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| 1 | Size distribution of chemical elements and their source apportionment in ambient coarse, fine, and ultrafine particles in Shanghai urban summer atmosphere显示文摘Ambient coarse particles (diameter 1.8-10 μm), fine particles (diameter 0.1-1.8 μm), and ultrafine particles (diameter < 0.1 μm) in the atmosphere of the city of Shanghai were sampled during the summer of 2008 (from Aug 27 to Sep 08). Microscopic characterization of the particles was investigated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM/EDX). Mass concentrations of Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb in the size-resolved particles were quantified by using synchrotron radiation X-ray fluorescence (SRXRF). Source apportionment of the chemical elements was analyzed by means of an enrichment factor method. Our results showed that the average mass concentrations of coarse particles, fine particles and ultrafine particles in the summer air were 9.38 ± 2.18, 8.82 ± 3.52, and 2.02 ± 0.41 μg/m3, respectively. The mass percentage of the fine particles accounted for 51.47% in the total mass of PM10, indicating that fine particles are the major component in the Shanghai ambient particles. SEM/EDX results showed that the coarse particles were dominated by minerals, fine particles by soot aggregates and fly ashes, and ultrafine particles by soot particles and unidentified particles. SRXRF results demonstrated that crustal elements were mainly distributed in the coarse particles, while heavy metals were in higher proportions in the fine particles. Source apportionment revealed that Si, K, Ca, Fe, Mn, Rb, and Sr were from crustal sources, and S, Cl, Cu, Zn, As, Se, Br, and Pb from anthropogenic sources. Levels of P, V, Cr, and Ni in particles might be contributed from multi-sources, and need further investigation. | Senlin Lu Rui Zhang Zhenkun Yao Fei Yi Jingjing Ren Minghong Wu Man Feng Qingyue Wang | 2012 | Journal of Environmental Sciences2012，24，5： | 22 |
| 2 | Nat Microbiol:已结首次构建出小鼠肠道微生物组数据库显示文摘小鼠模型通常被广泛用于药理学和医学研究。我们都知道小鼠肠道中的微生物群落通常会对研究结果产生明显的影响,然而目前研究者们并没有获取到关于小鼠肠道中栖息细菌群落的详细信息。近日刊登在国际杂志Nature Microbiology上的一篇研究报告中。德国慕尼黑理工大学的研究者通过研究首次收集到了小鼠肠道中的多种细菌群落。同时研究者还对其进行了分裂、特性分析。最后得到了100种细菌,其中还包括15种迄今为止未知的细菌群落。 | Lu, Qiulun Yao, Yufeng Hu, Zhenkun Hu, Changqing Song, Qixue Ye, Jian Xu, Chengqi Wang, Annabel Z. Chen, Qiuyun Wang, Qing Kenneth | 2016 | 现代生物医学进展2016，16，32： | 13 |
| 3 | Structural basis for blocking PD-l-mediated immune suppression by therapeutic antibody pembrolizumab显示文摘 | Zhenkun Na Siok Ping Yeo Sakshibeedu R Bharath Matthew W Bowler Esra Ballkci Cheng-I Wang Haiwei Song | 2017 | Cell Research2017，27，1： | 10 |
| 4 | Green fluorescent protein (GFP) transgenic pig produced by somatic cell nuclear transfer显示文摘Transgenic somatic cell nuclear transfer is a very promising route for producing transgenic farm ani-mals. Research on GFP transgenic pigs can provide useful information for breeding transgenic pigs, human disease models and human organ xenotransplantation. In this study, a liposomal transfection system was screened and transgenic embryos were reconstructed by nuclear transfer of GFP positive cells into enucleated in vitro matured oocytes. The development of reconstructed embryos both in vitro and in vivo was observed, and GFP expression was determined. The results showed that porcine fe-tal-derived fibroblast cells cultured with 4.0 μL/mL liposome and 1.6 μg/mL plasmid DNA for 6 h re-sulted in the highest transfection rate (3.6%). The percentage of GFP reconstructed embryos that de-veloped in vitro to the blastocyst stage was 10%. Of those the GFP positive percentage was 48%. Re-constructed transgenic embryos were transferred to 10 recipients. 5 of them were pregnant, and 3 de-livered 6 cloned piglets in which 4 piglets were transgenic for the GFP as verified by both GFP protein expression and GFP DNA sequence analysis. The percentage of reconstructed embryos that resulted in cloned piglets was 1.0%; while the percentage of piglets that were transgenic was 0.7%. This is the first group of transgenic cloned pigs born in China, marking a great progress in Chinese transgenic cloned pig research. | LIU ZhongHua SONG Jun WANG ZhenKun TIAN JiangTian KONG QingRan ZHENG Zhong YIN Zhi GAO Li MA HaiKun SUN Shuang LI YuTian WANG HongBin R S PRATHER | 2008 | Chinese Science Bulletin2008，53，7： | 8 |
