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| 1 | Observation of double indirect interlayer exciton in MoSe_(2)/WSe_(2) heterostructure显示文摘Interlayer excitons(IXS)are electron–hole pairs bound in the spatial separation layer by the Coulomb effect,and their lifetime is several orders of magnitude longer than that of direct excitons,providing an essential platform for long-lived exciton devices.The recent emergence of the van der Waals heterostructure(HS),which combines two layers of different transitional metal dichalcogenides(TMDs),has created new opportunities for IX research.Herein,we demonstrate the observation of double indirect interlayer excitons in the MoSe_(2)/WSe_(2)HS using photoluminescence(PL)spectroscopy.The intensities of the two peaks are essentially the same,and the energy difference is 22 meV,which is perfectly in line with the calculation result of density functional theory.Furthermore,the experience of variable excitation power also proves that the splitting of the IXs originates from the conduction band spin-splitting of MoSe_(2).The observation results provide a promising platform for further exploring the new physical properties and optoelectronic phenomena of TMD HS. | Biao Wu Yunpeng Wang Jiahong Zhong Cheng Zeng Yassine Madoune Wanting Zhu Zongwen Liu Yanping Liu | 2022 | Nano Research2022，15，3： | 3 |
| 2 | Activation of extrasynaptic GABA_A receptors inhibits cyclothiazideinduced epileptiform activity in hippocampal CA1 neurons显示文摘Extrasynaptic GABA_A receptors(GABA_ARs)-mediated tonic inhibition is reported to involve in the pathogenesis of epilepsy.In this study,we used cyclothiazide(CTZ)-induced in vitro brain slice seizure model to explore the effect of selective activation of extrasynaptic GABA_ARs by 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol(THIP)on the CTZ-induced epileptiform activity in hippocampal neurons.Perfusion with CTZ dose-dependently induced multiple epileptiform peaks of evoked population spikes(PSs)in CA1 pyramidal neurons,and treatment with THIP(5 umol/L)significantly reduced the multiple PS peaks induced by CTZ stimulation.Western blot showed that the 5-subunit of the GABA_AR,an extrasynaptic specific GABA_AR subunit,was also significantly down-regulated in the cell membrane 2h after CTZ treatment.Our results suggest that the CTZ-induced epileptiform activity in hippocampal CA1neurons is suppressed by the activation of extrasynaptic GABA_ARs,and further support the hypothesis that tonic inhibition mediated by extrasynaptic GABA_ARs plays a prominent role in seizure generation. | Li Wan Xu Liu Zheng Wu Wanting Ren Shuzhen Kong Raya Abou Dargham Longzhen Cheng Yun Wang | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 3 | Comparison of the differentiation of dental pulp stem cells and periodontal ligament stem cells into neuron-like cells and their effects on focal cerebral ischemia显示文摘Recent studies have reported an in creasing in cidence of ischemic stroke,particularly in younger age groups.Dental pulp stem cells(DPSCs)and periodontal ligament stem cells(PDLSCs)are the most comm on stem cells acquired from the teeth of adults,even elderly people.However,there are no detailed reports on whether DPSCs or PDLSCs are suitable for the treatment of ischemic stroke.In this study,the in vitro differentiation of DPSCs and PDLSCs into neuron-like cells was evaluated.Then,we established a rat model of cerebral ischemia.DPSCs or PDLSCs were administered to animals,and the therapeutic effects of these two types of cells were investigated.The results showed that PDLSCs had a higher differentiation rate than DPSCs.Immunofluorescence studies showed that the expression of the neuronal differentiation markerThy-1 was higher in PDLSCs than in DPSCs,and other gene markers of neuronal differentiation showed corresponding trends,which were confirmed by western blot analysis.In this process,the Notch and Wnt signaling pathways were inhibited and activated,respectively.Fin ally,rats with transient occlusion of the right middle cerebral artery were used as a model to assess the therapeutic effect of PDLSCs and DPSCs on ischemia.The results showed that rats in the PDLSC-treated group emitted significantly greater red fluorescence signal than the DPSC-treated group.PDLSC transplantation promoted the recovery of neurological function more effectively than DPSC transplantation.Hence,PDLSCs represent an autogenous source of adult mesenchymal stem cells with desirable biological properties and may be an ideal candidate for clinical applications. | Tingting Wu Wanting Xu Hanlin Chen Shasha Li Rengang Dou Hongtao Shen Xue Liu Xiaoyu Liu Yongfeng Hong Jiacai He | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 2 |
