealed that silane addition inhibits the diffusion of water, and consequently, sulfate ion diffusion rate decreases, thereby resulting in reduction in the rate of corrosion of cementitious composites by sulfuric acid. | 贺奎 YANG Hui LU Zhenbao JIA Fangfang WANG Erpo 董全霄 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 1 |
| 8 | Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs显示文摘Combinational therapy of lamivudine and oxymatrine has been employed in the battle against hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or active metabolism in intravenous/oral co-administration regime is poorly investigated. Herein,we evaluated the pharmacokinetic characteristic through a tailor-designed 3 way crossoverLatin square experiment in adult male beagle dogs. Six dogs were randomly treated by intravenous administration of lamivudine(2.5 mg/kg), oxymatrine(15 mg/kg) and combinational dosage, named as intravenous regime. Meanwhile the other six dogs were orally administrated with lamivudine(2.5 mg/kg), oxymatrine(15 mg/kg) and combinational dosage,named as oral regime. The pharmacokinetic feature in simultaneous oral treatment appeared to have no significant difference when compared with individual administration,even including matrine, the active metabolite of oxymatrine. In intravenous regime, the main pharmacokinetic parameters of simultaneous administration were nearly consistent with intravenous regime remedy. The collaborated application of lamivudine and oxymatrine contributed to non-distinctive pharmacokinetic fluctuations of beagle dogs in intravenous/oral regime, compared with individual employment, which established a vital base for the clinical co-administration against hepatitis B. Furthermore, the present study demonstrated that the determination of pharmacokinetics between combinational and individual therapy might assist in the development of drug compatibility in clinical therapy. | Zhenbao Li Lei Shang Chang Liu Panqin Ma Chunnuan Wu Wenjuan Zhang Yinghua Sun Yongjun Wang Xiaohong Liu Jin Sun | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 1 |
| 9 | Fabrication of Ordered Porous Structures by Self-Assembly of Zeolite Nanocrystals显示文摘 | Huang Limin Wang Zhenbao Sun Jinyu | 2000 | JAm Chem Soc2000，122，14： | 1 |
| 10 | Conserved peptides enhance immune efficiency of inactive vaccines against emerging avian influenza viruses in chicken显示文摘Avian influenza viruses(AIVs) such as H5N1 and H7N9 are a great threat to poultry economics and public health. Vaccination can effectively inhibit the spread of AIV in poultry, which is also a viable strategy for controlling virus transmission from poultry to human. Adjuvants that are commonly used in current inactivated vaccines to provide stronger anti-AIV immune responses are often limited in their capacity to quantitatively induce both humoral and cellular immune responses. Herein, we assessed the levels of immune responses generated by a vaccine formulation comprising inactivated H5N1 antigen and synthetic peptides covering conserved CD4^+, CD8^+ T cell, and B cell epitopes. We found that the synthetic peptides enhanced the antibody responses against conserved influenza virus antigen M2 e. Notably, the hemagglutination inhibition test results indicated that the peptides significantly augmented the antibody responses of inactivated H5N1 antigen even in the 1/10 or 1/5 dose group, in the identical antibody level as antigen alone used at the full dose. This indicates that the peptide can significantly reduce the use of inactivated virus, lowering the cost of the vaccine. Moreover, the peptides increased the transcript levels of interleukin-4 and interferon-γcytokines in chicken peripheral blood mononuclear cells, which may facilitate both humoral and cellular immune responses. Our data suggest that this peptide combined with inactivated H5N1 antigen enhances both the humoral and cellular immune responses,which may benefit the prediction and design of synthetic peptide-based adjuvants for vaccines in chicken. | Jin Xiao Lei Zhang Zhenbao Wang Wangzhen Xiang Ping Lu Yingze Zhao Min Han Airong Ma Peng Qi Ming Wang George F.Gao William J.Liu | 2017 | Science China(Life Sciences)2017，60，12： | 1 |