| 5 | Self-excitation of neurons leads to multiperiodicity of discrete-time neural networks with distributed delays显示文摘In this paper, we investigate the interesting multiperiodicity of discrete-time neural networks with excitatory self-connections and distributed delays. Due to self-excitation of neurons, we construct 2N close regions in state space for N-dimensional networks and attain the coexistence of 2N periodic sequence solutions in these close regions. Meanwhile we estimate exponential attracting domain for each periodic sequence solution and apply our results to discrete-time analogues of periodic or autonomous neural networks. Under self-excitation of neurons, numerical simulations are performed to illustrate the effectiveness of our results. | HUANG ZhenKun WANG XingHua SANNAY Mohamad | 2011 | Science China(Information Sciences)2011，54，2： | 4 |
| 6 | Regulation of sister chromatid cohesion by nuclear PD-L1显示文摘Programmed death ligand-1(PD-L1 or B7-H1)is well known for its role in immune checkpoint regulation,but its function inside the tumor cells has rarely been explored.Here we report that nuclear PD-L1 is important for cancer cell sister chromatid cohesion.We found that depletion of PD-L1 suppresses cancer cell proliferation,colony formation in vitro,and tumor growth in vivo in immune-deficient NSG mice independent of its role in immune checkpoint.Specifically,PD-L1 functions as a subunit of the cohesin complex,and its deficiency leads to formation of multinucleated cells and causes a defect in sister chromatid cohesion.Mechanistically,PD-L1 compensates for the loss of Sororin,whose expression is suppressed in cancer cells overexpressing PD-L1.PD-L1 competes with Wing Apart-Like(WAPL)for binding to PDS5B,and secures proper sister chromatid cohesion and segregation.Our findings suggest an important role for nuclear PD-L1 in cancer cells independent of its function in immune checkpoint. | Jia Yu Bo Qin Ann MMoyer Somaira Nowsheen Xinyi Tu Haidong Dong Judy CBoughey Matthew PGoetz Richard Weinshilboum Zhenkun Lou Liewei Wang | 2020 | Cell Research2020，30，7： | 3 |
| 7 | Generation of Tripotent Neural Progenitor Cells from Rat Embryonic Stem Cells显示文摘老鼠是为药理学和生理的研究的一个珍贵模型。胚胎的茎(物件) 房间衬里的 Germline 能干的老鼠成功地被建立了,维持物件细胞的自我更新的、无差别的状态的分子的网络也好揭开。然而,很少对区别策略和这些真老鼠 pluripotent 干细胞怎么产生特定的房间类型的内在的机制被知道。这研究的目的是调查物件房间的神经区别能力。借助于一个修改过程基于 激活mitogen 的蛋白质 kinase ( MAPK )和肝糖 synthase kinase 的以前的出版物联合 3 ( GSK3 )禁止者(二个禁止者, 2i )与喂调节中等,我们成功地从物件房间获得了高质量的老鼠胚胎植物或动物身体(美国南北战争时南军士兵)然后区分了他们到 tripotent 神经祖先。这些物件导出房间的神经祖先房间(rNPCs ) 能够自我更新并且产生所有三个神经的系,包括的星形细胞, oligodendrocytes,和神经原。而且,这些导出房间的神经原染色了的物件为 -aminobutyric 酸(伽马氨基丁酸) 和酷氨酸 hydroxylase (TH ) 积极。在摘要,我们为区分物件房间到 tripotent 开发一个试验性的系统神经祖先,它可以为学习象 Parkinson 的疾病和老鼠神经系统的开发那样的许多 neurodegenerative 混乱的致病为药理学测试和一个珍贵平台提供一个强大的工具。 | Zhenkun Wang Chao Sheng Tianda Li Fei Teng Lisi Sang Fenglin Cao Ziwei Wang Wanwan Zhu Wei Li Xiaoyang Zhao Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，12： | 2 |
| 8 | To move or stay?A cellular automata model to predict urban growth in coastal regions amidst rising sea levels显示文摘Low-lying coastal cities are widely acknowledged as the most densely populated places of urban settlement;they are also more vulnerable to risks resulting from intensive land use and land cover change,human activities,global climate change,and the rising sea levels.This study aims to predict how urban growth is affected by sea level rise(SLR)in the Australian context.We develop an urban cellular automata model incorporating urban planning policies as potential drivers or constraints of urban growth under different SLR scenarios and adaption strategies.Drawing on data capturing the socioeconomic and environmental factors in South East Queensland,Australia,our model is positioned to address one core research question:how does SLR affect future urban growth and human resettlement?Results show that urban growth in coastal regions varies depending on the extent to which the sea level rises and is affected by a combination of factors relating to urban planning and human adaptation strategies.Our study demonstrates the complexity of urban growth in coastal regions and the nuanced outcomes under different adaptation strategies in the context of rising sea levels. | Siqin Wang Yan Liu Yongjiu Feng Zhenkun Lei | 2021 | International Journal of Digital Earth2021，14，9： | 2 |