| 4 | Molecular Mechanism of Induction on Apoptosis of Human Esophageal Cancer HCE-4 Cells by Active Components from Astragalus membranaceus显示文摘[Objectives] To investigate the pharmacologic effects of active components from A. membranaceus on human esophageal cancer HCE-4 cells and its apoptosis mechanism. [Methods] The viabilities of HCE-4 cells were measured by MTT assay. The induction of active components from A. membranaceus on apoptosis of HCE-4 cells was detected by Annexin V-FITC/PI double staining. The apoptotic-related protein expression levels were determined by Western blotting. [Results] Formononetin and astragaloside IV suppressed the proliferation of HCE-4 cells in a dose-dependent manner. The Annexin V-FITC/PI double staining results showed that formononetin and astragaloside IV could induce HCE-4 cells apoptosis in a time-dependent manner. The Western blotting results showed that formononetin and astragaloside IV could significantly down-regulate p-AKT,pro-caspase-3,and increase cle-caspase-3 protein expression in HCE-4 cells. [Conclusions]Active components from A. membranaceus such as formononetin and astragaloside IV significantly inhibited the proliferation of human esophageal cancer HCE-4 cells by inducing mitochondrial dependent apoptosis via AKT signaling pathway. | Jiaru WANG Yinghua LUO Xianji PIAO Chang LIU Yi ZHANG Hao WANG Jinqian LI Wanting XU Yang LIU Yiqin WU Chenghao JIN | 2018 | Medicinal Plant2018，9，1： | 2 |
| 5 | Synthe- sis of 7-azaserotonin:Its photophysical properties associat- ed with excited state proton transfer reaction 显示文摘 | Wu Peiwen Hsieh Wanting Cheng Yiming | 2006 | JACS2006，128，12： | 1 |
| 6 | Poly(ether ether ketone ketone) based imidazolium as anion exchange membranes for alkaline fuel cells显示文摘An imidazolium functionalized poly(ether ether ketone ketone)(PEEKK-DIm OH)anion exchange membrane(AEM)readily soluble in certain low-boiling-point solvents(isopropanol)is prepared.The solubility results are consistent with the results of molecular dynamics simulations.By varying the chloromethylation reaction temperature or concentrated sulfuric acid concentration of PEEKK,the degrees of chloromethylation of PEEKK are changed from 54% to 92%,the corresponding PEEKK-DIm OH AEMs with the ion exchange capacities(IECs)of 1.14–1.65 mmol·g^(-1).The PEEKK-DIm OH 92% AEM shows high hydroxide conductivity(31 m S·cm^(-1)),suitable water uptake(94%)and acceptable swelling ratio(39%)at 60°C.In addition,the PEEKK-DIm OH AEMs possess good thermal and alkaline stability.The maximum power density(46.16 mW·cm^(-2))of fuel cell prepared with PEEKK-DIm OH 92%AEM as exchange membrane and ionomer is much higher than that with commercial AHA membranes.All the above results indicate that the PEEKK used in this study is a promising AEM matrix material for alkaline fuel cells. | Tiantian Li Xuemei Wu Wanting Chen Xiaoming Yan Dongxing Zhen Xue Gong Jiafei Liu Shaofeng Zhang Gaohong He | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 7 | Least squares particle filter 显示文摘 | WU Y WANT J ZHANG P C | 2014 | Electronics Letters2014，50，24： | 1 |
| 8 | Experience and inspirations of the Mass Drug Administration Programme with artemisinin-piperaquine in Moheli Island of the Comoros assisted by China显示文摘Malaria is one of the major diseases threatening the lives of people in Africa.Over the past decade,China has provided anti-malaria assistance to Africa.In November 2007,fast control malaria team of Guangzhou University of Chinese Medicine cooperated with the Comoros health authority.In Moheli Island of the Comoros,the anti-malaria team adopted a new strategy of Mass Drug Administration(MDA)and active intervention.They established an e ective anti-malaria system and reporting system,as well as a local anti-malaria team.Furthermore,they treated patients with malaria in Moheli Island and implemended health education in local people.In a very short time,they have achieved remarkable results.This paper summarized the experiences of the project in order to provide useful reference for China to better carry out anti-malaria action in Africa and expand foreign health assistance. | Qi Wang Yueming Yun Hongying Zhang Jiawen Guo Wanting Wu Changsheng Deng Bo Huang Zhiyong Xu Qin Xu Jianping Song | 2018 | Global Health Journal2018，2，3： | 1 |
