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| 1 | Feasibility of Estimating Heavy Metal Contaminations in Floodplain Soils Using Laboratory-Based Hyperspectral Data—A Case Study Along Le’an River, China显示文摘It is necessary to estimate heavy metal concentrations within soils for understanding heavy metal contaminations and for keeping the sustainable developments of ecosystems.This study,with the floodplain along Le'an River and its two branches in Jiangxi Province of China as a case study,aimed to explore the feasibility of estimating concentrations of heavy metal lead(Pb),copper(Cu) and zinc(Zn) within soils using laboratory-based hyperspectral data.Thirty soil samples were collected,and their hyperspectral data,soil organic matters and Pb,Cu and Zn concentrations were measured in the laboratory.The potential relations among hyperspectral data,soil organic matter and Pb,Cu and Zn concentrations were explored and further used to estimate Pb,Cu and Zn concentrations from hyperspectral data with soil organic matter as a bridge.The results showed that the ratio of the first-order derivatives of spectral absorbance at wavelengths 624 and 564 nm could explain 52% of the variation of soil organic matter;the soil organic matter could ex-plain 59%,51% and 50% of the variation of Pb,Cu and Zn concentrations with estimated standard errors of 1.41,48.27 and 45.15 mg·kg-1;and the absolute estimation errors were 8%-56%,12%-118% and 2%-22%,and 50%,67% and 100% of them were less than 25% for Pb,Cu and Zn concentration estimations.We concluded that the laboratory-based hyperspectral data hold potentials in esti-mating concentrations of heavy metal Pb,Cu and Zn in soils.More sampling points or other potential linear and non-linear regression methods should be used for improving the stabilities and accuracies of the estimation models. | LIU Yaolin LI Wei WU Guofeng XU Xinguo | 2011 | Geo-Spatial Information Science2011，14，1： | 7 |
| 2 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
| 3 | Selective oxidation of propane to acrylic acid over mixed metal oxide catalysts显示文摘MoVTeNbO 的催化表演上的原子比率,水内容,氧内容,和锻烧温度混合了的金属的效果为到丙烯酸的酸的丙烷的选择氧化的氧化物催化剂系统被调查了并且讨论。在学习的催化剂之中,在 600 ° C 的温度锻烧的 MoVTeNbO 催化剂在氮的气氛下面为丙烯酸的酸以丙烷变换和选择显示出最好的表演,这被发现。为丙烷的有效 MoVTeNbO 氧化物催化剂到丙烯酸的酸的选择氧化与比较喜欢的金属的联合被获得原子比率(瞬间 1 V 0.31 Te 0.23 Nb 0.12) 。为丙烷的选择氧化的最佳反应条件是 C 3 H 8:O2 :H 2 O:N 2= 4.4:12.8:15.3:36.9。在如此的条件下面,丙烷的变换和丙烯酸的酸的最大的收益分别地到达了大约 50% 和 21% 。 | Wei Zheng Zhenxing Yu Ping Zhang Yuhang Zhang Hongying Fu Xiaoli Zhang Qiquan Sun Xinguo Hu | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 3 |
| 4 | Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer’s disease显示文摘Gene therapy represents a promising treatment for the Alzheimer’s disease(AD). However,gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able to be specifically delivered to the amyloid plaques through surface modification with both CGN peptide for the blood–brain barrier(BBB)penetration and QSH peptide for β-amyloid binding. But, whether the as-designed nanocomplex could indeed improve the gene accumulation in the impaired neuron cells and ameliorate AD-associated symptoms remains further study. Herein, we prepared the nanocomplexes with an siRNA against β-site amyloid precursor protein-cleaving enzyme 1(BACE1), the rate-limiting enzyme of Aβ production, as the therapeutic siRNA of AD. The nanocomplexes exhibited high distribution in the Aβ deposits-enriched hippocampus, especially in the neurons near the amyloid plaques after intravenous administration. In APP/PS1 transgenic mice, the nanocomplexes down-regulated BACE1 in both mRNA and protein levels,as well as Aβ and amyloid plaques to the level of wild-type mice. Moreover, the nanocomplexes significantly increased the level of synaptophysin and rescued memory loss of the AD transgenic mice without hematological or histological toxicity. Taken together, this work presented direct evidences that the design of precise gene delivery to the AD lesions markedly improves the therapeutic outcome. | Qian Guo Xiaoyao Zheng Peng Yang Xiaoying Pang Kang Qian Pengzhen Wang Shuting Xu Dongyu Sheng Liuchang Wang Jinxu Cao Wei Lu Qizhi Zhang Xinguo Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 2 |