| 11 | The studies of PLGA nanoparticles loading atorvastatin calcium for oral administration in vitro and in vivo显示文摘A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium(AC) nanoparticles(AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental parameters, including stabilizer species, stabilizer concentration and pH of aqueous phase, on particle size were also evaluated. The resultant nanoparticles were in spherical shape with an average diameter of 174.7 nm and a narrow particle size distribution. And the drug loading and encapsulation efficiency were about 8% and 71%, respectively. The particle size and polydispersion were almost unchanged in 10 days. The release curves of AC-PLGA-NPs in vitro displaying sustained release characteristics indicated that its release mechanisms were matrix erosion and diffusion. The pharmacokinetic study in vivo revealed that the Cmax and AUC0-∞ of AC-PLGA-NPs in rats were nearly 3.7-fold and 4.7-fold higher than that of pure atorvastatin calcium suspension. Our results demonstrated that the delivery of AC-PLGANPs could be a promising approach for the oral delivery of AC for enhanced bioavailability. | Zhenbao Li Wenhui Tao Dong Zhang Chunnuan Wu Binbin Song Shang Wang Tianyang Wang Mingming Hu Xiaohong Liu Yongjun Wang Yinghua Sun Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，3： | 1 |
| 12 | Ab Initio Investigations for the Role of Compositional Complexities in Affecting Hydrogen Trapping and Hydrogen Embrittlement:A Review显示文摘ydrogen embrittlement(HE)seriously restricts the service safety of structural metallic materials applicate in aerospace,ocean,and transportation.Recent studies aiming at increasing the HE-resistance have been focusing on trapping diffusible H atoms by inherent microstructural features in materials.Alloying-induced compositional complexities,including different types of solute atoms,lattice chemical heterogeneities,and carbide precipitates,have attracted research efforts regarding the H trapping capabilities and potential to reduce the susceptibility to HE.In this paper,we review recent progress in exploiting compositional complexities to regulate the hydrogen trapping characteristics and mechanical properties in H-containing environments.The focus is placed on results and insights from ab initio calculations based on density functional theory(DFT).Quantitative predictions of trapping parameters and atomic scale details that are hardly to be gained through traditional experimental characterizations are provided.Additionally,we overview the electronic/atomistic mechanisms of H trapping energetics in metallic materials.Finally,we propose some key challenges and prospects in simulation of defect interactions,interpretation of experimental characterizations,and developing microstructure-based H diffusion prediction models.For the applications of first principle calculations,we illustrate how the DFT data can complement experimental characterizations to guide composition and microstructure design for better HE-resistant materials. | Boning Zhang Yong Mao Zhenbao Liu Jianxiong Liang Jun Zhang Maoqiu Wang Jie Su Kun Shen | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，7： | 0 |
| 13 | Resilience Evaluation of Housing Estates from the Perspective of Epidemic Prevention:A Case Study of A District in Handan City显示文摘The outbreak of COVID-19 at the beginning of 2020 has a great impact on public health security at home and abroad.Community is the basic unit of urban epidemic prevention,and improving community resilience is of great significance for reducing the spread of the epidemic and maintaining the normal life of residents during the epidemic.Based on the concept of resilience,10 indicators were selected from four dimensions of urban space,including facilities,space,nature and society,to construct a community resilience evaluation indicator system for epidemic prevention,and 56 housing estates in Congtai District,Handan City,were selected for scientific evaluation.The results showed that the overall resilience of this region was relatively low and the resilience index decreased from southwest to northeast with the degree of urban development.The accessibility of urban open space,the proportion of redundant space area and the area of public space per capita had the lowest resilience index.Finally,policy suggestions were put forward to improve the resilience of housing estates in the region,so as to promote the steady progress of the city towards the agenda for sustainable development. | WANG Zhenbao ZHU Lin WANG Fang | 2021 | Journal of Landscape Research2021，13，3： | 0 |
