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| 1 | Antimicrobial Activity of the Methanolic Extract and Compounds from the Stem Bark of Drypetes tessmanniana显示文摘从茎评估甲醇摘录的抗菌剂活动的目的 Drypetes tessmanniana ,部分( DTB1-5 )以及混合物吠叫[ friedelin ( 2 ), 3,7-dioxofriedelane ( 3 ), 3,15-dioxofriedelane ( 4 ), 3 尾-O-(E) -3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene ( 6 ),和 3 尾, 6 伪- dihydroxylup-20 ( 29 ) -ene ( 7 )。方法琼脂圆盘散开被用来决定上述样品的敏感,虽然 microdilution 方法被用于最小的禁止的集中(MIC ) 和最小的 microbicidal 集中(MMC ) 的决心。散开测试显示出的结果粗略的摘录能阻止所有的生长,这测试了有机体。所有另外的样品显示出选择活动。部分 DTB2 的禁止的效果在 63.7% 上被注意, 54.6% 上的 DTB1 和 DBT3,虽然 DTB4 和 DTB5 开是活跃的, 11 中的 9.1% 个测试了有机体。测试混合物为混合物阻止了 81.8% 测试微生物引起的种类的生长 3 和 4, 36.7% 为化合物 6,和 18.2% 为化合物 7。MIC 决心的结果为 DTB 和化合物显示了可察觉的价值 4 在 81.8% 测试有机体上。为另外的样品, MIC 在 0 鈥 ? 上被检测 3.7% 。为粗略的摘录和部分(DTB2 ) 的最低 MIC 价值(78.12 渭 g /mL ) 在 M 上被观察。audouinii。为孤立的混合物(156.25 渭 g /mL ) 的相应价值与混合物被注意 3 在 S 上。faecalis 并且 4 在 M 上。audouinii audouinii。MMC 决心的结果建议大多数学习微生物上的测试样品的 microbicidal 效果能被期望。结论从茎的甲醇摘录 Drypetes 吠叫。象一些孤立的混合物一样的 tessmanniana (Euphorbiaceae ) 可能是新抗菌剂药的潜在的来源。关键词 Drypetes tessmanniana - Euphorbiaceae - 混合物 - 抗菌剂活动为科学由国际基础支持了(没有。IFS/2624-3F ) 。 | Victor Kuete Marlise D.J.Dongfack Armelle T.Mbaveng Marie-Christine Lallemand Hanh T.Van-Dufat Jean-Duplex Wansi Elisabeth Seguin Francois Tillequin Jean Wandji | 2010 | Chinese Journal of Integrative Medicine2010，16，4： | 7 |
| 2 | A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata显示文摘新 friedelane 类型 triterpene 说出 3-hydroxyfriedelane-7,12,22-trione,以及九已知的混合物从 Drypetes laciniata 兔笼的整个茎被孤立。(Euphorbiaceae ) 。他们的结构根据分光镜的方法被建立。新 triterpene 衍生物和已知的 saponin 为抗菌剂和抗真菌的活动被测试,他们显得中等积极。 | Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack Jean Duplex Wansi Francois Tillequin Elisabeth Seguin Elizabeth Chosson Jean Wandji | 2011 | Chinese Chemical Letters2011，22，2： | 2 |
| 3 | New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii 显示文摘 | Chiozem D D Trinh-Van-Dufat H Wansi J D | 2009 | Chemical & Pharmaceutical Bulletin2009，57，10： | 1 |
| 4 | α-Glucosidaseinhibitory constituents from stem bark of Terminalia superba (Combretaceae)显示文摘 | Wansi JD Lallemand MC Chiozem DD | | 0，，15： | 1 |
| 5 | a-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii ( Rutaceae)显示文摘 | Mbaze L Poumale H Wansi J | 2007 | Phytochemistry2007，68，5： | 1 |
| 6 | Antileshmanial furanosesquiterpene and triterpenoids from Drypetes chevalieri Beille(Euphorbiaceae) 显示文摘 | Wansi J D Wandji J Lallemand M C | 2007 | Boletin Latinoamericano y del Caribe de Plants Medicinales y Aromaticas2007，6，1： | 1 |
| 7 | c-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae) 显示文摘 | Mbaze LM Poumale HM Wansi JD | 2007 | Phytochemistry2007，68，5： | 1 |
| 8 | Alpha-glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae)显示文摘 | Mbazc LM Poumale HM Wansi JD | | 0，，05： | 1 |
| 9 | ct-Glucosidase inhib- itory pentacyclic triterpenes from the stem bark of Fagara tess- mannii(Rutaceae)显示文摘 | Mbaze LM Poumale HM Wansi JD | 2007 | Phytochemistry2007，68，： | 1 |
| 10 | An- tileishmanial furansesquiterpene and triter- penoids from Drypetes chevalien Beille (Euphor- biaceae)显示文摘 | Wansi J D Wandji J Lallemand M C | 2007 | Bol Latinoam Caribe Plant Med Aromat2007，6，1： | 1 |
| 11 | New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii显示文摘 | Chiozem D D Trinh-Van-Dufat H Wansi J D | 2009 | Chem ical & Pharmaceutical Bulletin2009，，： | 1 |
| 12 | Antileshmanial furano- sesquiterpene and triterpenoids from Drypetes chevalieri Beille( Euphor- biaceae) 显示文摘 | Wansi J D Wandji J Lallemand M C | 2007 | Boletin Latinoamericano y del Caribe de Plants Medici- nales y Aromaticas2007，6，1： | 1 |
| 13 | Antibacterial constituents from Leucosceptrum canum显示文摘 | DEVKOTA K P LENTA B N WANSI J D | 2010 | Phytochem Lett2010，3，1： | 1 |
