|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death显示文摘混合的系 kinase 像域的蛋白质(MLKL ) 被识别受体交往下游地工作蛋白质 3 (RIP3 ) 在肿瘤坏死 factor-α(TNF ) 导致了坏死(也叫的 necroptosis ) 。然而, MLKL 怎么工作调停 necroptosis 是未知的。由在 MLKL 大美人房间的 MLKL 功能的宪法,我们证明 MLKL 的 N 终点在 necroptosis 为它的功能被要求。在对待 TNF 的房间的 MLKL 的 oligomerization 为 necroptosis 是必要的,当人工地由使用荷尔蒙绑定领域一起强迫 MLKL (HBD*) 扳机 necroptosis。尤其是,一起强迫 N 终端领域(ND ) 然而并非 MLKL 的 C 终端 kinase 领域引起 necroptosis。进一步的删除分析证明 four-α MLKL (1-130 氨基酸) 的螺旋捆是足够的触发 necroptosis。两 HBD*调停并且 MLKL (ND ) 或 MLKL 的导致 TNF 的建筑群是到血浆膜的类脂化合物椽子的这些建筑群的 tetramers,和 translocation 先于房间死亡。homo-oligomerization 为 MLKL translocation 被要求,为血浆膜地点的信号顺序位于第一和第二 α 的连接; MLKL 的 -helices。MLKL 或 MLKL (ND ) 的血浆膜 translocation 导致钠流入,并且从房间文化媒介的钠的弄空禁止 necroptosis。上述所有现象没在 apoptosis 被看见。因此, MLKL oligomerization 导致 MLKL 的 translocation 到血浆膜,和血浆膜的类脂化合物椽子由自己或经由到增加的另外的蛋白质的 MLKL 复杂行为任何一个钠流入,增加渗透的压力,最后导致膜破裂。 | Xin Chen Wenjuan Li Junming Ren Deli Huang Wan-ting He Yunlong Song Chao Yang Wanyun Li Xinru Zheng PengdaChen Jiahuai Han | 2014 | Cell Research2014，24，1： | 67 |
| 2 | Seasonal variation in surface ozone and its regional characteristics at global atmosphere watch stations in China显示文摘We investigated the seasonal and spatial ozone variations in China by using three-year surface ozone observation data from the six Chinese Global Atmosphere Watch(GAW)stations and tropospheric column ozone data from satellite retrieval over the period2010–2012. It is shown that the seasonal ozone variations at these GAW stations are rather different, particularly between the western and eastern locations. Compared with western China, eastern China has lower background ozone levels. However, the Asian summer monsoon(ASM) can transport photochemical pollutants from the southern to the northern areas in eastern China, leading to a northward gradual enhancement of background ozone levels at the eastern GAW stations. Over China, the tropospheric column ozone densities peak during spring and summer in the areas that are directly and/or indirectly affected by the ASM, and the peak time lags from the south to the north in eastern China. We also investigated the regional representativeness of seasonal variations of ozone at the six Chinese GAW stations using the yearly maximum tropospheric column month as indicator.The results show that the seasonal variation characteristics of ozone revealed by the Chinese GAW stations are typical, with each station having a considerable large surrounding area with the ozone maximum occurring at the same month. Ozone variations at the GAW stations are influenced by many complex factors and their regional representativeness needs to be investigated further in a broader sense. | Ningwei Liu Weili Lin Jianzhong Ma Wanyun Xu Xiaobin Xu | 2019 | Journal of Environmental Sciences2019，31，3： | 23 |
| 3 | A novel method for distinguishing fog and haze based on PM2.5, visibility, and relative humidity显示文摘Haze and fog are both low visibility events, but with different physical properties. Haze is caused by the increase of aerosol loading or the hygroscopic growth of aerosol at high relative humidity, whereas visibility degradation in fog is due to the light scattering of fog droplets, which are transited from aerosols via activation. Based on the difference of physical properties between haze and fog, this study presents a novel method to distinguish haze and fog using real time measurements of PM2.5, visibility, and relative humidity. In this method, a criterion can be developed based on the local historical data of particle number size distributions and aerosol hygroscopicity. Low visibility events can be classified into haze and fog according to this criterion. | MA Nan ZHAO ChunSheng CHEN Jing XU WanYun YAN Peng ZHOU XiuJi | 2014 | Science China Earth Sciences2014，57，9： | 10 |
| 4 | Variability of SO_2 in an intensive fog in North China Plain:Evidence of high solubility of SO_2显示文摘一个地实验在在 11 月 5 日和 2009 年 11 月 8 日之间的一个集中的雾事件被进行,在在诺思中国平原(NCP ) 的一个重重地弄脏 SO2 的区域,到措施 SO2 和其它空气污染物质,雾微滴的液体水内容(LWC ) ,和另外的基本气象学的参数。在雾时期期间, SO2 的集中在雾微滴与 LWC 有关仔细显示出大可变性,它是。, SO2 的平均集中在雾时期期间在非雾时期期间是大约 25 ppbv,它很快归结为大约 47 ppbv。SO2 的如此的大减小建议由于 SO2 的高溶解度, SO2 (大约 70%80%) 的一个多数在雾微滴在水里从气体回复了到水的阶段。然而,到水的阶段变换的计算气体被仅仅使用亨利 SO2 的法律常数大部分低估,因此在雾微滴建议 SO2 的那水的反应可能在提高 SO2 的溶解度起某重要作用。简化现象,一个有效溶解度系数在这研究被建议。SO2 测量的这可变性在 NCP 在雾微滴,为在云的酸味的更好的理解的因此提供的重要含意,猛冲,和雾在广泛的雾事件期间提供 SO2 的氧化的直接证据,现在在中国的一个中央环境焦点由于它的快速的经济发展。 | Qiang Zhang Xuexi Tie Weili Lin Junji Cao Jiannong Quan Liang Ran Wanyun Xu | 2013 | Particuology2013，11，1： | 8 |