| 9 | Associative properties of amphiphilic statistical polymers in aqueous media显示文摘 | WU X QIAO Y WANt' J | 2010 | J Chem Engin Data2010，55，2： | 1 |
| 10 | Lipid carriers for mRNA delivery显示文摘Messenger RNA(mRNA)is the template for protein biosynthesis and is emerging as an essential active molecule to combat various diseases,including viral infection and cancer.Especially,mRNA-based vaccines,as a new type of vaccine,have played a leading role in fighting against the current global pandemic of COVID-19.However,the inherent drawbacks,including large size,negative charge,and instability,hinder its use as a therapeutic agent.Lipid carriers are distinguishable and promising vehicles for mRNA delivery,owning the capacity to encapsulate and deliver negatively charged drugs to the targeted tissues and release cargoes at the desired time.Here,we first summarized the structure and properties of different lipid carriers,such as liposomes,liposome-like nanoparticles,solid lipid nanoparticles,lipid-polymer hybrid nanoparticles,nanoemulsions,exosomes and lipoprotein particles,and their applications in delivering mRNA.Then,the development of lipid-based formulations as vaccine delivery systems was discussed and highlighted.Recent advancements in the mRNA vaccine of COVID-19 were emphasized.Finally,we described our future vision and perspectives in this field. | Wanting Zhang Yuxin Jiang Yonglong He Hamza Boucetta Jun Wu Zhongjian Chen Wei He | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 1 |
| 11 | Rice disease identification method based on improved CNN-BiGRU显示文摘In the field of precision agriculture,diagnosing rice diseases from images remains challenging due to high error rates,multiple influencing factors,and unstable conditions.While machine learning and convolutional neural networks have shown promising results in identifying rice diseases,they were limited in their ability to explain the relationships among disease features.In this study,we proposed an improved rice disease classification method that combines a convolutional neural network(CNN)with a bidirectional gated recurrent unit(BiGRU).Specifically,we introduced a residual mechanism into the Inception module,expanded the module's depth,and integrated an improved Convolutional Block Attention Module(CBAM).We trained and tested the improved CNN and BiGRU,concatenated the outputs of the CNN and BiGRU modules,and passed them to the classification layer for recognition.Our experiments demonstrate that this approach achieves an accuracy of 98.21%in identifying four types of rice diseases,providing a reliable method for rice disease recognition research. | Yang Lu Xiaoxiao Wu Pengfei Liu Hang Li Wanting Liu | 2023 | Artificial Intelligence in Agriculture2023，，3： | 0 |
| 12 | TLE orbit determination using simplex method显示文摘Two-Line Element(TLE)datasets are the only orbital data source of Earth-orbiting space objects for many civil users for their research and applications.The datasets have uneven qualities that may affect the reliability of the propagated positions of space objects using a single TLE.The least squares approach to use multiple TLEs also suffers from the poor quality of some TLEs,and reliable error information cannot be available.This paper proposes a simplex algorithm to estimate an optimal TLE from multiple TLEs and obtain the uncertainty of each element.It is a derivative-free technique that can deal with various orbit types.Experiments have demonstrated that using the TLE estimated from the simplex method is more reliable,stable,and effective than those from the batch least squares method.As an application example,the optimal TLE and its uncertainty are used for predicting the fallen area,keeping the actual fallen site in the prediction areas. | Jinghong Liu Wanting Long Yunchen Wu Jin Xu Jizhang Sang Xiangxu Lei | 2023 | Geodesy and Geodynamics2023，14，5： | 0 |