| 5 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 6 | Lectin-conjugated PEG–PLA nanoparticles: Preparation and brain delivery after intranasal administration显示文摘 | Xiaoling Gao Weixing Tao Wei Lu Qizhi Zhang Yan Zhang Xinguo Jiang Shoukuan Fu | 2006 | Biomaterials2006，，18： | 1 |
| 7 | Effect of Respective Additions of Ga, Zr and Combined Additions of Co, Ga, Zr on Magnetic Properties of Remanence-enhanced Nd_(8.4) Fe_(87.1) B_(4.5) Alloy显示文摘The effect of a partial substitution of Zr, Ga; Co and Ga; Co. Ga and Zr; respectively, for Fe on the structure and magnetic properties of Nd8.4Fe87.1B4.5 alloy prepared by mechanical alloying has been studied in detail. It has been shown that, intrinsic coercivity μ0 Hc and maximum magnetic energy product (BH)max increase for only Zr or Ga-containing samples, which is mainly due to the refinement of soft grains. The combined addition of Co and Ga is less effective for improving μoHc and (BH)max than the respective addition of Co or Ga. which may be due to the formation of CsCl-type CoGa. μoHc and (BH)max for combined Co, Ga. Zr-added alloy are higher than those for the combined Co, Ga-added alloy but lower than those for only Zr-containing alloy. | Baozhi CUI, Xiaokai SUN, Wei LIU, Zhidong ZHANG, Dianyu GENG and Xinguo ZHAO (Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 2000 | Journal of Materials Science & Technology2000，16，2： | 1 |
| 8 | Structural and Magnetic Properties of Sm_3(Fe,Ti)_(29) and Sm_3(Fe,Ti)_(29)X_y (X=H, N) Compounds显示文摘The alloy with nominal composition Sm2(Fe0.94Ti0.06)17 is prepared by arc-melting, hydrogenation and nitrogenation processes. The Sm2(Fe0.94Ti0.06)17 alloy has a single phase of Sm3(Fe, Ti)29 with the Nd3(Fe, Ti)29-type structure. The corresponding hydride phase with the same phase structure of the parent alloy was formed after a hydrogen decrepitation (HD) process at 300℃. The hydrogenation at 800℃ mainly shows a HDDR process. The HD and nitrogenation at 500℃ result in increasing the Curie temperature of the alloy by 72℃ and by 158℃ due to lattice expansions, respectively. The anisotropic and isotropic Sm3(Fe. Ti)29Ny magnets are obtained after HD, HDDR and the consequent nitrogenation, respectively. The optimum magnetic properties of Sm3(Fe, Ti)29Ny powders achieved in the above two processes are: (i) Br=0;82 T, iHc=4.48 kA/cm. (BH)max=54.3 kJ/m3, (ii) Br=0.68 T, iHc=8.14 kA/cm, (BH)max=66.4 kJ/m3. | Xinguo ZHAO, Zhidong ZHANG, Zhijun GUO, Wei LIU, Dianyu GENG and Baozhi CUI (Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China | 2000 | Journal of Materials Science & Technology2000，16，2： | 1 |
| 9 | Hard Magnetic Properties of Sm-Fe-C Based Alloys Prepared by Mechanical Alloying显示文摘The structure and magnetic properties of Sm.Fel00-1.5y C0.5y(y=8-20) alloys prepared by mechanical alloying (MA) from Sm, Fe and graphite have been investigated systematically. In order to improve hard magnetic properties of the alloys prepared by mechanical alloying, a new method consisting of re-milling and re-annealing was developed. After being re-milled and re-annealed, the Curie temperature TC of the Sm-Fe-C alloys changes. The TC of 2:17 phase increases, whereas the TC of 2.14.1 phase decreases. After being re-annealed at low temperatures, the grain sizes of hard phases are smaller than those in the alloys annealed at high temperatures. The effects of Co or Ti substitution for Fe are studied. | Dianyu GENG, Zhidong ZHANG, Baozhi CUI, Zhijun GUO, Wei LIU and Xinguo ZHAO (International Center for Materials Physics, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 2000 | Journal of Materials Science & Technology2000，16，2： | 1 |
| 10 | Rapid startracking algorithm for star sensor 显示文摘 | Jiang Jie Zhang Guangjun Wei Xinguo | 2009 | IEEE Aerospace andElectronic Systems Magazine2009，24，9： | 1 |
| 11 | Subspace gradient domain mesh deformation显示文摘 | Jin Huang Xiaohan Shi Xinguo Liu Kun Zhou Li-Yi Wei Shang-Hua Teng Hujun Bao Baining Guo Heung-Yeung Shum | 2006 | ACM Transactions on Graphics (TOG)2006，，3： | 1 |
| 12 | Electrochemical properties of rechargeable lithium batteries with sulfur-containing composite cathode materials显示文摘 | Zheng Wei Hu Xinguo Zhang Cuifen | 2006 | Electrochemical and Solid-State Letters2006，9，7： | 1 |