| 5 | Three-dimensional structural changes in living hippocampal neurons imaged using magnetic AC mode atomic force microscopy.显示文摘 | Yunxu S Danying L Yanfang R Dong H Wanyun M | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 6 | Effects of elevated CO_2 on the nutrient compositions and enzymes activities of Nilaparvata lugens nymphs fed on rice plants显示文摘Elevated CO 2 may reduce the tolerance of Nilaparvata lugen (N. lugens) to adverse environmental factors through the biological and physiological degeneration of N. lugens. In an artificial climate box, under 375 and 750 μL L 1 CO 2 levels, the rice stems nutrient content, the nutrient content and enzyme activities of N. lugens nymph fed on rice seedlings exposed to ambient and elevated CO 2 were studied. The results showed that rice stems had significantly higher protein and total amino acid levels under ambient than elevated CO 2 levels. Nymphs had significantly higher protein levels in the ambient CO 2 treatment, while their glucose levels were significantly lower under ambient CO 2 conditions. Significantly higher trypsin activity was observed in nymphs grown in elevated CO 2 . Significantly lower activities of the protective enzymes total superoxide dismutase and catalase were observed in the nymphs under ambient CO 2 . Meanwhile, the activity of the detoxification enzyme glutathione S-transferase was significantly higher in the ambient CO 2 treatment. Measuring how energy and resources were allocated to enzymes in N. lugens nymphs under elevated CO 2 conditions can provide a more meaningful evaluation of their metabolic tolerances to adverse climatic conditions. | ZENG YunYun HUANG WenKun SU Li WU Gang ZHUANG Jing ZHAO WanYun HUA HongXia LI JunSheng XIAO NengWen XIONG-YanFei | 2012 | Science China(Life Sciences)2012，55，10： | 7 |
| 7 | Melatonin alters the secondary metabolite profile of grape berry skin by promoting VvMYB14-mediated ethylene biosynthesis显示文摘The interplay between melatonin and ethylene in the regulation of fruit metabolism and the underlying molecular mechanism of this interplay remain largely unclear.Here,widely targeted metabolomics analysis revealed a total of 464 metabolites present in berry skin.Among them,27 significantly differentially accumulated metabolites(DAMs)were produced in response to melatonin treatment in the presence or absence of 1-MCP.Most of the DAMs were secondary metabolites,including flavonoids,phenolic acids,stilbenes,and flavonols.Additionally,the accumulation of 25 DAMs was regulated by melatonin via ethylene.RNA-seq analysis indicated that melatonin primarily regulated the pathways of plant hormone signal transduction and secondary metabolite biosynthesis via ethylene.Gene-metabolite association analysis showed that melatonin regulated the expression of the VvSTS1,VvF3H,VvLAR2,and VvDFR genes,suggesting that these genes may play key roles in regulating secondary metabolites in the skin;additionally,VvMYB14 and VvACS1 were suggested to be involved in the regulation of secondary metabolites.Further experiments revealed that melatonin induced the expression of VvMYB14 and that VvMYB14 increased ethylene production by transcriptionally activating VvACS1,thereby affecting the accumulation of secondary metabolites.Collectively,melatonin promotes ethylene biosynthesis and alters secondary metabolite accumulation through the regulation of VvACS1 by VvMYB14. | Wanyun Ma Lili Xu Shiwei Gao Xingning Lyu Xiaolei Cao Yuxin Yao | 2021 | Horticulture Research2021，8，1： | 4 |
| 8 | Antidotal effects of calcium folinate against high-dose methotrexate-induced damages to mouse matured oocytes显示文摘Methotrexate(MTX)is a common folate antagonist and it blocks the dihydrofolate reductase,thereby causing tetrahydrofolate for mation disorder.Tetrahydrofolate is the active folate form and its related metabolic products are required for DNA synthesis and DNA methylation modification.The effects of MTX have been demonstrated by DNA methylation aberrations,DNA damage,and DNA synthesis obstruction,causing cell replication disorder and apoptosis[1,2].Since MTX passes through blood-brain,blood-testis,and blood-ocular barriers,high-dose MTX is commonly used to treat malignancies in clinic(the high dose generally is the total dosage of MTX>1 g once or single dose>20 mg/kg)[3],The main defect of MTX treatment is its insufficient tumor targeting because MTX kills cancer cells and at the same time also destroys the normal cells[2].Additionally,MTX has also been reported to reduce the oocyte quality[4]. | Ning Tian Wanyun Ma | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 3 |
