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| 1 | Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps显示文摘AIM:To elucidate the colonoscopic features of serrated lesions of the colorectum using magnifying colonoscopy.METHODS:Broad division of serrated lesions of the colorectum into hyperplastic polyps(HPs),traditional serrated adenomas(TSAs),and sessile serrated adenomas/polyps(SSA/Ps) has been proposed on the basis of recent molecular biological studies.However,few reports have examined the colonoscopic features of these divisions,including magnified colonoscopic findings.This study examined 118 lesions excised in our hospital as suspected serrated lesions after magnified observation between January 2008 and September 2011.Patient characteristics(sex,age),conventional colonoscopic findings(location,size,morphology,color,mucin) and magnified colonoscopic findings(pit pattern diagnosis) were interpreted by five colonoscopists with experience in over 1000 colonoscopies,and were compared with histopathological diagnoses.The pit patterns were categorized according to Kudo's classification,but a more detailed investigation was also performed using the subclassification [type Ⅱ-Open(type Ⅱ-O),type Ⅱ-Long(type Ⅱ-L),or type Ⅳ-Serrated(type Ⅳ-S)] proposed by Kimura T and Yamano H.RESULTS:Lesions comprised 23 HPs(23/118:19.5%),39 TSAs(39/118:33.1%:with cancer in one case),50 SSA/Ps(50/118:42.4%:complicated with cancer in three cases),and six others(6/118:5.1%).We excluded six others,including three regular adenomas,one hamartoma,one inflammatory polyp,and one juvenile polyp for further analysis.Conventional colonoscopy showed that SSA/Ps were characterized as larger in diameter than TSAs and HPs(SSA/P vs HP,13.62 ± 8.62 mm vs 7.74 ± 3.24 mm,P < 0.001;SSA/Ps vs TSA,13.62 ± 8.62 mm vs 9.89 ± 5.73 mm,P < 0.01);common in the right side of the colon [HPs,30.4%(7/23):TSAs,20.5%(8/39):SSA/P,84.0%(42/50),P < 0.001];flat-elevated lesion [HPs,30.4%(7/23):TSAs,5.1%(2/39):SSA/Ps,90.0%(45/50),P < 0.001];normal-colored or pale imucosa [HPs,34.8%(8/23):TSAs,10.3%(4/39):SSA/Ps,80%(40/50),P < 0.001];and with large amounts of mucin [HPs,21.7%(5/23):TSAs,17.9%(7/39):SSA/Ps,72.0%(36/50),P < 0.001].In magnified colonoscopic findings,17 lesions showed either type Ⅱ pit pattern alone or partial type Ⅱ pit pattern as the basic architecture,with 14 HPs(14/17,70.0%) and 3 SSA/Ps.Magnified colonoscopy showed the type Ⅱ-O pit pattern as characteristic of SSA/Ps [sensitivity 83.7%(41/49),specificity 85.7%(54/63)].Cancer was also present in three lesions,in all of which a type Ⅵ pit pattern was also present within the same lesion.There were four HPs and four TSAs each.The type Ⅳ-S pit pattern was characteristic of TSAs [sensitivity 96.7%(30/31),specificity 89.9%(72/81)].Cancer was present in one lesion,in which a type Ⅵ pit pattern was also present within the same lesion.In our study,serrated lesions of the colorectum also possessed the features described in previous reports of conventional colonoscopic findings.The pit pattern diagnosis using magnifying colonoscopy,particularly magnified colonoscopic findings using subclassifications of surface architecture,reflected the pathological characteristics of SSA/Ps and TSAs,and will be useful for colonoscopic diagnosis.CONCLUSION:We suggest that this system could be a good diagnostic tool for SSA/Ps using magnifying colonoscopy. | Shinya Ishigooka Masahito Nomoto Nobuyuki Obinata Yoshichika Oishi Yoshinori Sato Satoko Nakatsu Midori Suzuki Yoshiko Ikeda Tadateru Maehata Tomoaki Kimura Yoshiyuki Watanabe Takashi Nakajima Hiro-o Yamano Hiroshi Yasuda Fumio Itoh | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 2 | VISUALIZATION OF TURBULENT REACTIVE