| 13 | The immunoregulatory role of fish specific type Ⅱ SOCS via inhibiting metaflammation in the gut-liver axis显示文摘SOCS8,also known as CISHb,is a fish-specific type Ⅱ SOCS.Because CISH binds to cytokine receptors and may inhibit STAT5 activation(a substrate of the insulin receptor),SOCS8 may be involved in the control of metaflammation.The socs8-/-zebrafish were created,and both longer trunks and intestinal villi were observed in 1-month-old(mo)fish.Altered mucosal immunity and gut-liver metabolism were also found in socs8-/-fish.Increased intestinal neutrophils and macrophages,together with overexpression of cytokines and T cell markers in this mutant fish,suggested SOCS8's immunoregulating role.During modeling of soybean-induced enteritis using the 3 mo zebrafish,lower expression levels of inflammatory genes but more mucosa barrier disruption were discovered in socs8-/-zebrafish,compared with wide type counterparts.Furthermore,the shrunk villi at 6 mo in socs8-/-fish suggested that the mucosa might have been protected by SOCS8.This is also consistent with the assertion that metaflammation eventually leads to tissue degeneration and premature death.The fact that socs8-/-fish had more hepatic oil droplets compared to their wild-type counterparts suggested SOCS8's role in inhibiting hepatic metaflammation.Transcriptomic analysis as well as 16S rRNA gene sequencing were done on 3 mo socs8-/-fish to methodically reveal the altered immunity and metabolic reprogramming in the gut and liver caused by socs8-/-.The enriched GO terms for the intestinal tract,such as'cytokine-mediated signaling pathway'and'response to external biotic stimulus',as well as KEGG pathways in both gut and liver like'carbon metabolism'and'glycolysis/gluconeogenesis',were consistent with previously revealed pathological clues and improved growth performance at early age,respectively.In addition,the microbiota in the socs8-/-strain had adapted to the host's increased carbohydrate metabolism,as evidenced by higher levels of Bacteroidota.Furthermore,Verrucomicrobiota associated with immunoregulation were found in lower abundance in socs8-/-fish.As a result,current findings indicate that SOCS8 plays immunoregulatory and mucosa-protective roles in the fish gut and liver by inhibiting carbohydrate metabolism. | Qingsong Zhu Yuhang Liu Yingyin Cheng Wanting Zhang Nan Wu Xiao-Qin Xia | 2023 | Water Biology and Security2023，2，2： | 0 |
| 14 | Research progress on adaptive modifications of the gut microflora and regulation of host glucose and lipid metabolism by cold stimulation显示文摘The gut microflora is a combination of all microbes in intestine and their microenvironment,and its change can sensitively reflect the relevant response of the body to external environment and remarkably affect body's metabolism as well.Recent studies have found that cold exposure affects the body's gut microflora,which can lead to changes in the body's metabolism of glucose and lipid.This review summarizes recent research on the effects of cold exposure on gut microbes and metabolism of glucose and lipid,aiming to provide some new ideas on the approaches and measures for the prevention and treatment of diabetes and obesity. | Wanting Wei Guanyu Zhang Yongqiang Zhang Li Zhang Shuai Wu Xi Li Danfeng Yang | 2023 | Frigid Zone Medicine2023，3，1： | 0 |
| 15 | Bioinformatics Analysis of Xylanase xynMF13-GH10 Gene from Mangrove Fungi显示文摘[Objectives]The paper was to analyze and predict the structure and characteristics of xylanase xynMF13-GH10 gene and its encoded protein.[Methods]xynMF13-GH10 gene was predicted by NCBI and various information analysis tools in ExPASy website,as well as SignaIP 5.0,DNAman,TMHMM,SOPMA and SWISS-Model,and the characteristics and functions of protein structure encoded by the gene were predicted.[Results]The gene is 1332 bp in length,the coding region is 1-1332 bp,and the gene encodes 443 amino acids.The xynMF13-GH10 gene has high homology with xylanase in many species,and it has the highest homology with Paraphaeosphaeria sporulosa endoxylanase-like protein,with the consistency reaching 78.91%and e-value reaching 2e-159.The secondary structure consists of 48.31%random curl,30.25%α-helix structure,16.70%extended chain and 4.74%β-corner.[Conclusions]The results provide a reference for revealing the physiological function and expression regulation mechanism of xynMF13-GH10 gene in the future. | Junxia SONG Wanting WU Hongbing QI | 2022 | Asian Agricultural Research2022，14，5： | 0 |