| 13 | Identification of serum metabolites enhancing inflammatory responses in COVID-19显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is characterized by a strong production of inflammatory cytokines such as TNF and IL-6,which underlie the severity of the disease.However,the molecular mechanisms responsible for such a strong immune response remains unclear.Here,utilizing targeted tandem mass spectrometry to analyze serum metabolome and lipidome in COVID-19 patients at different temporal stages,we identified that 611 metabolites(of 1,039)were significantly altered in COVID-19 patients.Among them,two metabolites,agmatine and putrescine,were prominently elevated in the serum of patients;and 2-quinolinecarboxylate was changed in a biphasic manner,elevated during early COVID-19 infection but levelled off.When tested in mouse embryonic fibroblasts(MEFs)and macrophages,these 3 metabolites were found to activate the NF-κB pathway that plays a pivotal role in governing cytokine production.Importantly,these metabolites were each able to cause strong increase of TNF and IL-6 levels when administered to wildtype mice,but not in the mice lacking NF-κB.Intriguingly,these metabolites have little effects on the activation of interferon regulatory factors(IRFs)for the production of type I interferons(IFNs)for antiviral defenses.These data suggest that circulating metabolites resulting from COVID-19 infection may act as effectors to elicit the peculiar systemic inflammatory responses,exhibiting severely strong proinflammatory cytokine production with limited induction of the interferons.Our study may provide a rationale for development of drugs to alleviate inflammation in COVID-19 patients. | Chen-Song Zhang Bingchang Zhang Mengqi Li Xiaoyan Wei Kai Gong Zhiyong Li Xiangyang Yao Jianfeng Wu Cixiong Zhang Mingxia Zhu Lei Zhang Xiufeng Sun Yi-Hong Zhan Zhengye Jiang Wenpeng Zhao Wei Zhong Xinguo Zhuang Dawang Zhou Hai-Long Piao Sheng-Cai Lin Zhanxiang Wang | 2022 | Science China(Life Sciences)2022，65，10： | 1 |
| 14 | Iterative algorithm for autonomous star identification 显示文摘 | Li Jian Wei Xinguo Zhang Guangjun | 2015 | Aerospace and Electronic Systems IEEE Transactions on2015，51，1： | 1 |
| 15 | Preparation of Nimodipine-loaded Microemulsion for Intranal Delivery and Evaluation on the Targeting Efficiency to the Brain显示文摘 | Zhang Qizhi Jiang Xinguo Jiang Wenming Lu Wei Su Lina Shi Zhenqi | 2004 | International Journal of Pharmaceutics2004，275，12： | 1 |
| 16 | Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice显示文摘 | Wei Zhong Yantao Zhao Yunan Tang Xiaoli Wei Xue Shi Wenlong Sun Xiuhua Sun Xinmin Yin Xinguo Sun Seongho Kim Craig J. McClain Xiang Zhang Zhanxiang Zhou | 2012 | The American Journal of Pathology2012，，3： | 1 |
| 17 | Sorption properties of green waste biochar for two triazine pesticides显示文摘 | Wei Zheng Ming Xinguo Teresa Chow | 2010 | Journal of Hazardous Materials2010，181，13： | 1 |
| 18 | Preservation of Hepatocyte Nuclear Factor‐4α Contributes to the Beneficial Effect of Dietary Medium Chain Triglyceride on Alcohol‐Induced Hepatic Lipid Dyshomeostasis in Rats显示文摘 | Qiong Li Wei Zhong Yunping Qiu Xinqin Kang Xiuhua Sun Xiaobing Tan Yantao Zhao Xinguo Sun Wei Jia Zhanxiang Zhou | 2012 | Alcohol Clin Exp Res2012，，4： | 1 |
| 19 | S-curve centroiding error correction for star sensor显示文摘 | Xinguo Wei Jia Xu Jian Li Jinyun Yan Guangjun Zhang | 2014 | Acta Astronautica2014，，： | 1 |
| 20 | Phase Transformation and Magnetic Properties of Mechanically Alloyed PrCo5-based Magnets显示文摘基于 PrCo_5 的 nanograin Pr_xCo_(100x )(x=14~22 ) 有高 coercivitywere 的合金由机械 alloying 并且随后的退火综合了。结晶化,阶段部件和合金的磁性系统地被调查。为 x=14 的合金的主要阶段与菱形的 Th_2Zn_(17 ) 类型是 Pr_2Co_(17 ) 。Pr_2Co_(17 ) 的数量与增加 Pr 内容分阶段执行减少,并且有 hexagonalCaCu_5 类型的将近单个的阶段 PrCo_5 在 Pr_(19 )Co_(81 ) 合金被形成。 Pr 内容的另外的增加与它大约 350 deg C.Remanences 减少单调地与增加 Pr 满足的居里温度导致另一个有磁力地难的 Pr_2Co_7 阶段的形成,而 coercivities 增加,为更高的 Pr 内容为 2 min ,然后减少为 5 h 和退火的 at973 K 在Pri_( 19 )Co_( 81 )粉末 milled 到达 2040 kA/m ( 25.6 kOe )的最大值。高 coercivity 被归因于 PrCo_5 阶段和它的 nanoscale 谷物尺寸的高 anisotropy 地。 | Xinguo ZHAO Zhidong ZHANG Qi YAO Jinjun LIU Weijun REN Wei LIU Dianyu GENG | 2006 | Journal of Materials Science & Technology2006，22，6： | 1 |
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