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| 1 | Liver cancer incidence and mortality in China: Temporal trends and projections to 2030显示文摘Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths worldwide.The systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other countries.Methods: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries' data selected from Chinese National Cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to 2014.The burden of liver cancer through 2030 was projected using age-period-cohort model.Results: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in 2014.Western regions of China had the highest incidence and mortality rates.Incidence and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in China.The young generation,particularly for those aged under 40 years,showed a faster down trend.Conclusions: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western areas.Most cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups. | Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li Wenqiang Wei Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 132 |
| 2 | Design and test of robotic harvesting system for cherry tomato显示文摘Harvesting of fresh-eating cherry tomato was highly costly on labor and time.In order to achieve mechanical harvesting for the fresh-eating tomato,a new harvesting robot was designed,which consisted of a stereo visual unit,an end-effector,manipulator,a fruit collector,and a railed vehicle.The robot configuration and workflow design focused on the special cultivating condition.Three key parts were introduced in detail:a railroad vehicle capably moving on both ground and rail was adopted as the robot’s carrier,a visual servo unit was used to identify and locate the mature fruits bunch,and the end-effector to hold and separate the fruit bunch was designed based on the stalk’s mechanical features.The field test of the new developed robot was conducted and the results were analyzed.The successful harvest rate of the robot was 83%,however,each successful harvest averagely needed 1.4 times attempt,and a single successful harvesting cycle cost 8 s excluding the time cost on moving. | Qingchun Feng Wei Zou Pengfei Fan Chunfeng Zhang Xiu Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 8 |
| 3 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 4 | High Elevation Energy and Water Balance:the Roles of Surface Albedo and Temperature显示文摘Observation and modeling of the coupled energy and water balance is the key to understand hydrospheric and cryospheric processes at high elevation.The paper summarizes the progress to address this aspect in relation with different earth system elements,from glaciers to wetlands.The energy budget of two glaciers,i.e.Xiao Dongkemadi and Parlung No.4,was studied by means of extended field measurements and a distributed model of the coupled energy and mass balance was developed and evaluated.The need for accurate characterization of surface albedo was further documented for the entire Qinghai Tibet Plateau by numerical experiments with Weather Research and Forecast(WRF)on the sensitivity of the atmospheric boundary layer to the parameterization of land surface processes.A new approach to the calibration of a coupled distributed watershed model of the energy and water balance was demonstrated by a case study on the Heihe River Basin in northwestern China.The assimilation of land surface temperature did lead to the retrieval of critical soil and vegetation properties as the soil permeability and the canopy resistance to the exchange of vapour and carbon dioxide.The retrievals of actual Evapo-Transpiration(ET)were generated by the ETMonitor system and evaluated against eddy covariance measurements at sites spread throughout Asia.As regards glacier response to climate variability,the combined findings based on satellite data and model experiments showed that the spatial variability of surface albedo and temperature is significant and controls both glacier mass balance and flow.Experiments with both atmospheric and hydrosphere-cryosphere models documented the need and advantages of using accurate retrievals of land surface albedo to capture lan-atmosphere interactions at high elevation. | Massimo MENENTI Li JIA Marco MANCINI Xin LI Francesca PELLICCIOTTI Kun YANG Jiancheng SHI Maria Jose ESCORIHUELA Chiara CORBARI Shaoting REN Chunfeng MA Chaolei ZHENG Lian LIU Thomas SHAW Baohong DING Wei YANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 3 |
| 5 | Y6 and its derivatives:molecular design and physical mechanism显示文摘Non-fullerene-acceptor(NFA) materials in the bulk heterojunction(BHJ) play an important role in high-performance organic solar cells(OSCs). Recently,Y-series acceptors with an A-DA D-A structure have been a research hotspot and advanced device efficiency to 15%–18%. This perspective will focus on the discovery of Y6 and its derivatives as well as the intrinsic physical mechanism of Y-series-based devices, which provides a guideline for future molecular design. | Qingya Wei Jun Yuan Yuanping Yi Chunfeng Zhang Yingping Zou | 2021 | National Science Review2021，8，8： | 1 |
