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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Influence of Fe^3+ ions on the photocatalytic activity of TiO2 films prepared by micro-plasma oxidation method显示文摘 | Wu X H Wei Q Jiang Z H | 2006 | Thin Solid Films2006，496，2： | 1 |
| 4 | Effects of incubation temperatures on embryonic development in the Asian yellow pond turtle 显示文摘 | Zhu X P Wei C Q Zhao W H | 2006 | Aquaculture2006，259，： | 1 |
| 5 | Improved effects of a double suicide gene system on prostate cancer cells by targeted regulation of prostate-specific membrane antigen promoter and enhancer 显示文摘 | Zhang P Zeng H Wei Q | 2008 | Int J Urol2008，15，5： | 1 |
| 6 | An analysis of DNA repair as a determinant of survival in patients with nonsmall-cell lung cancer显示文摘 | BOSKEN C H WEI Q AMOS C I | 2002 | Natl Cancer Inst2002，94，14： | 1 |
| 7 | Tissue distribution and maternal transfer of poly-and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis) : implications for reproductive risk 显示文摘 | Peng H Wei Q W Wan Y | 2010 | Environ Sci Technol2010，44，5： | 1 |
| 8 | Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focol cerebral ischemia in rats 显示文摘 | ZHANG W P WEI E Q MEI R H | 2002 | Acta Pharmacol Sin2002，23，10： | 1 |
| 9 | Synthe- sis and electrochemical characterizations of amorphous manganese oxide and single walled carbon nanotube composites as supercapacitor electrode materials 显示文摘 | SUBRAMANIAN V ZHU H W WEI B Q | 2006 | Electrochem Commun2006，8，5： | 1 |
| 10 | Identification of log characteristics in computed tomography images using backpropagation neural networks with the resilient back-propagation training algorithm and textural analysis:preliminary results显示文摘 | Wei Q Chui Y H Leblon B | 2008 | Wood and Fiber Science2008，40，4： | 1 |
| 11 | Oxidation of Co-base superalloy 显示文摘 | HOU G~ LIU Z WEI I-I ZHENG Q SUN X GUAN H HU Z | 2008 | Journal of Material Science and Technology2008，24，： | 1 |
| 12 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 13 | Delta progradation and chenier formation in the Huanghe( Yellow River) delta,China 显示文摘 | YOSHIKI SAITO WEI H L ZHOU Y Q | 2000 | Journal of Asian Earth Sciences2000，18，： | 1 |
| 14 | Influence of Polyvinylpyrrolidone on the Precipitation of Calcium Carbonate and on the Transformation of Vaterite to Caleite显示文摘 | Wei H Shen Q Zhao Y | 2003 | Journal of Crystal Growth2003，250，34： | 1 |
| 15 | Cadmium accumulation in relation to organic acids and nonprotein thiols in leaves ofrecently found Cd hyperaccumulator Rorippa globosa and the Cd-accumulating plant Rorippa islandica显示文摘 | Sun R L Zhou Q X Wei S H | 2011 | Journal ofPlant Growth Regulation2011，30，1： | 1 |
| 16 | Montelukast, a cysteinyl leukotriene receptor-1 antago-nist, dose- and time-dependently protects against focal cerebral ischemia in mice 显示文摘 | YU G L WEI E Q ZHANG S H | 2005 | Pharmacology2005，73，1： | 1 |
| 17 | On the crystallization of calcium carbonate modulated by anionic suffactants显示文摘 | Wei H Shen Q Zhao Y | 2005 | Journal of Crystal Growth2005，279，34： | 1 |
| 18 | High efficiency regeneration of wheat plants from immature embryos显示文摘 | An H L Wei Z M Huang J Q | 2000 | Acta Phytophysiolo- gy Sinca2000，26，： | 1 |
| 19 | Chemical constituents of agarwood originating from the endemic genus Aquilaria plants显示文摘 | CHEN H Q WEI J H YANG J S | 2012 | Chem Biodivers2012，9，2： | 1 |
| 20 | The Orp and Ph Profiles During Simultaneous Nitrification and Denitrification of Low Carbon Municipal Wastewater显示文摘 | Fang Q Wei C H Zhang C S | 2009 | International Journal of Envi- ronment and Pollution2009，37，1： | 1 |
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