| 9 | Stress transfer in microdroplet tensile test: PVC - coated and uncoated Kevlar - 29 single fiber显示文摘 | LEI Zhenkun WANG Quan KANG Yilan | 2010 | Optics and Lasers in Engineering2010，，48： | 1 |
| 10 | Experimental investigation of interfacial fracture behavior in foam core sandwich beams with visco-elastic adhesive inteface显示文摘 | Wang Can Chen Haoran Lei Zhenkun | 2010 | Composite Structures2010，92，5： | 1 |
| 11 | DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability显示文摘 | Bo Qin Katherine Minter-Dykhouse Jia Yu Jun Zhang Tongzheng Liu Haoxing Zhang SeungBaek Lee JungJin Kim Liewei Wang Zhenkun Lou | 2015 | Cell Reports2015，，： | 1 |
| 12 | Experimentalinvestigation of interfacial fracture behavior in foam coresandwich beams with visco-elastic adhesive interface显示文摘 | Wang Can Chen Haoran Lei Zhenkun | 2010 | Composite Structures2010，92，5： | 1 |
| 13 | A general chelate-assisted co assembly to metallic nanoparticles-incorporated ordered mesoporous car- bon catalysts for fischer-tropsch synthesis显示文摘 | Sun Zhenkun Sun Bo Qiao Minghua Wei Jing Yue Q Wang Chun | 2012 | Journal of the American Chemical Society2012，134，17： | 1 |
| 14 | Wavelength-swept fiber laser based on bidirectional used linear chirped fiber Bragg grating显示文摘A wavelength-swept fiber laser is proposed and successfully demonstrated based on a bidirectional used linear chirped fiber Bragg grating(LC-FBG). The wavelength-swept operation principle is based on intracavity pulse stretching and compression. The LC-FBG can introduce equivalent positive and negative dispersion simultaneously, which enables a perfect dispersion matching to obtain wide-bandwidth mode-locking. Experimental results demonstrate a wavelength-swept fiber laser that exhibits a sweep rate of about 5.4 MHz over a 2.1 nm range at a center wavelength of 1550 nm. It has the advantages of simple configuration and perfect dispersion matching in the laser cavity. | LIN WANG MINGGUI WAN ZHENKUN SHEN XUDONG WANG YUAN CAO XINHUAN FENG BAI-OU GUAN | 2017 | Photonics Research2017，5，3： | 1 |
| 15 | Smoke venting and fire safety in an industrial warehouse显示文摘 | Yaping He Jian Wang Zhenkun Wu Lu Hu Yi Xiong Weicheng Fan | 2002 | Fire Safety Journal2002，37，： | 1 |
| 16 | Experimental investigation of interracial fracture behavior in foam core sandwich beams with visco-elastic adhesive interface 显示文摘 | Wang Can Chen Haoran Lei Zhenkun | 2010 | Composite Structures2010，92，： | 1 |
| 17 | High 一fre-quency properties of discontinuous FeCoSi/native - oxidemultilayer films 显示文摘 | Zuo Huaping Ge Shihui Wang Zhenkun | 2009 | Journal of Magnetism and MagneticMaterials2009，321，20： | 1 |
| 18 | Complication following gastric pull-up reconstruction for advanced hypopharyngeal or cervical esophageal carcinoma: a 20-year review in a Chinese institute显示文摘 | He Shuangba Sun Jingwu Wang Yinfeng Hu Yanming Lv Qiuping Li Xianguang Xu Weiqing Wang Shengjun Yu Zhenkun | 2011 | American Journal of Otolaryngology--Head and Neck Medicine and Surgery2011，，4： | 1 |
| 19 | Stress transfer in microdroplet tensile test: PVC-coated and uncoated Kevlar-29 single fiber显示文摘 | Lei Zhenkun Wang Quan Kang Yilan | 2010 | Optics and Lasers in Engineering2010，48，1： | 1 |
| 20 | Experimental investigation of interracial fracture behavior in foam core sandwich beams with visco-elastic adhesive interface显示文摘 | Wang Can Chen Haoran Lei Zhenkun | 2010 | Composite Structures2010，92，5： | 1 |
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