| 14 | Reinforcement learning based UAV formation control in GPS-denied environment显示文摘Highly accurate positioning is a crucial prerequisite of multi Unmanned Aerial Vehicle close-formation flight for target tracking,formation keeping,and collision avoidance.Although the position of a UAV can be obtained through the Global Positioning System(GPS),it is difficult for a UAV to obtain highly accurate positioning data in a GPS-denied environment(e.g.,a GPS jamming area,suburb,urban canyon,or mountain area);this may cause it to miss a tracking target or collide with another UAV.In particular,UAV close-formation control in GPS-denied environments faces difficulties owing to the low-accuracy position,close distance between vehicles,and nonholonomic dynamics of a UAV.In this paper,on the one hand,we develop an innovative UAV formation localization method to address the formation localization issues in GPS-denied environments;on the other hand,we design a novel reinforcement learning based algorithm to achieve the high-efficiency and robust performance of the controller.First,a novel Lidar-based localization algorithm is developed to measure the localization of each aircraft in the formation flight.In our solution,each UAV is equipped with Lidar as the position measurement sensor instead of the GPS module.The k-means algorithm is implemented to calculate the center point position of UAV.A novel formation position vector matching method is proposed to match center points with UAVs in the formation and estimate their position information.Second,a reinforcement learning based UAV formation control algorithm is developed by selecting the optimal policy to control UAV swarm to start and keep flying in a close formation of a specific geometry.Third,the innovative collision risk evaluation module is proposed to address the collision-free issues in the formation group.Finally,a novel experience replay method is also provided in this paper to enhance the learning efficiency.Experimental results validate the accuracy,effectiveness,and robustness of the proposed scheme. | Bodi MA Zhenbao LIU Feihong JIANG Wen ZHAO Qingqing DANG Xiao WANG Junhong ZHANG Lina WANG | 2023 | Chinese Journal of Aeronautics2023，36，11： | 0 |
| 15 | Development of Liposome containing sodium deoxycholate to enhance oral bioavailability of itraconazole显示文摘The aim of this study was to enhance oral bioavailability of itraconazole(ITZ) by developing Liposome containing sodium deoxycholate(ITZ-Lip-NaDC). The liposome, consisting of egg yolk lecithin and sodium deoxycholate, was prepared by thin-film dispersion method.Differential Scanning Calorimetry(DSC) results indicated an amorphous state in the liposome. The physicochemical characteristics including particle size, morphology, entrapment efficiency, dissolution properties were also investigated. The performance of single-pass intestinal infusion exhibited that the transport order of intestinal segment was jejunum,duodenum, colon and ileum, and that all the segments participated in the absorption of ITZ in intestinal tract. The bioavailability study in rats showed that the AUC0-72 of the liposome was nearly 1.67-fold higher than that of commercial capsules(SPORANOX) in terms of oral administration, and the RSD of AUC0-72 of ITZ-Lip-NaD C was also decreased. Our results indicated that ITZ-Lip-NaDC liposome was facilitated to improve dissolution efficiency,augment transmembrane absorption, and then enhance the oral bioavailability of ITZ,successfully. | Zhenbao Li Meiyu Zhang Chang Liu Shiwei Zhou Wenjuan Zhang Tianyang Wang Mei Zhou Xiaohong Liu Yongjun Wang Yinghua Sun Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，2： | 0 |
| 16 | The Method and Practice of Street Renewal Based on Innovative Design Thinking显示文摘In order to solve the practical problems of streets,create a pleasant street space and improve the participation of designers and users,the process and method of street renewal based on innovative design thinking were put forward on the basis of the core idea of“user centered”design thinking.The main steps included:setting up workshop and establishing project,understanding and observation,synthesis,creativity,prototype and test feedback.Taking the streets around Anju Dongcheng Community in Handan City as an example,the main process included setting up workshops,carrying out research and data analysis,focusing on outstanding issues,putting forward a variety of renewal and transformation schemes,scheme testing and prototype expression.The whole practice process improved the designer’s design thinking ability,enhanced the participation consciousness of street users,and provided a new idea for street renewal design. | WANG Zhenbao XIANG Sirong ZHU Jiaxin GUO Shuming | 2020 | Journal of Landscape Research2020，12，4： | 0 |