| 14 | Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)显示文摘 | Luc Meva’a Mbaze Jean Alexandre Lado Jean Duplex Wansi Tze Chieh Shiao David Dako Chiozem Muhammad Ahmed Mesaik Muhammad Iqbal Choudhary Marie-Aleth Lacaille-Dubois Jean Wandji René Roy Norbert Sewald | 2009 | Phytochemistry2009，，11： | 1 |
| 15 | Oxidative Burst Inhibitory and Cytotoxic Indoloquinazoline and Furoquinoline Alkaloids from Oricia suaveolens 显示文摘 | WANSI J D MESAIK M A CHIOZEM D D | 2008 | J Nat Prod2008，71，： | 1 |
| 16 | Avian leukosis virus subgroup A and B infection in wild birds of Northeast China显示文摘 | Delong Li Liting Qin Honglei Gao Bo Yang Wansi Liu Xiaole Qi Yongqiang Wang Xiangwei Zeng Sidang Liu Xiaomei Wang Yulong Gao | 2013 | Veterinary Microbiology (-)2013，，3： | 1 |
| 17 | α-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae) 显示文摘 | Mbaze L M Poumale H M P Wansi J D | 2007 | Phytochemistry2007，68，： | 1 |
| 18 | α-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae) 显示文摘 | Wansi J D Lallemand M C Chiozem D D | 2007 | Phytochemistry2007，68，： | 1 |
| 19 | HDAC6 inhibitor loaded bimetallene nanosheets with antagonizing thermoresistance for augmented mild photothermal therapy显示文摘Photothermal therapy(PTT)induces thermoresistance through cellular heat shock response,which impairs the therapeutic efficacy of the PTT.To resolve this problem,we developed a photothermal theranostics(denoted as PMH),which integrated the photothermal conversion agent of PdMo bimetallene with histone deacetylase 6(HDAC6)selected inhibitor(ACY-1215),showing the synergistic antitumor effect both in vitro and in vivo.Mechanistically,under the photoacoustic imaging(PA)navigation,the released ACY-1215 triggered by NIR laser irradiation decrease the heat shock proteins(HSPs)expression and weaken the HDAC6-regulated HSP90 deacetylation,thus hindering the degradation of PTT-induced misfolded or unfold proteins through proteasome dependent pathway.Moreover,mild photothermal therapy(mPTT)treatment compromised the autophagy,which induced by HDAC6 inhibition,leading to mPTTinduced misfolded or unfold proteins further accumulation.Given that inhibition of HDAC6 plus m PTT contribute to tumor eradication.This study develops a promising combination strategy based on m PTT for future cancer treatment. | Lingyu Qiu Shan Lei Jing Zhang Ruhan Yan Wansi Chen Jing Lin Wei-Guo Zhu Peng Huang | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 20 | AMP-activated protein kinaseβ1 orβ2 deletion enhances colon cancer cell growth and tumorigenesis显示文摘Abnormal metabolism is a major hallmark of cancer and has been validated as a therapeutic target.Adenine monophosphate-activated protein kinase(AMPK),anαβγheterotrimer,performs essential functions in cancer progression due to its central role in maintaining the homeostasis of cellular energy.While the contributions of AMPKαand AMPKγsubunits to cancer development have been established,specific roles of AMPKβ1 and AMPKβ2 isoforms in cancer development are poorly understood.Here,we show the functions of AMPKβ1 and AMPKβ2 in colon cancer.Specifically,deletion of AMPKβ1 or AMPKβ2 leads to increased cell proliferation,colony formation,migration,and tumorigenesis in HCT116 and HT29 colon cancer cells.Interestingly,the AMPKβ1 and AMPKβ2 isoforms have slightly different effects on regulating cancer metabolism,as colon cancer cells with AMPKβ1 knockout showed decreased rates of glycolysis-related oxygen consumption,while AMPKβ2 deletion led to enhanced rates of oxygen consumption due to oxidative phosphorylation.These results demonstrate that functional AMPKβ1 and AMPKβ2 inhibit growth and tumorigenesis in colon cancer cells,suggesting their potential as effective targets for colon cancer therapy. | Fuli Shi Zhimin Tang Shanshan Jiang Zhijuan Xiong Wansi Zhang Yuanjun Li Hui Lin Zhijun Luo Ying Ying | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 0 |
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