| 6 | AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma显示文摘Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma(HCC)in individuals infected with the hepatitis virus.However,the molecular pathways leading to its bioactivation and subsequent toxicity in hepatocytes have not been well-defined.Here,we carried out a genome-wide CRISPR-Cas9 genetic screen to identify aflatoxin B1(AFB1)targets.Among the most significant hits was the aryl hydrocarbon receptor(AHR),a ligand-binding transcription factor regulating cell metabolism,differentiation,and immunity. | Qing Zhu Yarui Ma Junbo Liang Zhewen Wei Mo Li Ying Zhang Mei Liu Huan He Chunfeng Qu Jianqiang Cai Xiaobing Wang Yixin Zeng Yuchen Jiao | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 7 | Alkaloid profiling in crude and processed strychnos nux-vomica seeds by matrixassisted laser desorption/ionization-time of flight mass spectrometry显示文摘 | Wu Wei Qiao Chunfeng Liang Zhiliang | 2007 | J Pharm and Biomed Anal2007，45，： | 1 |
| 8 | Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis显示文摘Extensive macrophage inflammatory responses and osteoclast formation are predominant during inflammatory or infective osteolysis.Mesenchymal stem cell(MSC)-derived small extracellular vesicles(MSC-sEV)have been shown to exert therapeutic effects on bone defects.However,cultured MSCs are typically exposed to normoxia(21%O2)in vitro,which differs largely from the oxygen concentration in vivo under hypoxic conditions.It is largely unknown whether sEV derived from dental pulp stem cells(DPSCs)cultured under hypoxic conditions(Hypo-sEV)exert better therapeutic effects on lipopolysaccharide(LPS)-induced inflammatory osteolysis than those cultured under normoxic conditions(Nor-sEV)by simultaneously inhibiting the macrophage inflammatory response and osteoclastogenesis.In this study,we show that hypoxia significantly induces the release of sEV from DPSCs.Moreover,Hypo-sEV exhibit significantly improved efficacy in promoting M2 macrophage polarization and suppressing osteoclast formation to alleviate LPS-induced inflammatory calvarial bone loss compared with Nor-sEV.Mechanistically,hypoxia preconditioning markedly alters the miRNA profiles of DPSC-sEV.MiR-210-3p is enriched in Hypo-sEV,and can simultaneously induce M2 macrophage generation and inhibit osteoclastogenesis by targeting NF-κB1 p105,which attenuates osteolysis.Our study suggests a promising potential for hypoxia-induced DPSC-sEV to treat inflammatory or infective osteolysis and identifies a novel role of miR-210-3p in concurrently hindering osteoclastogenesis and macrophage inflammatory response by inhibiting NF-kB1 expression. | Jun Tian Weiyang Chen Yuhua Xiong Qianer Li Siyi Kong Mengjie Li Chunfeng Pang Yu Qiu Zhezhen Xu Qimei Gong Xi Wei | 2023 | Bioactive Materials2023，，4： | 1 |
| 9 | High-speed fastener detection system based on machine vision显示文摘 | Yang Jinfeng Tao Wei Lyu Chunfeng | 2012 | Sensors and Transducers2012，145，10： | 1 |
| 10 | Interface synergistic effects induced multi-mode luminescence显示文摘Mechanoluminescence(ML)has become the most promising material for broad applications in display and sensing devices,in which ZnS is the most commonly studied one due to its stable and highly repetitive ML performances.In this work,we have successfully prepared the biphase ZnS on a large scale through the facile in-air molten salt protection strategy.The obtained biphase has the best ML properties,which is mainly attributed to the synergistic effects of piezo-photonic,defect,and interface dislocations.DFT calculations have confirmed that the defects activate the local S and Zn sites and reduce the energy barrier for electron transfer.The much stronger X-ray induced luminescence than the commercial scintillator is also reached.The application of ZnS particles in both papers and inks delivers superior performance.Meanwhile,ZnS particles based screen printing ink is able to directly print on paper,plastic and other carriers to form clear marks.These proposed paper and ink hold great potentials in applications of information security and anti-counterfeiting based on the multi-mode luminescence properties.This work provides a new avenue to understand and realize the high-performance multi-mode luminescence,inspiring more future works to extend on other ML materials and boosting their practical applications. | Ronghua Ma Chunfeng Wang Wei Yan Mingzi Sun Jianxiong Zhao Yuantian Zheng Xu Li Longbiao Huang Bing Chen Feng Wang Bolong Huang Dengfeng Peng | 2022 | Nano Research2022，15，5： | 1 |
| 11 | Sandwich-type Electrochemi-luminescence Immunosensor Based on N-(amino butyl)-Nethylisoluminol Labeling and Gold Nanoparticle Amplification显示文摘 | Tian Dayong Duan Chunfeng Wang Wei | 2009 | Talanta2009，78，2： | 1 |
| 12 | Practical decoy-state quantum secure direct communication显示文摘Quantum secure direct communication(QSDC) has been demonstrated in both fiber-based and free-space channels using attenuated lasers. Decoy-state QSDC by exploiting four decoy states has been proposed to address the problem of photon-numbersplitting attacks caused by the use of attenuated lasers. In this study, we present an analysis of the practical aspects of decoy-state QSDC. First, we design a two-decoy-state protocol that only requires two decoy states, thereby significantly reducing experimental complexity. Second, we successfully perform full parameter optimization for a real-life QSDC system by introducing a genetic algorithm. Our simulation results show that the two-decoy-state protocol could be the best choice for developing a practical QSDC system. Furthermore, full optimization is crucial for a high-performance QSDC system. Our work serves as a major step toward the further development of practical decoy-state QSDC systems. | Xin Liu Zijian Li Di Luo Chunfeng Huang Di Ma Minming Geng Junwei Wang Zhenrong Zhang Kejin Wei | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 1 |