| 17 | Low Carbon Urban Design Concept Planning of Handan Eastern New District显示文摘Currently urban issues show a dramatically increasing rely on auto use,which seriously affects the sustainable development of the city and makes how to build low-carbon cities become one of the urgent problems to be solved in the process of urban development.Therefore,low-carbon cities have become principles for China’s next generation of growth and the research hot spot of urban traffic planning.By taking a look at the concepts such as Compact City,transit-oriented development(TOD)city and‘small block’zoning,the article combined the relationship between urban spatial layout patterns and traffic development mode to build a green,low-carbon and sustainable urban development model.Finally,taking the urban design of the new district in the east of Handan City as an example,this research applied the concepts and approaches to planning practice,hoping to provide reference for building low carbon cities. | WANG Zhenbao ZHU Lin WANG Xiao HU Yiqing LIU Yuanli | 2020 | Journal of Landscape Research2020，12，3： | 0 |
| 18 | Polymorphism analysis and supertype definition of swine leukocyte antigen class I molecules in three-way crossbred(Landrace,Duroc,and Yorkshire)pigs:implications for the vaccine development of African swine fever virus显示文摘Dear Editor,Swine major histocompatibility complex(MHC)is a highly polymorphic gene in pigs and is also called swine leukocyte antigen(SLA)(Fan et al.,2018).SLA is divided into three major categories,SLA I(SLA-1,-2,-3),SLA II,and SLA III(Smith et al.,2005).SLA I plays an important role in cellular immunity which can eliminate viruses and other foreign antigens in pigs(Macdonald et al.,2010).SLA-1,SLA-2 and SLA-3 are important SLA I alleles and are highly polymorphic.Polymorphism causes extreme difficulties in screening broadly protective cytotoxic lymphocyte(CTL)epitope antigens.The supertype which is built based on peptide-binding specificity of each SLA I can overcome this difficulty to some extent(Thomsen et al.,2013). | Limin Ba Zhenbao Wang William J Liu Dongxun Wu Wangzhen Xiang Peng Qi Chunna Dong Yanxin Hu Ping Lu Jin Xiao Changyuan Yu | 2020 | Science China(Life Sciences)2020，63，10： | 0 |
| 19 | Molecular Identification of Hyalomma anatolicum,Hyalomma asiaticum and Hyalomma detritum显示文摘Hyalomma anatolicum,Hyalomma asiaticum and Hyalomma detritum are wide-spread tick vectors in China. They could transmit a great variety of serious animal and human pathogens,which are great threats to the health of human beings and the safety of stockbreeding. Most of them are distributed in Xinjiang and Inner Mongolia,and they share similar morphologies. This study is to establish a method for identifying H. anatolicum,H. asiaticum and H. detritum with molecular markers and to revealing the phylogenetic relationship of these ticks. Ticks were collected from domestic animals in Xinjiang and Inner Mongolia autonomous regions and classified by morphological characters. 16 S rRNA and mitochondrial cytochrome oxidase subunit I gene( COI) of ticks were amplified by PCR and subsequently sequenced. Phylogenetic trees were constructed by MEGA 5. 0 and Mrbayes 3. 2. On the 16 S rRNA-based phylogenetic tree,H. anatolicum and H. aisaticum were clustered together with their respective classes. H. detritum was clustered with their respective class and the H. anatolicum,H. asiaticum formed distinct branches on the phylogenetic trees based on the COI. The method based on morphology that combined with molecular 16 S rRNA and COI seemed a simple and accurate method for species identification of H. anatolicum,H. asiaticum and H. detritum. | Lv Jizhou Wu Shaoqiang Zhang Yongning Wang Zhenbao Feng Chunyan Wang Caixia Deng Junhua Yuan Xiangfen Lin Xiangmei | 2014 | Animal Husbandry and Feed Science2014，6，3： | 0 |
| 20 | Occurrence Regularity and Green Prevention and Control Technology of Bradysia odoriphaga in Shandong Province显示文摘The occurrence regularity,damage characteristics and difficulties in prevention and control of Bradysia odoriphaga in Shandong Province were elaborated,and effective,economic,no residue,simple and feasible green prevention and control technology were put forward,in order to better guide the Chinese chive production.The study would also promote benign development of Chinese chive industry in Shandong Province. | Li Zhaoxia Xu Nianfang Zang Chuanjiang Song Jiping Wang Zhenbao Fu Zaiqiu | 2019 | Plant Diseases and Pests2019，10，4： | 0 |
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