| 9 | Quantitative Analysis of Relationship Between Pore Structure and Compressive Strength of Foamed Concrete显示文摘The effect of dry density,water-cement ratio,the addition of fly ash,and sand content on the porosity and pore distribution of foamed concrete is investigated.Digital microscopy and Image J software are employed to examine the landscape of pores with different sizes.Based on the Balshin empirical formula,a mathematical model is established to quantitatively predict the relationship between the pore structures and the compressive strength of foamed concrete.The results well demonstrate that there is a significant correlation between the modified formula and empirical parameters. | Geng Fei Yin Wanyun Xie Jianguang Liu Shoucheng Li Haoran Gui Jingneng | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，3： | 2 |
| 10 | Controlled release of brefeldin A from electrospun PEG-PLLA nanofibers and their in vitro antitumor activity against HepG2 cells显示文摘 | LIU Wanyun WEI Junchao HUO Ping | 2013 | Materials Science and Engineering:C2013，33，5： | 1 |
| 11 | Reviews on the research status and prospect of the pre- fabricated concrete shear wall structure显示文摘 | Ding Kewei Ling Ru Yin Wanyun Liu Shoucheng Ni Shumei | 2013 | Applied Mechanics and Materials2013，291，： | 1 |
| 12 | Chemical Constituents of lscais indigotica显示文摘 | Xiaoyun Wu Yunhai Liu Wanyun Sheng | 1997 | Planta Med1997，63，： | 1 |
| 13 | Ozone pro-duction in summer in the megacities of Tianjin and Shanghai,China: a comparative study 显示文摘 | RAN Liang ZHAO Chunsheng XU Wanyun | 2012 | Atmospheric Chemistry andPhysics?2012，12，16： | 1 |
| 14 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 15 | Chlorofluorocarbons,hydrochlorofluorocarbons,and hydrofluorocarbons in theatmosphere of four Chinese cities显示文摘 | Wu Jing Fang Xuekun Xu Wanyun | 2013 | Atmospheric Environment2013，75，： | 1 |
| 16 | Novel U-shape gold nanoparticles modified optical fiberfor localized plasmon res- onance chemical sensing 显示文摘 | Chen Chien-hsing Tsao Tzu-chien Li Wanyun | 2010 | Microsyst Technol2010，16，： | 1 |
| 17 | Non-competitive immunoassay for alpha-fetoprotein using micellar electrokinetic capillary chromatography and laser-induced fluorescence detection显示文摘 | Xiaoning Lu Wanyun Ma | 2002 | J chromatogr B2002，779，： | 1 |
| 18 | Determination of biodegradation process of benzene,toluene,ethylbenzene and xylenes in seabed sediment by purge and trap gas chromatography显示文摘 | Han Dongqiang Ma Wanyun Chen Dieyan | | 0，，11： | 1 |
| 19 | Analyzing crude oils from the Junggar Basin(NW China) using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry(GC×GC-TOFMS)显示文摘As a new technology of analyzing crude oils,comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry(GC×GCTOFMS) has received much research attention.Here we present a case study in the Junggar Basin of NW China.Results show that the hydrocarbons,including saturates and aromatics,were all well-separated without large coelution,which cannot be realized by conventional one-dimensional GC-MS.The GC×GC technique is especially effective for analyzing aromatics and low-to-middlemolecular-weight hydrocarbons,such as diamondoids.The geochemical characteristics of crude oils in the study area were investigated through geochemical parameters extracted by GC×GC-TOFMS,improving upon the understanding obtained by GC-MS.Thus,the work here represents a new successful application of GC×GCTOFMS,showing its broad usefulness in petroleum geochemistry. | Yuce Wang Wanyun Ma Ni Zhou Jiangling Ren Jian Cao | 2017 | Acta Geochimica2017，36，1： | 1 |
| 20 | Highly Efficient Bulky a-Diimine Palladium Complexes for Suzuki-Miyaura Cross-Coupling Reaction显示文摘A series of bulky 9,10-dihydro-9,10-ethanoanthracene-11,12-diimine methyl palladium chloride complexes (C1 --C6) with different steric and electronic substituent have been applied in Suzuki-Miyaura cross-coupling reactionsThe influence of these substituents was investigated by comparing the catalytic performance of the complexes in thecross-coupling reactions and it can be found that the complex with bulky and electron-donating substituent is facili-tated for the cross-coupling reaction of aryl halides with arylboronic acids under ambient atmosphere. The most ac-tive complex shows a wide substrate scope in excellent yields using very low catalyst concentration of 0.01 mol%. | Ping Huo Jingbo Li Wanyun Liu Guangquan Mei | 2017 | Chinese Journal of Chemistry2017，35，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员