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| 1 | Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis显示文摘OBJECTIVE:To investigate the effectiveness of Banxia Xiexin decoction(BXD)in a rat model of chronic atrophic gastritis(CAG).METHODS:Sixty 6-week-old healthy Wistar rats(30 males,30 females)were used in the present study.A rat model of CAG was successfully established using the combined active immunization/ethanol/sodium deoxycholate method.BXD was prepared from a mixture of seven Chinese herbs,and was intragastrically administered to CAG rats at three different doses(6,12,and 24 g·kg^-1·d^-1).Af-ter 24 weeks,the rats were euthanized,and gastric tissue specimens were collected.Gastric mucosal specimens were stained with hematoxylin and eosin for histological examination to evaluate the degree of inflammation and morphological changes.Immunohistochemical staining was performed to examine the mucosal expression of proliferating cell nuclear antigen.Serum gastrin levels were measured using radioimmunoassay.The expression of Notch signaling-associated genes was examined by quantitative polymerase chain reaction and Western blot assay.RESULTS:BXD at all three doses significantly reversed the adverse effects generated by CAG in rats.Compared with control rats,the CAG rats who were administered BXD had an accelerated growth rate,reduced inflammatory cell infiltration,improved gastric mucosal morphology,augmented thickness of the gastric mucosa,increased number of gastric glands,enhanced mucosal expression of proliferating cell nuclear antigen,and elevated serum gastrin levels. | Bai Yu Chen Yongcan Chen Yu Yan Maoxiang Wei Hongquan Wang Hengcang Zeng Guoliang Yang Xiyin | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 14 |
| 2 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 3 | Effect of a Traditional Chinese Medicine combined therapy on adolescent idiopathic scoliosis:a randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness of a combined Traditional Chinese Medicine(TCM) therapy versus conventional treatment on adolescent idiopathic scoliosis.METHODS:One hundred twenty outpatients with mild and moderate adolescent idiopathic scoliosis were randomly divided into a TCM group(TCMG)and a brace group(CG).TCMG patients underwent Daoyin,Tuina,and acupotomology therapies.CG patients were treated with a Milwaukee brace.Each patient's Cobb angle was measured after 12 and 24 months of treatment,and pulmonary function was determined after 12 months of treatment.Average electromyogram(AEMG) ratio of the surface electromyogram was measured after 6 and 12 months of treatment and followed-up after 18 and 24 months.RESULTS:The Cobb angle significantly decreased in both groups after 12 months of treatment compared with before treatment(P< 0.05).The percentages of original Cobb angle in TCMG and CG were51.4%and 47.8%(P > 0.05) after 12 months and62.5%and 34.7%(P < 0.05) after 24 months,respectively.Pulmonary function significantly improved after 12 months in TCMG(P < 0.05) but significantly decreased in CG(P < 0.05).The AEMG ratio was significantly lower(P < 0.01) and tended to remain at1 after stopping treatment in TCMG,but increased in CG(P<0.05).CONCLUSION:TCM combined therapy can prevent the progression of scoliosis.The AEMG ratio is a promising index that could replace radiography in the evaluation of treatment effect and progression in scoliosis. | Wei Hui Xu Jinyuan Jiang Zhong Ye Shuliang Song Hongquan Ning Xitao Huang Huanmin Chen Wei Pei Jianwei Jiang Nengyi Chen Shao Du Honggen | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 9 |
| 4 | Kindlin-2 expression in adult tissues correlates with their embryonic origins显示文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development. | ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan | 2014 | Science China(Life Sciences)2014，57，7： | 8 |
| 5 | Cloning and bioinformatics analysis of a full-length cDNA of porcine CRl-like gene显示文摘 | Jing Cheng Junbing Jiang Junxing Zhao Zhirui Wang Yaogui Sun Haili Ma Kuohai Fan Wei Yin Na Sun Zhiwei Wang Xin Zhao Hongquan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 7 |