| 16 | tsrCert:Traceable Self-Randomization Certificate and Its Application to Blockchain Supervision显示文摘Traditional public key infrastructure(PKI)only provides authentication for network communication,and the standard X.509 certificate used in this architecture reveals the user’s identity.This lack of privacy protection no longer satisfies the increasing demands for personal privacy.Though an optimized anonymous PKI certificate realizes anonymity,it has the potential to be abused due to the lack of identity tracking.Therefore,maintaining a balance between user anonymity and traceability has become an increasing requirement for current PKI.This paper introduces a novel traceable self-randomization certificate authentication scheme based on PKI architecture that achieves both anonymity and traceability.We propose a traceable self-randomization certificate authentication scheme based on the short randomizable signature.Specifically,certificate users can randomize the initial certificate and public key into multiple anonymous certificates and public keys by themselves under the premise of traceability,which possesses lower computational complexity and fewer interactive operations.Users can exhibit different attributes of themselves in different scenarios,randomizing the attributes that do not necessarily need to be displayed.Through security and performance analysis,we demonstrate the suitability of the improved PKI architecture for practical applications.Additionally,we provide an application of the proposed scheme to the permissioned blockchain for supervision. | Yan Zhu Haibin Zheng Bo Qin Wanting Fu Zhenwei Guo Yujue Wang Qianhong Wu Bingyu Li Xuan Ding | 2023 | Tsinghua Science and Technology2023，28，6： | 0 |
| 17 | The Research of the Localization Marketing Strategy of Amazon in Germany显示文摘Amazon Germany has formulated a series of marketing strategies based on the shopping habits of German consumers and it has achieved success.This article summarizes the current marketing strategies of Amazon in Germany,and explores the key factors for the success of this marketing strategy.By comparing with other e-commerce platforms,this article critically analyzes the innovation and deficiency of Amazon in Germany. | Xixi Zhu Yingxin Wu Wanting He Lianghui Zhao | 2020 | Proceedings of Business and Economic Studies2020，3，6： | 0 |
| 18 | Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator显示文摘The use of checkpoint-blockade antibodies is still restricted in several malignancies due to the modest efficacy,despite considerable success in anti-tumor immunotherapy.The poor response of cancer cells to immune destruction is an essential contributor to the failure of checkpoint therapy.We hypothesized that combining checkpoint therapy with natural-product chemosensitizer could enhance immune response.Herein,a targeted diterpenoid derivative was integrated with the checkpoint blockade(anti-CTLA-4)to improve immunotherapy using thermo sensitive liposomes as carriers.In vivo,the liposomes enabled the co-delivery of the two drug payloads into the tumor.Consequently,the regulatory T cell proliferation was restrained,the cytotoxic T cell infiltration was enhanced,and the profound immunotherapeutic effect was achieved.In addition,the immunotherapeutic effect of another clinically used checkpoint antibody,anti-PD-1,also benefited from the diterpenoid derivative.Of note,our mechanism study revealed that the targeted diterpenoid derivative increased the sensitivity of cancer cells to immune attack via THBS1 downregulation and the resultant destruction of THBS1-CD47 interaction.Collectively,co-delivering THBS1 inhibitor and checkpoint blockade is promising to boost cancer immunotherapy.We first time discovered that THBS1 suppression could strengthen checkpoint therapy. | Qingqing Xiao Xiaotong Li Chang Liu Yuxin Jiang Yonglong He Wanting Zhang Helena SAzevedo Wei Wu Yuanzheng Xia Wei He | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
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