JET BY USING DIRECT NUMERICAL SIMULATION显示文摘Direct numerical simulation(DNS)of turbulent planar jet with a second-order chemical reaction(A+B→R)is performed to investigate the processes of mixing and chemical reactions in spatially developing turbulent free shear flows.Reactant A is premixed into the jet flow,and reactant B is premixed into the ambient flow.DNS is performed at three different Damk¨ohler numbers(Da=0.1,1,and 10).Damk¨ohler number is a ratio of a time scale of a flow to that of chemical reactions,and in this study,the large Da means a fast chemical reaction,and the small Da means a slow chemical reaction.The visualization of velocity field shows that the jet flow is developed by entraining the ambient fluid.The visualization of concentration of reactant A shows that concentration of reactant A for Da=1 and 10 becomes very small in the downstream region because the chemical reaction consumes the reactants and reactant A is diffused with the jet development.By comparison of the profiles of chemical reaction rate and concentration of product R,it is found that product R for Da=10 is produced by the chemical reaction at the interface between the jet and the ambient fluids and is diffused into the jet flow,whereas product R for Da=0.1 is produced in the jet flow after reactants A and B are well mixed. | TOMOAKI WATANABE YASUHIKO SAKAI KOUJI NAGATA OSAMU TERASHIMA HIROKI SUZUKI TOSHIYUKI HAYASE YASUMASA ITO | 2013 | International Journal of Modeling, Simulation, and Scientific Computing2013，4，S01： | 2 |
| 3 | Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells显示文摘AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning. | Kazuaki Tejima Masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio Yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 4 | Elasto-Plastic Analysis of PC Girder with Corrugated Steel Web by an Efficient Beam Theory显示文摘 | Jean- Francois Bariant Tomoaki Utsunomiya Eiichi Watanabe | 2006 | Structure Engineering/Earthquake Engineering2006，，23： | 1 |
| 5 | Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy显示文摘 | Daisuke Watanabe Kiyoshi Suzuma Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Masafumi Kurimoto Tomoaki Murakami Tetsushi Kimura Hitoshi Takagi | 2005 | American Journal of Ophthalmology2005，，3： | 1 |
| 6 | Low-temperature crystallization of Eu-doped red-emitting CaAlSiNB3 from alloy-derived ammonom etallates显示文摘 | Jiwang Li Tomoaki Watanabe Hiroshi Wada | 2007 | Chem Mater2007，19，： | 1 |
| 7 | Synthesis of a multinary nitride,Eu-doped CaAlSiNB3 from alloy at low temperatures显示文摘 | Jiwang Li Tomoaki Watanabe Naonori Sakamoto | 2008 | Chem Mater2008，20，： | 1 |
| 8 | Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy显示文摘 | Daisuke Watanabe Kiyoshi Suzuma Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Masafumi Kurimoto Tomoaki Murakami Tetsushi Kimura Hitoshi Takagi | 2005 | American Journal of Ophthalmology2005，，3： | 1 |
| 9 | Novel role of erythropoietin in proliferative diabetic retinopathy显示文摘 | Hitoshi Takagi Daisuke Watanabe Kiyoshi Suzuma Masafumi Kurimoto Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Tomoaki Murakami | 2007 | Diabetes Research and Clinical Practice2007，，3： | 1 |
| 10 | A case of solitary amyloidosis localized within the transverse colon presenting as a submucosal tumor显示文摘 | Tomoaki Watanabe Kimitoshi Kato Masahiko Sugitani Nobuaki Kaneda Naohisa Hoshino Kazuhiro Imatake Teruaki Matsui Fumio Kawamura Ariyoshi Iwasaki Yasuyuki Arakawa | 1999 | Gastrointestinal Endoscopy1999，，5： | 1 |
| 11 | Devel- opment of realistic high-resolution whole-body voxel models of Japanese adult males and females of average height and weight, and application of models to radio-frequency electro- magnetic-field dosimetry显示文摘 | Tomoaki Nagaoka Soichi Watanabe Kiyoko Sakurai | 2004 | Physics in Medicine and Biolo- gy2004，，49： | 1 |