| 6 | Fast Secret Key Generation Based on Dynamic Private Pilot from Static Wireless Channels显示文摘In static or quasi-static wireless channel environments, secret key generation(SKG) based on wireless channels is vulnerable to active attacks due to the openness and invariance of public pilot, especially man-inthe-middle(MITM) attacks, where attacker acts as a transparent relay to manipulate channel measurements and derive the generated keys. In order to fight against this attack, a dynamic private pilot is designed, where both private pilot and secret key are derived from the characteristics of wireless channels and private to third party. In static or quasi-static environments, we use singular value decomposition techniques to reconstitute the wireless channels to improve the randomness of the wireless channels. Private pilot can encrypt and authenticate the wireless channels, which can make channel state information intercepted by MITM attacker reduced to zero and the SKG rate close to that without attacks. Results of analysis and simulation show the proposed SKG scheme can withdraw the MITM attacks. | Yu Huang Liang Jin Hongquan Wei Zhou Zhong Shengjun Zhang | 2018 | China Communications2018，15，11： | 4 |
| 7 | Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls显示文摘heterotrimeric guanine 核苷酸绑定蛋白质(G 蛋白质) 被表明了各种各样的发信号调停在植物的小径。然而,它在发信号的 phytochrome A (phyA ) 的角色留下逃犯。在这研究,我们发现新调停 phyA 的显型指明了 far-red 照耀(FR ) preconditioned 房间死亡,它仅仅在跟随暴露到白光(WL ) 的 FR-grown 幼苗的胚轴发生。房间死亡在 G 变异的 gpa1 被减轻,但是与野类型(WT ) 比较在 G 变异的 agb1 加重了,在调停 phyA 的房间死亡小径的 GPA1 和 AGB1 的对抗角色的陈述语气。进一步的调查显示 nonphotoconvertible protochlorophyllide (Pchlide633 ) 的导致 FR 的累积,在暴露上产生反应的氧种类(ROS ) 到 WL,为前提 FR 的房间死亡被要求。而且, ROS 主要在叶绿体被检测用荧光灯探查。有趣地,到黑暗成年的幼苗的 H2O2 的申请导致类似于前提 FR 的房间死亡的显型。这表明 ROS 是为房间死亡的一个批评调停人。另外,我们观察到 agb1 比 WT 幼苗对 H2O2 更敏感,显示 G 蛋白质可以也修改到 ROS 应力的幼苗的敏感。一起拿这些结果,我们推断 G 蛋白质可以涉及表明小径调整 Arabidopsis 胚轴的前提 FR 的房间死亡的 phyA。在 phyA 位于 G 蛋白质的参与下面发信号的可能的机制在这研究被讨论。 | Qing Wei Wenbin Zhou Guangzhen Hu Jiamian Wei Hongquan Yang Jirong Huang | 2008 | Cell Research2008，18，9： | 4 |
| 8 | CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells显示文摘Slug,a member of the Snail family of transcriptional repressors,plays a key role in cancer progression,cellular plasticity,and epithelial to mesenchymal transition(EMT).Slug is a fast-turnover protein and its stability is controlled by post-translational modifications.Here,we identified that Slug is acetylated by acetyltransferase CREB-binding protein(CBP)in breast cancer cells.CBP directly interacts with the C-terminal domain of Slug through its catalytic histone acetyltransferase(HAT)domain,leading to acetylation of Slug at lysines 166 and 211.Analysis with acetylation-specific antibodies revealed that Slug is highly acetylated in metastatic breast cancer cells.Notably,Slug acetylation,mediated by CBP at lysines 166 and 211,doubles its halflife and increases its stability.Further,acetylated Slug downregulates the expression of E-cadherin,the epithelial marker,and upregulates the expression of N-cadherin and vimentin,thereby promoting breast cancer cell migration.In conclusion,the present study demonstrates that CBP-mediated Slug acetylation increases its stability,promoting EMT and migration of breast cancer cells. | Xiaoyan Dai Yanli Xin Weizhi Xu Xinxia Tian Xiaofan Wei Hongquan Zhang | 2021 | Science China(Life Sciences)2021，64，4： | 4 |
| 9 | The application of three-dimensional seismic spectral decomposition and semblance attribute to characterizing the deepwater channel depositional elements in the Taranaki Basin of New Zealand显示文摘In the past few years, three-dimensional(3-D) seismogram has become an essential tool for the interpretation of subsurface stratigraphy and depositional systems. Seismic stratigraphy in conjunction with seismic geomorphology has elevated the degree to which seismic data can facilitate geological interpretation, especially in a deepwater environment. Technologies such as time slicing and interval attribute analysis can enhance geomorphological interpretations, and, when integrated with stratigraphic analyses, can yield insights regarding distribution of seal and reservoir facies. Multiple attributes corendering can further bring out features of geological interest that other technologies may overlook. This method involves corender spectral decomposition components(SDC) with semblance attributes to describe the distribution of deepwater channel elements and the boundaries of deepwater sinuous