| 13 | Cold Hydrostatic Sintering:From shaping to 3D printing显示文摘We developed a novel consolidation technique,Cold Hydrostatic Sintering(CHS),which allows near full densification of silica.The technique is inspired by biosilicification and geological formation of siliceous rocks.Unlike established cold sintering method which is based on uniaxial pressure,CHS employs an isostatic pressure to enable room temperature consolidation of bulks having a complex threedimensional shape.The resulting material is transparent(in line transmittance exceeding 70% in the visible range)and amorphous.After drying,the Vickers hardness was as high 1.4 GPa which half of materials consolidated at 1200℃ and it is the highest among all materials processed at room temperature.The CHS method,because of its simplicity,might be suitable for broad range of applications including 3D printing,mould forming and preparation of multi-layered devices.Because of the absence of the firing step,CHS could be directly integrated in the manufacturing of a wide range of hybrid(organic/inorganic)materials for functional and biological applications. | Anna Jiang Daoyao Ke Ludi Xu Qiang Xu Jiang Li Jiabei Wei Chunfeng Hu Salvatore Grasso | 2019 | Journal of Materiomics2019，5，3： | 0 |
| 14 | Fiber-based quantum secure direct communication without active polarization compensation显示文摘Quantum secure direct communication(QSDC)that allows people to directly transmit confidential information through insecure channels is an important branch of quantum communication.The widespread adoption of the QSDC demands the development of simple and stable systems.However,most of the existent QSDC systems involve a complex self-alignment process at the initial stage and additional hardware to compensate environmental disturbance.In this study,we present a fiber-based QSDC system without active polarization compensation.Our system comprises a stable transmitter and a novel Sagnac-Mach-Zehnder interferometer for security detection.This robust system simplifies the self-alignment and is immune to environmental disturbance.The robustness of the system was theoretically and experimentally verified,and low bit error rates in a 12 min continuous operation with an active polarization scrambler were attained.In addition,we performed a proof-of-principle QSDC demonstration,and a secrecy capacity of 3.43 kbps over a 5 km fiber with a detection bit error rate of 0.85%±0.07%and a quantum bit error rate of 0.42%±0.05%were achieved.Experimental results confirm the viability of the proposed QSDC system for practical applications. | Xin Liu Di Luo Guangshen Lin Zihao Chen Chunfeng Huang Shizhuo Li Chengxian Zhang Zhenrong Zhang Kejin Wei | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，12： | 0 |
| 15 | Effects of Dietary Carbohydrates Sources on Lipids Compositions in Abalone, Haliotis discus hannai Ino显示文摘A study was conducted to evaluate the effects of dietary carbohydrates on triglyceride, cholesterol and fatty acid concentrations in abalone, Haliotis discus hannai Ino. Six semi-purified diets with different carbohydrates (dextrin, heat-treated wheat starch, wheat starch, corn starch, tapioca starch and potato starch, respectively), all containing a carbohydrate level of 33.5%, were fed to abalone (initial shell length: 29.98mm±0.09mm; initial weight: 3.42g±0.02g) for 24 weeks in a recirculation system. The results indicate that serum triglyceride concentrations were significantly (P <0.05) higher in the abalone fed with dextrin, heat-treated wheat starch and wheat starch than those fed with corn starch, and serum cholesterol concentrations were significantly (P <0.05) higher in the abalone fed with dextrin, heat-treated wheat starch than those fed with corn starch. Fatty acid C20:4n-6 in the foot muscles were significantly (P<0.05) lower in the abalone fed with dextrin than those fed with wheat starch, corn starch, tapioca starch and potato starch. Fatty acid C20:4n-6 in hepatopancreas was significantly (P<0.05) lower in abalone fed with heat-treated wheat starch than those fed with corn starch, tapioca starch and potato starch. Fatty acid C22:6n-3 in the foot muscles were significantly (P<0.05) lower in the abalone fed with dextrin and heat-treated wheat starch than those fed with wheat starch and potato starch. | WANG Weifang MAI Kangsen ZHANG Wenbing XU Wei AI Qinghui YAO Chunfeng LI Huitao | 2009 | Journal of Ocean University of China2009，8，3： | 0 |