| 12 | Synthesis of a Multinary Nitride,Eu-Doped CaAlSiN3,from Alloy at Low Temperature显示文摘 | Jin Wang Li Tomoaki Watanabe | 2008 | Chem Mater2008，20，： | 1 |
| 13 | Direct fabrication of crystalline vanadates films by hydrothermalelectrochemical method显示文摘 | TOMOAKI Watanabe WOO-SEOK Cho | 2001 | Solid State Sciences2001，3，： | 1 |
| 14 | In Situ Fabrication of SrTiO3-BaTiO3 Layered Thin Films by Hydrothermal-electrochemical Technique 显示文摘 | Masahiro Yoshimura Wojciech L Suchanel Tomoaki Watanabe | 1999 | Journal of the European Ceramic Society1999，19，67： | 1 |
| 15 | Effect of steam explosion pretreatment on treatment with Pleurotus ostreatus for the enzymatic hydrolysis of rice straw显示文摘 | Masayuki Taniguchi Daisuke Takakashi Daisuke Watanabe Kenji Sakai Kazuhiro Hoshino Tomoaki Kouya Takaaki Tanaka | | Journal of Bioscience and Bioengineering0，2010，： | 1 |
| 16 | EphrinA1 Inhibits Vascular Endothelial Growth Factor-Induced Intracellular Signaling and Suppresses Retinal Neovascularization and Blood-Retinal Barrier Breakdown显示文摘 | Tomonari Ojima Hitoshi Takagi Kiyoshi Suzuma Hideyasu Oh Izumi Suzuma Hirokazu Ohashi Daisuke Watanabe Eri Suganami Tomoaki Murakami Masafumi Kurimoto Yoshihito Honda Nagahisa Yoshimura | 2006 | The American Journal of Pathology2006，，1： | 1 |
| 17 | An eigenfunction-matching method for analyzing the wave- induced responses of an elastic floating p/ate显示文摘 | Wu Chong Watanabe Eiichi Utsunomiya Tomoaki | 1995 | Applied Ocean Research1995，17，5： | 1 |
| 18 | Colorectal neuroendocrine carcinoma: A case report and review of the literature显示文摘BACKGROUND Colorectal neuroendocrine carcinoma (NEC) is a rare tumor that demonstrates aggressive growth pattern with ingrowth into the tract, metastasis to the other organs, and invasion to the surrounding organs;these clinical characteristics result in poor prognosis. Surgical resection appears as an effective approach;however, because it is difficult to accurately diagnose NEC during the early stage and owing to its aggressive growth pattern, development of a reliable standard chemotherapy regimen and management strategies are essential. CASE SUMMARY Here, we report the case of patient with NEC showing an aggressive growth pattern that resulted in the rupture of the tumor to the outside the colon after stenting of the internal colonic stenosis. In addition, the tumor invaded into the duodenum, thereby causing duodenal stenosis that required an additional stent in the duodenum. This aggressive growth pattern is one of the main features of the NEC that is different from adenocarcinoma. To clarify the clinical characteristics, we reviewed 60 recently reported cases, including data on tumor location, size, treatment, and prognosis. CONCLUSION We consider that the information presented here is of great significance for the diagnosis, treatment, and management of symptoms of the patients with NEC. | Tomoaki Yoshida Kenya Kamimura Kazunori Hosaka Koji Doumori Hiromitsu Oka Akito Sato Yasuo Fukuhara Shoji Watanabe Tomomi Sato Akira Yoshikawa Takashi Tomidokoro Shuji Terai | 2019 | World Journal of Clinical Cases2019，7，14： | 1 |
| 19 | Low temperature ammonothermal synthesis of europium-doped SrA1SiN3 for a nitride red phosphor显示文摘 | Tomoaki Watanabe Kazumichi Nonaka Li J W | 2012 | Journal of the Ce- ramic Society of Japan2012，120，11： | 1 |
| 20 | Preparation and characterization of sodium tantalate thin films by hydrothermal-electrochemical synthesis显示文摘 | Lee Yungi Watanabe Tomoaki Takata Tsuyoshi | 2005 | Chem Mater2005，17，： | 1 |
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