channel. Applying this technology to four elements is observed:(1) point-bars,(2) migration of channel meander loops,(3) channel erosion/cut, and(4) avulsion. The planview expression of the deepwater channel ranges from low sinuosity to high sinuosity. Furthermore, this technology has enabled interpreters to visualize details of complex depositional elements and can be used to predict net-to-gross ratio in channel systems, which can be incorporated into borehole planning for exploration as well as development needs to improve risk management significantly. The technology is applied to the study area in an effort to illustrate the variety of interpretation technologies available to the geoscientist. | LI Quan WU Wei YU Shui KANG Hongquan TONG Liqing CAO Xiangyang LIU Xiaolong | 2017 | Acta Oceanologica Sinica2017，36，9： | 3 |
| 10 | Identification of novel Lynch syndrome mutations in Chinese patients with endometriod endometrial cancer显示文摘Objective:Lynch syndrome(LS)predisposes patients to early onset endometrioid endometrial cancer(EEC).However,little is known about LS-related EEC in the Chinese population.The aim of this study was to investigate the prevalence of LS and to identify the specific variants of LS in Chinese patients with EEC.Methods:We applied universal immunohistochemistry screening to detect the expression of mismatch repair(MMR)proteins,which was followed by MLH1 methylation analysis to identify suspected LS cases,next-generation sequencing(NGS)to confirm LS,and microsatellite instability(MSI)analysis to verify LS.Results:We collected 211 samples with EEC.Twenty-seven(27/211,12.8%)EEC cases had a loss of MMR protein expression.After MLH1 methylation analysis,16 EEC cases were suggested to be associated with LS.Finally,through NGS and MSI analysis,we determined that 10 EEC(10/209,4.78%)cases were associated with LS.Among those cases,3 unreported mutations(1 frameshift and 2 nonsense)were identified.M SH6 c.597_597delC,found in 4 patients,is likely to be a founder mutation in China.Conclusions:We demonstrated the feasibility of a process for LS screening in Chinese patients with EEC,by using universal immunohistochemistry screening followed by MLH1 methylation analysis and confirmation through NGS and MSI analysis.The novel mutations identified in this study expand knowledge of LS. | Caixia Ren Yan Liu Yuxiang Wang Yan Tang Yawei Wei Congrong Liu Hongquan Zhang | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 11 | The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis显示文摘PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor progression.Inhibition of DNA methyltransferases(DNMTs)leads to elevated hyaluronan levels;however,whether DNMT inhibitors control PH20 remains unclear.Here,we report that the DNMT1 inhibitor,decitabine,suppresses PH20 expression by activating the long non-coding RNA PHACTR2-AS1(PAS1).PAS1 forms a tripartite complex with the RNA-binding protein vigilin and histone methyltransferase SUV39H1.The interaction between PAS1 and vigilin maintains the stability of PAS1.Meanwhile,PAS1 recruits SUV39H1 to trigger the H3K9 methylation of PH20,resulting in its silencing.Functionally,PAS1 inhibits breast cancer growth and metastasis,at least partially,by suppressing PH20.Combination therapy of decitabine and PAS1-30nt-RNA,which directly binds to SUV39H1,effectively blocked breast cancer growth and metastasis in mice.Taken together,DNMT1,PAS1,and PH20 comprise a regulatory axis to control breast cancer growth and metastasis.These findings reveal that the DNMT1-PAS1-PH20 axis is a potential therapeutic target for breast cancer. | Yenan Fu Xi Zhang Xiao Liu Peng Wang Wenhui Chu Wei Zhao Yunling Wang Guangbiao Zhou Yu Yu Hongquan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 12 | Four and a half LIM domains protein 1 can be as a double-edged sword in cancer progression显示文摘Four and a half LIM domains protein 1(FH L1),as the name suggests,contains four and a half LIM domains capable o f interacting with various molecules,including structural proteins,kinases,and transcriptional machinery.FHL1 contains a zinc-finger domain and performs diverse roles in regulation of gene transcription,cytoarchitecture,cell proliferation,and signal transduction.Several studies have validated the importance of FHL1 in muscle development,myopathy,and