| 16 | Correction: AHR mediates the Aflatoxin B1 toxicity associated with hepatocellular carcinoma显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfsxvqp0cocwpob666n.ffgz.tsg.suse.edu.cn/10.1038/s41392-021-00713-1 z published online 9 August 2021 After online publication of the article^(1),the authors noticed one inadvertent mistake occurred during the production process in Fig.7 that needs to be corrected.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Qing Zhu Yarui Ma Junbo Liang Zhewen Wei Mo Li Ying Zhang Mei Liu Huan He Chunfeng Qu Jianqiang Cai Xiaobing Wang Yixin Zeng Yuchen Jiao | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 17 | HMIBase: An Hierarchical Indexing System for Storing and Querying Big Data显示文摘Relational database management systems are usually deployed on single-node machines and have strict limitations in terms of da-ta structure. This means they do not work well with big data, and No SQL has been proposed as a solution. To make data queryingmore efficient, indexes and memory cache techniques are used in No SQL databases. In this paper, we propose a hierarchical in-dexing mechanism and a prototype distributed data-storage system, called HMIBase, which has hierarchical indexes for non-prima-ry keys in tables and makes data querying more efficient. HMIBase uses HBase as the lower data storage and creates a memorycache for more efficient data transmission. HMIBase supports coprocessor-to-process update requests. It also provides a client withquery and update APIs and a server to support RPCs from the client and finish jobs. To improve the cache hit ratio, we propose amemory cache replacement strategy, called Hot Score algorithm, in HMIBase. The experimental results show that Hot Score algo-rithm is better than other cache-replacement strategies. | Shengmei Luo Di Zhao Wei Ge Rong Gu Chunfeng Yuan Yihua Huang | 2014 | ZTE Communications2014，12，4： | 0 |
| 18 | A cost-efficient quantum access network with qubit-based synchronization显示文摘Quantum key distribution(QKD)is a physical layer encryption technique that enables two distant parties to exchange secure keys with information-theoretic security.In the last two decades,QKD has transitioned from laboratory research to real-world applications,including multi-user quantum access networks(QANs).This network structure allows users to share a single-photon detector at a network node through time-division multiplexing,thereby significantly reducing the network cost.However,current QAN implementations require additional hardware for auxiliary tasks such as time synchronization.To address this issue,we propose a cost-efficient QAN that uses qubit-based synchronization.In this approach,the transmitted qubits facilitate time synchronization,eliminating the need for additional synchronization hardware.We tested our scheme by implementing a network for two users and successfully achieved average secure key rates of 53.84 kbps and 71.90 kbps for each user over a 50-km commercial fiber spool.In addition,we investigated the capacity of the access network under cross-talk and loss conditions.The simulation results demonstrate that this scheme can support a QAN with 64 users with key rates up to 1070 bps.Our work provides a feasible and cost-effective way to implement a multi-user QKD network,further promoting the widespread application of QKD. | Chunfeng Huang Ye Chen Tingting Luo Wenjie He Xin Liu Zhenrong Zhang Kejin Wei | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，4： | 0 |
| 19 | Present Situation of West Wetland in Jilin Province and Countermeasures for Restoration显示文摘The western region of Jilin Province is rich in wetland resources,and its biodiversity is rich. However in recent years,due to the reduction of natural precipitation,human activities and other causes,wetland shrivels and degenerates,biodiversity reduces,and ecosystem security is threatened. In this paper,the rivers and lakes connecting project in western Jilin Province is proposed to restore the damaged wetlands and protect important wetlands. | Wang Xuege Lv Jun Wang Yanmei Wei Chunfeng | 2017 | Meteorological and Environmental Research2017，8，5： | 0 |
| 20 | Resource-efficient quantum key distribution with integrated silicon photonics显示文摘Integrated photonics provides a promising platform for quantum key distribution(QKD)system in terms of miniaturization,robustness,and scalability.Tremendous QKD works based on integrated photonics have been reported.Nonetheless,most current chip-based QKD implementations require additional off-chip hardware to demodulate quantum states or perform auxiliary tasks such as time synchronization and polarization basis tracking.Here,we report a demonstration of resource-efficient chip-based BB84 QKD with a silicon-based encoder and a decoder.In our scheme,the time synchronization and polarization compensation are implemented relying on the preparation and measurement of the quantum states generated by on-chip devices;thus,we need no additional hardware.The experimental tests show that our scheme is highly stable with a low intrinsic quantum bit error rate of 0.50%±0.02%in a 6 h continuous run.Furthermore,over a commercial fiber channel up to150 km,the system enables the realization of secure key distribution at a rate of 866 bit/s.Our demonstration paves the way for a low-cost,wafer-scale manufactured QKD system. | KEJIN WEI XIAO HU YONGQIANG DU XIN HUA ZHENGENG ZHAO YE CHEN CHUNFENG HUANG XI XIAO | 2023 | Photonics Research2023，11，8： | 0 |
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