cardiovascular diseases.Mutations in the FHL1 gene are associated with various myopathies.Recently,FHL1 was identified as a major host factor for chikungunya virus(CHIKV)infection in both humans and mice.Based on more recent findings over the last decade,FHL1 is proposed to play a dual role in cancer progression.On the one hand,FHL1 expression is suppressed in several cancer types,which correlates with increased metastatic disease and decreased survival.Moreover,FHL1 is reported to inhibit tum or cell growth and migration by associating with diverse signals,such as TGF-P and ER,and therefore considered a tumor suppressor.On the other hand,FHL1 can function as an oncogenic protein that promotes tumor progression upon phosphorylation,reflecting complex roles in cancer.This review primarily focuses on the dual role and underlying mechanisms of action of FHL1 in human cancer progression and its clinical relevance. | Xiaofan Wei Hongquan Zhang | 2020 | Cancer Biology & Medicine2020，17，2： | 2 |
| 13 | Study on Temperature Modulation Techniques for Micro Gas Sensors显示文摘The sensitivity and selectivity of gas sensors are related with not only sensing material,but also their operating temperatures.Applying this property,temperature modulation technique has been proposed to improve the selectivity of gas sensors.With a newly developed alumina based micro gas sensor,the sensitivity to CO and CH_4 at different operating temperatures was investigated.By modulating the temperature of the sensor at pulse and sine wave modes with different frequencies and amplitudes,the dynamic responses of the sensor were measured and processed.Results show that the modulating waveshape plays an important role in the improvement of selectivity,while the influence of frequency is small at the suitable sampling frequency in the range of 25 mHz~200 mHz. | Guangfen Wei Zhenan Tang Hongquan Zhang Yanbing Xue Jun Yu | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 14 | Securities Transaction Tax and Stock Market Behavior in an Agent-Based Financial Market Model显示文摘 | Hongquan Li Mengyun Tang Wei Shang Shouyang Wang | 2013 | Procedia Computer Science2013，，： | 1 |
| 15 | Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm显示文摘Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues originate. We compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos. Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues. | ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan | 2015 | Science China(Life Sciences)2015，58，5： | 1 |
| 16 | Synthesis and characterization of maleated ionomers viaring-opening reaction of epoxidized styrene-butadiene rubber with potassium hydrogen maleate and study of their behavior as compatibilizer显示文摘 | Xie Hongquan Chen Yong Yang Wei | 2006 | J Appl Polym Sci2006，101，1： | 1 |
| 17 | Synthesis of sulfonated rubber ionomers by the ring-opening reaction of epoxidized styrene-butadiene rubber, their characterization and their properties显示文摘 | Xie Hongquan Chen Yong Yang Wei | 2006 | J Appl Polym Sci2006，101，5： | 1 |
| 18 | AN EXPERIMENTAL STUDY OF THE LARGE SCALE COHERENT STRUCTURES IN A FORCED FREE SHEAR LAYER显示文摘The dynamic characteristics of the large scale coherent structures in a forced free shear layer are experi-mentally studied by means of flow visualization. The quantitative measurements are acquired by the use of a LDV. Itis shown that the development of the coherent structures can be greatly influenced by upstream artificial perturbationsand as a result the mixing in the layer can be controlled. Like vortex merging, vortex splitting is also a common evolu-tion pattern in the development of the coherent structures. | Zhang Hongquan Shu Wei, Department of Mechanics, Tianfin University, Tianjin, China | 1990 | Acta Mechanica Sinica1990，6，1： | 1 |
| 19 | Synthesis and characterization of maleated ionomers via ring-opening reaction of epoxidized SBR with potassium hydrogen maleate and study of their behavior as compatibilizer显示文摘 | Xie Hongquan Chen Yong Yang Wei | 2006 | J Appl Polym Sci2006，101，1： | 1 |
| 20 | Opti- mizing the method used to design the trajectory of a hori zontal well 显示文摘 | Qi Bin Chen Ping Xia Hongquan Wei Chenxing | 2014 | Chemistry and Technology of Fuels and Oils2014，50，4： | 1 |
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